RCC
Les récepteurs des chimiokines C-C (CCRs) sont un groupe de GPCR qui répondent aux chimiokines, des molécules de signalisation qui guident la migration des cellules immunitaires vers les sites d'inflammation ou d'infection. Les CCR jouent un rôle crucial dans les réponses immunitaires, l'inflammation et le développement de diverses maladies, y compris les troubles auto-immuns et le cancer. La modulation de l'activité des CCR est explorée comme une stratégie thérapeutique pour des affections telles que la polyarthrite rhumatoïde, la sclérose en plaques et l'infection par le VIH. Chez CymitQuimica, nous offrons une gamme de modulateurs de CCR de haute qualité pour soutenir vos recherches en immunologie, inflammation et développement thérapeutique.
143 produits trouvés pour "RCC"
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Vicriviroc
CAS :Vicriviroc, also known as MK4176 is a CCR5 antagonist.Formule :C28H38F3N5O2Couleur et forme :SolidMasse moléculaire :533.63RS 504393
CAS :RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).Formule :C25H27N3O3Degré de pureté :98.64% - 99.62%Couleur et forme :SolidMasse moléculaire :417.5CCR2 antagonist 4 hydrochloride
CAS :CCR2 antagonist 4 hydrochloride is a specific CCR2 antagonist (IC50s: 180 nM for CCR2b). It potently inhibits MCP-1-induced chemotaxis (IC50: 24 nM).Formule :C21H22Cl2F3N3O2Couleur et forme :SolidMasse moléculaire :476.32Vicriviroc maleate
CAS :Vicriviroc maleate (SCH-417690 (maleate))(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus.Formule :C32H42F3N5O6Degré de pureté :98.16% - 98.37%Couleur et forme :SolidMasse moléculaire :649.7BMS-813160
CAS :BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular.Formule :C25H40N8O2Degré de pureté :99.66% - 99.79%Couleur et forme :SolidMasse moléculaire :484.64Ref: TM-T4584
1mg63,00€5mg137,00€1mL*10mM (DMSO)145,00€10mg187,00€25mg341,00€50mg567,00€100mg810,00€500mg1.644,00€R243
CAS :R243 is CCR8 signaling and chemotaxis inhibitor.Formule :C21H27NO4Degré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :357.44Ref: TM-T24700
1mg40,00€2mg52,00€5mg80,00€1mL*10mM (DMSO)90,00€10mg117,00€25mg207,00€50mg333,00€100mg495,00€Cenicriviroc
CAS :Cenicriviroc (TAK-652), oral CCR2/CCR5 blocker, inhibits HIV-1/HIV-2, with strong anti-infective/anti-inflammatory effects.Formule :C41H52N4O4SDegré de pureté :97.87%Couleur et forme :SolidMasse moléculaire :696.94Ref: TM-TQ0297
1mg63,00€2mg90,00€5mg133,00€1mL*10mM (DMSO)200,00€10mg212,00€25mg423,00€50mg550,00€100mg715,00€200mg964,00€BX471
CAS :BX471 (BX 471) is a potent, selective non-peptide CCR1 antagonist.Formule :C21H24ClFN4O3Degré de pureté :98% - 99.98%Couleur et forme :SolidMasse moléculaire :434.89Ref: TM-T2375
1mg35,00€5mg86,00€1mL*10mM (DMSO)95,00€10mg117,00€25mg200,00€50mg313,00€100mg489,00€200mg740,00€DAPTA
CAS :DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities.Formule :C35H56N10O15Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :856.88RE-640
CAS :NSC-5844 (RE-640) (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities.Formule :C20H16Cl2N4Degré de pureté :99.60% - 99.87%Couleur et forme :SolidMasse moléculaire :383.27PF-4136309
CAS :PF-4136309 (INCB8761) is a specific, effective, and orally bioavailable CCR2 antagonist.Formule :C29H31F3N6O3Degré de pureté :98.85% - 99.47%Couleur et forme :SolidMasse moléculaire :568.59ZK 756326
CAS :ZK 756326: Selective CCR8 agonist, IC50 1.8 μM (human), 2.6 μM (mouse), no CCR4/5, CXCR3/4 action, 28-fold selectivity vs 26 GPCRs, anti-HIV fusion.Formule :C21H28N2O3Degré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :356.46C-021
CAS :C 021 dihydrochloride is a potent CCR4 antagonist.Formule :C27H41N5O2Degré de pureté :99.74% - 99.90%Couleur et forme :SolidMasse moléculaire :467.65Ref: TM-T21870
1mg49,00€2mg67,00€5mg90,00€1mL*10mM (DMSO)90,00€10mg144,00€25mg286,00€50mg444,00€100mg622,00€Maraviroc
CAS :Maraviroc: a CCR5 antagonist blocking HIV-1 entry; IC50s—MIP-1α: 3.3nM, MIP-1β: 7.2nM, RANTES: 5.2nM.Formule :C29H41F2N5ODegré de pureté :97.13% - 99.59%Couleur et forme :Brown SolidMasse moléculaire :513.67Ref: TM-T6016
