Signalisation JAK/STAT
Les inhibiteurs de la signalisation JAK/STAT sont des composés qui perturbent la voie des kinases Janus (JAK) et du transducteur et activateur de transcription (STAT), impliquée dans la signalisation des cytokines, la croissance cellulaire et la réponse immunitaire. Ces inhibiteurs sont des outils importants pour étudier la régulation de cette voie et son rôle dans diverses maladies, notamment les cancers, les troubles immunitaires et les affections inflammatoires. Les inhibiteurs JAK/STAT sont également en cours de développement en tant que thérapies ciblées pour ces maladies. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de haute qualité de la signalisation JAK/STAT pour soutenir vos recherches en biologie moléculaire, oncologie et immunologie.
Sous-catégories appartenant à la catégorie "Signalisation JAK/STAT"
363 produits trouvés pour "Signalisation JAK/STAT".
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CHZ868
CAS :CHZ868 is a type II JAK inhibitor with potential antitumor activity that reverses the persistence of type I JAK inhibitors and can be used to study leukemia.Formule :C22H19F2N5O2Degré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :423.42AK-1690
CAS :AK-1690 is a potent and selective STAT6 PROTAC degrader that induces degradation of STAT6 proteins in cells and depletes STAT6 proteins in mouse tissues.Formule :C51H56F2N5O11PSDegré de pureté :99.95% - 99.96%Couleur et forme :White SolidMasse moléculaire :1016.05DTP3
CAS :DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.Formule :C26H35N7O5Couleur et forme :SolidMasse moléculaire :525.6Nifuroxazide (Standard)
CAS :Nifuroxazide (Standard) is the standard substance of Nifuroxazide, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Nifuroxazide (Diarlidan) is an orally available and cell-permeable nitrofuran-based antidiarrheal agent. It has the inhibitory effect against the activation of cellular STAT1/3/5 transcription.Formule :C12H9N3O5Couleur et forme :SolidMasse moléculaire :275.22Ifidancitinib
CAS :Ifidancitinib (ATI-50002) is a JAK kinase 1/3 inhibitor used to study autoimmune diseases.Formule :C20H18FN5O3Degré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :395.39Atinvicitinib
CAS :Atinvicitinib, a selective JAK1 inhibitor, blocks cytokine signaling, modulating itch, allergy, and inflammatory responses, immune and therapeutic studies.Formule :C16H17FN6O3Degré de pureté :99.36%Couleur et forme :White SolidMasse moléculaire :360.35Ref: TM-T39646
1mg138,00€1mL*10mM (DMSO)264,00€5mg334,00€10mg550,00€25mg1.063,00€50mg1.738,00€100mg2.547,00€SMI-16a
CAS :SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (Formule :C13H13NO3SDegré de pureté :99.99%Couleur et forme :White SolidMasse moléculaire :263.31Ref: TM-T3989
1mg34,00€2mg46,00€5mg66,00€1mL*10mM (DMSO)87,00€10mg93,00€25mg152,00€50mg222,00€100mg334,00€NVP-BSK805 trihydrochloride
CAS :NVP-BSK805 trihydrochloride inhibits JAK2 (0.48 nM IC50); also affects JAK1, JAK3, TYK2.Formule :C27H31Cl3F2N6OCouleur et forme :SolidMasse moléculaire :599.93Ritlecitinib
CAS :Ritlecitinib (PF-06651600) is an orally available, selective JAK3 inhibitor and does not affect the activity of JAK1/2.Cost-effective and quality-assured.Formule :C15H19N5ODegré de pureté :98.09% - 99.92%Couleur et forme :SolidMasse moléculaire :285.34Ref: TM-T5382
