RCC
Les récepteurs des chimiokines C-C (CCRs) sont un groupe de GPCR qui répondent aux chimiokines, des molécules de signalisation qui guident la migration des cellules immunitaires vers les sites d'inflammation ou d'infection. Les CCR jouent un rôle crucial dans les réponses immunitaires, l'inflammation et le développement de diverses maladies, y compris les troubles auto-immuns et le cancer. La modulation de l'activité des CCR est explorée comme une stratégie thérapeutique pour des affections telles que la polyarthrite rhumatoïde, la sclérose en plaques et l'infection par le VIH. Chez CymitQuimica, nous offrons une gamme de modulateurs de CCR de haute qualité pour soutenir vos recherches en immunologie, inflammation et développement thérapeutique.
136 produits trouvés pour "RCC"
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Leronlimab
CAS :<p>Leronlimab (PRO 140), a humanized IgG4 monoclonal antibody, targets CCR5 to combat HIV and cancer.</p>Degré de pureté :SDS-PAGE:95.0%;SEC-HPLC:99.6%Couleur et forme :LiquidMasse moléculaire :146.66 kDaMogamulizumab
CAS :<p>Mogamulizumab is a monoclonal antibody targeting CC chemokine receptor 4 with anticancer effects, used in ATLL and CTCL studies.</p>Degré de pureté :SDS-PAGE:97.3%;SEC-HPLC:99.4%Couleur et forme :LiquidMasse moléculaire :146.43 kDaINCB-9471
CAS :<p>INCB-9471 is a CCR5 antagonist with anti-HIV activity and inhibits the interaction between HIV-1 gp120.</p>Formule :C30H40F3N5O2Degré de pureté :98.80%Couleur et forme :SolidMasse moléculaire :559.666CCR2-RA-[R]
CAS :<p>CCR2-RA-[R] is a C-C chemokine receptor type 2 (CCR2) allosteric antagonist (IC50: 103 nM).</p>Formule :C18H19ClFNO3Degré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :351.8CCX140
CAS :<p>CCX140 (CCX140-B) (CCX140-B) is an antagonist of CCR2.</p>Formule :C20H13ClF3N5O3SDegré de pureté :99.66% - 99.95%Couleur et forme :SolidMasse moléculaire :495.86AZ084
CAS :<p>AZ084 is a potent, selective, allosteric, and oral active CCR8 antagonist (Ki: 0.9 nM). It has the potential to treat asthma.</p>Formule :C26H34N4O2Degré de pureté :97.12%Couleur et forme :SolidMasse moléculaire :434.57ML604086
CAS :<p>ML604086 suppresses CCL1 mediated chemotaxis and enhances intracellular Ca2 concentrations.</p>Formule :C27H32N4O4SDegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :508.63RS102895 hydrochloride
CAS :<p>RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).</p>Formule :C21H22ClF3N2O2Degré de pureté :98.95%Couleur et forme :SolidMasse moléculaire :426.86MK-0812 Succinate
CAS :<p>MK-0812 Succinate is an effective and selective CCR2 antagonist.</p>Formule :C28H40F3N3O7Degré de pureté :98.62% - 99.93%Couleur et forme :SolidMasse moléculaire :587.63J-113863
CAS :<p>J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM).</p>Formule :C30H37Cl2IN2O2Degré de pureté :95.11%Couleur et forme :SolidMasse moléculaire :655.44CCR4 antagonist 3
CAS :<p>Orally active CCR4 antagonist with piperidinyl-azetidine; IC50: 22 nM (calcium flux), 50 nM (CTX); antitumor effects.</p>Formule :C24H27Cl2N7OCouleur et forme :SolidMasse moléculaire :500.43Plozalizumab
CAS :<p>Plozalizumab (MLN-1202) is a humanized selective and potent anti-CCR2 antibody.Plozalizumab has antitumor activity.Plozalizumab is used in the study of</p>Degré de pureté :96.4%Couleur et forme :LiquidMasse moléculaire :146.02 kDaCCR8 antagonist 1
CAS :<p>CCR8 antagonist 1 is an antagonist of C-C Motif Chemokine Receptor 8 (CCR8) with a Ki value of 1.6 nM.</p>Formule :C26H29N3O5SDegré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :495.59Denikitug
<p>Denikitug is a chimeric antibody of the IgG1κ type that targets CCR8, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.</p>Couleur et forme :Odour LiquidLanerkitug
