MRT67307

CAS : 1190378-57-4

Ref. TM-T0097

Informations sur le produit

• Nom: MRT67307
• Synonymes: MRT67307 HCl
• CAS: 1190378-57-4

Description

Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy. MRT67307 prevents the phosphorylation of IRF3 and the production of IFN-β and increases toll-like receptor-induced IL-10 and IL-1ra secretion in macrophages. MRT67307 is a kinase inhibitor that has been shown to inhibit TBK1, MARK1-4, IKKε, and NUAK1 (IC50 values are 19, 27-52, 160, and 230 nM, respectively), the salt-inducible kinases (SIKs; IC50s =250, 67, and 430 nM for SIK1, SIK2, and SIK3, respectively) and ULK1 and ULK2 (IC50s = 45 and 38 nM, respectively).

• Marque: Targetmol

Propriétés chimiques

• Masse moléculaire: 464.6
• Formule: C₂₆H₃₆N₆O₂
• Degré de pureté: 99.79%
• Couleur/Forme: Solid