Signalisation JAK/STAT
Les inhibiteurs de la signalisation JAK/STAT sont des composés qui perturbent la voie des kinases Janus (JAK) et du transducteur et activateur de transcription (STAT), impliquée dans la signalisation des cytokines, la croissance cellulaire et la réponse immunitaire. Ces inhibiteurs sont des outils importants pour étudier la régulation de cette voie et son rôle dans diverses maladies, notamment les cancers, les troubles immunitaires et les affections inflammatoires. Les inhibiteurs JAK/STAT sont également en cours de développement en tant que thérapies ciblées pour ces maladies. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de haute qualité de la signalisation JAK/STAT pour soutenir vos recherches en biologie moléculaire, oncologie et immunologie.
Sous-catégories appartenant à la catégorie "Signalisation JAK/STAT"
365 produits trouvés pour "Signalisation JAK/STAT"
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Ruxolitinib phosphate
CAS :Ruxolitinib phosphate (INCB18424 phosphate) is a JAK1/2 inhibitor with IC50 of 3.3 nM/2.8 nM. Cost-effective and quality-assured.Formule :C17H21N6O4PDegré de pureté :98% - >99.99%Couleur et forme :SolidMasse moléculaire :404.36Ref: TM-T3043
5mg49,00€1mL*10mM (DMSO)56,00€10mg62,00€25mg78,00€50mg92,00€100mg138,00€200mg215,00€500mg395,00€1g583,00€GLPG0634 analog
CAS :GLPG0634 analog (GLPG0634 analogue) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.Formule :C23H18N6O2Degré de pureté :99.52% - >99.99%Couleur et forme :SolidMasse moléculaire :410.43Ref: TM-T3076
1mg38,00€2mg50,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg137,00€25mg250,00€50mg442,00€100mg623,00€500mg1.305,00€TCS PIM-1 1
CAS :TCS PIM-1 1 (SC 204330) is a potent ATP-competitive inhibitor of Pim-1 kinase with an IC50 of 50 nM, selective over MEK1/2 and Pim-2.Formule :C18H11BrN2O2Degré de pureté :97% - 97.98%Couleur et forme :SolidMasse moléculaire :367.2Ref: TM-T2253
1mg34,00€5mg60,00€1mL*10mM (DMSO)92,00€10mg94,00€25mg177,00€50mg269,00€100mg401,00€200mg580,00€Peramivir Trihydrate
CAS :Peramivir Trihydrate (RWJ-270201) is a neuraminidase inhibitor (IC50: 0.09 nM) which prevents normal processing of virus particles such that virus particles are
Formule :C15H28N4O4·3H2ODegré de pureté :99.52% - ≥95%Couleur et forme :SolidMasse moléculaire :382.45Ref: TM-T2522
2mg47,00€5mg70,00€10mg103,00€25mg188,00€50mg311,00€100mg439,00€200mg635,00€500mg938,00€Baricitinib
CAS :Baricitinib (INCB028050) is an orally JAK1 and JAK2 inhibitor. Baricitinib has anti-inflammatory and anti-tumor activity. Cost-effective and quality-assured.Formule :C16H17N7O2SDegré de pureté :99% - >99.99%Couleur et forme :SolidMasse moléculaire :371.42Ref: TM-T2485
5mg48,00€1mL*10mM (DMSO)65,00€10mg70,00€25mg95,00€50mg109,00€100mg137,00€200mg178,00€500mg295,00€NVP-BSK805 trihydrochloride
CAS :NVP-BSK805 trihydrochloride inhibits JAK2 (0.48 nM IC50); also affects JAK1, JAK3, TYK2.Formule :C27H31Cl3F2N6OCouleur et forme :SolidMasse moléculaire :599.93GDC-0214
CAS :GDC-0214 is an inhaled small-molecule JAK1 inhibitor and reduces fractional exhaled nitric oxide (Feno).Formule :C28H28ClF2N9O3Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :612.03Ref: TM-T9826
1mg93,00€5mg182,00€1mL*10mM (DMSO)245,00€10mg269,00€25mg429,00€50mg610,00€100mg820,00€200mg1.099,00€RO8191
CAS :RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.Formule :C14H5F6N5ODegré de pureté :98% - 98.85%Couleur et forme :SolidMasse moléculaire :373.21Ref: TM-T22142
