JNK
Les JNK (c-Jun N-terminal kinases) sont un sous-groupe de la famille MAPK qui répondent aux stimuli de stress, tels que les cytokines, les radiations ultraviolettes et les chocs thermiques, et sont impliqués dans le contrôle de l'apoptose, de l'inflammation et des réponses immunitaires. La signalisation JNK est cruciale pour la régulation des réponses cellulaires au stress et a été impliquée dans diverses maladies, y compris les troubles neurodégénératifs, le cancer et les affections inflammatoires. Chez CymitQuimica, nous offrons une gamme de modulateurs de la voie JNK pour soutenir vos recherches sur la signalisation du stress, l'apoptose et la pathologie des maladies.
105 produits trouvés pour "JNK".
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TOMATIDINE HYDROCHLORIDE
CAS :Tomatidine hydrochloride (Tomatidine HCl) is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway.Formule :C27H46ClNO2Degré de pureté :99.75% - ≥95%Couleur et forme :White SolidMasse moléculaire :452.11Actein
CAS :Actein stimulates bone formation, counters osteoporosis and oxidative damage, and may treat lipid disorders and cancer, inhibiting breast cancer cell growth.Formule :C37H56O11Degré de pureté :98% - ≥98%Couleur et forme :White SolidMasse moléculaire :676.83Polyphyllin I
CAS :Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax,Formule :C44H70O16Degré de pureté :98% - 99.36%Couleur et forme :SolidMasse moléculaire :855.02Ro 31-8220 Mesylate
CAS :Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) is a pan-PKC inhibitor, and also shows potent inhibition against MSK1, MAPKAP-K1b, S6K1, and GSK3β.Formule :C25H23N5O2S·CH4O3SDegré de pureté :98.79% - 99.02%Couleur et forme :Orange SolidMasse moléculaire :553.65Ref: TM-T6643
1mg49,00€2mg64,00€5mg92,00€1mL*10mM (DMSO)133,00€10mg150,00€25mg230,00€50mg319,00€100mg475,00€Guggulsterone
CAS :Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.Formule :C21H28O2Degré de pureté :99.4% - 99.8%Couleur et forme :SolidMasse moléculaire :312.45Ref: TM-T5574
1mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg93,00€25mg152,00€50mg205,00€100mg289,00€200mg432,00€JNK-IN-7
CAS :JNK-IN-7 (JNK inhibitor) is a selective JNK1/2/3 inhibitor (IC50: 1.54/1.99/0.75 nM).Formule :C28H27N7O2Degré de pureté :98.02% - 99.53%Couleur et forme :White SolidMasse moléculaire :493.56Ref: TM-T3598
1mg93,00€2mg149,00€5mg215,00€1mL*10mM (DMSO)233,00€10mg275,00€25mg495,00€50mg712,00€100mg973,00€CC-401 Hydrochloride
CAS :CC-401 Hydrochloride (CC401 HCl) is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with antineoplastic activity.Formule :C22H25ClN6ODegré de pureté :99.71% - ≥95%Couleur et forme :White SolidMasse moléculaire :424.93JIP-1 (153-163) acetate(438567-88-5 free base)
JNK peptide inhibitor. Mimics JIP-1 residues 153-163. Micromolar affinity, little effect on p38, ERK.Formule :C63H108N20O16Degré de pureté :92.89%Couleur et forme :SolidMasse moléculaire :1401.65Ro 31-8220
CAS :Ro 31-8220: potent PKC inhibitor (IC50: 5-27 nM). Affects MAPKAP-K1b, MSK1, S6K1, GSK3β (IC50: 3-38 nM), not MKK3/4/6/7.Formule :C25H23N5O2SCouleur et forme :SolidMasse moléculaire :457.55Bentamapimod
CAS :Bentamapimod (AS 602801) is a novel, orally active inhibitor of JNK.Formule :C25H23N5O2SDegré de pureté :97.04% - 99.92%Couleur et forme :SolidMasse moléculaire :457.55Ref: TM-T2675
2mg43,00€5mg63,00€10mg94,00€25mg154,00€50mg187,00€100mg333,00€500mg1.089,00€1g1.972,00€2g2.655,00€Astragaloside IV