<p>Lanerkitug is a humanized IgG1λ2 antibody that targets CCR8, with HumanIgG1lambda2, Isotype Control serving as its corresponding isotype control.</p>Couleur et forme :Odour LiquidCCR4 antagonist 3 hydrochloride
CAS :<p>Orally active CCR4 antagonist 3 hydrochloride with potent selectivity, IC50s: 22/50 nM; has antitumor properties.</p>Formule :C24H27Cl2N7O·xHClCouleur et forme :SolidSQA1
CAS :<p>SQA1 is a derivative of a phthalamide (SQA) and acts as a CCR6 antagonist with a Kd of 250 nM, as well as a CXCR2 inhibitor. It occupies an intracellular pocket that overlaps with the G protein binding site, stabilizing the pocket's closed conformation.</p>Formule :C22H26N4O5Couleur et forme :SolidMasse moléculaire :426.47Zn-DPA-maytansinoid conjugate 1
<p>Zn-DPA-maytansinoid 1 targets checkpoints, shrinks tumors, and heats TME.</p>Formule :C115H145ClN18O31S2Zn2Couleur et forme :SolidMasse moléculaire :2505.83Maceneolignan H
CAS :<p>Maceneolignan H, a neolignane from Myristica fragrans, selectively blocks CCR3 (EC50=1.4μM) with allergy research potential.</p>Formule :C24H30O7Couleur et forme :SolidMasse moléculaire :430.49CKLF1-C27 TFA
<p>CKLF1-C27 peptide activates ERK1/2 via CCR4, competes with CKLF1, promotes HUVEC growth, and has psoriasis research potential.</p>Formule :C153H244F3N39O39Couleur et forme :SolidMasse moléculaire :3310.8CCR2 antagonist 1
CAS :<p>CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM).</p>Formule :C28H32BrF3N2OCouleur et forme :SolidMasse moléculaire :549.47Denrakibart
<p>Denrakibart is a humanized IgG2κ antibody targeting CCL17, with HumanIgG2kappa, Isotype Control serving as the corresponding isotype control.</p>Couleur et forme :Odour LiquidAzirkitug
<p>Azirkitug is a humanized IgG1κ antibody targeting CCR8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.</p>Couleur et forme :Odour LiquidINCB 3284 dimesylate
CAS :<p>INCB 3284 dimesylate: oral CCR2 antagonist, blocks MCP-1/hCCR2 binding (IC50: 3.7 nM), potential in acute liver failure research.</p>Formule :C28H39F3N4O10S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :712.76Nebokitug
<p>Nebokitug is a humanized IgG1κ antibody targeting CCL24, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.</p>Couleur et forme :Odour LiquidCafelkibart
<p>Cafelkibart is a chimeric IgG1κ monoclonal antibody targeting CCR8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.</p>Couleur et forme :Odour LiquidCCR6 inhibitor 1
CAS :<p>CCR6 inhibitor 1 selectively blocks CCR6 (0.45 nM in monkeys, 6 nM in humans), aiding in vitro/vivo disease studies.</p>Formule :C24H23F3N4O3SDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :504.522-Methoxyhydroquinone
CAS :<p>2-Methoxyhydroquinone inhibits MAO-A and MAO-B and reduces TNF-α-induced CCL2 production, a precursor for synthesising the Hsp90 inhibitor Geldanamycin.</p>Formule :C7H8O3Degré de pureté :98.25%Couleur et forme :SolidMasse moléculaire :140.14CAP-100
<p>CAP-100 is a monoclonal antibody targeting CCR7. It neutralizes the ligand binding site and signaling of CCR7. This compound effectively inhibits migration, extravasation, homing, and survival in chronic lymphocytic leukemia (CLL) samples induced by CCR7. CAP-100 can mediate potent tumor cell killing through host immune mechanisms and exhibits favorable toxicity profiles in related hematopoietic cell subsets. It is involved in research on antitumor activity and diseases like chronic lymphocytic leukemia (CLL).</p>Couleur et forme :Odour LiquidChemokine Inhibitor Library
<p>A unique collection of xnum chemokines or chemokine receptors targeted compounds for high throughput and high content screening;</p>Couleur et forme :Odour SolidWAY-639418
CAS :<p>WAY-639418 has potential anti-inflammatory and anti-HIV activity and can be used to study CCR5-mediated inflammatory and immunomodulatory diseases.</p>Formule :C17H16ClN5Degré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :325.8CCR8 agonist 1
