MAPK
Les MAPK sont une famille de kinases protéiques impliquées dans une variété de processus cellulaires, y compris la croissance, la prolifération, la différenciation et les réponses au stress. La voie de signalisation MAPK comprend plusieurs niveaux, y compris ERK, JNK et p38 MAPK, chacun jouant des rôles distincts dans la fonction cellulaire. La dérégulation de la signalisation MAPK est liée au cancer, aux maladies inflammatoires et aux troubles métaboliques. Chez CymitQuimica, nous offrons un large éventail d'inhibiteurs et d'activateurs de MAPK pour soutenir vos recherches en biologie cellulaire, transduction de signaux et mécanismes des maladies.
886 produits trouvés pour "MAPK"
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CC-90003
CAS :<p>CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.</p>Formule :C22H21F3N6O2Degré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :458.44ERK5-IN-5
CAS :<p>ERK5-IN-5 is extracellular signal-regulated kinase 5 (ERK5) inhibitor with anticancer activity anticonvulsant activity inhibits A549 cell proliferation.</p>Formule :C19H16ClN3ODegré de pureté :99.77%Couleur et forme :SoildMasse moléculaire :337.8LUT014
CAS :<p>LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.</p>Formule :C27H19F3N8ODegré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :528.49MAP4K4-IN-3
CAS :<p>MAP4K4-IN-3 (Compound 17) may be a viable target for antidiabetic agents, a serine/threonine protein kinase.</p>Formule :C15H12ClN5Degré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :297.74Pepinh-TRIF TFA
<p>Pepinh-TRIF TFA is a 30 aa peptide associated with the immune system that blocks TRIF signaling by interfering with TLR-TRIF interaction (TLR-TRIF interaction</p>Formule :C180H279F3N58O40S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4014.09741ERK5-IN-6
CAS :<p>ERK5-IN-6 is an ERK5 kinase inhibitor with antiproliferative, anticonvulsant, and antitumor activity for the study of central nervous system related diseases.</p>Formule :C23H21N3Degré de pureté :98.59%Couleur et forme :SoildMasse moléculaire :339.43B-Raf IN 2
CAS :<p>B-Raf IN 2, compound Ia, is a highly effective and specific inhibitor of BRAF. It exhibits significant potential for cancer research.</p>Formule :C20H17F2N5O4SDegré de pureté :98.86%Couleur et forme :SolidMasse moléculaire :461.44MRTX-1257
CAS :<p>MRTX-1257: selective, irreversible KRAS G12C inhibitor; IC50 of 900 pM; 31% bioavailable in mice; 77% target engagement.</p>Formule :C33H39N7O2Degré de pureté :97.3% - 99.07%Couleur et forme :SolidMasse moléculaire :565.71AX-15836
CAS :<p>AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).</p>Formule :C32H40N8O5SDegré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :648.78MRTX0902
CAS :<p>MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM.</p>Formule :C22H24N6ODegré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :388.47ACBI3
CAS :<p>ACBI3 is a selective pan-KRAS degrader with anticancer activity that degrades oncogenic KRAS. ACBI3 inhibits the growth of most cancer cell lines driven by KRAS mutations.</p>Formule :C50H62N14O6S2Degré de pureté :99.24%Couleur et forme :SolidMasse moléculaire :1019.25HI-TOPK-032
CAS :<p>HI-TOPK-032 is an effective and specific inhibitor of TOPK.</p>Formule :C20H11N5OSDegré de pureté :98.52%Couleur et forme :SolidMasse moléculaire :369.4GW806742X