2mg37,00€5mg52,00€1mL*10mM (DMSO)58,00€10mg90,00€25mg205,00€50mg290,00€100mg408,00€200mg595,00€ZM39923 hydrochloride
CAS :ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.Formule :C23H25NO·HClDegré de pureté :98.05% - 99.48%Couleur et forme :White SolidMasse moléculaire :367.91Momelotinib HCl
CAS :Momelotinib HCl is a JAK1/2 inhibitor, reducing anemia in myelofibrosis (MF) patients.Formule :C23H24Cl2N6O2Couleur et forme :SolidMasse moléculaire :487.38Peramivir Trihydrate
CAS :Peramivir Trihydrate (RWJ-270201) is a neuraminidase inhibitor (IC50: 0.09 nM) which prevents normal processing of virus particles such that virus particles areFormule :C15H28N4O4·3H2ODegré de pureté :99.52% - 99.87%Couleur et forme :SolidMasse moléculaire :382.45Gandotinib
CAS :LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM).Formule :C23H25ClFN7ODegré de pureté :99.33% - 99.86%Couleur et forme :SolidMasse moléculaire :469.94SAR-20347
CAS :SAR-20347 is an inhibitor of TYK2, JAK1/2/3 (IC50: 0.6/23/26/41 nM).Formule :C21H18ClFN4O4Degré de pureté :98.99% - 99.77%Couleur et forme :SolidMasse moléculaire :444.84Ref: TM-T4210
1mg34,00€5mg75,00€1mL*10mM (DMSO)84,00€10mg110,00€25mg215,00€50mg334,00€100mg557,00€200mg775,00€SC99
CAS :SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.Formule :C15H8Cl2FN3ODegré de pureté :99.56%Couleur et forme :Yellow SolidMasse moléculaire :336.15BD750
CAS :BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM inFormule :C14H13N3OSDegré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :271.34Ruxolitinib (S enantiomer)
CAS :Ruxolitinib S enantiomer (INCB18424) is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor.Formule :C17H18N6Degré de pureté :99.37% - 99.79%Couleur et forme :SolidMasse moléculaire :306.36WHI-P97 HCl
WHI-P97 HCl is a potent and selective JAK-3 inhibitor.Formule :C16H14Br2ClN3O3Degré de pureté :99.49%Couleur et forme :Green SolidMasse moléculaire :491.56Ref: TM-T4657L
2mg34,00€5mg48,00€1mL*10mM (DMSO)73,00€10mg86,00€25mg138,00€50mg182,00€100mg261,00€200mg371,00€Upadacitinib
CAS :Upadacitinib (ABT-494), a selective JAK1 inhibitor, is researched for autoimmune diseases; IC50: 43 nM.Formule :C17H19F3N6ODegré de pureté :98.96% - 99.94%Couleur et forme :SolidMasse moléculaire :380.37Ref: TM-T7503
1mL*10mM (DMSO)44,00€2mg55,00€5mg89,00€10mg116,00€25mg198,00€50mg276,00€100mg389,00€200mg595,00€Cerdulatinib
CAS :Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor.Formule :C20H27N7O3SDegré de pureté :98.74% - 99.49%Couleur et forme :SolidMasse moléculaire :445.54Ref: TM-T2487
1mg42,00€2mg52,00€5mg74,00€1mL*10mM (DMSO)81,00€10mg101,00€25mg175,00€50mg268,00€100mg409,00€200mg573,00€500mg888,00€Quercetagetin
CAS :Quercetagetin, a flavonoid from Citrus unshiu, inhibits pim-1 kinase (IC50: 0.34 μM), cell-permeable.Formule :C15H10O8Degré de pureté :99.65% - 99.91%Couleur et forme :SolidMasse moléculaire :318.24Ref: TM-T8114
1mg94,00€5mg192,00€1mL*10mM (DMSO)202,00€10mg286,00€25mg482,00€50mg695,00€100mg945,00€500mg1.882,00€NT157
CAS :NT157, a small tyrphostin, inhibits IRS, IGF-1R, and STAT3 in TME, reducing cancer cell survival.Formule :C16H14BrNO5SDegré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :412.26Protosappanin A
CAS :Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.Formule :C15H12O5Degré de pureté :99.42% - 99.82%Couleur et forme :White SolidMasse moléculaire :272.25Ref: TM-TJS1779
