TGF-beta/Smad
Les inhibiteurs de la voie TGF-beta/Smad sont des composés qui interfèrent avec la voie de signalisation TGF-beta (Transforming Growth Factor-beta), médiée par les protéines Smad. Cette voie est impliquée dans la régulation de la croissance cellulaire, de la différenciation, de l'apoptose et de la fonction des cellules souches. La dérégulation de la signalisation TGF-beta/Smad est associée au cancer, à la fibrose et à d'autres maladies. Les inhibiteurs de cette voie sont des outils importants pour étudier ces conditions et développer des thérapies potentielles. Chez CymitQuimica, nous fournissons des inhibiteurs de TGF-beta/Smad pour soutenir vos recherches en signalisation cellulaire, en oncologie et en réparation des tissus.
70 produits trouvés pour "TGF-beta/Smad".
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TGFβ-IN-5
CAS :TGFβ-IN-5 (WAY-641966) is a potent TGFβ inhibitor with anti-prion activity for the study of fibroproliferative diseases associated with TGF-β signaling.Formule :C20H16N4Degré de pureté :99.55% - 99.62%Couleur et forme :SolidMasse moléculaire :312.37Myristoyl tetrapeptide-12
CAS :Myristoyl Tetrapeptide-12 activates SMAD2 and facilitates the association of SMAD3 with DNA, promoting eyelash hair growth [1] [2].Formule :C32H63N7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :625.89DT-6
CAS :DT-6, a potent TGF-β1 inhibitor, impedes M2 macrophage-induced epithelial-to-mesenchymal transition and the invasive migration of cancer cells, thereby showingFormule :C89H130N20O29S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2008.23TP0427736
CAS :TP0427736: ALK5 inhibitor, IC50=2.72 nM, 300x > ALK3 selectivity; counters TGF-β in human cells, extends anagen in mice.Formule :C14H10N4S2Degré de pureté :97.26%Couleur et forme :SolidMasse moléculaire :298.39(+)-ITD-1
CAS :(+)-ITD-1 is an inhibitor of TGF-β, effectively inhibiting TGF-β2 with an IC50 of 0.46 μM. It promotes the degradation of the TGF-β type II receptor (TGFBR2) and the differentiation of cardiomyocytes. Additionally, it suppresses the formation of the mesoderm during the early differentiation of mouse embryonic stem cells (mESCs).Formule :C27H29NO3Couleur et forme :SolidMasse moléculaire :415.52CDD-1431
CAS :CDD-1431 is a highly selective BMPR2 kinase inhibitor with a Kiapp of 20.6 nM. It inhibits BRE reporter gene activity, exhibiting an IC50 of 4.87 μM. BMPs regulate cellular processes across various tissue types such as the kidneys, skeletal muscle, heart, and reproductive organs, and can induce ectopic bone formation.Formule :C33H38N8O5SCouleur et forme :SolidMasse moléculaire :658.77TGFβRII-IN-3
CAS :TGFβRII-IN-3 (Compound 2r) is a selective inhibitor of the TGFβ type II receptor (TGFβ RII) with an IC50 of 4.1 μM. It inhibits TGFβ signaling by promoting protein degradation of TGFβ RII. Additionally, TGFβRI-IN-7 can block the transition from endothelial to mesenchymal states and inhibit cell migration, making it useful for cancer research.Formule :C27H27F3N2O2Couleur et forme :SolidMasse moléculaire :468.51TGFβ1-IN-1
CAS :TGFβ1-IN-1 is a TGF-β1 inhibitor that inhibits the production of TGF-β1-induced fibrosis markers (α-SMA and fibronectin) and can be used in cancer research.Formule :C22H24N2O3Degré de pureté :99.89% - 99.89%Couleur et forme :White SolidMasse moléculaire :364.438Ref: TM-T61389
1mg50,00€5mg105,00€1mL*10mM (DMSO)117,00€10mg170,00€25mg340,00€50mg557,00€100mg893,00€200mg1.198,00€Kartogenin sodium
CAS :Kartogenin (KGN) sodium acts as an inducer of chondrogenic tissue formation (EC 50: 100 nM). It promotes chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and modulating the CBFβ-RUNX1 transcriptional program. Additionally, Kartogenin sodium aids tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. It is extensively utilized in cell-free therapies for cartilage regeneration and protection, tendon-bone healing, wound healing, and limb development. The compound is also vital for cartilage repair, coordinating limb development, and osteoarthritis (OA) research [1] [2] [3] [4].Formule :C20H14NNaO3Couleur et forme :SolidMasse moléculaire :339.32TGFβRI-IN-3
CAS :TGFβRI-IN-3 inhibits TGFβR1 with an IC 50 of 0.79 nM with 2000-fold selectivity against MAP4K4.Formule :C28H23N3O2SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :465.57Ref: TM-T9523
1mg84,00€5mg177,00€1mL*10mM (DMSO)177,00€10mg281,00€25mg552,00€50mg859,00€100mg1.234,00€500mg2.457,00€
