STAT
Les protéines STAT sont des composants critiques de la voie de signalisation JAK/STAT, qui transmet les signaux extracellulaires des cytokines et des facteurs de croissance au noyau cellulaire, influençant ainsi l'expression génique. Les protéines STAT sont impliquées dans la régulation des réponses immunitaires, de la croissance cellulaire, de la différenciation et de la survie. La dérégulation de la signalisation STAT est impliquée dans diverses maladies, y compris le cancer, les troubles auto-immuns et l'inflammation chronique. Chez CymitQuimica, nous proposons une gamme complète de modulateurs de la voie STAT pour soutenir vos recherches en transduction de signal, immunologie et développement thérapeutique.
98 produits trouvés pour "STAT"
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Nitidine chloride
CAS :<p>1.</p>Formule :C21H18ClNO4Degré de pureté :96.59% - 98.91%Couleur et forme :SolidMasse moléculaire :383.82RO8191
CAS :<p>RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.</p>Formule :C14H5F6N5ODegré de pureté :98% - 98.85%Couleur et forme :SolidMasse moléculaire :373.21Balsalazide disodium dihydrate
CAS :<p>Balsalazide sodium hydrate treats mild-to-moderate ulcerative colitis; higher doses enhance remission maintenance; it's safe and effective.</p>Formule :C17H17N3Na2O8Degré de pureté :98.95% - 99.49%Couleur et forme :Yellow To Orange Crystalline PowderMasse moléculaire :437.31BP-1-102
CAS :<p>BP-1-102 is an orally active, effective and specific STAT3 inhibitor.</p>Formule :C29H27F5N2O6SDegré de pureté :99.25% - 99.44%Couleur et forme :SolidMasse moléculaire :626.59ML116
CAS :<p>ML116 is a potent and selective STAT3 inhibitor.</p>Formule :C18H19N3SDegré de pureté :99.49%Couleur et forme :SolidMasse moléculaire :309.43Picroside I
CAS :<p>Picroside I (6'-Cinnamoylcatalpol), a hepatoprotective agent, is reported to be antimicrobial and used against hepatitis B.</p>Formule :C24H28O11Degré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :492.47SH5-07
CAS :<p>SH5-07 is a hydroxamic acid-based Stat3 inhibitor (IC50: 3.9 μM).</p>Formule :C29H28F5N3O5SDegré de pureté :95.54%Couleur et forme :SolidMasse moléculaire :625.61FLLL32
CAS :<p>FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).</p>Formule :C28H32O6Degré de pureté :97% - 97.90%Couleur et forme :SolidMasse moléculaire :464.552-(1,8-naphthyridin-2-yl)phenol
CAS :<p>2-NP is a STAT1 enhancer.</p>Formule :C14H10N2ODegré de pureté :99.33% - 99.82%Couleur et forme :SolidMasse moléculaire :222.24TPCA-1
CAS :<p>TPCA-1 (TPCA1) is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM); shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinases</p>Formule :C12H10FN3O2SDegré de pureté :95.03% - 97.86%Couleur et forme :SolidMasse moléculaire :279.29Saikosaponin D
CAS :<p>Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.</p>Formule :C42H68O13Degré de pureté :98.34% - 99.73%Couleur et forme :White PowderMasse moléculaire :780.98Protosappanin A
CAS :<p>Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.</p>Formule :C15H12O5Degré de pureté :99.42% - 99.82%Couleur et forme :SolidMasse moléculaire :272.25AS1517499
CAS :<p>AS1517499 is a blood-brain barrier permeable inhibitor of STAT6 phosphorylation (IC50= 21 nM). High-Quality, Low-Cost!</p>Formule :C20H20ClN5O2Degré de pureté :98.27% - 98.7%Couleur et forme :SolidMasse moléculaire :397.86BD750
CAS :<p>BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM in</p>Formule :C14H13N3OSDegré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :271.34Astaxanthin
CAS :<p>Astaxanthin, a keto-carotenoid and xanthophyll, offers antioxidant benefits, present in red aquatic species, and used as a colorant in animal feed.</p>Formule :C40H52O4Degré de pureté :95.1% - 99.79%Couleur et forme :Needles From Acetone/Light Petroleum SolidMasse moléculaire :596.84AS1810722
