MAPK
Les MAPK sont une famille de kinases protéiques impliquées dans une variété de processus cellulaires, y compris la croissance, la prolifération, la différenciation et les réponses au stress. La voie de signalisation MAPK comprend plusieurs niveaux, y compris ERK, JNK et p38 MAPK, chacun jouant des rôles distincts dans la fonction cellulaire. La dérégulation de la signalisation MAPK est liée au cancer, aux maladies inflammatoires et aux troubles métaboliques. Chez CymitQuimica, nous offrons un large éventail d'inhibiteurs et d'activateurs de MAPK pour soutenir vos recherches en biologie cellulaire, transduction de signaux et mécanismes des maladies.
886 produits trouvés pour "MAPK"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
KRpep-2d
CAS :KRpep-2d, a potent inhibitor of K-Ras, effectively suppresses the proliferation of cancer cells driven by K-Ras.Formule :C109H183N43O25S2Couleur et forme :SolidMasse moléculaire :2560.02JNK3 inhibitor-8
<p>JNK3 inhibitor-8: potent, selective, oral, BBB-penetrating, IC50: JNK3=21 nM, JNK2=2203 nM, JNK1>10,000 nM; potential in Alzheimer's research.</p>Formule :C32H30FN7O3Couleur et forme :SolidMasse moléculaire :579.62SCH772984 HCl
<p>SCH772984 HCl selectively inhibits ERK1/2, acts like type I/II kinase inhibitors, and is potent at 4/1 nM IC50s in certain mutated tumor cells.</p>Formule :C33H34ClN9O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :624.14MLKL-IN-2
CAS :<p>MLKL-IN-2 is an MLKL inhibitor with potential tumorigenic activity for the study of cellular necrosis-related diseases.</p>Formule :C26H25N5ODegré de pureté :98.30%Couleur et forme :SolidMasse moléculaire :423.51JNK-IN-12
<p>JNK-IN-12 (compound P2) is a mitochondrial-targeted JNK inhibitor with an IC50 value of 66.3 nM, comprising a mitochondrial-specific cell-penetrating peptide</p>Formule :C56H82N16O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1091.35JNK-IN-14
<p>JNK-IN-14 is a potent inhibitor of JNK with IC50 values of 1.81 nM for JNK1, 12.7 nM for JNK2, and 10.5 nM for JNK3.</p>Formule :C27H31N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :521.63Tagarafdeg
CAS :<p>Tagarafdeg (CFT1946) is a PROTAC degradator targeting mutant BRAF, capable of degrading BRAF V600E, G469A, G466V mutations, anti proliferation.</p>Formule :C45H49F2N11O9SDegré de pureté :＞99.99%Couleur et forme :SolidMasse moléculaire :958StRIP16
<p>Rab8a GTPase-binding stapled peptide (Kd = 12.7 μM). Cell permeable; localizes to the endomembrane system.</p>Couleur et forme :SolidGAGGVGKSAL
CAS :<p>GAGGVGKSAL, a wild-type KRAS G12D 10mer peptide, serves as an immunogenic neoantigen in cancer immunotherapy research [1].</p>Formule :C34H61N11O12Couleur et forme :SolidMasse moléculaire :815.91KRAS inhibitor-24
CAS :<p>KRAS inhibitor-24 (compound 115c), a pyrido-pyridine class KRAS inhibitor, exhibits potent activity against KRas G12V, KRas WT, and KRas G12R, with IC50 values all below 100 nM.</p>Formule :C33H39ClF2N6O3Couleur et forme :SolidMasse moléculaire :641.15PD 198306
CAS :<p>PD 198306: a MEK inhibitor with antihyperalgesic properties, reduces Streptozocin-boosted active ERK1.</p>Formule :C18H16F3IN2O2Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :476.23PPM-3
<p>PPM-3, a selective PROTAC ERK5 degrader, exhibits a potent inhibitory concentration (IC 50) of 62.4 nM.</p>Formule :C54H69N11O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1000.26PROTAC SOS1 degrader-5
CAS :<p>PROTAC SOS1 degrader-5 (compound 4) serves as an effective degrader of PROTAC SOS1, exhibiting a DC50 of 13 nM. It robustly suppresses the proliferation of NCI-H358 cells, with an IC50 value of 5 nM [1].</p>Formule :C45H51F3N8O7Couleur et forme :SolidMasse moléculaire :872.93MEK1/2-IN-3
<p>MEK1/2-IN-3 (Compound M15) is an inhibitor of MEK1, with an IC50 value of 10.29 nM. It effectively suppresses tumor cell proliferation and migration, induces apoptosis, and exhibits good liver microsomal stability. MEK1/2-IN-3 is applicable in the study of solid tumors.</p>Formule :C28H23F3IN3O4Couleur et forme :SolidMasse moléculaire :649.4G12 TFA
<p>G12 (Ras5-17) TFA is a wild-type Ras peptide comprising amino acids 5-17 (KLVVVGAGGVGKS). It serves as a control in studies involving mutant Ras peptides, such as V12.</p>Formule :C54H96F3N15O17Masse moléculaire :1283.70607WYE-687
CAS :<p>WYE-687 is a selective mTOR inhibitor (IC50: 7 nM), over 100x more selective for mTOR than PI3Kα/γ, affecting mTORC1/pS6K and mTORC2/P-AKT(S473).</p>Formule :C28H32N8O3Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :528.61Pan-RAS-IN-6
Pan-RAS-IN-6 (compound 24) serves as a DUSP6 inhibitor, effectively reducing MAPK activation in the NCI-H1373-Luc model (DUSP6). It concurrently exhibits notable tumor growth inhibition and regression in the NSCLC brain metastasis mouse model. The compound displays high selectivity and potent inhibitory effects, particularly on KRAS mutation-associated signaling pathways. It demonstrates varied inhibitory activities against distinct KRAS mutants and their interacting proteins. The IC 50 values for KRAS G12C, G12D, and G12V are 1.3 nM, 4.7 nM, and 0.3 nM, respectively.Formule :C46H60N8O5SCouleur et forme :SolidMasse moléculaire :837.08Anti-osteoporosis agent-8
<p>Anti-osteoporosis agent-8 (Compound 4aa) is a RANKL inhibitor, capable of preventing RANKL-induced osteoclastogenesis and osteoclast differentiation, with an IC50 of 2.41 μM. Furthermore, Anti-osteoporosis agent-8 has been shown to mitigate bone loss in an ovariectomized (OVX) mouse model.</p>Formule :C18H19F3N2O2SeMasse moléculaire :432.05638Ro-3201195
