STAT
Les protéines STAT sont des composants critiques de la voie de signalisation JAK/STAT, qui transmet les signaux extracellulaires des cytokines et des facteurs de croissance au noyau cellulaire, influençant ainsi l'expression génique. Les protéines STAT sont impliquées dans la régulation des réponses immunitaires, de la croissance cellulaire, de la différenciation et de la survie. La dérégulation de la signalisation STAT est impliquée dans diverses maladies, y compris le cancer, les troubles auto-immuns et l'inflammation chronique. Chez CymitQuimica, nous proposons une gamme complète de modulateurs de la voie STAT pour soutenir vos recherches en transduction de signal, immunologie et développement thérapeutique.
98 produits trouvés pour "STAT"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
L002
CAS :L002 is a potent inhibitor of acetyltransferase p300 with an IC50 of 1.98 μM, blocking histone and p53 acetylation, and may treat cardiac hypertrophy.Formule :C15H15NO5SDegré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :321.35UC-514321
CAS :UC-514321 directly targets STAT3/5 and represses TET1 expression.Formule :C26H35NO5Degré de pureté :98.50%Couleur et forme :SolidMasse moléculaire :441.56Ref: TM-T13950
1mg71,00€5mg152,00€10mg236,00€25mg477,00€50mg713,00€100mg1.071,00€200mg1.468,00€1mL*10mM (DMSO)167,00€Fludarabine
CAS :Fludarabine (Fludarabinum) is a fluorinated purine analog, an inhibitor of nucleic acid synthesis and an inhibitor of STAT1 activation.
Formule :C10H12FN5O4Degré de pureté :99.65% - 99.89%Couleur et forme :White SolidMasse moléculaire :285.23Nifuroxazide
CAS :Nifuroxazide (Diarlidan), an oral nitrofuran antidiarrheal, blocks STAT1/3/5 activation.Formule :C12H9N3O5Degré de pureté :99.79% - 99.95%Couleur et forme :Yellow SolidMasse moléculaire :275.22Garcinone C
CAS :Garcinone C, a xanthone from Garcinia oblongifolia, is anti-inflammatory, promotes healing, and may fight some cancers.Formule :C23H26O7Degré de pureté :99.13% - 99.92%Couleur et forme :SolidMasse moléculaire :414.45Niclosamide
CAS :Niclosamide (Niclocide)(BAY2353) is used to treat most tapeworm infections by inhibiting DNA replication.Formule :C13H8Cl2N2O4Degré de pureté :98.47% - 99.1%Couleur et forme :Pale Yellow Crystals SolidMasse moléculaire :327.12STAT3-IN-1
CAS :STAT3-IN-1 selective and orally active inhibitor of STAT3(in HT29 and MDA-MB 231 cells, with IC50 values of 1.82 μM and 2.14 μM , respectively), induces tumorFormule :C28H29NO6Degré de pureté :95.89% - 95.89%Couleur et forme :SolidMasse moléculaire :475.53Ref: TM-T13009
1mg60,00€2mg88,00€5mg131,00€10mg192,00€25mg349,00€50mg523,00€100mg753,00€500mg1.549,00€1mL*10mM (DMSO)137,00€Artesunate
CAS :Artesunate (WR-256283) is part of the artemisinin group of drugs that treat malaria.Formule :C19H28O8Degré de pureté :97.67% - 99.9%Couleur et forme :White Crystalline PowderMasse moléculaire :384.42Niclosamide olamine
CAS :Niclosamide olamine (Niclosamide Ethanolamine salt) is an Repellent, Insect Attractant and Chemosterilant.
Formule :C15H15Cl2N3O5Degré de pureté :99.89%Couleur et forme :Bright Yellow Crystalline Physical Description Yellow Solid Insoluble In Water (Ntp 1992)Masse moléculaire :388.20Diosgenin
CAS :Diosgenin (Nitogenin) is a spirostan found in DIOSCOREA and other plants.Formule :C27H42O3Degré de pureté :99.87%Couleur et forme :Flaky Or Needle CrystalMasse moléculaire :414.62Ac-GpYLPQTV-NH2 acetate
Ac-GpYLPQTV-NH2 acetate is a STAT3 inhibitor with an IC50 value of 0.33 μM. It also exhibits antitumor properties.Formule :C38H60N9O14P·xC2H4O2Couleur et forme :SolidMasse moléculaire :897.91 (free base)STAT4-IN-1
STAT4-IN-1 is a STAT4 inhibitor with a Ki of 0.35 μM. It holds promise for research into autoimmune diseases, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes.Couleur et forme :Odour SolidSTAT3-IN-41
STAT3-IN-41 (Compound 16) is a prodrug of compound 1. It gradually releases compound 1, which inhibits the STAT3 signaling pathway. STAT3-IN-41 exhibits antitumor activity against lung cancer, hepatocellular carcinoma, and pancreatic cancer.Formule :C22H30F3NO7Couleur et forme :SolidMasse moléculaire :477.471STAT3-IN-23
CAS :STAT3-IN-23 (PY*LKTK) acts as a potent inhibitor of STAT3 [1].Formule :C36H61N8O12PCouleur et forme :SolidMasse moléculaire :828.89MNK8
CAS :MNK8 is a potent STAT3 inhibitor, impairs DNA binding, and inhibits liver cancer cell growth.Formule :C15H12N2O2Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :252.27CMD178
CMD178 is an important polypeptide that consistently reduces the expression of Foxp3 and STAT5 by inhibiting the IL-2/s IL-2Rα signaling pathway.Formule :C46H59N9O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :850.03STAT5-IN-3
STAT5-IN-3 (Compound 14a) is a STAT5 inhibitor with anticancer properties. It works by blocking the tyrosine phosphorylation of STAT5A/5B at the Y694/699 sites, significantly reducing the expression of the STAT5B protein. This leads to the inhibition of downstream gene transcription, thereby preventing the proliferation and survival of leukemia cells. Additionally, STAT5-IN-3 has significant potential in overcoming chemotherapy resistance.Formule :C25H27N5OCouleur et forme :SolidMasse moléculaire :413.51STAT3-IN-34
STAT3-IN-34 (Compound 15E) acts as a STAT3 inhibitor, blocking both the nuclear translocation and the transcriptional regulator activity of STAT3. It effectively inhibits HaCaT cell proliferation with an IC50 value of 0.008 μM. Additionally, STAT3-IN-34 reduces IL-17A expression and mitigates Imiquimod-induced psoriasis in mouse models.Formule :C19H16N2O4SCouleur et forme :SolidMasse moléculaire :368.41STAT3-IN-31
STAT3-IN-31 (compound K2071), derived from STATtic, acts as an inhibitor of both STAT3 and mitotic processes. This compound interrupts mitotic progression and impacts the formation of the mitotic spindle. Additionally, STAT3-IN-31 hampers migration in glioblastoma cells, suppresses cellular proliferation within tumor spheroids, induces senescence in glioblastoma, and inhibits the growth of Temozolomide-resistant cells while reducing the secretion of the pro-inflammatory cytokine monocyte chemoattractant protein (MCP-1).Formule :C16H15NO3SCouleur et forme :SolidMasse moléculaire :301.36JAK-STAT Compound Library
A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;Couleur et forme :Odour SolidRef: TM-L3700
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demander