CAS :Astragaloside IV suppresses ERK1/2, JNK, MMP-2/9 in breast cancer; inhibits adenovirus and protects cardiovascular, immune, digestive, nervous systems.Formule :C41H68O14Degré de pureté :99% - 99.84%Couleur et forme :SolidMasse moléculaire :784.97JNK-IN-8
CAS :JNK-IN-8 (JNK Inhibitor XVI) is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM).Formule :C29H29N7O2Degré de pureté :99.24% - >99.99%Couleur et forme :White SolidMasse moléculaire :507.59Ref: TM-T2668
2mg44,00€5mg73,00€1mL*10mM (DMSO)82,00€10mg113,00€25mg197,00€50mg326,00€100mg482,00€200mg685,00€Epieriocalyxin A
CAS :Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.Formule :C20H24O5Degré de pureté :97.00%Couleur et forme :SolidMasse moléculaire :344.4D-JNKI-1 acetate
D-JNKI-1 acetate (AM-111 acetate) is a highly potent and cell-permeable peptide inhibitor of JNK.Formule :C166H290N66O42Degré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :3882.5Ref: TM-T10937L
1mg156,00€5mg296,00€10mg442,00€25mg707,00€50mg1.009,00€1mL*10mM (DMSO)1.089,00€100mg1.333,00€TRi-1
CAS :TRi-1 irreversibly inhibits TXNRD1 (IC50: 12 nM) with low mitochondrial toxicity for cancer treatment.Formule :C12H9ClN2O5SDegré de pureté :97.14%Couleur et forme :SolidMasse moléculaire :328.73Ref: TM-T5481
1mg70,00€2mg89,00€5mg137,00€1mL*10mM (DMSO)150,00€10mg205,00€25mg340,00€50mg485,00€100mg700,00€Isovitexin
CAS :1.Formule :C21H20O10Degré de pureté :99.79% - 99.97%Couleur et forme :SolidMasse moléculaire :432.38Ref: TM-T6S1371
1mg49,00€5mg92,00€1mL*10mM (DMSO)100,00€10mg133,00€25mg259,00€50mg358,00€100mg530,00€200mg755,00€IQ-3
CAS :IQ3 inhibits JNK3 (Kd 66 nM), JNK1/2, NF-κB/AP1 in THP1-Blue cells (IC50 1.4 μM), and reduces TNF-α/IL-6 production.Formule :C20H11N3O3Degré de pureté :≥98%Couleur et forme :White SolidMasse moléculaire :341.32Indirubin-3′-oxime
CAS :Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.Formule :C16H11N3O2Degré de pureté :98.34%Couleur et forme :SolidMasse moléculaire :277.28Ref: TM-T9138
1mg44,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg120,00€25mg236,00€50mg356,00€100mg532,00€200mg772,00€IQ-1S free acid
CAS :IQ-1S free acid (IQ-1S) is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity.Formule :C15H9N3ODegré de pureté :97.92% - 99.05%Couleur et forme :SolidMasse moléculaire :247.25Ref: TM-T3627
5mg44,00€1mL*10mM (DMSO)48,00€10mg50,00€25mg90,00€50mg160,00€100mg289,00€200mg430,00€500mg695,00€Taurochenodeoxycholic acid sodium
CAS :Sodium taurochenodeoxycholate: induces apoptosis, anti-inflammatory, boosts insulin, stimulates α2-cells, increases [Ca(2+)](c).Formule :C26H44NNaO6SDegré de pureté :98.23% - 99.56%Couleur et forme :White SolidMasse moléculaire :521.68Fasudil hydrochloride
CAS :Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.Formule :C14H18ClN3O2SDegré de pureté :99.54% - ≥95%Couleur et forme :White SolidMasse moléculaire :327.83CC-90001
CAS :CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2.Formule :C16H27N5O2Degré de pureté :99.96%Couleur et forme :White SolidMasse moléculaire :321.42Esculentoside H
CAS :Phytolaccaceae has anti-tumor activity, the mechanism may be related to the capacity of Esculentoside H for TNF release.Formule :C48H76O21Degré de pureté :98.9% - 99.3%Couleur et forme :White SolidMasse moléculaire :989.1TCS JNK 5a
CAS :TCS JNK 5a (SC202671) is an effective, specific inhibitor of JNK3(pIC50= 6.7), JNK2(pIC50=6.5).Formule :C20H16N2OSDegré de pureté :99.22% - 99.51%Couleur et forme :SolidMasse moléculaire :332.42Ginsenoside Re