<p>CCR8 agonist1 (Compound 2) is an activator of CCR8 and is applicable in studies related to autoimmune diseases.</p>Formule :C22H29NO3Couleur et forme :SolidMasse moléculaire :355.47BMS-753426
CAS :<p>BMS-753426 is a potent and orally bioavailable antagonist of CCR2 .</p>Formule :C25H33F3N6O2Couleur et forme :SolidMasse moléculaire :506.574PF-232798
CAS :<p>PF-232798 is a second generation oral CCR5 antagonist with potent broad-spectrum anti-HIV-1 activity.</p>Formule :C29H40FN5O2Couleur et forme :SolidMasse moléculaire :509.66CCR6 antagonist 1
CAS :<p>CCR6 antagonist 1 blocks CCL20/CCR6, aiding autoimmune and IBD research.</p>Formule :C17H12F3NO2Degré de pureté :99.83%Couleur et forme :SoildMasse moléculaire :319.28NI-0701
<p>NI-0701 is a humanized antibody targeting CCL5/RANTES.</p>Degré de pureté :95.4% (SDS-PAGE); 99.4% (SEC-HPLC) - 95.4% (SDS-PAGE); 99.4% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :145.5kDaINCB3344 R-isomer
<p>INCB3344 is a potent CCR2 antagonist. INCB3344 R-isomer is the R-isomer of INCB3344.</p>Formule :C29H34F3N3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :577.59CHS-114
<p>CHS-114 (SRF-114) is a fully human IgG1 antibody targeting the (CCR8) receptor. It shows potential for research in head and neck squamous cell carcinoma (HNSCC). The isotype control for CHS-114 can be referred to as HumanIgG1kappa, Isotype Control.</p>Couleur et forme :Odour LiquidCCR6 antagonist 2
<p>CCR6 antagonist2 (Compound 20c) acts as a CCR6 antagonist with a Ki of 1.1 nM. It inhibits CCL20-induced calcium influx with an IC50 of 4.9 nM and suppresses the chemotactic migration of CCR6+ T cells with an IC50 of 190 nM.</p>Formule :C19H24N4O4Couleur et forme :SolidMasse moléculaire :372.42GSK-3050002
<p>GSK-3050002 (HGS-1035) is a humanized IgG1 antibody that targets and binds to CCL20. It holds potential for inflammation research. For isotype control, refer to Human IgG1 kappa, Isotype Control.</p>Couleur et forme :Odour LiquidMet-RANTES,human,acetate
<p>Met-RANTES (human) acetate is the acetate salt form of Met-RANTES (human). It acts as an antagonist for CCR1 and CCR5 receptors. This compound inhibits the human chemokines MIP-1α and MIP-1β, with respective IC50 values of 5 and 2 nM. Additionally, Met-RANTES (human) acetate reduces bone destruction and alleviates adjuvant-induced arthritis (AIA) in rats.</p>Couleur et forme :Odour SolidMLN-3897 TFA
<p>MLN-3897 TFA is a potent CCR1 antagonist that inhibits the binding of 125I-MIP-1α to THP-1 cell membranes.</p>Formule :C32H32ClF3N2O6Degré de pureté :98.62%Couleur et forme :SolidMasse moléculaire :633.05CH-0076989
CAS :<p>CH-0076989 is a chemokine receptor CCR3 agonist.</p>Formule :C24H22Br2N2O2Couleur et forme :SolidMasse moléculaire :530.25Bertilimumab
CAS :<p>Bertilimumab (CAT 213; iCo-008), a human monoclonal antibody that targets eotaxin-1 (CCL11), shows promise in the research of allergic disorders [1].</p>Couleur et forme :LiquidCCR2 antagonist 4 hydrochloride
CAS :<p>CCR2 antagonist 4 hydrochloride is a specific CCR2 antagonist (IC50s: 180 nM for CCR2b). It potently inhibits MCP-1-induced chemotaxis (IC50: 24 nM).</p>Formule :C21H22Cl2F3N3O2Couleur et forme :SolidMasse moléculaire :476.32TAK-779
CAS :<p>TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).</p>Formule :C33H39ClN2O2Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :531.13ZK 756326
CAS :<p>ZK 756326: Selective CCR8 agonist, IC50 1.8 μM (human), 2.6 μM (mouse), no CCR4/5, CXCR3/4 action, 28-fold selectivity vs 26 GPCRs, anti-HIV fusion.</p>Formule :C21H28N2O3Degré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :356.46PF-4136309
CAS :<p>PF-4136309 (INCB8761) is a specific, effective, and orally bioavailable CCR2 antagonist.</p>Formule :C29H31F3N6O3Degré de pureté :98.85% - 99.47%Couleur et forme :SolidMasse moléculaire :568.59RS102895