CAS :<p>GW806742X inhibits MLKL with Kd 9.3 μM, preventing necroptosis; also targets VEGFR2.</p>Formule :C25H22F3N7O4SDegré de pureté :98.3%Couleur et forme :SolidMasse moléculaire :573.55JNK-IN-13
CAS :<p>JNK-IN-13 is a JNK inhibitor that inhibits JNK3 and JNK2 and can be used in the study of diabetes, inflammation, and neurological disorders.</p>Formule :C13H7ClN4SDegré de pureté :98.74%Couleur et forme :SolidMasse moléculaire :286.74(R)-Ketorolac
CAS :<p>(R)-Ketorolac ((+)-Ketorolac) is the R-enantiomer of Ketorolac, with potent analgesic activity.</p>Formule :C15H13NO3Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :255.27Cephradine
CAS :<p>Cephradine (Anspor) is a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity.</p>Formule :C16H19N3O4SDegré de pureté :99.63%Couleur et forme :White Crystalline Powder; Polymorphic SolidMasse moléculaire :349.40BI-3406
CAS :<p>BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.</p>Formule :C23H25F3N4O3Degré de pureté :99.2% - 99.66%Couleur et forme :SolidMasse moléculaire :462.46ETC-206
CAS :<p>ETC-206 is a selective inhibitor of MNK1 and MNK2 (IC50s: 64 nM and 86 nM).</p>Formule :C25H20N4O2Degré de pureté :99.72% - 99.79%Couleur et forme :SolidMasse moléculaire :408.45Xl-281
CAS :<p>XL-281: potent oral RAF kinase inhibitor, effective on wild-type and mutants, reduces tumor growth and cell proliferation, increases apoptosis.</p>Formule :C24H19ClN4O4Degré de pureté :95.77% - 98.83%Couleur et forme :SolidMasse moléculaire :462.89MK2-IN-3 hydrate
CAS :<p>MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)</p>Formule :C21H18N4O2Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :358.39KRAS G12C inhibitor 19
CAS :<p>KRAS G12C inhibitor 19 is a potent KRAS G12C inhibitor that shows anti-tumor activity in cellular assays, and the family inhibits tumor growth.</p>Formule :C25H19ClF2N4O3SDegré de pureté :97.46%Couleur et forme :SolidMasse moléculaire :528.96PF-3644022
CAS :<p>PF-3644022 is a selective MK2 inhibitor, effective against TNFα (IC50: 5.2 nM, Ki: 3 nM), with anti-inflammatory properties. Also blocks MK3 and PRAK.</p>Formule :C21H18N4OSDegré de pureté :98.13%Couleur et forme :SolidMasse moléculaire :374.46Methylthiouracil
CAS :<p>Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.</p>Formule :C5H6N2OSDegré de pureté :99.89% - >99.99%Couleur et forme :Crystals Saturated Aqueous Solution Is Neutral Or Slightly Acidic (Ntp 1992)Masse moléculaire :142.18INH154
CAS :<p>INH154 is a potent Nek2 and Hec1 binding (INH) inhibitor with IC50s of 120 nM in MB468 cells and 200 nM in Hela cells for INH.</p>Formule :C22H24N4OSDegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :392.52Tanzisertib
CAS :<p>Tanzisertib (CC-930) (CC-930) is a potent inhibitor of JNK1/2/3 with IC50s of 61/7/6 nM, respectively, with potential antifibrotic activity.</p>Formule :C21H23F3N6O2Degré de pureté :98.66% - 99.28%Couleur et forme :SolidMasse moléculaire :448.44Azelnidipine
CAS :<p>Azelnidipine (UR-12592) is a dihydropyridine used as calcium channel blocker.</p>Formule :C33H34N4O6Degré de pureté :99.78%Couleur et forme :Light Yellowish PowderMasse moléculaire :582.65SU3327
CAS :<p>SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).</p>Formule :C5H3N5O2S3Degré de pureté :98.39%Couleur et forme :SolidMasse moléculaire :261.3K-Ras G12C-IN-4