1mg88,00€1mL*10mM (DMSO)178,00€5mg195,00€10mg318,00€25mg523,00€50mg743,00€100mg999,00€GLPG0634 analog
CAS :GLPG0634 analog (GLPG0634 analogue) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.Formule :C23H18N6O2Degré de pureté :99.52% - >99.99%Couleur et forme :SolidMasse moléculaire :410.43Ref: TM-T3076
1mg38,00€2mg50,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg137,00€25mg250,00€50mg442,00€100mg623,00€500mg1.305,00€Gusacitinib HCl
CAS :Gusacitinib (ASN-002/EN-3351), a potent SYK/JAK inhibitor, has strong antitumor activity in various cancers.Formule :C24H29ClN8O2Couleur et forme :SolidMasse moléculaire :497SHR0302
CAS :SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3,Formule :C18H22N8O2SDegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :414.48Ref: TM-T9195
1mg75,00€1mL*10mM (DMSO)164,00€5mg173,00€10mg281,00€25mg485,00€50mg773,00€100mg1.243,00€TP-3654
CAS :TP-3654 is a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM).Formule :C22H25F3N4ODegré de pureté :99.8% - 99.95%Couleur et forme :SolidMasse moléculaire :418.462,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
CAS :2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity and physicochemical properties.Formule :C16H13Cl2N3O2Degré de pureté :98.77%Couleur et forme :White SolidMasse moléculaire :350.2Peficitinib
CAS :Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.Formule :C18H22N4O2Degré de pureté :98.67% - 99.89%Couleur et forme :SolidMasse moléculaire :326.39Ref: TM-T6933
2mg38,00€5mg63,00€1mL*10mM (DMSO)70,00€10mg99,00€25mg172,00€50mg268,00€100mg416,00€200mg610,00€HODHBt
CAS :HODHBt is a STAT5-SUMO protein-protein interaction inhibitor.Formule :C7H5N3O2Degré de pureté :99.45% - 99.95%Couleur et forme :SolidMasse moléculaire :163.13Thymidylate Kinase Inhibitor, YMU1
CAS :YMU1 inhibits hTMPK, stabilizes its LID region, and blocks the catalytic/ATP-binding site.Formule :C17H22N4O4SDegré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :378.45AS1810722
CAS :AS1810722, a fused bicyclic pyrimidine derivative, is an orally active and potent inhibitor of STAT6, demonstrating an IC50 of 1.9 nM.Formule :C25H25F2N7ODegré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :477.51Tofacitinib Citrate
CAS :Tofacitinib Citrate (CP-690550 citrate) is a a potent, cell-permeable inhibitor of JAK1/2/3 (IC50s: 1/20/112 nM).Formule :C22H28N6O8Degré de pureté :99.19% - 99.75%Couleur et forme :White SolidMasse moléculaire :504.49TCS-PIM-1-4a
CAS :SMI-4a, a Pim inhibitor, activates AMPK, halts mTORC1, and kills various myeloid/lymphoid cells (IC50=0.8-40μM).Formule :C11H6F3NO2SDegré de pureté :98.82% - 99.89%Couleur et forme :White SolidMasse moléculaire :273.23XL019
CAS :XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, 100 fold selectivity over JAK1.Formule :C25H28N6O2Degré de pureté :99.19%Couleur et forme :SolidMasse moléculaire :444.53Ref: TM-T3072
2mg43,00€5mg63,00€1mL*10mM (DMSO)69,00€10mg92,00€25mg150,00€50mg215,00€100mg321,00€200mg477,00€Ruxolitinib phosphate
CAS :Ruxolitinib phosphate (INCB18424 phosphate) is a JAK1/2 inhibitor with IC50 of 3.3 nM/2.8 nM. Cost-effective and quality-assured.Formule :C17H21N6O4PDegré de pureté :98% - >99.99%Couleur et forme :White SolidMasse moléculaire :404.36Ref: TM-T3043