CAS :<p>RS102895 is a potent CCR2 antagonist (IC50: 360 nM) and shows no effect on CCR1.</p>Formule :C21H21F3N2O2Degré de pureté :97.64% - 99.80%Couleur et forme :SolidMasse moléculaire :390.4AZD-4818
CAS :<p>AZD-4818 (CCR1 antagonist) is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease.</p>Formule :C27H32Cl2N2O7Degré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :567.46Vercirnon
CAS :<p>Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.</p>Formule :C22H21ClN2O4SDegré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :444.93Maraviroc
CAS :<p>Maraviroc: a CCR5 antagonist blocking HIV-1 entry; IC50s—MIP-1α: 3.3nM, MIP-1β: 7.2nM, RANTES: 5.2nM.</p>Formule :C29H41F2N5ODegré de pureté :97.13% - 99.59%Couleur et forme :Brown SolidMasse moléculaire :513.67C-021
CAS :<p>C 021 dihydrochloride is a potent CCR4 antagonist.</p>Formule :C27H41N5O2Degré de pureté :99.74% - 99.90%Couleur et forme :SolidMasse moléculaire :467.65R243
CAS :<p>R243 is CCR8 signaling and chemotaxis inhibitor.</p>Formule :C21H27NO4Degré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :357.44RE-640
CAS :<p>NSC-5844 (RE-640) (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities.</p>Formule :C20H16Cl2N4Degré de pureté :99.60% - 99.87%Couleur et forme :SolidMasse moléculaire :383.27Vicriviroc maleate
CAS :<p>Vicriviroc maleate (SCH-417690 (maleate))(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus.</p>Formule :C32H42F3N5O6Degré de pureté :98.16% - 98.37%Couleur et forme :SolidMasse moléculaire :649.7BX471
CAS :<p>BX471 (BX 471) is a potent, selective non-peptide CCR1 antagonist.</p>Formule :C21H24ClFN4O3Degré de pureté :98% - 99.94%Couleur et forme :SolidMasse moléculaire :434.89SB297006
CAS :<p>SB297006 is an antagonist of C-C chemokine receptor 3, which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ.</p>Formule :C18H18N2O5Degré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :342.35Bindarit
CAS :<p>Bindarit is a selective inhibitor of monocyte chemoattractant proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.Cost-effective and quality-assured.</p>Formule :C19H20N2O3Degré de pureté :98.35% - 98.55%Couleur et forme :SolidMasse moléculaire :324.377,4'-Dihydroxyflavone
CAS :<p>7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti.</p>Formule :C15H10O4Degré de pureté :99.39% - 99.6%Couleur et forme :SolidMasse moléculaire :254.24RS 504393
CAS :<p>RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).</p>Formule :C25H27N3O3Degré de pureté :98.64% - 99.62%Couleur et forme :SolidMasse moléculaire :417.5BMS-813160
CAS :<p>BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular.</p>Formule :C25H40N8O2Degré de pureté :99.66% - 99.79%Couleur et forme :SolidMasse moléculaire :484.64DAPTA
CAS :<p>DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities.</p>Formule :C35H56N10O15Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :856.88Vercirnon sodium
CAS :<p>Vercirnon (GSK1605786A) sodium: oral CCR9 antagonist, inhibits Ca2+ mobilization/chemotaxis, IC50 = 2.6-5.4 nM, selective for CCR9 vs. CCR1-12/CX3CR1-7.</p>Formule :C22H21ClN2NaO4SCouleur et forme :SolidMasse moléculaire :467.92AZD2098
CAS :<p>AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor used for asthma research.</p>Formule :C11H9Cl2N3O3SDegré de pureté :99.80% - >99.99%Couleur et forme :SolidMasse moléculaire :334.18Cenicriviroc
CAS :<p>Cenicriviroc (TAK-652), oral CCR2/CCR5 blocker, inhibits HIV-1/HIV-2, with strong anti-infective/anti-inflammatory effects.</p>Formule :C41H52N4O4SDegré de pureté :97.87%Couleur et forme :SolidMasse moléculaire :696.94INCB 3284
CAS :<p>INCB 3284, a potent human CCR2 antagonist with an IC50 of 3.7 nM, is researchable for acute liver failure and inhibits MCP-1/hCCR2 binding.</p>Formule :C26H31F3N4O4Degré de pureté :97.81% - 99.42%Couleur et forme :SolidMasse moléculaire :520.54Carlumab
