TGF-beta/Smad
Les inhibiteurs de la voie TGF-beta/Smad sont des composés qui interfèrent avec la voie de signalisation TGF-beta (Transforming Growth Factor-beta), médiée par les protéines Smad. Cette voie est impliquée dans la régulation de la croissance cellulaire, de la différenciation, de l'apoptose et de la fonction des cellules souches. La dérégulation de la signalisation TGF-beta/Smad est associée au cancer, à la fibrose et à d'autres maladies. Les inhibiteurs de cette voie sont des outils importants pour étudier ces conditions et développer des thérapies potentielles. Chez CymitQuimica, nous fournissons des inhibiteurs de TGF-beta/Smad pour soutenir vos recherches en signalisation cellulaire, en oncologie et en réparation des tissus.
70 produits trouvés pour "TGF-beta/Smad".
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LY3200882
CAS :LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).Formule :C24H29N5O3Degré de pureté :99.46% - 99.63%Couleur et forme :SolidMasse moléculaire :435.52SD-208
CAS :SD-208 (ALK5 Inhibitor V), a selective TGF-βRI (ALK5) inhibitor (IC50: 48 nM), is >100-fold selectivity over TGF-βRII.Formule :C17H10ClFN6Degré de pureté :98.72% - 99.65%Couleur et forme :SolidMasse moléculaire :352.75Livmoniplimab
CAS :Livmoniplimab (ABBV-151; ARGX-115) is a humanised monoclonal antibody targeting LRRC32 (GARP)/TGFβ1, which blocks TGFβ1 release mediated by LRRC32Degré de pureté :95%Couleur et forme :Transparent LiquidMasse moléculaire :~150 kDaMetelimumab
CAS :Metelimumab (CAT-192) is a humanised monoclonal antibody targeting TGFβ1, which can be used to study diffuse systemic sclerosis (d-SSc).Degré de pureté :95%Couleur et forme :Transparent LiquidMasse moléculaire :~150 kDaAnti-Mouse/Human/Rat/Monkey/Hamster/Canine TGFβ Antibody (1D11.16.8)
Anti-Mouse/Human/Rat/Monkey/Hamster/Canine/Bovine TGF-β Antibody (1D11.16.8) is an IgG antibody inhibitor targeting TGF-β in multiple species including mouse, human, rabbit, monkey, hamster, dog, and cow. For information on the isotype control, refer to Mouse IgG1 kappa, Isotype Control.Couleur et forme :Odour LiquidTrevogrumab
CAS :Trevogrumab is a human monoclonal antibody that inhibits myostatin (GDF8) to promote muscle growth, and is under research for treating age-related muscle loss (sarcopenia).Degré de pureté :95% - 97.6% (SDS-PAGE); 95.9% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :144.02 kDaGinisortamab
CAS :Ginisortamab (UCB6114) is a fully humanized monoclonal antibody targeting Gremlin-1, IC50=8.2 nM and 9 nM against human and mouse Gremlin-1, respectively.Degré de pureté :95% - 96.0% (SDS-PAGE); 97.0% (SEC-HPLC)Couleur et forme :Transparent LiquidMasse moléculaire :147.55 kDaNisevokitug
CAS :Nisevokitug (anti-TGF-β mAb) neutralizes TGF-β and is being studied for its ability to modulate the immunosuppressive tumor microenvironment.Degré de pureté :95%Couleur et forme :LiquidMasse moléculaire :143.51 kDaEmugrobart
Emugrobart is a humanized IgG1κ antibody targeted at GDF8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Couleur et forme :Odour LiquidRilogrotug
CAS :Rilogrotug is a humanized IgG1κ monoclonal antibody targeting GDF15, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.Couleur et forme :SoildHalofuginone
CAS :Halofuginone (RU-19110) inhibits prolyl-tRNA synthetase (Ki=18.3 nM), down-regulates Smad3, and blocks TGF-β at 10 ng/ml.Formule :C16H17BrClN3O3Degré de pureté :99.53%Couleur et forme :Yellow SolidMasse moléculaire :414.68Ref: TM-T6856
1mg34,00€5mg82,00€1mL*10mM (DMSO)92,00€10mg116,00€25mg227,00€50mg344,00€100mg517,00€500mg1.134,00€(Rac)-SIS3 free base
CAS :SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.Formule :C28H27N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :453.53TGFβRI-IN-1
CAS :TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII,Formule :C20H14D3N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :362.4DMH2
CAS :DMH2 is a selective BMP type I receptor (ALK2/ALK3) inhibitor. DMH2 inhibits the proliferation of lung cancer cell lines and induces cell death.Formule :C27H25N5O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :451.52Halofuginone hydrobromide
CAS :Halofuginone specifically inhibits collagen type I and MMP-2 gene expression, which may result in the suppression of angiogenesis and tumor cell growth.Formule :C16H17BrClN3O3·HBrDegré de pureté :97.01% - 99.73%Couleur et forme :SolidMasse moléculaire :495.59Ref: TM-T3524
1mg34,00€2mg49,00€5mg74,00€1mL*10mM (DMSO)84,00€10mg106,00€25mg207,00€50mg310,00€100mg469,00€500mg897,00€Chromenone 1
CAS :Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP).Formule :C18H10F3N3O2Degré de pureté :99.81% - 99.83%Couleur et forme :SolidMasse moléculaire :357.29Ref: TM-T61301
1mg50,00€5mg105,00€1mL*10mM (DMSO)107,00€10mg154,00€25mg224,00€50mg314,00€100mg427,00€200mg575,00€PF-06952229
CAS :PF-06952229 is a selective inhibitor of TGFβRI. PF-06952229 can be used in studies about the treatment of solid tumors, specifically metastatic breast cancer.Formule :C23H24ClFN4O3Degré de pureté :99.73% - 99.73%Couleur et forme :SolidMasse moléculaire :458.91Ref: TM-T12433
1mgÀ demander5mgÀ demander10mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander1mL*10mM (DMSO)À demander200mgÀ demanderCJJ300
CAS :CJJ300 is a TGF-β inhibitor disrupting TGF-β-TβR complex formation, with an IC50 of 5.3 μM, and halts cell migration.Formule :C30H33N3Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :435.6Ref: TM-T62483
2mg34,00€5mg49,00€1mL*10mM (DMSO)54,00€10mg86,00€25mg156,00€50mg245,00€100mg371,00€200mg523,00€SJ000063181
CAS :SJ000063181 activates BMP signaling (EC50 ≤1μM), usable as probe in zebrafish embryos.Formule :C14H14ClFN2O2Degré de pureté :99.94%Couleur et forme :White SolidMasse moléculaire :296.72Ref: TM-T60644
1mg49,00€1mL*10mM (DMSO)90,00€5mg92,00€10mg141,00€25mg268,00€50mg520,00€100mg750,00€500mg1.521,00€3,7-DMF
CAS :3,7-Dimethylfumarate (3,7-DMF) serves as an oral inhibitor of transforming growth factor-beta 1 (TGF-β1)-mediated hepatic stellate cell (HSC) activation.Formule :C17H14O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :282.29