CAS :<p>Ro-3201195 is a novel orally available p38 MAPK inhibitor with high selectivity.</p>Formule :C19H18FN3O4Degré de pureté :99.15%Couleur et forme :SolidMasse moléculaire :371.36MNK-IN-4
<p>MNK-IN-4 (compound D25) is a potent and selective MNK inhibitor used in treating acute spleen injury related to sepsis.</p>Formule :C15H17N5Masse moléculaire :267.1484NUCC-0200808
<p>NUCC-0200808 (Compound 12g) is an MNK1 inhibitor with an IC50 of 42 nM. It reduces eIF4E phosphorylation and cell viability in AML cells and induces apoptosis. NUCC-0200808 shows potential for research in the field of leukemia.</p>Couleur et forme :Odour Solidp38α inhibitor 5
CAS :<p>The compound p38α inhibitor5 (compound 1) is a PROTAC-type ligand that targets p38 and is utilized in the synthesis of NR-11c.</p>Formule :C26H23BrF2N2O3Couleur et forme :SolidMasse moléculaire :529.37IQ-1S
CAS :<p>IQ-1S is an inhibitor of NF-κB/activating protein 1 (AP-1) with an IC50 of 1.8 μM. It exhibits high binding affinity to all three JNKs, with Kd values for JNK3, JNK2, and JNK1 being 87 nM, 360 nM, and 390 nM, respectively.</p>Formule :C15H8N3NaOCouleur et forme :SolidMasse moléculaire :269.23HS220
CAS :<p>HS220 is an inhibitor of TAK1 which plays a key role in the signaling pathways of inflammation and cell survival.</p>Formule :C18H17N3O3Degré de pureté :99.39%Couleur et forme :SoildMasse moléculaire :323.35Pan-RAS-IN-5
<p>Pan-RAS-IN-5 (compound 7A) is a molecular glue that facilitates the formation of a ternary complex with cyclophilin A (CYPA) and RAS(ON) protein. This complex inhibits the binding of RAF downstream of RAS, demonstrating antitumor activity.</p>Formule :C45H58N8O5SMasse moléculaire :822.42509QL-X-138 HCl
<p>QL-X-138 HCl is a BTK/MNK dual kinase inhibitor with anticancer activity and anti-dengue virus 2 activity that inhibits BTK, MNK1, and MNK2 kinases.</p>Formule :C25H20ClN5O2Degré de pureté :99.25%Couleur et forme :SoildMasse moléculaire :457.91KRAS G12D inhibitor 20
KRAS G12D inhibitor 20 (Compound 14) is a selective G12D KRAS inhibitor with antitumor activity.Formule :C18H26N6OMasse moléculaire :342.21681KRAS G12D inhibitor 15
CAS :<p>Potent KRAS G12D inhibitor 15 targets cancer, potential for disease research. (WO2022042630A1, compound 243)</p>Formule :C53H71F2N7O5Couleur et forme :SolidMasse moléculaire :924.17YN14
<p>YN14 is a highly potent and selective KRASG12C proteolysis targeting chimera (PROTAC) capable of forming a stable KRASG12C: YN14: VHL ternary complex with low</p>Degré de pureté :98%Couleur et forme :Odour SolidVem-L-Cy5
<p>Vem-L-Cy5 (compound 3), a Vemurafenib-based BRAF inhibitor conjugated with the near-infrared (NIR) fluorophore cyanine-5 (Cy5), selectively targets the BRAF</p>Formule :C63H68F5N7O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1194.31JTP10-△-R9 TFA
<p>JTP10-△-R9 TFA is a selective inhibitor of JNK2 peptide (IC50: 89 nM), exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.</p>Formule :C119H214F3N53O26Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2860.31ZINC05007751
CAS :<p>ZINC05007751 inhibits NEK6 (IC50=3.4μM), selective for NEK1/6, inactive on NEK2/7/9.</p>Formule :C18H12N2O3Degré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :304.3PROTAC MLKL Degrader-1
<p>PROTAC MLKL Degrader-1 (Compound 36) is a selective PROTAC degrader targeting MLKL, achieving a degradation maximum (D max) over 90%.</p>Formule :C46H55F2N9O9SCouleur et forme :SolidMasse moléculaire :948.05KRASG12C IN-2
<p>KRASG12C IN-2 (compound 17) is an orally active inhibitor of KRAS G12C, which effectively suppresses tumor growth in mice [1].</p>Couleur et forme :SolidScio-323
CAS :<p>Scio-323是一种可口服的 p38丝裂原活化蛋白（MAPK）激酶抑制剂。</p>Formule :C27H30FN3O4Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :479.54JNK3 inhibitor-7
<p>Potent, oral JNK3 inhibitor-7 crosses blood-brain barrier, IC50: 53 nM (JNK3), offers neuroprotection, potential in AD research.</p>Formule :C32H31N7O3Couleur et forme :SolidMasse moléculaire :561.63JTP10-△-TATi TFA
<p>JTP10-△-TATi TFA is a selective inhibitor of JNK2 peptide (IC50: 92 nM), exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.</p>Formule :C120H213F3N48O28Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2833.28KP-14
<p>KP-14 is a PROTAC specifically designed to target KRAS.</p>Formule :C41H41Cl3N6O8Couleur et forme :SolidMasse moléculaire :852.16KRAS G12D inhibitor 3 TFA
CAS :<p>KRAS G12D Inhibitor 3 TFA, exhibiting an inhibitory concentration (IC50) of less than 500 nM, is effective as an antitumor agent.</p>Formule :C36H32ClF6N5O4Couleur et forme :SolidMasse moléculaire :748.11CHPG hydrochloride
<p>CHPG hydrochloride is a selective agonist of mGluR5.</p>Formule :C8H9Cl2NO3Degré de pureté :98.1%Couleur et forme :SoildMasse moléculaire :238.07KRAS G12D inhibitor 6
CAS :<p>KRAS G12D inhibitor 6 is an efficacious compound that effectively inhibits KRAS G12D.</p>Formule :C32H37ClN8O2Couleur et forme :SolidMasse moléculaire :601.15HPK1-IN-53
<p>HPK1-IN-53 (compound 3a) is the most potent inhibitor of HPK1, exhibiting an IC50 value of 48 nM.</p>Couleur et forme :Odour SolidJNK-IN-18
<p>JNK-IN-18 (compound 23b) is a potent inhibitor of JNK1, boasting an IC50 of 2 nM. It demonstrates superior efficacy when compared to its IC50 values of 125 nM for JNK2 and 98 nM for BRAF(V600E).</p>Couleur et forme :Odour SolidPROTAC K-Ras Degrader-4