CAS :<p>AS1810722, a fused bicyclic pyrimidine derivative, is an orally active and potent inhibitor of STAT6, demonstrating an IC50 of 1.9 nM.</p>Formule :C25H25F2N7ODegré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :477.511-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea
CAS :<p>SC-1 is a a derivative of the multiple tyrosine kinase inhibitor sorafenib.</p>Formule :C21H13ClF3N3O2Degré de pureté :99.41%Couleur et forme :SolidMasse moléculaire :431.8Atractylenolide I
CAS :<p>Atractylenolide-I reduces inflammation, improves sepsis, liver, and kidney function, and enhances EOC cell sensitivity to paclitaxel.</p>Formule :C15H18O2Degré de pureté :97.55% - 99.92%Couleur et forme :SolidMasse moléculaire :230.3C188-9
CAS :<p>C188-9 (TTI-101) is a Stat3 inhibitor with an IC50 of 4-7 μM.</p>Formule :C27H21NO5SDegré de pureté :98.07% - >99.99%Couleur et forme :SolidMasse moléculaire :471.52Casticin
CAS :<p>Casticin combats vascular inflammation by blocking ROS-NF-κB and could lead in prostate cancer treatment.</p>Formule :C19H18O8Degré de pureté :99.37% - ≥95%Couleur et forme :SolidMasse moléculaire :374.34Fraxinellone
CAS :<p>1.</p>Formule :C14H16O3Degré de pureté :99.35% - 99.92%Couleur et forme :SolidMasse moléculaire :232.27Corylifol A
CAS :<p>1.</p>Formule :C25H26O4Degré de pureté :97.19% - 99.5%Couleur et forme :SolidMasse moléculaire :390.47AG490
CAS :<p>AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.</p>Formule :C17H14N2O3Degré de pureté :98.6% - 99.39%Couleur et forme :Yellow SolidMasse moléculaire :294.3Alantolactone
CAS :<p>Alantolactone is a selective inhibitor of STAT3 that induces cancer-associated apoptosis and has antitumor activity.Cost-effective and quality-assured.</p>Formule :C15H20O2Degré de pureté :99.02% - 99.66%Couleur et forme :Crystalline PowderMasse moléculaire :232.32Angoline
CAS :<p>Angoline hydrochloride: IL6/STAT3 inhibitor, IC50: 11.56 μM, blocks STAT3 phosphorylation and cancer cell growth.</p>Formule :C22H21NO5Degré de pureté :99.43% - 99.96%Couleur et forme :SolidMasse moléculaire :379.41Mogrol
CAS :<p>Mogrol, a biometabolite of mogrosides, functions by inhibiting the ERK1/2 and STAT3 pathways, diminishing CREB activation, and activating AMPK signaling.</p>Formule :C30H52O4Degré de pureté :99.85% - 99.90%Couleur et forme :SolidMasse moléculaire :476.73Colivelin
CAS :<p>Colivelin is a neuroprotective peptide and activator of STAT3. Colivelin is a hybrid peptide synthesized to enhance the neuroprotective effects of humanin (HN).</p>Formule :C119H206N32O35Degré de pureté :96.56%Couleur et forme :SolidMasse moléculaire :2645.1Curculigoside
CAS :<p>1.</p>Formule :C22H26O11Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :466.44Stafia-1
CAS :<p>Stafia-1 is a potent STAT5a inhibitor ( IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members.</p>Formule :C24H27O10PDegré de pureté :98.08%Couleur et forme :SolidMasse moléculaire :506.44Ochromycinone
CAS :<p>Ochromycinone (STA 21) is a selective STAT3 inhibitor.</p>Formule :C19H14O4Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :306.31Panaxadiol
CAS :<p>Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.</p>Formule :C30H52O3Degré de pureté :98% - 99.9%Couleur et forme :SolidMasse moléculaire :460.73Tetramethylcurcumin
CAS :<p>Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it also</p>Formule :C25H28O6Degré de pureté :97.69% - 99.94%Couleur et forme :SolidMasse moléculaire :424.49Stattic
CAS :<p>Stattic (STAT3 Inhibitor V) is a STAT3 inhibitor (IC50=5.1 μM) that selectively inhibits STAT3 activation, dimerization, and nuclear translocation.</p>Formule :C8H5NO4SDegré de pureté :98.32% - 99.76%Couleur et forme :SolidMasse moléculaire :211.19Homoharringtonine
CAS :<p>Homoharringtonine (HHT) is an alkaloid combatting myeloid cancers and potentially some myelodysplastic syndromes, may treat leukemia and resistant NSC-LC.</p>Formule :C29H39NO9Degré de pureté :98.21% - 99.78%Couleur et forme :Off-White CrystMasse moléculaire :545.62inS3-54-A26