CAS :<p>Carlumab is a high-affinity human monoclonal antibody that targets CCL2, suppressing the recruitment of monocytes/macrophages in the tumour microenvironment.</p>Degré de pureté :95%Couleur et forme :LiquidTivumecirnon
CAS :<p>Tivumecirnon (FLX475) is a selective and oral CCR4 antagonist inhibits the infiltration and migration of Treg into the tumour microenvironment, antitumour</p>Formule :C24H27Cl2F3N6ODegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :543.41BI-6901
CAS :<p>BI-6901 is a CCR10 antagonist. In a mouse model of DNFB exposure hypersensitivity, BI 6901 displays its anti-inflammatory response in a dose-dependent manner.</p>Formule :C23H27N5O3SDegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :453.56CCR4 antagonist 3-1
CAS :<p>CCR4 antagonist 3-1 is a weak inhibitor of [125I]TARC binding and CEM cell migration, with IC50 values of 1.7 μM and 6.4 μM, respectively.</p>Formule :C14H12N2SDegré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :240.32CCR1 antagonist 9
CAS :<p>CCR1 antagonist 9 (compound 19e) is a selective CCR1 antagonist based on aziridine. CCR1 inhibition in calcium flux assays.</p>Formule :C20H16FN5O3SDegré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :425.44CCR8 antagonist 2
CAS :<p>CCR8 antagonist 2 blocks CCR8 activity, mainly on Treg and Th2 cells, for treating related diseases. See WO2022000443A1, compound 220.</p>Formule :C23H30ClN3O3SCouleur et forme :SolidMasse moléculaire :464.02YM022
CAS :<p>YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist.</p>Formule :C32H28N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :516.59CCR2 antagonist 3
CAS :<p>CCR2 antagonist 3 (AZD-2927) is an antagonist of CCR2.</p>Formule :C17H25FN2O2Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :308.39GW 766994
CAS :<p>GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.</p>Formule :C21H24Cl2N4O3Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :451.35CCR1 antagonist 7
CAS :<p>CCR1 antagonist 7 (compound 16r) is an antagonist of chemokine receptor 1 (CCR1) with an IC 50 of 4 nM [1].</p>Formule :C21H24ClN5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.96RPT193
CAS :<p>RPT193 is an oral CCR4 inhibitor reducing Th2 cell migration in atopic dermatitis, asthma, and allergies.</p>Formule :C27H34Cl3N5O2Couleur et forme :SolidMasse moléculaire :566.95ALK4290
CAS :<p>ALK4290 (AKST4290), a potent oral CCR3 inhibitor with a Ki of 3.2 nM, may treat macular degeneration and Parkinsonism.</p>Formule :C27H34ClN5O3Couleur et forme :SolidMasse moléculaire :512.04CCX354
CAS :<p>CCX354 (CCR1 antagonist 1) is a potent small molecule CCR1 antagonist with anti-inflammatory activity for the treatment of rheumatoid arthritis.</p>Formule :C22H22ClN7O2Degré de pureté :99.82% - 99.82%Couleur et forme :SolidMasse moléculaire :451.91PNU-177864 hydrochloride
CAS :<p>PNU-177864 hydrochloride is a potent, selective and orally active antagonist of dopamine D3 receptor.</p>Formule :C18H22ClF3N2O3SDegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :438.89PNU-177864
CAS :<p>PNU-177864 is a selective dopamine D3 receptor antagonist.</p>Formule :C18H21F3N2O3SDegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :402.43BMS-457
CAS :<p>BMS-457 is a potent, CCR1-selective antagonist.</p>Formule :C24H35ClN2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :451AZD-1678
CAS :<p>AZD-1678 is a potent CCR4 receptor antagonist.</p>Formule :C11H8Cl2FN3O3SCouleur et forme :SolidMasse moléculaire :352.17MLN3126
CAS :<p>MLN3126: Oral CCR9 blocker, hinders CCL25-triggered chemotaxis/thymocyte calcium influx, IC50 of 6.3 nM.</p>Formule :C21H19ClN2O5SCouleur et forme :SolidMasse moléculaire :446.9JNJ-27141491
CAS :<p>JNJ-27141491 is a potent, noncompetitive antagonist of human CCR2.</p>Formule :C17H15F2N3O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :379.38TAK-220