CAS :<p>PROTAC K-Ras Degrader-4 is a molecule designed to selectively degrade oncogenic K-Ras mutants, a novel strategy for cancer research.</p>Formule :C50H60N12O6S2Couleur et forme :SoildMasse moléculaire :989.22Cobimetinib (R-enantiomer)
CAS :<p>Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib which is a selective MEK inhibitor.</p>Formule :C21H21F3IN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :531.318PROTAC SOS1 degrader-4
<p>PROTAC SOS1 Degrader-4 (compound 10) is a potent degrader of SOS1 and exhibits antiproliferative activity [1].</p>Formule :C53H65ClN8O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :993.65MEK ligand-2
CAS :<p>MEK ligand-2, a ligand for the target protein for PROTAC (Ligand for Target Protein for PROTAC), functions as an inhibitor for both MEK1 and MEK2. This compound plays a crucial role in MS934, which is a VHL-recruiting MEK1/2 PROTAC degrader.</p>Formule :C13H8F3IN2O2Couleur et forme :SolidMasse moléculaire :408.12RTIL 13
CAS :<p>RTIL 13 inhibits dynamin GTPase (IC50: 2.3 μM), targets its lipid binding domain, and suppresses endocytosis (IC50: 9.3 & 7.1 μM).</p>Formule :C30H55BrN2O3Couleur et forme :SolidMasse moléculaire :571.685KRpep-2d TFA
<p>KRpep-2d (TFA) is a potent inhibitor of K-Ras, effectively hindering the proliferation of K-Ras-driven cancer cells, thereby serving as a valuable asset for</p>Formule :C110H183F3N44O27S2Couleur et forme :SolidMasse moléculaire :2675.03Enniatin B1
CAS :<p>Enniatin B1, a Fusarium mycotoxin, crosses the blood-brain barrier and modulates ERK, NF-κB, and ACAT with an IC50 of 73 μM.</p>Formule :C34H59N3O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :653.858LC-2
CAS :<p>LC-2 (PROTAC KRASG12C Degrader-LC-2) is a novel von Hippel-Lindau-based PROTAC degrader of endogenous KRAS G12C with a DC50 between 0.25 and 0.76 μM.LC-2 is a</p>Formule :C59H71ClFN11O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1132.78Tunlametinib
CAS :<p>Tunlametinib is a MEK1/2 inhibitor (IC50=1.9 nM) for treating RAS/RAF-driven cancers.</p>Formule :C16H12F2IN3O3SDegré de pureté :98.72%Couleur et forme :SolidMasse moléculaire :491.25Anti-ERK2 Antibody (5V598)
<p>Anti-ERK2 Antibody (5V598) is a Rabbit antibody targeting ERK2. Anti-ERK2 Antibody (5V598) can be used in ELISA.</p>Couleur et forme :Odour LiquidAnti-ERK2 Antibody (4F551)
<p>Anti-ERK2 Antibody (4F551) is a Rabbit antibody targeting ERK2. Anti-ERK2 Antibody (4F551) can be used in ELISA,FCM.</p>Couleur et forme :Odour LiquidAnti-ERK2 Antibody (9C922)
<p>Anti-ERK2 Antibody (9C922) is a Mouse antibody targeting ERK2. Anti-ERK2 Antibody (9C922) can be used in WB,ELISA.</p>Couleur et forme :Odour LiquidRAS GTPase inhibitor 1
CAS :<p>RAS GTPase inhibitor 1 is a RAS GTPase inhibitor with potential antitumor activity.</p>Formule :C27H28ClF4N5O2Degré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :565.99TRPM4 inhibitor 8
CAS :<p>TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.</p>Formule :C11H17BrN2Degré de pureté :97%Couleur et forme :SolidMasse moléculaire :257.17S6K1-IN-DG2
CAS :<p>S6K1-IN-DG2(S6K1InhibitorDG2) is a potent p70S6K inhibitor with an IC50 value of less than 100 nM.</p>Formule :C16H17BrN6ODegré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :389.25Enniatin B
CAS :<p>Enniatins B decreases the activation of ERK (p44/p42).</p>Formule :C33H57N3O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :639.831EM127
CAS :<p>EM127: covalent SMYD3 inhibitor, KD 13μM, impedes ERK1/2, hinders SMYD3 gene regulation, long-term methyltransferase reduction, potential in cancer study.</p>Formule :C14H18ClN3O3Degré de pureté :97.61%Couleur et forme :SolidMasse moléculaire :311.76TAK1-IN-3
CAS :<p>TAK1-IN-3 is a novel ATP-competitive TAK1 inhibitor for the study of cancer.</p>Formule :C16H19N3O2SDegré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :317.41JH295
CAS :<p>JH295: potent, selective Nek2 inhibitor (IC50 = 770 nM), irreversibly targets Cys22, no effect on Cdk1, Aurora B, Plk1, or spindle mechanisms.</p>Formule :C18H16N4O2Couleur et forme :SolidMasse moléculaire :320.352TAK-580
CAS :<p>TAK-580 (MLN2480) is an oral, selective pan-Raf kinase inhibitor in Clinicalal trials.</p>Formule :C17H12Cl2F3N7O2SDegré de pureté :99.25% - 99.77%Couleur et forme :SolidMasse moléculaire :506.29PROTAC BRAF-V600E degrader-1
CAS :<p>PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.</p>Formule :C48H54F2N10O10SDegré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :1001.07Gypenoside L
CAS :<p>Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.</p>Formule :C42H72O14Degré de pureté :99.42% - 99.65%Couleur et forme :SolidMasse moléculaire :801.01LY-2584702 free base
CAS :<p>LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM).</p>Formule :C21H19F4N7Degré de pureté :98.72% - 99.51%Couleur et forme :SolidMasse moléculaire :445.42A-674563 2HCl(552325-73-2(fb-2hcl))
<p>A-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.</p>Formule :C22H24Cl2N4ODegré de pureté :94.66%Couleur et forme :SolidMasse moléculaire :431.36NG25
CAS :<p>NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.</p>Formule :C29H30F3N5O2Degré de pureté :98.32% - ≥95%Couleur et forme :SolidMasse moléculaire :537.58Isoliquiritin apioside
CAS :<p>Isoliquiritin apioside, from Glycyrrhizae radix, inhibits MMP9, MAPK, NF-κB, reduces cancer cell invasion, angiogenesis, and fights oxidative DNA damage.</p>Formule :C26H30O13Degré de pureté :98.84% - 99.27%Couleur et forme :SolidMasse moléculaire :550.51PH-797804