1mg43,00€2mg55,00€5mg93,00€10mg137,00€25mg254,00€50mg380,00€100mg573,00€500mg1.189,00€TG101209
CAS :TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM.Formule :C26H35N7O2SDegré de pureté :99% - >99.99%Couleur et forme :SolidMasse moléculaire :509.67JAK3-IN-6
CAS :JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nMFormule :C19H18N4O3Degré de pureté :99.94% - 99.94%Couleur et forme :SolidMasse moléculaire :350.37(E/Z)-Zotiraciclib
CAS :(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.Formule :C23H24N4ODegré de pureté :97.75% - 99.92%Couleur et forme :SolidMasse moléculaire :372.46Ref: TM-T21503
1mg43,00€2mg56,00€1mL*10mM (DMSO)90,00€5mg93,00€10mg113,00€25mg200,00€50mg330,00€100mg480,00€G5-7
CAS :G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.Formule :C22H19F2NO3Degré de pureté :97.3%Couleur et forme :SolidMasse moléculaire :383.39Ref: TM-T8742
1mg35,00€5mg71,00€1mL*10mM (DMSO)78,00€10mg96,00€25mg172,00€50mg248,00€100mg348,00€200mg470,00€Fedratinib hydrochloride hydrate
CAS :Fedratinib hydrochloride hydrate (SAR 302503 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor.Formule :C27H40Cl2N6O4SDegré de pureté :98.96% - 99.87%Couleur et forme :SolidMasse moléculaire :615.61RGB-286638 free base
CAS :RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Formule :C29H35N7O4Degré de pureté :98% - 99.91%Couleur et forme :SolidMasse moléculaire :545.63Niclosamide sodium
CAS :Niclosamide (BAY2353) sodium: oral antihelminthic, STAT3 inhibitor (IC50 0.25 μM), anti-cancer, and DNA replication blocker.Formule :C13H7Cl2N2NaO4Couleur et forme :SolidMasse moléculaire :349.1FLLL32
CAS :FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).Formule :C28H32O6Degré de pureté :97% - 97.90%Couleur et forme :SolidMasse moléculaire :464.55Ref: TM-T6838
2mg43,00€5mg63,00€1mL*10mM (DMSO)69,00€10mg88,00€25mg117,00€50mg187,00€100mg333,00€500mg797,00€JANEX-1
CAS :JANEX-1: cell-permeable, reversible Jak3 inhibitor (IC50: 78 μM), ATP-competitive, selective; weak on JAK1/2, Zap/Syk, SRC.Formule :C16H15N3O3Degré de pureté :98% - 99.81%Couleur et forme :SolidMasse moléculaire :297.31Abrocitinib
CAS :Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).Formule :C14H21N5O2SDegré de pureté :99.09% - 99.91%Couleur et forme :SolidMasse moléculaire :323.41Decernotinib
CAS :Decernotinib (VRT-831509)(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays.Formule :C18H19F3N6ODegré de pureté :99.28% - >99.99%Couleur et forme :SolidMasse moléculaire :392.38Ref: TM-T2636
1mg34,00€2mg48,00€5mg71,00€1mL*10mM (DMSO)79,00€10mg99,00€25mg197,00€50mg295,00€100mg447,00€AZD1208
CAS :AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.Formule :C21H21N3O2SDegré de pureté :97.24% - 99.83%Couleur et forme :SolidMasse moléculaire :379.48Ref: TM-T2300
2mg35,00€5mg49,00€1mL*10mM (DMSO)54,00€10mg71,00€25mg112,00€50mg202,00€100mg358,00€200mg470,00€500mg750,00€AMG-47a
CAS :AMG-47a inhibits Lck, T cell growth, and degrades KRAS oncoprotein, affecting EGFP-KRASG12V but not EGFP.Formule :C29H28F3N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :535.56Pacritinib hydrochloride
CAS :Pacritinib HCl: strong JAK2/Wild-type & JAK2V617F inhibitor (IC50: 23/19 nM), used in AML & MF research.Formule :C28H32N4O3·xClHCouleur et forme :SolidSTAT5-IN-1
CAS :STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.Formule :C16H11N3O3Degré de pureté :99.44% - ≥95%Couleur et forme :SolidMasse moléculaire :293.28TP-3654