CAS :<p>TAK-220: Oral CCR5 antagonist. IC50: 3.5 nM (RANTES), 1.4 nM (MIP-1α).</p>Formule :C31H41ClN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :553.14C-021 dihydrochloride
CAS :<p>C-021 dihydrochloride is a potent CCR4 antagonist. It potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM.</p>Formule :C27H43Cl2N5O2Degré de pureté :98.67%Couleur et forme :SolidMasse moléculaire :540.57CCR1 antagonist 6
CAS :<p>CCR1 antagonist 6 is a CCR1 antagonist (IC50: 3 nM).</p>Formule :C21H23ClN4O3SDegré de pureté :99.02% - 99.15%Couleur et forme :SolidMasse moléculaire :446.95Ancriviroc
CAS :<p>Ancriviroc (SCH-351125) is an orally bioavailable small molecule chemokine receptor CCR5 antagonist.Cost-effective and quality-assured.</p>Formule :C28H37BrN4O3Degré de pureté :99.76% - 99.82%Couleur et forme :SolidMasse moléculaire :557.52BMS CCR2 22
CAS :<p>BMS CCR2 22 is a potent and selective antagonist of CCR2 with calcium flux IC50 of 18 nM, chemotaxis IC50 of 1 nM, and binding IC50 of 5.1 nM.</p>Formule :C28H34F3N5O4SDegré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :593.66CCR2 antagonist 5
CAS :<p>JNJ-41443532: oral hCCR2 antagonist, IC50=37 nM, anti-chemotaxis, treats inflammation & diabetes.</p>Formule :C22H25F3N4O3SDegré de pureté :99.09%Couleur et forme :SolidMasse moléculaire :482.52BMS-817399
CAS :<p>BMS-817399: oral CCR1 antagonist with binding and chemotaxis inhibition IC50s, potential for rheumatoid arthritis research.</p>Formule :C23H36ClN3O4Degré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :454SB 328437
CAS :<p>SB 328437 ((S)-methyl 2-(1-naphthamido)-3-(4-nitrophenyl)propanoate) is an effective and selective antagonist of CCR3 (IC50 = 4.5 nM).</p>Formule :C21H18N2O5Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :378.38Cosalane
CAS :<p>Cosalane (NSC 658586) is an HIV replication inhibitor and an inhibitor of chemokine receptor 7 (CCR7) signalling in humans and mice.</p>Formule :C45H60Cl2O6Degré de pureté :99.53% - 99.78%Couleur et forme :SolidMasse moléculaire :767.86GSK2239633A
CAS :<p>GSK2239633A is an allosteric antagonist of CC-chemokine receptor 4 (CCR4) with a pIC50 of 7.96 for the binding of [125I]-TARC to human CCR4.</p>Formule :C24H25ClN4O5S2Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :549.06VCH-286
CAS :<p>VCH-286 is a C-C chemokine receptor type 5 (CCR5) receptor antagonist.</p>Formule :C34H50F2N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :600.78PF-04634817 succinate
CAS :<p>PF-0463481 succinate is a potent and orally active dual antagonist of CCR2/CCR5 with comparable human and rodent CCR2 potency with IC50 of 20.8 nM.</p>Formule :C29H42F3N5O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :629.67CCR2 antagonist 4
CAS :<p>CCR2 antagonist 4 (Teijin compound 1) is a potent and specific antagonist of CCR2(IC50s of 180 nM), and potently inhibits MCP-1-induced chemotaxis(IC50 of 24 nM</p>Formule :C21H21ClF3N3O2Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :439.86CCR4 antagonist 4
CAS :<p>CCR4 Antagonist 4 (Compound 22) is a potent and selective antagonist of the CC chemokine receptor-4 (CCR4), displaying an IC50 value of 0.02 μM. It also inhibits MDC-mediated chemotaxis and Ca2+ mobilization, with IC50 values of 0.007 μM and 0.003 μM, respectively. This compound is utilized in research on allergic inflammation [1].</p>Formule :C24H27Cl2N7OCouleur et forme :SolidMasse moléculaire :500.42IPG7236
CAS :<p>IPG7236, a selective CCR8 antagonist, demonstrates notable tumor suppression in a mouse xenograft model of human breast cancer and is applicable in cancer</p>Formule :C23H31N3O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :429.58(1S)-CCR2 antagonist 1
CAS :<p>(1S)-CCR2 antagonist 1, a left-handed chiral form of CCR2 antagonist 1, exhibits high affinity and a long residence time as a CCR2 antagonist, with an inhibition constant (K i) of 2.4 nM [1].</p>Formule :C28H32BrF3N2OCouleur et forme :SolidMasse moléculaire :549.47MLN-3897