5mg49,00€1mL*10mM (DMSO)56,00€10mg90,00€25mg152,00€50mg259,00€100mg465,00€200mg600,00€500mg945,00€Vercirnon
CAS :Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.Formule :C22H21ClN2O4SDegré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :444.93Ref: TM-T17225
1mg100,00€5mg245,00€1mL*10mM (DMSO)344,00€10mg385,00€25mg645,00€50mg888,00€100mg1.234,00€500mg2.457,00€AZD-4818
CAS :AZD-4818 (CCR1 antagonist) is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease.Formule :C27H32Cl2N2O7Degré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :567.46RS102895
CAS :RS102895 is a potent CCR2 antagonist (IC50: 360 nM) and shows no effect on CCR1.Formule :C21H21F3N2O2Degré de pureté :97.64% - 99.80%Couleur et forme :SolidMasse moléculaire :390.4TAK-779
CAS :TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).Formule :C33H39ClN2O2Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :531.13INCB 3284
CAS :INCB 3284, a potent human CCR2 antagonist with an IC50 of 3.7 nM, is researchable for acute liver failure and inhibits MCP-1/hCCR2 binding.Formule :C26H31F3N4O4Degré de pureté :97.81% - 99.42%Couleur et forme :SolidMasse moléculaire :520.54Carlumab
CAS :Carlumab is a high-affinity human monoclonal antibody that targets CCL2, suppressing the recruitment of monocytes/macrophages in the tumour microenvironment.Degré de pureté :95%Couleur et forme :LiquidMasse moléculaire :144.87 kDaTivumecirnon
CAS :Tivumecirnon (FLX475) is a selective and oral CCR4 antagonist inhibits the infiltration and migration of Treg into the tumour microenvironment, antitumourFormule :C24H27Cl2F3N6ODegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :543.41Ref: TM-T69834
1mg171,00€5mg418,00€1mL*10mM (DMSO)500,00€10mg666,00€25mg1.334,00€50mg2.071,00€100mg2.879,00€CCR8 antagonist 2
CAS :CCR8 antagonist 2 blocks CCR8 activity, mainly on Treg and Th2 cells, for treating related diseases. See WO2022000443A1, compound 220.Formule :C23H30ClN3O3SCouleur et forme :SolidMasse moléculaire :464.02TAK-220
CAS :TAK-220: Oral CCR5 antagonist. IC50: 3.5 nM (RANTES), 1.4 nM (MIP-1α).Formule :C31H41ClN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :553.14MLN3126
CAS :MLN3126: Oral CCR9 blocker, hinders CCL25-triggered chemotaxis/thymocyte calcium influx, IC50 of 6.3 nM.Formule :C21H19ClN2O5SCouleur et forme :SolidMasse moléculaire :446.9AZD-1678
CAS :AZD-1678 is a potent CCR4 receptor antagonist.Formule :C11H8Cl2FN3O3SCouleur et forme :SolidMasse moléculaire :352.17YM022
CAS :YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist.Formule :C32H28N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :516.59ALK4290
CAS :ALK4290 (AKST4290), a potent oral CCR3 inhibitor with a Ki of 3.2 nM, may treat macular degeneration and Parkinsonism.Formule :C27H34ClN5O3Couleur et forme :SolidMasse moléculaire :512.04RPT193
CAS :RPT193 is an oral CCR4 inhibitor reducing Th2 cell migration in atopic dermatitis, asthma, and allergies.Formule :C27H34Cl3N5O2Couleur et forme :SolidMasse moléculaire :566.95CCR1 antagonist 9
CAS :CCR1 antagonist 9 (compound 19e) is a selective CCR1 antagonist based on aziridine. CCR1 inhibition in calcium flux assays.Formule :C20H16FN5O3SDegré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :425.44Ref: TM-T10710
1mg101,00€5mg241,00€1mL*10mM (DMSO)265,00€10mg402,00€25mg727,00€50mg1.046,00€100mg1.525,00€CCR2 antagonist 3
CAS :CCR2 antagonist 3 (AZD-2927) is an antagonist of CCR2.Formule :C17H25FN2O2Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :308.39Ref: TM-T10712
1mg66,00€5mg147,00€1mL*10mM (DMSO)161,00€10mg225,00€25mg398,00€50mg532,00€100mg745,00€200mg982,00€BI-6901
CAS :BI-6901 is a CCR10 antagonist. In a mouse model of DNFB exposure hypersensitivity, BI 6901 displays its anti-inflammatory response in a dose-dependent manner.Formule :C23H27N5O3SDegré de pureté :99.83% - 99.94%Couleur et forme :SolidMasse moléculaire :453.56PNU-177864 hydrochloride
CAS :PNU-177864 hydrochloride is a potent, selective and orally active antagonist of dopamine D3 receptor.