CAS :Ginsenoside Re (Ginsenoside B2) may have properties that inhibit or prevent the growth of tumors.Formule :C48H82O18Degré de pureté :99.12% - >99.99%Couleur et forme :SolidMasse moléculaire :947.15Ref: TM-T2872
2mg34,00€5mg48,00€10mg63,00€1mL*10mM (DMSO)65,00€25mg92,00€50mg138,00€100mg197,00€200mg290,00€Tomatidine
CAS :Tomatidine serves as an anti-inflammatory agent by inhibiting NF-κB and JNK signaling pathways.Formule :C27H45NO2Degré de pureté :99.94% - 99.98%Couleur et forme :White SolidMasse moléculaire :415.65Sesamolin
CAS :Sesamolin and sesamin guard nerves, reduce microglia damage by blocking p38 MAPK and caspase-3, and curb nitric oxide in stimulated cells.Formule :C20H18O7Degré de pureté :98.77% - 99.04%Couleur et forme :White SolidMasse moléculaire :370.35Ref: TM-T5S2283
1mg35,00€2mg50,00€5mg75,00€1mL*10mM (DMSO)84,00€10mg120,00€25mg197,00€50mg294,00€100mg437,00€200mg622,00€Pamapimod
CAS :Pamapimod (R1503) (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase.Formule :C19H20F2N4O4Degré de pureté :99.52% - 99.99%Couleur et forme :SolidMasse moléculaire :406.38SR-3737
CAS :SR-3737 is potent both JNK3 and p38 inhibitor.Formule :C29H25FN4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :512.53SX 011
CAS :SX 011 is a p38α inhibitor.Formule :C26H27ClFN3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :483.96TOPK-p38/JNK-IN-1
CAS :TOPK-p38/JNK-IN-1 (Compound B12) is an orally active inhibitor of the TOPK-p38/JNK signaling pathway, with an IC50 value of 2.14 μM for the inhibition of NOFormule :C17H15F3N2O4Couleur et forme :SolidMasse moléculaire :368.31BSJ-04-122
CAS :BSJ-04-122: MKK4/7 inhibitor with IC50s of 4 nM & 181 nM, used in cancer research.Formule :C15H12ClN5ODegré de pureté :98.09%Couleur et forme :SolidMasse moléculaire :313.74SR 3576
CAS :JNK3 inhibitor, potent and selectiveFormule :C27H27N5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :501.53GSK649A
CAS :GSK649A is a novel activator of Satellite Cell Proliferation, it could enhance repair of Damaged Muscle.Formule :C15H12ClFN6OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :378.81J30-8
CAS :J30-8 is a JNK3 inhibitor (IC50: 40 nM) with neuroprotective activity and can be used to study neurodegenerative diseases such as Alzheimer's disease.Formule :C17H9ClFN3O2SDegré de pureté :99.90%Couleur et forme :Red SolidMasse moléculaire :373.79ZG-10
CAS :ZG-10 (JNK-IN-2) is an inhibitor of JNK, blocking JNK1, JNK2, and JNK3, and is used in studies of SARS-CoV-2 virus infection.Formule :C28H27N7O2Degré de pureté :99.41% - 99.91%Couleur et forme :Yellow SolidMasse moléculaire :493.56JNK3 inhibitor-4
CAS :JNK3 inhibitor-4: potent, selective JNK3 blocker (IC50=1.0nM), neuroprotective, BBB-permeable.Formule :C28H27N7OCouleur et forme :SolidMasse moléculaire :477.56SR-3306
CAS :SR-3306 is a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor with IC50 values of 67 nM, 283 nM, 159 nM.Cost-effective and quality-assured.Formule :C28H26N8ODegré de pureté :99.38% - 99.71%Couleur et forme :SolidMasse moléculaire :490.56Ref: TM-T16927
1mg49,00€5mg98,00€1mL*10mM (DMSO)108,00€10mg152,00€25mg288,00€50mg520,00€100mg835,00€500mg1.674,00€JNK-1-IN-1
CAS :JNK-1-IN-1 is an inhibitor specifically targeting JNK-1, also exhibiting inhibition of MKK7 with an IC50 value of 7.8μM.Formule :C24H22N6SCouleur et forme :SolidMasse moléculaire :426.54JNK-IN-11