CAS :<p>K-Ras G12C-IN-4 是一种 KRAS G12C 共价抑制剂。</p>Formule :C31H33ClN4O4Degré de pureté :99.00%Couleur et forme :SolidMasse moléculaire :561.07ARS-1630
CAS :<p>ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.</p>Formule :C21H17ClF2N4O2Degré de pureté :97.78%Couleur et forme :SolidMasse moléculaire :430.84Divarasib
CAS :<p>Divarasib (GDC-6036), an investigational KRAS G12C inhibitor for solid tumors, has an IC50 of <0.01 μM.</p>Formule :C29H32ClF4N7O2Degré de pureté :99.237% - 99.83%Couleur et forme :SolidMasse moléculaire :622.06RMC-6236
CAS :<p>RMC-6236 is a potent RAS(ON)MULTI inhibitor with broad-spectrum inhibitory activity against RAS-GTP.Cost-effective and quality-assured.</p>Formule :C44H58N8O5SDegré de pureté :98.24% - 99.92%Couleur et forme :SolidMasse moléculaire :811.05Regorafénib N-oxyde (M2)
CAS :<p>Regorafénib N-oxyde M2 is an active metabolite of Regorafenib.</p>Formule :C21H15ClF4N4O4Degré de pureté :98.03% - 98.26%Couleur et forme :SolidMasse moléculaire :498.81Dilmapimod
CAS :<p>Dilmapimod (SB-681323) is a potent inhibitor of p38 MAPK ,it potentially suppresses inflammation in chronic obstructive pulmonary disease.</p>Formule :C23H19F3N4O3Degré de pureté :97.53%Couleur et forme :SolidMasse moléculaire :456.42MRTF-A-IN-1
<p>MRTF-A-IN-1 (compound 14) is an inhibitor of MRTF-A. It effectively suppresses cell proliferation and induces senescence in HCC cells.</p>Formule :C22H21N3Couleur et forme :SolidMasse moléculaire :327.42Debromohymenialdisine
CAS :<p>Debromohymenialdisine is a natural product for research related to life sciences. The catalog number is T35596 and the CAS number is 75593-17-8.</p>Formule :C11H11N5O2Couleur et forme :SolidMasse moléculaire :245.242ERK1/2 inhibitor 3
CAS :<p>ERK1/2 inhibitor 3, a strong ERK1/2 blocker, may aid in cancer and inflammation research.</p>Formule :C28H31ClFN5O6SCouleur et forme :SolidMasse moléculaire :620.09JIP-1(153-163)
CAS :<p>Peptide based on JIP-1(153-163) inhibits JNK with micromolar affinity; barely affects p38, ERK.</p>Formule :C61H104N20O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1341.6PROTAC KRAS G12C degrader-1
<p>PROTAC KRAS G12C degrader-1, a cereblon-based degrader, promotes CRBN/KRAS G12C dimerization and facilitates the degradation of GFP-KRAS G12C in reporter cells</p>Formule :C50H54ClFN8O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :917.47NK7-902
<p>NK7-902 is a CRBN molecular glue degrader of NEK7. It fully degrades NEK7 in human primary monocytes and whole blood, yet only partially inhibits NLRP3-dependent IL-1β production. NK7-902 results in profound and lasting degradation of NEK7, but only temporarily blocks NLRP3 inflammasome activation in non-human primates via oral administration. The compound demonstrates activity in mouse systems.</p>Couleur et forme :Odour SolidRapaprutug
CAS :<p>Rapaprutug is a monoclonal antibody that targets human KARS1 (lysyl-tRNA synthetase 1). It can block inflammation-related signaling pathways involving KARS1, thereby reducing the production and release of inflammatory factors. Rapaprutug shows potential for research into inflammatory diseases.</p>Couleur et forme :LiquidCC-401
CAS :<p>CC-401 is a specific inhibitor of JNK (Ki: 25-50nM).</p>Formule :C22H24N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :388.47MC 976