Formule :C18H22ClF3N2O3SDegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :438.89PNU-177864
CAS :PNU-177864 is a selective dopamine D3 receptor antagonist.Formule :C18H21F3N2O3SDegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :402.43CCR4 antagonist 3-1
CAS :CCR4 antagonist 3-1 is a weak inhibitor of [125I]TARC binding and CEM cell migration, with IC50 values of 1.7 μM and 6.4 μM, respectively.Formule :C14H12N2SDegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :240.32C-021 dihydrochloride
CAS :C-021 dihydrochloride is a potent CCR4 antagonist. It potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM.Formule :C27H43Cl2N5O2Degré de pureté :98.67%Couleur et forme :SolidMasse moléculaire :540.57CCX354
CAS :CCX354 (CCR1 antagonist 1) is a potent small molecule CCR1 antagonist with anti-inflammatory activity for the treatment of rheumatoid arthritis.Formule :C22H22ClN7O2Degré de pureté :99.43% - 99.44%Couleur et forme :SolidMasse moléculaire :451.91APC-3316 tosylate
CAS :APC-3316 tosylate is a vinyl sulfone cysteine protease inhibitor and selective CCR4 antagonist.Formule :C39H46N4O7S2Couleur et forme :SolidMasse moléculaire :746.94AF-399/42018025
CAS :AF-399/42018025 is a small-molecule CCR4 antagonist applied to investigate chemokine-mediated immune cell trafficking and inflammatory disease mechanisms.Formule :C26H16ClN3O4S3Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :566.07GW 766994
CAS :GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.Formule :C21H24Cl2N4O3Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :451.35CCR1 antagonist 7
CAS :CCR1 antagonist 7 (compound 16r) is an antagonist of chemokine receptor 1 (CCR1) with an IC 50 of 4 nM [1].Formule :C21H24ClN5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.96BMS-457
CAS :BMS-457 is a potent, CCR1-selective antagonist.Formule :C24H35ClN2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :451JNJ-27141491
CAS :JNJ-27141491 is a potent, noncompetitive antagonist of human CCR2.Formule :C17H15F2N3O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :379.38SB 328437
CAS :SB 328437 ((S)-methyl 2-(1-naphthamido)-3-(4-nitrophenyl)propanoate) is an effective and selective antagonist of CCR3 (IC50 = 4.5 nM).Formule :C21H18N2O5Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :378.38Ref: TM-T23321
1mg39,00€1mL*10mM (DMSO)69,00€5mg82,00€10mg123,00€25mg250,00€50mg394,00€100mg618,00€200mg874,00€BMS CCR2 22
CAS :BMS CCR2 22 is a potent and selective antagonist of CCR2 with calcium flux IC50 of 18 nM, chemotaxis IC50 of 1 nM, and binding IC50 of 5.1 nM.Formule :C28H34F3N5O4SDegré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :593.66Ref: TM-T14688
1mg55,00€5mg110,00€1mL*10mM (DMSO)147,00€10mg173,00€25mg349,00€50mg532,00€100mg718,00€200mg964,00€CCR1 antagonist 6
CAS :CCR1 antagonist 6 is a CCR1 antagonist (IC50: 3 nM).Formule :C21H23ClN4O3SDegré de pureté :99.15% - 99.92%Couleur et forme :SolidMasse moléculaire :446.95Cosalane
CAS :Cosalane (NSC 658586) is an HIV replication inhibitor and an inhibitor of chemokine receptor 7 (CCR7) signalling in humans and mice.Formule :C45H60Cl2O6Degré de pureté :99.53% - 99.78%Couleur et forme :SolidMasse moléculaire :767.86Tanimilast
CAS :Tanimilast (CHF-6001) is a potent PDE4 inhibitor with IC50 of 0.026 nM, used topically for obstructive lung disease.Formule :C30H30Cl2F2N2O8SDegré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :687.54CCR2 antagonist 5
CAS :JNJ-41443532: oral hCCR2 antagonist, IC50=37 nM, anti-chemotaxis, treats inflammation & diabetes.Formule :C22H25F3N4O3SDegré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :482.52GSK2239633A
CAS :GSK2239633A is an allosteric antagonist of CC-chemokine receptor 4 (CCR4) with a pIC50 of 7.96 for the binding of [125I]-TARC to human CCR4.Formule :C24H25ClN4O5S2Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :549.06Ref: TM-T11481
500mgÀ demander1mg35,00€5mg79,00€1mL*10mM (DMSO)87,00€10mg118,00€25mg245,00€50mg355,00€100mg515,00€Ancriviroc
CAS :Ancriviroc (SCH-351125) is an orally bioavailable small molecule chemokine receptor CCR5 antagonist.Cost-effective and quality-assured.Formule :C28H37BrN4O3Degré de pureté :99.76% - 99.82%Couleur et forme :SolidMasse moléculaire :557.533