CAS :<p>PH-797804 is a pyridinone inhibitor of p38α (IC50: 26 nM, in a cell-free assay); 4-fold more selective versus p38β and does not inhibit JNK2.</p>Formule :C22H19BrF2N2O3Degré de pureté :97.90% - 98.27%Couleur et forme :SolidMasse moléculaire :477.3K-Ras(G12C) inhibitor 6
CAS :<p>Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.</p>Formule :C17H22Cl2N2O3SDegré de pureté :89.07% - 97.09%Couleur et forme :SolidMasse moléculaire :405.34LY-364947
CAS :<p>LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I.</p>Formule :C17H12N4Degré de pureté :99.41% - 99.96%Couleur et forme :SolidMasse moléculaire :272.3DMX-5804
CAS :<p>DMX-5804 is a potent, selective MAP4K4 inhibitor, with an IC50 of 3 nM.DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice</p>Formule :C21H19N3O3Degré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :361.39methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate
CAS :<p>methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate is a biochemical.</p>Formule :C13H13NO5Degré de pureté :97.69%Couleur et forme :SolidMasse moléculaire :263.25R1487
CAS :<p>R1487 is an orally bioavailable and highly selective p38α mitogen-activated protein kinase inhibitor.</p>Formule :C19H18F2N4O3Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :388.37PF-06260933 HCl
CAS :<p>PF-06260933 Dihydrochloride, a MAP4K4 inhibitor, hinders HGK, Mink, Tnik (IC50s: 140, 8, 13 nM) and lessens mouse fasting hyperglycemia.</p>Formule :C16H15Cl3N4Couleur et forme :SolidMasse moléculaire :369.68AZD8330
CAS :<p>AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.</p>Formule :C16H17FIN3O4Degré de pureté :98.72%Couleur et forme :SolidMasse moléculaire :461.23GS87
CAS :<p>GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.</p>Formule :C16H11N5O2SDegré de pureté :98.86%Couleur et forme :SolidMasse moléculaire :337.36Kobe2602
CAS :<p>Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.</p>Formule :C14H9F4N5O4SDegré de pureté :98.36% - 99.39%Couleur et forme :SolidMasse moléculaire :419.31IQ-3
CAS :<p>IQ3 inhibits JNK3 (Kd 66 nM), JNK1/2, NF-κB/AP1 in THP1-Blue cells (IC50 1.4 μM), and reduces TNF-α/IL-6 production.</p>Formule :C20H11N3O3Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :341.32Belvarafenib
CAS :<p>Belvarafenib (HM95573) is a potent pan-RAF inhibitor with antitumor activity and inhibits B-RAF, B-RAFv600E, and C-RAF.Cost-effective and quality-assured.</p>Formule :C23H16ClFN6OSDegré de pureté :98% - 99.65%Couleur et forme :SolidMasse moléculaire :478.93Ravoxertinib
CAS :<p>Ravoxertinib (GDC-0994) is an effective and orally available ERK1/2 inhibitor (IC50: 1.1/0.3 nM).</p>Formule :C21H18ClFN6O2Degré de pureté :98% - 99.87%Couleur et forme :SolidMasse moléculaire :440.86Agerafenib
CAS :<p>Agerafenib (CEP32496) is a highly potent inhibitor of BRAF.</p>Formule :C24H22F3N5O5Degré de pureté :95.78% - 99.23%Couleur et forme :SolidMasse moléculaire :517.46Vemurafenib
CAS :<p>Vemurafenib (RG7204) is a B-RAF inhibitor that inhibits RAFV600E and c-RAF-1 (IC50=31/48 nM) selectively and potently.</p>Formule :C23H18ClF2N3O3SDegré de pureté :98% - 99.65%Couleur et forme :SolidMasse moléculaire :489.92B-Raf IN 11
CAS :<p>B-Raf IN 11 is a novel selective inhibitor.</p>Formule :C17H14BrF2N3O3SDegré de pureté :99.947%Couleur et forme :SolidMasse moléculaire :458.28Regorafenib Hydrochloride
CAS :<p>Regorafenib HCl (BAY73-4506) is an oral inhibitor targeting angiogenic, stromal, and cancer kinases with strong antitumor effects.</p>Formule :C21H16Cl2F4N4O3Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :519.28LY-2584702 tosylate salt
CAS :<p>LY-2584702 tosylate salt is a selective, ATP-competitive p70S6K inhibitor, used in trials studying the treatment of cancer.</p>Formule :C28H27F4N7O3SDegré de pureté :98.5% - 98.51%Couleur et forme :SolidMasse moléculaire :617.62Dabrafenib Mesylate
CAS :<p>Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).</p>Formule :C24H24F3N5O5S3Degré de pureté :99.45% - 99.82%Couleur et forme :SolidMasse moléculaire :615.67Bohemine
CAS :<p>Bohemine is a cyclin-dependent kinase inhibitor.</p>Formule :C18H24N6ODegré de pureté :99.09% - 99.53%Couleur et forme :SolidMasse moléculaire :340.42MW-150
CAS :<p>MW-150 (MW01-18-150SRM) is a unique protein kinase inhibitor, is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM.</p>Formule :C24H23N5Degré de pureté :97.35% - 99.27%Couleur et forme :SolidMasse moléculaire :381.47RAF709
CAS :<p>RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively.</p>Formule :C28H29F3N4O4Degré de pureté :99.28% - 99.8%Couleur et forme :SolidMasse moléculaire :542.55Maohuoside A
CAS :<p>Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways.</p>Formule :C27H32O12Degré de pureté :98.91% - 99.57%Couleur et forme :SolidMasse moléculaire :548.54GNE-495
CAS :<p>GNE-495 is a potent and specific MAP4K4 inhibitor (IC50: 3.7 nM).</p>Formule :C22H20FN5O2Degré de pureté :99.22% - 99.57%Couleur et forme :SolidMasse moléculaire :405.42APS-2-79 hydrochloride
CAS :<p>APS-2-79 hydrochloride (APS-2-79 HCl) is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization.</p>Formule :C23H21N3O3·HClDegré de pureté :98.64% - 99.55%Couleur et forme :SolidMasse moléculaire :423.89AMG 900
CAS :<p>AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM.</p>Formule :C28H21N7OSDegré de pureté :98.4% - 99.51%Couleur et forme :SolidMasse moléculaire :503.58Raf inhibitor 1 dihydrochloride