CAS :<p>MC 976 is a derivative of Vitamin D3.</p>Formule :C27H42O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :414.63PROTAC SOS1 degrader-1
CAS :<p>PROTAC SOS1 degrader-1: potent, DC50 98.4 nM, inhibits KRAS mutant cancer cells, low-toxic antitumor.</p>Formule :C57H76O4ClFN10SCouleur et forme :SoildMasse moléculaire :1050.54443R18
CAS :<p>14.3.3 protein antagonist, blocks binding to Raf-1/Bad/ASK1/exoenzyme S, competitive, no phosphorylation needed, KD ~80 nM.</p>Formule :C101H157N27O29S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2309.69Rineterkib hydrochloride
CAS :<p>Rineterkib hydrochloride (B) is an oral RAF/ERK1/2 inhibitor for MAPK-driven cancers, including KRAS/BRAF-mutant NSCLC and CRC.</p>Formule :C26H28BrClF3N5O2Couleur et forme :SolidMasse moléculaire :614.89LC 2 Epimer
CAS :<p>Negative control for LC 2.</p>Formule :C59H71ClFN11O7SCouleur et forme :SolidMasse moléculaire :1132.8Pan-RAS-IN-7
CAS :<p>Pan-RAS-IN-7 (Compound D101) is a broad-spectrum RAS inhibitor used in the synthesis of antibody-drug conjugates (ADCs). It is also applicable in cancer research.</p>Formule :C59H76N8O8Couleur et forme :SolidMasse moléculaire :1025.28Rutamycin
CAS :<p>Rutamycin: a macrolide antibiotic from Streptomyces rutgersensis; blocks ATPases, uncouples oxidative phosphorylation.</p>Formule :C44H72O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :777.049DS03090629
<p>DS03090629, an orally active MEK inhibitor, functions by competitively inhibiting MEK activity in the presence of ATP. This compound demonstrates strong binding affinity to both MEK and phosphorylated MEK, with dissociation constants (Kd) of 0.11 and 0.15 nM, respectively. It has shown efficacy in suppressing the proliferation of melanoma cell lines that overexpress BRAF mutations, achieving IC50 values of 74.3 and 97.8 nM for BRAF V600E and MEK1 F53L transfected A375 cells, respectively. DS03090629 is thus considered promising for anti-melanoma therapies.</p>Formule :C25H26ClN5O2Couleur et forme :SolidMasse moléculaire :463.96HSND80
<p>HSND80 (Compound 1) is an orally active MNK/p70S6K inhibitor, exhibiting a Kd value of 44 nM for MNK1 and 4 nM for MNK2. The residence time of HSND80 on MNK1 and MNK2 is 45 minutes and 58 minutes, respectively. HSND80 effectively inhibits non-small cell lung cancer (NSCLC) both in vitro and in vivo, and suppresses the growth of triple-negative breast cancer (TNBC) cells in vitro.</p>Couleur et forme :Odour SolidAnti-inflammatory agent 31
<p>Andrographolide derivative 31 is an anti-inflammatory that blocks NF-κB, PI3K/Akt, and ERK1/2 MAPK, and restores GSH levels to protect the liver.</p>Formule :C19H30O3Couleur et forme :SolidMasse moléculaire :306.44MEK/RAF-IN-1
<p>MEK/RAF-IN-1 (Compound 16b) serves as an inhibitor targeting both MEK and RAF, demonstrating potent efficacy with IC 50 values reported at 28 nM for MEK1, and 3 nM for both BRAF and BRAFV600E. This compound exhibits significant antitumor capabilities, effectively curbing cell proliferation in vitro in MIA PaCa-2 (G12C KRAS), HCT116 (G13D KRAS), and C26 (G12D KRAS) cells. Furthermore, MEK/RAF-IN-1 significantly restricts tumor growth in xenograft mouse models employed in the study of colorectal cancer.</p>Formule :C28H29F3N6O5SCouleur et forme :SolidMasse moléculaire :618.63Vacquinol-1