5mg49,00€1mL*10mM (DMSO)56,00€10mg62,00€25mg78,00€50mg92,00€100mg138,00€200mg215,00€500mg395,00€1g583,00€Napabucasin
CAS :Napabucasin (BBI608) is an orally available Stat3 and Y cell stemness inhibitor.Formule :C14H8O4Degré de pureté :98.43% - 99.85%Couleur et forme :SolidMasse moléculaire :240.21S3I-201
CAS :S3I-201 (S3I-201) is a selective Stat3 inhibitor (IC50: 86±33 μM) and low effect towards STAT1/5.Formule :C16H15NO7SDegré de pureté :97.83%Couleur et forme :SolidMasse moléculaire :365.36Cucurbitacin I
CAS :Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.Formule :C30H42O7Degré de pureté :96.69% - 99.8%Couleur et forme :SolidMasse moléculaire :514.65Pacritinib
CAS :Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays).Formule :C28H32N4O3Degré de pureté :99.25% - 99.49%Couleur et forme :SolidMasse moléculaire :472.58HJ-PI01
CAS :HJ-PI01 (HJ-PI01) is a Pim-2 inhibitor. HJ-PI01 (HJ-PI01) induces apoptosis and autophagic cell death in triple-negative human breast cancer.Formule :C14H11NO2Degré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :225.24Ref: TM-T9583
1mg34,00€1mL*10mM (DMSO)73,00€5mg75,00€10mg110,00€25mg245,00€50mg363,00€100mg515,00€200mg700,00€JANEX-1
CAS :JANEX-1: cell-permeable, reversible Jak3 inhibitor (IC50: 78 μM), ATP-competitive, selective; weak on JAK1/2, Zap/Syk, SRC.Formule :C16H15N3O3Degré de pureté :98% - 99.81%Couleur et forme :SolidMasse moléculaire :297.31Fedratinib
CAS :Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.Formule :C27H36N6O3SDegré de pureté :97.31% - 99.96%Couleur et forme :SolidMasse moléculaire :524.68Ref: TM-T1995
5mg50,00€1mL*10mM (DMSO)54,00€10mg65,00€50mg107,00€100mg127,00€200mg205,00€500mg447,00€1g592,00€FLLL32
CAS :FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).Formule :C28H32O6Degré de pureté :97.90% - 99.10%Couleur et forme :SolidMasse moléculaire :464.55Ref: TM-T6838
2mg43,00€5mg63,00€1mL*10mM (DMSO)69,00€10mg88,00€25mg117,00€50mg187,00€100mg333,00€500mg797,00€Baricitinib phosphate
CAS :Baricitinib phosphate (INCB028050) is a selective orally bioavailable JAK1/JAK2 inhibitor.Formule :C16H20N7O6PSDegré de pureté :99.4% - 99.91%Couleur et forme :White SolidMasse moléculaire :469.41Ref: TM-T2360
5mg40,00€1mL*10mM (DMSO)46,00€10mg52,00€25mg73,00€50mg93,00€100mg105,00€200mg157,00€500mg260,00€Curculigoside
CAS :1.Formule :C22H26O11Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :466.44RGB-286638 free base
CAS :RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Formule :C29H35N7O4Degré de pureté :98% - 99.91%Couleur et forme :SolidMasse moléculaire :545.63Pacritinib hydrochloride
CAS :Pacritinib HCl: strong JAK2/Wild-type & JAK2V617F inhibitor (IC50: 23/19 nM), used in AML & MF research.Formule :C28H32N4O3·xClHCouleur et forme :SolidAZD1208
CAS :AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.Formule :C21H21N3O2SDegré de pureté :97.24% - 99.83%Couleur et forme :Yellow SolidMasse moléculaire :379.48Ref: TM-T2300
2mg35,00€5mg49,00€1mL*10mM (DMSO)54,00€10mg71,00€25mg112,00€50mg202,00€100mg358,00€200mg470,00€500mg750,00€AT9283
CAS :AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).Formule :C19H23N7O2Degré de pureté :99.83% - 99.98%Couleur et forme :White SolidMasse moléculaire :381.43Ref: TM-T3068
2mg39,00€5mg75,00€1mL*10mM (DMSO)84,00€10mg111,00€25mg231,00€50mg371,00€100mg595,00€200mg833,00€