CAS :<p>inS3-54-A26 is an inhibitor of the DNA-binding domain of STAT3. inS3-54-A26 suppresses tumor growth, metastasis and the gene expression of STAT3.</p>Formule :C25H19ClN2O2Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :414.88STAT3-IN-B9
CAS :<p>STAT3-IN-B9 (B9) is an inhibitor of abnormal STAT3 activation and inhibits the proliferation of tumor cells including MDA-MB-468, MDA-MB-231, and DU145.</p>Formule :C20H13NO5SDegré de pureté :98.19%Couleur et forme :SolidMasse moléculaire :379.39inS3-54A18
CAS :<p>inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.</p>Formule :C23H16ClNO2Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :373.83Stafib-2
CAS :<p>Stafib-2 is a potent and selective inhibitor of the transcription factor STAT5b.Stafib-2 inhibits STAT5b and STAT5a with IC50 values of 82 nM and 1.7 μM,</p>Formule :C28H26N2O12P2Degré de pureté :98.48%Couleur et forme :SolidMasse moléculaire :644.46ML115
CAS :<p>ML115 is a potent and selective activator of transcription 3 (STAT3), with abn EC50 of 2.0 nM, and is inactive against the related STAT1 and NFκB anti-targets.</p>Formule :C15H15ClN2O4Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :322.74STAT6-IN-3
CAS :<p>STAT6-IN-3 (Compound 18a) serves as an inhibitor of STAT6 with an IC50 value of 44 nM, specifically targeting the Src Homology 2 (SH2) domain.</p>Formule :C32H35IN3O7PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :731.51STAT3-IN-20
CAS :<p>STAT3-IN-20 (Compound 40), with an IC50 of 0.65 μM, is a selective inhibitor targeting the SH2 domain of STAT3, thereby impeding its phosphorylation, nuclear</p>Formule :C30H27F4N7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :593.64Antitumor agent-73
CAS :<p>Antitumor Agent-73, derived from Diosgenin, blocks STAT3 and activates Pdia3, showing strong cancer cell line efficacy.</p>Formule :C50H82BrO4PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :858.06STAT6-IN-2
CAS :<p>STAT6-IN-2(R)-84 is a STAT6 inhibitor that inhibits the secretion of eotaxin-3 and the tyrosine phosphorylation of STAT6.</p>Formule :C28H31N5O2Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :469.58WZ-2-033
CAS :<p>WZ-2-033 is a potent STAT3 inhibitor. It inhibits proliferation, colony survival, migration, and invasion of MDA-MB-231, HCC70, and MDA-MB231-4175 cells, with IC50 values of 0.7, 1.3, and 1.3 μM respectively.</p>Formule :C25H18F3N3O4SCouleur et forme :SolidMasse moléculaire :513.49STAT3-IN-35
CAS :<p>STAT3-IN-35 is a STAT3 inhibitor that binds to the SH2 domain. This compound inhibits the phosphorylation of STAT3 and exhibits antiproliferative activity in triple-negative breast cancer (TNBC) cell lines. Additionally, STAT3-IN-35 has demonstrated toxicity and potent antitumor activity in TNBC xenograft models.</p>Formule :C21H23NO4Couleur et forme :SolidMasse moléculaire :353.41PMMB-187
CAS :<p>PMMB-187, a selective STAT3 inhibitor, exhibits an IC50 of 1.81 μM in MDA-MB-231 cells. This compound induces apoptosis in MDA-MB-231 cells by inhibiting STAT3 transcriptional activity and nuclear translocation, reducing mitochondrial membrane potential, increasing reactive oxygen species (ROS) production, and upregulating the expression of apoptosis-related proteins. PMMB-187 is useful for research in the field of cancer.</p>Formule :C27H23BrN2O6S2Couleur et forme :SolidMasse moléculaire :615.52STAT3-IN-8
CAS :<p>"STAT3-IN-8 (compound H172) is a potent inhibitor of STAT3 with potential applications in cancer research [1]."</p>Formule :C19H7F7N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :444.26STAT3-IN-36
CAS :<p>STAT3-IN-36 (compound 11g) is a tritarget inhibitor that selectively targets LRPPRC, STAT3, and CDK1, exhibiting potent anticancer activity. This compound binds to LRPPRC, STAT3, and CDK1, demonstrating more effective anticancer effects than those of TMF or Capecitabine. Additionally, STAT3-IN-36 exhibits an IC50 value of 1.8 μM in HGC27 cells.</p>Formule :C30H24F2N2O9S2Couleur et forme :SolidMasse moléculaire :658.65