CAS :<p>Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.</p>Formule :C21H21ClN2ODegré de pureté :98.67%Couleur et forme :SolidMasse moléculaire :352.86RM-018
CAS :<p>RM-018 inhibits active KRAS G12C & G12C/Y96D, possibly beating resistance with unique traits.</p>Formule :C56H72N8O8Couleur et forme :SolidMasse moléculaire :985.24PROTAC K-Ras Degrader-2
CAS :<p>PROTAC K-Ras degrader-2 (compound 48) is a broad-spectrum KRAS mutant PROTAC degrader that demonstrates an IC50 of ≤200 nM for KRAS G12V/RAF1. Additionally, PROTAC K-Ras degrader-2 achieves a DC50 of ≤200 nM in degrading SW620 KRAS G12D and inhibits the growth of SW620 3D cells with an IC50 of ≤20 nM.</p>Formule :C52H60F4N8O5Couleur et forme :SolidMasse moléculaire :953.077JNK3 inhibitor-8
<p>JNK3 inhibitor-8: potent, selective, oral, BBB-penetrating, IC50: JNK3=21 nM, JNK2=2203 nM, JNK1>10,000 nM; potential in Alzheimer's research.</p>Formule :C32H30FN7O3Couleur et forme :SolidMasse moléculaire :579.62KRAS inhibitor-38
CAS :<p>KRAS Inhibitor-38 (Example 18) is a potent inhibitor capable of effectively suppressing the activity of KRAS G12C, KRAS G12D, and KRAS G12V in vivo.</p>Formule :C53H68ClF2N9O8SCouleur et forme :SolidMasse moléculaire :1064.68Mitogen-activated protein kinase 1
CAS :<p>Mitogen-activated protein kinase 1 (MAPK1) activates the p38/NF-κB pathway and regulates cellular processes in sepsis-associated diseases.</p>Degré de pureté :98%Couleur et forme :SolidRac1 Inhibitor W56
CAS :<p>Peptide (45-60) blocks Rac1 binding with TrioN, GEF-H1, Tiam1 GEFs.</p>Formule :C74H117N19O23SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1671.93SOS1-IN-18
<p>SOS1-IN-18 (Compound 8) is an inhibitor of the Son of Sevenless 1 protein (SOS1) with a dissociation constant (KD) of 2.6 nM. It disrupts the SOS1-KRAS G12C interaction with an IC50 of 3.4 nM, inhibits ERK phosphorylation in H358 cells with an IC50 of 31 nM, and curtails the proliferation of H358 cells with an IC50 of 5 nM.</p>Formule :C26H29F3N4O2Couleur et forme :SolidMasse moléculaire :486.53NecroX-2
CAS :<p>NecroX-2 is a cell-permeable necrosis inhibitor with antioxidant properties. NecroX-2 selectively suppresses necrotic cell death triggered by oxidative stress. NecroX-2 does not confer protection against apoptosis induced by staurosporine or etoposide but shows protective effects under conditions such as cold shock, hypoxia, and oxidative stress in vitro.</p>Formule :C25H32N4O4S2Degré de pureté :97.12%Couleur et forme :SolidMasse moléculaire :516.68S6 Kinase Substrate Peptide 32
<p>S6 Kinase Substrate Peptide 32 is a peptide that measures the activity of kinases that phosphorylate ribosomal protein S6. It can also be used as a substrate.</p>Formule :C149H270N56O49Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3630.1PROTAC MLKL Degrader-1
<p>PROTAC MLKL Degrader-1 (Compound 36) is a selective PROTAC degrader targeting MLKL, achieving a degradation maximum (D max) over 90%.</p>Formule :C46H55F2N9O9SCouleur et forme :SolidMasse moléculaire :948.05BI1701963
<p>BI1701963 is an orally effective inhibitor that targets the SOS1 and KRAS interaction, specifically inhibiting the activation of KRAS by blocking its GTP loading. This compound is utilized in cancer research to explore potential therapeutic effects against KRAS-driven malignancies.</p>Formule :C47H62N8O4SCouleur et forme :SolidMasse moléculaire :835.11(R)-BI-2852