CAS :<p>Raf inhibitor 1 dihydrochloride (B-Raf inhibitor 1 dihydrochloride) is a potent and selective B-Raf inhibitor.</p>Formule :C26H19ClN8HClDegré de pureté :98.19% - 99.54%Couleur et forme :SolidMasse moléculaire :551.86NVP-BHG712
CAS :<p>NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and</p>Formule :C26H20F3N7ODegré de pureté :97.32% - 98.63%Couleur et forme :SolidMasse moléculaire :503.48SLV-2436
CAS :<p>SLV-2436 (SEL201-88) is a novel effective and ATP-competitive inhibitor of MNK1 and MNK2 (IC50: 10.8/5.4 nM).</p>Formule :C19H15ClN4ODegré de pureté :98.56%Couleur et forme :SolidMasse moléculaire :350.8ASK1-IN-1
CAS :<p>ASK1-IN-1 inhibits apoptosis kinase 1, crucial in cell stress responses, with 21 nM IC50.</p>Formule :C19H19N9O2Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :405.41Necrosulfonamide
CAS :<p>Necrosulfonamide ((E)-Necrosulfonamide) is a necroptosis inhibitor that targets MLKL and is selective. High-Quality, Low-Cost!</p>Formule :C18H15N5O6S2Degré de pureté :98.85% - 99.49%Couleur et forme :SolidMasse moléculaire :461.47ASP2453
CAS :<p>ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C.</p>Formule :C40H48F3N7O4Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :747.85PLX-4720
CAS :<p>PLX-4720 is a potent and selective B-Raf (V600E) inhibitor designed to block the ATP-binding site of oncogenic B-Raf.Cost-effective and quality-assured.</p>Formule :C17H14ClF2N3O3SDegré de pureté :97.78% - 99.83%Couleur et forme :SolidMasse moléculaire :413.83ERK-IN-3
CAS :<p>ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK.</p>Formule :C22H25ClFN7O2Degré de pureté :99.55% - 99.76%Couleur et forme :SolidMasse moléculaire :473.93ERK5-IN-2
CAS :<p>ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively.</p>Formule :C17H11BrFN3O2Degré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :388.19SKF-86002
CAS :<p>SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).</p>Formule :C16H12FN3SDegré de pureté :98% - 99.85%Couleur et forme :SolidMasse moléculaire :297.35BAY-293
CAS :<p>BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).</p>Formule :C25H28N4O2SDegré de pureté :97.16%Couleur et forme :SolidMasse moléculaire :448.58(S)-AMG-510
CAS :<p>(S)-AMG-510 is the S-type compound of AMG-510 (Sotorasib), which effectively and selectively inhibits KRASG12C.Cost-effective and quality-assured.</p>Formule :C30H30F2N6O3Degré de pureté :99.05% - 99.76%Couleur et forme :SolidMasse moléculaire :560.594BI-D1870
CAS :<p>BI-D1870 is a highly specific, blood-brain-permeable, and ATP-competitive inhibitor of the N-terminal AGC kinase domain of RSK.Cost-effective and quality-assured.</p>Formule :C19H23F2N5O2Degré de pureté :98.51% - 99.43%Couleur et forme :SolidMasse moléculaire :391.42Locostatin
CAS :<p>Locostatin is a potent and cell permeable inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration.</p>Formule :C14H15NO3Degré de pureté :97.13%Couleur et forme :SolidMasse moléculaire :245.27SB 239063
CAS :<p>SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.</p>Formule :C20H21FN4O2Degré de pureté :99.42% - 99.81%Couleur et forme :SolidMasse moléculaire :368.4Pimasertib
CAS :<p>Pimasertib (AS703026) is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.</p>Formule :C15H15FIN3O3Degré de pureté :98.25% - 99.57%Couleur et forme :SolidMasse moléculaire :431.2Skepinone-L
CAS :<p>Skepinone-L (CBS3830) is a selective p38 mitogen-activated protein kinase inhibitor.</p>Formule :C24H21F2NO4Degré de pureté :99.56% - >99.99%Couleur et forme :SolidMasse moléculaire :425.42LM22B-10
CAS :<p>LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.</p>Formule :C27H33ClN2O4Degré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :485.01Tomivosertib
CAS :<p>Tomivosertib (eFT508) is a potent, highly selective MNK1 and MNK2 inhibitor with IC50 value of 1-2 nM.</p>Formule :C17H20N6O2Degré de pureté :97.34% - 99.72%Couleur et forme :SolidMasse moléculaire :340.38APS6-45
CAS :<p>APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.</p>Formule :C23H16F8N4O3Degré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :548.39GW 284543 hydrochloride
CAS :<p>GW 284543 hydrochloride is a selective inhibitor of MEK5 .</p>Formule :C23H21ClN2O3Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :408.87CC-401 Hydrochloride
CAS :<p>CC-401 Hydrochloride (CC401 HCl) is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with antineoplastic activity.</p>Formule :C22H25ClN6ODegré de pureté :99.71% - ≥95%Couleur et forme :SolidMasse moléculaire :424.93PF-4708671
CAS :<p>PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) .In cell-free assays, PF-4708671 is potent for S6K1(Ki50=20 nM, IC50=160 nM).</p>Formule :C19H21F3N6Degré de pureté :99.48% - 99.67%Couleur et forme :SolidMasse moléculaire :390.41BI-78D3
CAS :<p>BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.</p>Formule :C13H9N5O5S2Degré de pureté :97.89% - >99.99%Couleur et forme :SolidMasse moléculaire :379.37PLX8394
CAS :<p>Plixorafenib (PLX8394) is an orally active inhibitor of the serine/threonine protein kinase B-Raf (BRAF) protein.Cost-effective and quality-assured.</p>Formule :C25H21F3N6O3SDegré de pureté :98.75% - >99.99%Couleur et forme :SolidMasse moléculaire :542.53Sotorasib
CAS :<p>Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C.</p>Formule :C30H30F2N6O3Degré de pureté :98% - 99.95%Couleur et forme :SolidMasse moléculaire :560.594S6K-18