CAS :TP-3654 is a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM).Formule :C22H25F3N4ODegré de pureté :99.8% - 99.95%Couleur et forme :SolidMasse moléculaire :418.46Hispidulin
CAS :Hispidulin, a natural flavone with a broad spectrum of biological activities, is a Pim-1 inhibitor (IC50: 2.71 μM).Formule :C16H12O6Degré de pureté :98.53% - 99.87%Couleur et forme :SolidMasse moléculaire :300.26Brevilin A
CAS :Brevilin A, a sesquiterpene from Centipeda minima, hinders JAK and blocks STAT3 (IC50=10.6μM), inducing apoptosis and autophagy in cancer cells.Formule :C20H26O5Degré de pureté :99.97% - >99.99%Couleur et forme :SolidMasse moléculaire :346.42Ref: TM-T4672
1mg90,00€5mg203,00€1mL*10mM (DMSO)224,00€10mg350,00€25mg578,00€50mg797,00€100mg1.071,00€500mg2.187,00€Stafia-1
CAS :Stafia-1 is a potent STAT5a inhibitor ( IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members.Formule :C24H27O10PDegré de pureté :98.08%Couleur et forme :SolidMasse moléculaire :506.44Ref: TM-T9339
1mg81,00€5mg177,00€1mL*10mM (DMSO)207,00€10mg294,00€25mg497,00€50mg717,00€100mg982,00€500mg1.998,00€Cerdulatinib
CAS :Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor.Formule :C20H27N7O3SDegré de pureté :98.74% - 99.49%Couleur et forme :SolidMasse moléculaire :445.54Ref: TM-T2487
1mg42,00€2mg52,00€5mg74,00€1mL*10mM (DMSO)81,00€10mg101,00€25mg175,00€50mg268,00€100mg409,00€200mg573,00€500mg888,00€Upadacitinib
CAS :Upadacitinib (ABT-494), a selective JAK1 inhibitor, is researched for autoimmune diseases; IC50: 43 nM.Formule :C17H19F3N6ODegré de pureté :98.96% - 99.94%Couleur et forme :SolidMasse moléculaire :380.37Ref: TM-T7503
1mL*10mM (DMSO)44,00€2mg55,00€5mg89,00€10mg116,00€25mg198,00€50mg276,00€100mg389,00€200mg595,00€SH5-07
CAS :SH5-07 is a hydroxamic acid-based Stat3 inhibitor (IC50: 3.9 μM).Formule :C29H28F5N3O5SDegré de pureté :95.54%Couleur et forme :SolidMasse moléculaire :625.61WDR5-0103 hydrochloride[890190-22-4(free base)]
WDR5-0103 hydrochloride[890190-22-4(free base)] (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd:Formule :C21H26ClN3O4Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :419.9BD750
CAS :BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM inFormule :C14H13N3OSDegré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :271.34Atractylenolide I
CAS :Atractylenolide-I reduces inflammation, improves sepsis, liver, and kidney function, and enhances EOC cell sensitivity to paclitaxel.Formule :C15H18O2Degré de pureté :97.55% - 99.92%Couleur et forme :SolidMasse moléculaire :230.30WHI-P154
CAS :WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor.Formule :C16H14BrN3O3Degré de pureté :98% - 99.67%Couleur et forme :SolidMasse moléculaire :376.2XL019
CAS :XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, 100 fold selectivity over JAK1.Formule :C25H28N6O2Degré de pureté :99.19%Couleur et forme :SolidMasse moléculaire :444.53Ref: TM-T3072
2mg43,00€5mg63,00€1mL*10mM (DMSO)78,00€10mg92,00€25mg150,00€50mg215,00€100mg321,00€200mg477,00€TCS-PIM-1-4a
CAS :SMI-4a, a Pim inhibitor, activates AMPK, halts mTORC1, and kills various myeloid/lymphoid cells (IC50=0.8-40μM).Formule :C11H6F3NO2SDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :273.23SHR0302
CAS :SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3,Formule :C18H22N8O2SDegré de pureté :99.11%Couleur et forme :SolidMasse moléculaire :414.48Ref: TM-T9195
1mg75,00€1mL*10mM (DMSO)164,00€5mg173,00€10mg281,00€25mg485,00€50mg773,00€100mg1.243,00€ZM39923 hydrochloride