CAS :<p>(R)-5-hydroxy isoindolin-1-one is an RAS protein inhibitor with antiproliferative and antitumor properties.</p>Formule :C31H28N6O2Degré de pureté :97.78%Couleur et forme :SoildMasse moléculaire :516.59L-JNKI-1
L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK, it has been shown to effectively inhibit JNK activity in in vivo studies.Formule :C164H286N66O40Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3822.44IPS-06061
<p>IPS-06061 is an orally active molecular glue that forms a ternary complex with CRBN and KRASG12D, capable of degrading KRAS G12D, with a DC50 of less than 500 nM.</p>Formule :C22H26O3Couleur et forme :SolidMasse moléculaire :338.44SIAIS562055
<p>SIAIS562055, a potent cereblon-based SOS1PROTAC, exhibits a dissociation constant (Kd) of 95.9 nM. It effectively degrades SOS1 and inhibits the downstream ERK pathway. SIAIS562055 disrupts the interaction between KRASG12C or KRASG12D and SOS1, with IC50 values of 95.7 nM and 134.5 nM, respectively. This compound demonstrates strong anticancer activity.</p>Formule :C49H62F3N7O5SCouleur et forme :SolidMasse moléculaire :918.12PROTAC SOS1 degrader-4
<p>PROTAC SOS1 Degrader-4 (compound 10) is a potent degrader of SOS1 and exhibits antiproliferative activity [1].</p>Formule :C53H65ClN8O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :993.65KRAS G12D inhibitor 7
CAS :<p>KRAS G12D inhibitor 7, is a highly potent inhibitor specifically targeting KRAS G12D.</p>Formule :C32H38N8O3Couleur et forme :SolidMasse moléculaire :582.709YN14
<p>YN14 is a highly potent and selective KRASG12C proteolysis targeting chimera (PROTAC) capable of forming a stable KRASG12C: YN14: VHL ternary complex with low</p>Degré de pureté :98%Couleur et forme :Odour SolidSS47
CAS :<p>SS47 is a PROTAC that degrades immunosuppressive HPK1 via proteasome; boosts BCMA CAR-T cell cancer therapy.</p>Formule :C49H56N6O12SCouleur et forme :SolidMasse moléculaire :953.07KRAS G12D inhibitor 6
CAS :<p>KRAS G12D inhibitor 6 is an efficacious compound that effectively inhibits KRAS G12D.</p>Formule :C32H37ClN8O2Couleur et forme :SolidMasse moléculaire :601.15Ras Inhibitory Peptide acetate
<p>Ras Inhibitory Peptide acetate, involved in cancer-related Ras signaling.</p>Formule :C55H95N19O13Degré de pureté :96.63%Couleur et forme :SolidMasse moléculaire :1230.464′-Demethylnobiletin
CAS :<p>4′-Demethylnobiletin, a bioactive metabolite, activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, and</p>Formule :C20H20O8Couleur et forme :SolidMasse moléculaire :388.37PPM-3
<p>PPM-3, a selective PROTAC ERK5 degrader, exhibits a potent inhibitory concentration (IC 50) of 62.4 nM.</p>Formule :C54H69N11O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1000.26Cobimetinib (R-enantiomer)
CAS :<p>Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib which is a selective MEK inhibitor.</p>Formule :C21H21F3IN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :531.318p38 MAP Kinase Inhibitor Ⅵ
CAS :<p>p38 MAP Kinase Inhibitor Ⅵ is a potent p38 MAP Kinase inhibitor with anti-inflammatory activity.</p>Formule :C16H13FN2OS2Degré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :332.42KRAS G12C inhibitor 69