CAS :<p>S6K-18, a highly selective S6K1 inhibitor, inhibits S6K1 with IC50 of 52nM.</p>Formule :C17H18N4O3SDegré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :358.41Binimetinib
CAS :<p>Binimetinib (ARRY-162) is a MEK1/2 inhibitor (IC50=12 nM) with selective and oral activity. Binimetinib has antitumor activity. Cost-effective and quality-assured.</p>Formule :C17H15BrF2N4O3Degré de pureté :98.03% - >99.99%Couleur et forme :SolidMasse moléculaire :441.23SGX-523
CAS :<p>SGX-523 is a selective Met inhibitor (IC50: 4 nM), no inhibitory to Abl, BRAFV599E, p38α, and c-Raf.</p>Formule :C18H13N7SDegré de pureté :99% - >99.99%Couleur et forme :SolidMasse moléculaire :359.41SB 242235
CAS :<p>SB 242235 is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases.</p>Formule :C19H20FN5ODegré de pureté :99.13% - 99.68%Couleur et forme :SolidMasse moléculaire :353.39TA-01
CAS :<p>TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.</p>Formule :C20H12F3N3Degré de pureté :99.55% - 99.94%Couleur et forme :SolidMasse moléculaire :351.32Tizoxanide
CAS :<p>Tizoxanide (Desacetyl-nitazoxanide) is a metabolite of lamivudine.</p>Formule :C10H7N3O4SDegré de pureté :98.89% - 99.28%Couleur et forme :SolidMasse moléculaire :265.25Losmapimod
CAS :<p>Losmapimod (GSK-AHAB) (GW856553X; SB856553; GSK-AHAB) is a specific, potent, and orally active p38 MAPK inhibitor (pKi: 8.1/7.6 for p38α/β).</p>Formule :C22H26FN3O2Degré de pureté :98.35% - 99.89%Couleur et forme :SolidMasse moléculaire :383.46Dabrafenib
CAS :<p>Dabrafenib (GSK2118436A) is a Raf inhibitor that inhibits C-Raf and B-RafV600E (IC50=5/0.6 nM) and is ATP-competitive.</p>Formule :C23H20F3N5O2S2Degré de pureté :99.62% - >99.99%Couleur et forme :SolidMasse moléculaire :519.56BIX02189
CAS :<p>BIX02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM).</p>Formule :C27H28N4O2Degré de pureté :97.84%Couleur et forme :SolidMasse moléculaire :440.54Theaflavin 3,3′-digallate
CAS :<p>Theaflavin 3,3'-digallate, a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer</p>Formule :C43H32O20Degré de pureté :98.71% - 99.86%Couleur et forme :SolidMasse moléculaire :868.7Raf inhibitor 2
CAS :<p>Raf inhibitor 2 (CID 25014542) is novel inhibitor of Raf kinases.</p>Formule :C15H8Br2ClNO2Degré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :429.49Ro 5126766
CAS :<p>RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.</p>Formule :C21H18FN5O5SDegré de pureté :98.3% - 98.81%Couleur et forme :SolidMasse moléculaire :471.46SCH54292
CAS :<p>SCH-54292 is a GDP exchange inhibitor.</p>Formule :C24H28N2O9SDegré de pureté :95.65%Couleur et forme :SolidMasse moléculaire :520.55BAY885
CAS :<p>BAY885 is a new ERK5 inhibitor.</p>Formule :C25H28F3N7O2Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :515.53NG25 trihydrochloride
CAS :<p>NG25 trihydrochloride: kinase inhibitor for MAP4K2, TAK1, Src, LYN, Abl, CSK, FER, p38α; blocks TNF-α signals; impedes IFN secretion; anti-cancer properties.</p>Formule :C29H33Cl3F3N5O2Couleur et forme :SolidMasse moléculaire :646.96SL327
CAS :<p>SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.</p>Formule :C16H12F3N3SDegré de pureté :97.98% - >99.99%Couleur et forme :SolidMasse moléculaire :335.35LY3009120
CAS :<p>LY3009120 (DP-4978) is a potent pan-Raf inhibitor with IC50 of 44 nM, 31-47 nM, and 42 nM for A-raf, B-Raf, and C-Raf in A375 cells, respectively. Phase 1.</p>Formule :C23H29FN6ODegré de pureté :96.96% - ≥95%Couleur et forme :SolidMasse moléculaire :424.51SR-318
CAS :<p>SR-318 inhibits TNF-α (IC50=283 nM), selectively targets p38 MAPK: IC50 of 5nM (p38α), 32nM (p38β), 6.11μM (p38α/β).</p>Formule :C27H33N5O2Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :459.58TAO Kinase inhibitor 1
CAS :TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death.Formule :C25H24N2O2Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :384.47A-443654
CAS :<p>A-443654 is a pan-Akt inhibitor. A-443654 has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).</p>Formule :C24H23N5ODegré de pureté :98.04% - 99.51%Couleur et forme :SolidMasse moléculaire :397.47JIP-1 (153-163) acetate(438567-88-5 free base)
<p>JNK peptide inhibitor. Mimics JIP-1 residues 153-163. Micromolar affinity, little effect on p38, ERK.</p>Formule :C63H108N20O16Degré de pureté :92.89%Couleur et forme :SolidMasse moléculaire :1401.65TAK-632
CAS :<p>TAK-632 is a potent pan-Raf inhibitor.</p>Formule :C27H18F4N4O3SDegré de pureté :98% - 99.5%Couleur et forme :SolidMasse moléculaire :554.522-(4-methoxyphenyl)-2-oxoethyl 2-hydroxy-5-methylbenzoate
CAS :<p>Pro-neurotropic drug boosts brain acetylcholine synthesis and release, inhibits breakdown.</p>Formule :C17H16O5Degré de pureté :98.68%Couleur et forme :SolidMasse moléculaire :300.31Pluripotin
CAS :<p>Pluripotin (SC1) (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and</p>Formule :C27H25F3N8O2Degré de pureté :98.77% - 98.82%Couleur et forme :SolidMasse moléculaire :550.53SCH772984
CAS :<p>SCH772984 is an ERK inhibitor and is highly selective and ATP-competitive. SCH772984 exhibits antitumor activity. Cost-effective and quality-assured.</p>Formule :C33H33N9O2Degré de pureté :97.565% - 98.75%Couleur et forme :SolidMasse moléculaire :587.67TAK-715
CAS :<p>TAK-715 is a p38 MAPK inhibitor for p38α.</p>Formule :C24H21N3OSDegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :399.51APS-2-79