CAS :ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.Formule :C23H25NO·HClDegré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :367.91Peficitinib
CAS :Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.Formule :C18H22N4O2Degré de pureté :98.67% - 99.4%Couleur et forme :SolidMasse moléculaire :326.39Ref: TM-T6933
2mg38,00€5mg63,00€1mL*10mM (DMSO)70,00€10mg99,00€25mg172,00€50mg268,00€100mg416,00€200mg610,00€Protosappanin A
CAS :Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.Formule :C15H12O5Degré de pureté :99.42% - 99.82%Couleur et forme :SolidMasse moléculaire :272.25Ref: TM-TJS1779
1mg88,00€1mL*10mM (DMSO)178,00€5mg195,00€10mg318,00€25mg523,00€50mg743,00€100mg999,00€AG490
CAS :AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.Formule :C17H14N2O3Degré de pureté :98.6% - 99.85%Couleur et forme :Yellow SolidMasse moléculaire :294.3BMS-911543
CAS :BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.Formule :C23H28N8ODegré de pureté :97.69% - 99.98%Couleur et forme :SolidMasse moléculaire :432.52FM-381
CAS :FM381, a JAK3 inhibitor with 127 pM IC50, is 410-3600x more selective over JAK1/2/TYK2.Formule :C24H24N6O2Degré de pureté :98.44%Couleur et forme :SolidMasse moléculaire :428.49Ref: TM-T5091
1mg47,00€2mg62,00€5mg92,00€1mL*10mM (DMSO)107,00€10mg128,00€25mg212,00€50mg319,00€100mg485,00€Deucravacitinib
CAS :Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable, allosteric TYK2 inhibitor.Cost-effective and quality-assured.Formule :C20H19D3N8O3Degré de pureté :98.52% - >99.99%Couleur et forme :SolidMasse moléculaire :425.46Ref: TM-T14687
1mg56,00€5mg137,00€1mL*10mM (DMSO)149,00€10mg248,00€25mg389,00€50mg575,00€100mg817,00€Momelotinib
CAS :Momelotinib (LM-1149), an oral JAK1/2 inhibitor with IC50s 11/18 nM, blocks ATP binding, disrupting JAK-STAT pathway and reducing tumor growth.Formule :C23H22N6O2Degré de pureté :97.07% - 99.56%Couleur et forme :SolidMasse moléculaire :414.46Ref: TM-T1849
1mg35,00€2mg50,00€5mg77,00€1mL*10mM (DMSO)84,00€10mg89,00€25mg158,00€50mg245,00€100mg385,00€200mg592,00€RO495
CAS :RO495 (CS-2667), a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested in cell-based pharmacological assaysFormule :C17H14Cl2N6ODegré de pureté :97.94%Couleur et forme :SolidMasse moléculaire :389.24Ref: TM-T22416
1mg46,00€5mg86,00€1mL*10mM (DMSO)94,00€10mg126,00€25mg235,00€50mg344,00€100mg465,00€200mg625,00€(Z)-LFM-A13
CAS :(Z)-LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and IRK.Formule :C11H8Br2N2O2Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :360AT9283
CAS :AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).Formule :C19H23N7O2Degré de pureté :99.83% - 99.98%Couleur et forme :SolidMasse moléculaire :381.43Ref: TM-T3068
2mg39,00€5mg75,00€1mL*10mM (DMSO)84,00€10mg111,00€25mg231,00€50mg371,00€100mg595,00€200mg833,00€Osunprotafib
CAS :Osunprotafib (ABBV-CLS-484) is a potent, orally bioavailable PTP1B/PTPN2 inhibitor in clinical trials for solid tumors.Cost-effective and quality-assured.Formule :C17H24FN3O4SDegré de pureté :97.11% - 99.91%Couleur et forme :SolidMasse moléculaire :385.45CX-6258 hydrochloride
CAS :CX-6258 hydrochloride (Pim-Kinase Inhibitor X) is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM).Formule :C26H24ClN3O3·HClDegré de pureté :96.03% - 98.60%Couleur et forme :SolidMasse moléculaire :498.4Ref: TM-T6148
1mg40,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg120,00€25mg222,00€50mg356,00€100mg537,00€200mg762,00€
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