<p>KRAS G12C inhibitor 69 (Compound K09) is an inhibitor of the mutant RAS protein KRAS G12C with an IC50 of 4.36 nM. In the cell lines NCI-H358 and MIA-PACA-2, it suppresses ERK phosphorylation with IC50 values of 12 nM and 7 nM, respectively. Additionally, KRAS G12C inhibitor 69 hinders the proliferation of NCI-H358 and MIA-PACA-2 cancer cells, with IC50 values of 3.15 nM and 2.33 nM, respectively.</p>Formule :C29H29ClF3N5O3Couleur et forme :SolidMasse moléculaire :588.02KRAS G12C inhibitor 60
<p>KRAS G12C Inhibitor 60 (compound 23), a selective inhibitor targeting the Kras-G12C mutation, is utilized in the investigation of lung, colorectal, and</p>Formule :C31H30F5N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :627.61Tagarafdeg
CAS :<p>Tagarafdeg (CFT1946) is a PROTAC degradator targeting mutant BRAF, capable of degrading BRAF V600E, G469A, G466V mutations, anti proliferation.</p>Formule :C45H49F2N11O9SDegré de pureté :＞99.99%Couleur et forme :SolidMasse moléculaire :958HPK1-IN-39
<p>HPK1-IN-39 (Compound 10n), a selective inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) with an inhibitory concentration (IC50) of 29 nM, impedes the</p>Formule :C26H27N7O2Couleur et forme :SolidMasse moléculaire :469.54Antimicrobial agent-21
CAS :<p>Antimicrobial agent-21 is a potent mitogen activated protein kinase inhibitor with antibacterial, anti-inflammatory and antitumor activity for the treatment of</p>Formule :C18H13N3OSDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :319.38KRASG12C IN-14
<p>KRASG12C IN-14 (compound 15), a potent inhibitor specifically designed for the KRAS G12C mutation, exhibits impressive efficacy in impeding CYPA-dependent KRAS-BRAF interaction and ERK phosphorylation in NCI-H358 cells, both with an IC 50 of 0.002 μM.</p>Formule :C51H65F4N9O9S2Couleur et forme :SolidMasse moléculaire :1088.24Pan-RAS-IN-6
Pan-RAS-IN-6 (compound 24) serves as a DUSP6 inhibitor, effectively reducing MAPK activation in the NCI-H1373-Luc model (DUSP6). It concurrently exhibits notable tumor growth inhibition and regression in the NSCLC brain metastasis mouse model. The compound displays high selectivity and potent inhibitory effects, particularly on KRAS mutation-associated signaling pathways. It demonstrates varied inhibitory activities against distinct KRAS mutants and their interacting proteins. The IC 50 values for KRAS G12C, G12D, and G12V are 1.3 nM, 4.7 nM, and 0.3 nM, respectively.Formule :C46H60N8O5SCouleur et forme :SolidMasse moléculaire :837.08BAS 00489700
CAS :<p>BAS 00489700 is a N-UTR interaction inhibitor. BAS 00489700 inhibits virus replication in cell culture.</p>Formule :C19H16N2O4Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :336.34HPK1-IN-20
CAS :<p>HPK1-IN-19 is a potent inhibitor of hematopoietic progenitor kinase 1 (HPK1).</p>Formule :C26H28N6O2Couleur et forme :SolidMasse moléculaire :456.55LYMTAC-2
<p>LYMTAC-2 is a lysosome-targeting chimera (LYMTAC) developed to degrade membrane-associated proteins through lysosomal membrane proteins (LMP) such as RNF152, LAPTM4a, and LAPTM5. It forms a ternary complex with target proteins like KRASG12D, facilitating their relocation to lysosomes and resulting in ubiquitin-dependent degradation. This compound has potential for studying membrane protein regulation and devising strategies to counter resistance in KRAS-driven signaling pathways.</p>Couleur et forme :SolidMasse moléculaire :1248.44Klotho-derived peptide 1 hydrochloride