CAS :<p>MLN-3897 is an oral CCR1 antagonist, Ki 2.3 nM, blocks 125I-MIP-1α binding, and inhibits Akt signaling in MM cells.</p>Formule :C30H31ClN2O4Degré de pureté :98.62%Couleur et forme :SolidMasse moléculaire :519.03AZD2423
CAS :<p>AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM for</p>Formule :C20H29ClFN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :425.93SB-649701
CAS :<p>SB-649701 is a potent antagonist of the human CCR8 receptor, exhibiting a pIC50 value of 7.7, and is utilized in asthma research [1].</p>Formule :C27H28N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :456.54cis-J-113863
CAS :<p>Cis-J-113863 is a competitive antagonist for the chemokine receptor 1 (CCR1), demonstrating inhibitory concentration 50 (IC50) values of 0.9 nM for human CCR1 receptors and 5.8 nM for mouse CCR1 receptors, respectively [1].</p>Formule :C30H37Cl2IN2O2Couleur et forme :SolidMasse moléculaire :655.44PF-04634817
CAS :<p>PF-0463481: safe, well-tolerated, dual CCR2/CCR5 antagonist for diabetic nephropathy; similar human/rodent CCR2 potency, less rodent CCR5 effect.</p>Formule :C25H36F3N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :511.58(Rac)-PF-4136309(1341224-83-6 Free base)
CAS :<p>PF-4136309 (INCB8761, PF-04136309) is a highly effective and selective oral CCR2 antagonist with good bioavailability, with an IC50 value of 5.2 nM for human</p>Formule :C29H31F3N6O3Couleur et forme :SolidMasse moléculaire :568.59CMPD167
CAS :<p>CMPD167 (MRK-1) is a potent, orally active inhibitor of CCR5 with significant in vitro antiviral efficacy [1].</p>Formule :C35H47FN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :574.77RP-23618
CAS :<p>RP-23618 is a non-peptidic antagonist of RANTES.</p>Formule :C30H35N5O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :577.76trans-J-113863
CAS :<p>Trans-J-113863 serves as a potent antagonist of chemokine receptors CCR1 and CCR3, effectively inhibiting MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants, with respective half-maximal inhibitory concentrations (IC50) of 9.57 nM and 93.8 nM [1] [2].</p>Formule :C30H37Cl2IN2O2Couleur et forme :SolidMasse moléculaire :655.44BMS-639623
CAS :<p>BMS-639623 is a CCR3 antagonist with a picomolar inhibitory effect on eosinophilic chemotaxis and can be used in the treatment of asthma.</p>Formule :C25H32FN7O2Couleur et forme :SolidMasse moléculaire :481.57LMD-009
CAS :<p>LMD-009 is a non-peptide, selective CCR8 agonist that mediates chemotaxis, inositol phosphate accumulation, and calcium release, with an EC50 of 11–87 nM.</p>Formule :C29H33N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.59K777
CAS :<p>K777: Oral cysteine protease inhibitor, CYP3A4 blocker (IC50=60 nM), CCR4 antagonist, anti-Trypanosoma cruzi, antiviral, halts EBOV/SARS-CoV entry (IC50<1 nM).</p>Formule :C32H38N4O4SDegré de pureté :98.43% - 99.14%Couleur et forme :SolidMasse moléculaire :574.73CCR3 antagonist 1
CAS :<p>CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases.</p>Formule :C19H21Cl2N3O4S2Degré de pureté :98.28%Couleur et forme :SolidMasse moléculaire :490.42INCB3344
CAS :<p>INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8</p>Formule :C29H34F3N3O6Degré de pureté :98% - 98.2%Couleur et forme :SolidMasse moléculaire :577.59CP-865569
CAS :<p>CP-865569 is a CCR1 antagonist useful in the research of inflammatory and autoimmune diseases, including conditions such as rheumatoid arthritis and multiple sclerosis.</p>Formule :C22H26ClFN2O5SCouleur et forme :SolidMasse moléculaire :484.969Aplaviroc
CAS :<p>Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist. With IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.</p>Formule :C33H43N3O6Degré de pureté :97.98% - 98.26%Couleur et forme :SolidMasse moléculaire :577.71CCR5 antagonist 1