CAS :JNK-IN-11 inhibits JNK1/2/3 (IC50: 2.2/21.4/1.8 μM); promising for Alzheimer's/Parkinson's research.Formule :C12H11NO3S2Degré de pureté :99.24%Couleur et forme :Yellow SolidMasse moléculaire :281.35Ezatiostat hydrochloride
CAS :Ezatiostat HCl (TLK199) inhibits glutathione S-transferase, GSTP1-1 specifically, and may treat cytopenias.Formule :C27H36ClN3O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :566.11Ref: TM-T22776
2mg55,00€5mg78,00€1mL*10mM (DMSO)112,00€10mg114,00€25mg190,00€50mg290,00€100mg490,00€200mg735,00€500mg1.104,00€JNK3 inhibitor-1
CAS :JNK3 inhibitor-1: potent, selective, IC50 of 0.005 μM, orally bioavailable, brain-penetrant.Formule :C21H17ClFN5O2SCouleur et forme :SolidMasse moléculaire :457.91JNK3 inhibitor-3
CAS :JNK3 Inhibitor-3 selectively blocks JNK3 (>4.1 nM), crosses the blood-brain barrier, is orally active, and improves memory in dementia mice.Formule :C26H25N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :467.52TC ASK 10
CAS :TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1,IC50 = 14 nM). The IC50 value for ASK2 is 0.51 μM.Formule :C21H23Cl2N5ODegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :432.35Ref: TM-T13099
1mg33,00€5mg86,00€1mL*10mM (DMSO)95,00€10mg124,00€25mg236,00€50mg371,00€100mg532,00€200mg705,00€Nitric oxide production-IN-11k
CAS :Nitric oxide production-IN-11k is a compound that inhibits TLR4, JNK, and NF-κB signaling pathways.Formule :C23H20O3Couleur et forme :SolidMasse moléculaire :344.403p38 Kinase inhibitor 8
CAS :p38 Kinase inhibitor 8 (Compound CCLXXVIII) is an orally active inhibitor targeting p38β and JNK2α2, with IC50 values of 6.3 nM and 53.6 nM, respectively. It has demonstrated anti-inflammatory effects in a rat model of collagen-induced arthritis.Formule :C22H21FN6O2Couleur et forme :SolidMasse moléculaire :420.44JNK-1-IN-4
CAS :JNK-1-IN-4 (Compound E1) is an inhibitor of JNK, targeting JNK-1, JNK-2, and JNK-3 with IC50 values of 2.7, 19.0, and 9.0 nM, respectively. This compound inhibits the phosphorylation of c-Jun and reduces the expression of TGF-β1-induced EMT markers (such as fibronectin and α-SMA). JNK-1-IN-4 exhibits favorable pharmacokinetic properties with a bioavailability of 69%. Additionally, it demonstrates antifibrotic effects in a Bleomycin-induced mouse model of idiopathic pulmonary fibrosis.Formule :C22H25BrN6O3Couleur et forme :SolidMasse moléculaire :501.38PT109
CAS :PT109 is a multikinase inhibitor that targets JNK and other kinases, playing a crucial role in anti-inflammatory, antioxidative, neurogenic, and synaptogenic processes. Specifically, PT109 inhibits JNK isoforms with the following IC50 values: JNK1 at 0.143 μM, JNK2 at 0.831 μM, and JNK3 at 0.285 μM. It also inhibits SGK isoforms (SGK1: IC50=1.34 μM; SGK2: IC50=5.6 μM; SGK3: IC50=26.4 μM) and ROCK2 (IC50=34 μM). Additionally, PT109 reprograms polymorphic glioblastoma multiforme (GBM) into oligodendroglia via the PTBP1/PKM1/2 pathway and alters the metabolic pattern of GBM to exhibit antiglioma activity.Formule :C23H31N3OS2Couleur et forme :SolidMasse moléculaire :429.64JNK-IN-21
CAS :JNK-IN-21 (Compound 62) is an inhibitor of JNK-1.Formule :C19H16N2O2SCouleur et forme :SolidMasse moléculaire :336.408JD118
CAS :JD118 is an inhibitor of JNK. It effectively suppresses the activity of JNK1 and the expression of cJun (1 - 135).Formule :C13H12N4S2Couleur et forme :SolidMasse moléculaire :288.391