CAS :<p>APS-2-79: KSR-dependent MEK inhibitor, blocks ATP biotin at KSR2, IC50 of 120 nM, disrupts Ras-MAPK signaling.</p>Formule :C23H21N3O3Couleur et forme :SolidMasse moléculaire :387.43Acumapimod
CAS :<p>Acumapimod (BCT-197) is an orally active inhibitor of p38α MAPK (IC50 <1 μM).</p>Formule :C22H19N5O2Degré de pureté :≥95%Couleur et forme :SolidMasse moléculaire :385.42KO-947
CAS :<p>KO-947 is a potent and specific inhibitor of ERK1/2 kinases.</p>Formule :C21H17N5ODegré de pureté :97.84%Couleur et forme :SolidMasse moléculaire :355.39BMS-582949 hydrochloride
CAS :<p>The BMS-582949 hydrochloride (BMS-582949 HCl) is a highly specific p38α MAPK inhibitor (IC50: 13 nM).</p>Formule :C22H27ClN6O2Degré de pureté :97.57% - 98.75%Couleur et forme :SolidMasse moléculaire :442.95sodium lauroyl-α-hydroxyethyl sulfonate
CAS :<p>Sodium houttuyfonate is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.</p>Formule :C14H27NaO5SDegré de pureté :≥98% - ≥98%Couleur et forme :SolidMasse moléculaire :330.41DB07268
CAS :<p>DB07268 is a potent and selective JNK1 inhibitor.</p>Formule :C17H15N5O2Degré de pureté :98.2% - 98.91%Couleur et forme :SolidMasse moléculaire :321.33p-Cresyl sulfate potassium
CAS :<p>p-Cresyl sulfate potassium (p-Tolyl sulfate potassium salt) is a prototype protein-bound uremic toxin derived from the metabolites of tyrosine and phenylalanine</p>Formule :C7H7KO4SDegré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :226.29XMD17-109
CAS :<p>XMD17-109 (ERK5-IN-1) is a new selective ERK-5 inhibitor (EC50: 4.2 uM, HEK293 cells).</p>Formule :C36H46N8O3Degré de pureté :98.75% - 99.7%Couleur et forme :SolidMasse moléculaire :638.8Compound 3344 hydrochloride
<p>Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions，with an affnity of 126nm.</p>Formule :C24H27ClN2O3Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :426.94Rasarfin
CAS :<p>Rasarfin inhibits Ras and ARF6.</p>Formule :C23H24ClN3O3Degré de pureté :97.98%Couleur et forme :SolidMasse moléculaire :425.91BMS582949
CAS :<p>BMS-582949 inhibits p38 MAPK with 13 nM IC50, blocking kinase activity and activation.</p>Formule :C22H26N6O2Degré de pureté :98.11%Couleur et forme :SolidMasse moléculaire :406.48CAY10404
CAS :<p>CAY10404: potent COX-1/2 inhibitor; blocks PKB/Akt, MAPK pathways; triggers NSC-LC apoptosis; analgesic, anti-inflammatory, anti-cancer.</p>Formule :C17H12F3NO3SDegré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :367.34K-Ras(G12C) inhibitor 9
CAS :<p>K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).</p>Formule :C16H21ClIN3O4SDegré de pureté :97.33% - 97.45%Couleur et forme :SolidMasse moléculaire :513.78SB-590885
CAS :<p>SB590885 is an effective B-Raf inhibitor (Ki: 0.16 nM, in a cell-free assay).</p>Formule :C27H27N5O2Degré de pureté :95.42% - 99.06%Couleur et forme :SolidMasse moléculaire :453.54ZT-12-037-01
CAS :<p>Zt-12-037-01 is a ATP competitive STK19 inhibitor（IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).</p>Formule :C21H31N5O2Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :385.5JNK-IN-7
CAS :<p>JNK-IN-7 (JNK inhibitor) is a selective JNK1/2/3 inhibitor (IC50: 1.54/1.99/0.75 nM).</p>Formule :C28H27N7O2Degré de pureté :98.02% - 99.53%Couleur et forme :SolidMasse moléculaire :493.56PF-06260933
CAS :<p>PF-06260933 is a highly selective small-molecule MAP4K4 inhibitor with IC50s of 3.7 and 160 nM for kinase and cell, respectively.</p>Formule :C16H13ClN4Degré de pureté :99.63% - 99.97%Couleur et forme :SolidMasse moléculaire :296.75CK1-IN-1
CAS :<p>CK1-IN-1, a CK1 inhibitor with IC50: 15nM CK1δ, 16nM CK1ε, 73nM p38σ; patent WO2015119579A1.</p>Formule :C24H15F2N3Degré de pureté :98.79%Couleur et forme :SolidMasse moléculaire :383.39N-tert-butyl-α-Phenylnitrone
CAS :<p>N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity.</p>Formule :C11H15NODegré de pureté :99.46% - 99.84%Couleur et forme :SolidMasse moléculaire :177.24B-Raf IN 1
CAS :<p>B-Raf IN 1 is a B-Raf (IC50: 24 nM) and c-Raf (IC50: 25 nM) inhibitor.</p>Formule :C29H24F3N5ODegré de pureté :97.22% - 99.27%Couleur et forme :SolidMasse moléculaire :515.53ERK5-IN-1
CAS :<p>ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM).</p>Formule :C25H29N7O2Degré de pureté :97.70%Couleur et forme :SolidMasse moléculaire :459.54Ulixertinib
CAS :<p>Ulixertinib (VRT752271) (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2.</p>Formule :C21H22Cl2N4O2Degré de pureté :99.31% - 99.95%Couleur et forme :SolidMasse moléculaire :433.33I-49 free base
<p>I-49 free base (Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-6-(tetrahydro-2H-pyran-4-yl)-) is a novel</p>Formule :C23H26ClF3N4O2Degré de pureté :99.64% - 99.88%Couleur et forme :SolidMasse moléculaire :482.92JNK Inhibitor VIII
CAS :<p>JNK Inhibitor VIII (TCS JNK 6o) is an ATP-competitive selective inhibitor of c-Jun N-terminal kinase (JNK)(IC50 values of 45 nM and 160 nM for JNK-1 and -2,</p>Formule :C18H20N4O4Degré de pureté :98.93%Couleur et forme :SolidMasse moléculaire :356.38ARS-1620
CAS :<p>ARS-1620 is a covalent inhibitor of K-RASG12C.</p>Formule :C21H17ClF2N4O2Degré de pureté :98.86%Couleur et forme :SolidMasse moléculaire :430.84Neflamapimod
CAS :<p>Neflamapimod (VX-745) , a specific and effective inhibitor of p38α(IC50=10 nM), is 22-fold greater specificity against p38β and no inhibition activity to p38γ.</p>Formule :C19H9Cl2F2N3OSDegré de pureté :97.88% - 99.75%Couleur et forme :SolidMasse moléculaire :436.26Belvarafenib TFA
