Nrf2
Nrf2 est un facteur de transcription qui régule l'expression des protéines antioxydantes et des enzymes de détoxification, jouant un rôle crucial dans la défense cellulaire contre le stress oxydatif et l'inflammation. L'activation de la signalisation Nrf2 offre une protection contre diverses maladies, notamment le cancer, la neurodégénérescence et les troubles cardiovasculaires. Les modulateurs de Nrf2 sont explorés pour leurs potentielles applications thérapeutiques dans la réduction des dommages oxydatifs et de l'inflammation. Chez CymitQuimica, nous offrons une gamme de modulateurs de la voie Nrf2 de haute qualité pour soutenir vos recherches sur le stress oxydatif, l'inflammation et la prévention des maladies.
84 produits trouvés pour "Nrf2".
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(E/Z)-BCI
CAS :(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROSFormule :C22H23NODegré de pureté :99.94%Couleur et forme :White SolidMasse moléculaire :317.4241NK-252
CAS :NK-252 is a potential activator of Nrf2. It has great Nrf2-activating potential.Formule :C13H11N5O3Degré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :285.26BPK-29 hydrochloride
CAS :"BPK-29 hydrochloride targets NR0B1, altering C274 and hinders KEAP1-mutant cancer cell growth."Formule :C26H33Cl2N3O3Degré de pureté :99.06%Couleur et forme :SolidMasse moléculaire :506.465AA147
CAS :AA147 is an ER proteostasis regulator that selectively activates the ATF6 arm of UPR as a prodrug.Formule :C16H17NO2Degré de pureté :99.24%Couleur et forme :White SolidMasse moléculaire :255.3117Anticonvulsant agent 10
Anticonvulsant agent 10 (Compound 6d) is an inhibitor targeting the Keap1-Nrf2 interaction, with a strong activity showing an ED50 of 0.04 mmol/kg. By inhibiting the Keap1-Nrf2 binding, it activates the Nrf2/ARE pathway, providing anticonvulsant and neuroprotective effects, making it useful for research in epilepsy and neuroprotection.Couleur et forme :Odour SolidKeap1/Nrf2/ARE activator 1
Keap1/Nrf2/ARE activator 1 (compound HT-3) functions as an activator of the Keap1/Nrf2/ARE pathway. This compound has antioxidant properties and offers neuroprotective effects.Formule :C19H20O6Couleur et forme :SolidMasse moléculaire :344.12599Fraxinellone analog 1
Fraxinellone analog 1 (compound 2) is an effective and rapid activator of the Nrf2-mediated antioxidative defense system, providing protection against glutamate-mediated excitotoxicity. It induces the expression of antioxidative genes Gpx4, Sod1, and Nqo1. Additionally, Fraxinellone analog 1 exerts neuroprotective effects and modulates oxidative stress and inflammation, making it suitable for research on neurodegenerative diseases.Couleur et forme :Odour Solid17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid
CAS :Aspirin-enhanced COX-2 metabolite of DHA, activates Nrf2 and PPARγ, inhibits inflammation, with EC50 ~200 nM, effective at 5-25 μM.Formule :C22H30O3Couleur et forme :SolidMasse moléculaire :342.479Ac-LDEETGEFL-NH2
CAS :Ac-LDEETGEFL-NH2 is a fluorescent molecule designed to target the interaction between the Kelch-like ECH-associated protein 1 (Keap1) and nuclear factorFormule :C48H72N10O19Couleur et forme :SolidMasse moléculaire :1093.14TAT 14
CAS :TAT 14: a 14-mer peptide Nrf2 activator, anti-inflammatory, boosts Nrf2 protein, targets Keap1, no effect on mRNA.Formule :C137H230N48O39Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3173.59Dibenzoylmethane
CAS :Dibenzoylmethane, with CAS No. 120-46-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Dibenzoylmethane provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formule :C15H12O2Degré de pureté :99.22%Masse moléculaire :224.2546Keap1-Nrf2-IN-9
CAS :Keap1-Nrf2-IN-9 inhibits Keap1-Nrf2 PPI with 0.575 µM IC50, boosts Nrf2 genes, non-toxic in ARPE19 cells.Formule :C31H30N2O11S2Couleur et forme :SolidMasse moléculaire :670.71S217879
CAS :S217879 is a potent and selective activator of NRF2 that disrupts the KEAP1-NRF2 interaction, resulting in significant activation of the NRF2 pathway.Formule :C30H32N4O7SCouleur et forme :SolidMasse moléculaire :592.67Nrf2 activator-6
CAS :Nrf2 activator-6, a tetrahydroisoquinoline, inhibits Kelch-Nrf2 at 5 nM IC50 (WO2021214470A1).Formule :C31H37ClFN5O5Couleur et forme :SolidMasse moléculaire :614.11Keap1-Nrf2-IN-23
CAS :Keap1-Nrf2-IN-23 (compound 56) acts as an inhibitor of the Keap1–Nrf2 PPI (IC50=16.0 nM). It exhibits a Kd value of 3.07 nM when binding to Keap1 and demonstrates oral activity.Formule :C30H31ClN4O5Couleur et forme :SolidMasse moléculaire :563.04Keap1-Nrf2-IN-27
Keap1-Nrf2-IN-27 is an inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI) with a KD2 value of 0.119 μM. It suppresses the expression of pro-inflammatory cytokines TNF-α and IL-6 in an LPS-induced RAW264.7 cell model.Couleur et forme :Odour SolidTPNA10168
CAS :TPNA10168 ,with CAS No. 957942-34-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. TPNA10168 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formule :C9H9ClO2S2Couleur et forme :SolidMasse moléculaire :248.75Nrf2/HO-1 activator 3
Nrf2/HO-1 Activator 3 (Compound C3a) is an activator of the Nrf2 signaling pathway that facilitates the translocation of Nrf2 into the nucleus and enhances the expression of heme oxygenase-1 (HO-1). In H9c2 cardiomyocytes subjected to H2O2 or high glucose stimulation, Nrf2/HO-1 Activator 3 inhibits the excessive expression of ROS and MDA, suppressing cell viability and colony formation, thereby exhibiting antioxidant activity.Formule :C27H26N2O6Couleur et forme :SolidMasse moléculaire :474.51Butan-1-amine hydrochloride
CAS :1-Butylamine hydrochloride,butylamine, a potential agonist of Nrf2/ARE (Nuclear Factor Erythroid 2 Associated Factor 2/Antioxidant Response Element).Formule :C4H12ClNCouleur et forme :SolidMasse moléculaire :109.598Deacetylgedunin
CAS :Deacetylgedunin is a limonoid that is the 7-deacetyl derivative of gedunin. It has been isolated from Azadirachta indica.Formule :C26H32O6Couleur et forme :SolidMasse moléculaire :440.53