<p>Klotho-derived peptide 1 (KP1 human) hydrochloride inhibits the interaction between TGF-β and TGF-β receptor 2, suppressing the activation of TGF-β-induced Smad2/3 and mitogen-activated protein kinase (MAPK). Additionally, it exhibits antifibrotic and renal protective effects in mouse models.</p>Couleur et forme :Odour SolidNUCC-0200808
<p>NUCC-0200808 (Compound 12g) is an MNK1 inhibitor with an IC50 of 42 nM. It reduces eIF4E phosphorylation and cell viability in AML cells and induces apoptosis. NUCC-0200808 shows potential for research in the field of leukemia.</p>Couleur et forme :Odour SolidMAP4K4-IN-6
<p>MAP4K4-IN-6 (Compound 15f) is a MAP4K4 inhibitor with an IC50 of 80 nM. It reduces the phosphorylation of c-Jun and exhibits neuroprotective effects. Additionally, MAP4K4-IN-6 enhances the vitality of motor neurons and can be utilized in the study of amyotrophic lateral sclerosis (ALS).</p>Couleur et forme :Odour SolidKRAS G12C inhibitor 18
CAS :<p>KRAS G12C inhibitor 18 is a potent, orally active compound that inhibits KRAS G12C and exhibits anti-tumor activities.</p>Formule :C25H20ClFN4O3SCouleur et forme :SolidMasse moléculaire :510.97RTIL 13
CAS :<p>RTIL 13 inhibits dynamin GTPase (IC50: 2.3 μM), targets its lipid binding domain, and suppresses endocytosis (IC50: 9.3 & 7.1 μM).</p>Formule :C30H55BrN2O3Couleur et forme :SolidMasse moléculaire :571.685PROTAC MEK1 Degrader-1
CAS :<p>PROTAC MEK1 Degrader-1, a targeted protein degradation agent, combines a MEK1 inhibitor with a von Hippel-Lindau ligand to effectively inhibit ERK1/2</p>Formule :C53H66FIN8O11S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1201.17KG5
CAS :<p>KG5 inhibits PDGFRβ, B-Raf, FLT3, KIT, c-Raf; has anticancer and antiangiogenic effects; Kd: 520 nM (PDGFRβ), 300 nM (PDGFRα).</p>Formule :C20H16F3N7OSDegré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :459.45FAM49B (190-198) mouse
CAS :<p>FAM49B (190-198) mouse represents a peptide fragment of the mitochondria-localized protein FAM49B, which is instrumental in regulating mitochondrial fission, function, and integrity, in addition to influencing tumor progression. Beyond its role in mitochondrial dynamics, FAM49B serves as a negative regulator of T cell activation by inhibiting GTPase Rac activity and affecting cytoskeleton reorganization.</p>Formule :C49H71N9O14SCouleur et forme :SolidMasse moléculaire :1042.2Setidegrasib
CAS :<p>KRAS G12D inhibitor 17, a quinazoline-linked prolinamide, degrades mutant KRAS protein; a PROTAC.</p>Formule :C60H65FN12O7SCouleur et forme :SolidMasse moléculaire :1117.3DB-10
<p>DB-10 serves as a precursor to 3-nbutylphthalide (NBP). It is absorbed by cells in a temperature and energy-dependent manner through the pyrilamine cation transporter. DB-10 enhances cell survival and rapidly converts into an active form in vivo, increasing accumulation within the brain. This compound is applicable in ischemic stroke research.</p>Couleur et forme :Odour SolidGNE-9815
CAS :<p>GNE-9815 (3-(2-cyanopropan-2-yl)-N-[2-fluoro-4-methyl-5-(7-methyl-8-oxo-7,8-dihydropyrido[2,3-d]pyridazin-3-yl)phenyl]benzamide) is a high kinase-selective</p>Formule :C26H22FN5O2Degré de pureté :99.08% - 99.1%Couleur et forme :SolidMasse moléculaire :455.48U0124
CAS :<p>Inactive analog of U0126(MEK-1/2 inhibitor), used as a negative control</p>Formule :C8H10N4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :226.32