<p>Belvarafenib TFA (HM95573 TFA) inhibits RAF: B-RAF (56 nM), B-RAFv600E (7 nM), C-RAF (5 nM) effectively.</p>Formule :C25H17ClF4N6O3SCouleur et forme :SolidMasse moléculaire :592.95K-Ras-IN-1
CAS :<p>K-Ras-IN-1 is a K-Ras inhibitor.</p>Formule :C11H13NOSDegré de pureté :98.72%Couleur et forme :SolidMasse moléculaire :207.29JNK-IN-8
CAS :<p>JNK-IN-8 (JNK Inhibitor XVI) is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM).</p>Formule :C29H29N7O2Degré de pureté :99.24% - >99.99%Couleur et forme :SolidMasse moléculaire :507.59SUN11602
CAS :<p>SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor.</p>Formule :C26H37N5O2Degré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :451.6KRPEP-2D acetate
<p>KRPEP-2D acetate: inhibitor targeting K-Ras(G12D) mutant, a crucial cancer-related protein.</p>Formule :C110H186N44O27S2Degré de pureté :98.94%Couleur et forme :SolidMasse moléculaire :2621.06VX-11e
CAS :<p>VX-11e (TCS ERK 11e) is a potent, selective, and orally bioavailable ERK(Extracellular Signal-Regulated Kinase) inhibitor; antitumor agent.</p>Formule :C24H20Cl2FN5O2Degré de pureté :98.92% - ≥98%Couleur et forme :SolidMasse moléculaire :500.35Plx-4032
CAS :<p>Plx-4032 (Vemurafenib) is a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.</p>Formule :C23H18ClF2N3O3SDegré de pureté :98.53% - 99.36%Couleur et forme :SolidMasse moléculaire :489.92Refametinib
CAS :<p>Refametinib (RDEA119) (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM).</p>Formule :C19H20F3IN2O5SDegré de pureté :99.53% - >99.99%Couleur et forme :SolidMasse moléculaire :572.34TA-02
CAS :<p>TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM.TA-02 especially inhibits TGFBR-2.</p>Formule :C20H13F2N3Degré de pureté :99.35% - 99.79%Couleur et forme :SolidMasse moléculaire :333.33SD-169
CAS :<p>SD-169 (SD 169) is a selective and ATP competitive the MAP kinases p38α and p38β inhibitor.</p>Formule :C9H8N2ODegré de pureté :98.6%Couleur et forme :SolidMasse moléculaire :160.17SM-7368
CAS :<p>The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.</p>Formule :C10H5ClN4O5SDegré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :328.696H05 (TFA)
CAS :<p>6H05 TFA (6H05 trifluoroacetate) is a selective, and allosteric oncogenic mutant K-Ras(G12C) inhibitor.</p>Formule :C22H31ClF3N3O4S3Degré de pureté :98.83%Couleur et forme :SolidMasse moléculaire :590.14ML-098
CAS :<p>ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 (EC50: 77.6 nM).</p>Formule :C19H19NO3Degré de pureté :99.06% - 99.23%Couleur et forme :SolidMasse moléculaire :309.36MK2-IN-3
CAS :<p>MK2-IN-3 is a potent MK-2 inhibitor, cell-permeable, for rheumatoid arthritis treatment.</p>Formule :C21H16N4ODegré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :340.381-(4-methansulfinylphenyl)ethanone
CAS :<p>The compound inhibits Ras function and therefore inhibits the abnormal growth of cells.</p>Formule :C9H10O2SDegré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :182.24CCT196969
CAS :<p>CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. It also inhibits SRC, LCK, and the p38 MAPKs.</p>Formule :C27H24FN7O3Degré de pureté :98.93% - 99.65%Couleur et forme :SolidMasse moléculaire :513.52Cefotetan
CAS :<p>Cefotetan, a cephamycin antibiotic, fights various bacteria by disrupting cell wall synthesis.</p>Formule :C17H17N7O8S4Degré de pureté :95.72% - 99.38%Couleur et forme :SolidMasse moléculaire :575.62SD 0006
CAS :<p>SD 0006 (SD-06) is a MAPK p38 alpha inhibitor( IC50 : 110 nM) for the treatment of arthritis.</p>Formule :C20H20ClN5O2Degré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :397.86CMPD1
CAS :<p>CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM).</p>Formule :C22H20FNO2Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :349.4Talmapimod
CAS :<p>Talmapimod (SCIO-469): Oral ATP-competitive p38α inhibitor, IC50 = 9 nM (p38α), 90 nM (p38β), >2000-fold selectivity over 20 kinases.</p>Formule :C27H30ClFN4O3Degré de pureté :98% - 99.9%Couleur et forme :SolidMasse moléculaire :513AZ7550
CAS :<p>AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).</p>Formule :C27H31N7O2Degré de pureté :97.07% - 99.75%Couleur et forme :SolidMasse moléculaire :485.581588-A4
CAS :<p>1588-A4 (ARS-1620 Intermediate) is an intermediate of ARS-1620 which is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.</p>Formule :C17H19BrClFN4O2Degré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :445.71GSK-114
CAS :<p>GSK-114, a TNNI3K inhibitor with a 25 nM IC50, is 40x more selective than B-Raf and good for in vivo studies.</p>Formule :C19H23N5O4SDegré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :417.48Varenicline Tartrate
CAS :<p>Varenicline Tartrate (CP 526555-18) is a benzazepine derivative that functions as an ALPHA4/BETA2 NICOTINIC RECEPTOR partial agonist.</p>Formule :C13H13N3·C4H6O6Degré de pureté :98.23% - 98.32%Couleur et forme :Tan SolidMasse moléculaire :361.35Encorafenib
CAS :<p>Encorafenib (LGX818) is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.</p>Formule :C22H27ClFN7O4SDegré de pureté :99.51% - 99.83%Couleur et forme :SolidMasse moléculaire :540.01AG126
CAS :<p>AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42). AG-126 weakly inhibits epidermal GFRK and platelet-derived GFRK.</p>Formule :C10H5N3O3Degré de pureté :97.35%Couleur et forme :SolidMasse moléculaire :215.16D-JNKI-1 acetate
<p>D-JNKI-1 acetate (AM-111 acetate) is a highly potent and cell-permeable peptide inhibitor of JNK.</p>Formule :C166H290N66O42Degré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :3882.5