CAS :<p>CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.</p>Formule :C39H46ClF2N5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :738.33CXCR2/CCR7 antagonist-1
CAS :<p>CXCR2/CCR7 antagonist-1 (compound 6) is a potent dual antagonist of CXCR2 and CCR7, with IC50 values of 0.0046 μM and 0.0014 μM, respectively. It is valuable for research in tumor metastasis and autoimmune diseases.</p>Formule :C23H27N3O5Couleur et forme :SolidMasse moléculaire :425.48CCR7 Ligand 1
CAS :<p>CCR7-Cmp2105 is a thiadiazole-dioxide allosteric antagonist for CCR7 with a Kd of 3 nM and IC50 of 7.3 μM against arrestin binding.</p>Formule :C22H29N5O5SCouleur et forme :SolidMasse moléculaire :475.56PF-07054894
CAS :<p>PF-07054894: potent CCR6 antagonist, targets GPCR, for inflammatory bowel disease research.</p>Formule :C24H30N6O4Couleur et forme :SolidMasse moléculaire :466.53Aplaviroc hydrochloride
CAS :<p>Aplaviroc, a potent CCR5 inhibitor, binds selectively, blocking HIV entry and specific monoclonal antibody attachment in vitro.</p>Formule :C33H44ClN3O6Couleur et forme :SolidMasse moléculaire :614.17INCB-9471 dihydrochloride
CAS :<p>INCB-9471 HCl: a potent CCR5 antagonist, blocks monocyte migration & HIV-1.</p>Formule :C30H42Cl2F3N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :632.59CCR1 antagonist 11 hydrochloride
<p>Oral CCR1 antagonist A1B1 targets h/m/rCCR1 (IC50: 0.03/0.58/0.32 μM), potential for treating inflammatory diseases.</p>Couleur et forme :SolidTAK-661
CAS :<p>TAK-661 is an inhibitor of eosinophil chemotaxis (eosinophil chemotaxis) that significantly alleviates late-phase bronchoconstriction while inhibiting the proliferation of eosinophils in bronchoalveolar lavage (BAL) and their infiltration into the airway walls.</p>Formule :C13H21N5O3SCouleur et forme :SolidMasse moléculaire :327.40CP-481715
CAS :<p>CP 481715 is an effective selective CCR1 antagonist with potential therapeutic significance for inflammatory diseases.</p>Formule :C26H31FN4O4Couleur et forme :SolidMasse moléculaire :482.55Ophiobolin C
CAS :<p>inhibitor of human CCR5 binding to HIV-1 gp120</p>Formule :C25H38O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :386.57BAY-3153
CAS :<p>BAY-3153 is a selective CCR1 ( C-C motif chemokine receptor 1 ) antagonist (human IC 50 =3 nM ; rat IC 50 =11 nM ; mice IC 50 =81 nM) .</p>Formule :C25H29Cl2N3O4Couleur et forme :SolidMasse moléculaire :506.42BI 639667
CAS :<p>BI 639667, an azaindazole-class compound, potently inhibits CCR1 (IC50=1.8 nM in calcium flux assays).</p>Formule :C22H18FN5O3SDegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :451.47CCR1 antagonist 13
CAS :<p>CCR1 antagonist13 is a selective small molecule antagonist of CCR1.</p>Formule :C25H27ClFN3O4Couleur et forme :SolidMasse moléculaire :487.95BMS-741672
CAS :<p>BMS-741672 is a potent, selective CCR2 antagonist for the treatment of neuropathic pain.</p>Formule :C25H33F3N6O2Couleur et forme :SolidMasse moléculaire :506.56Nifeviroc
CAS :<p>Nifeviroc (TD-0232) is an orally active CCR5 antagonist, useful in HIV-1 infection research.</p>Formule :C33H42N4O6Degré de pureté :98.14%Couleur et forme :SolidMasse moléculaire :590.71MK-0812
CAS :<p>MK-0812 is a dual antagonist of the CCR2 and CCR5 receptors that can alleviate adipose inflammation in ob/ob mice.</p>Formule :C24H34F3N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :469.54AZD-5672
CAS :<p>AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM.</p>Formule :C32H38F2N2O5S2Degré de pureté :98.1%Couleur et forme :SolidMasse moléculaire :632.78BX471 hydrochloride
CAS :<p>BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist with a Ki of 1 nM for human CCR1, exhibiting 250-fold selectivity over CCR2, CCR5, and CXCR4.</p>Formule :C21H25Cl2FN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.35
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