MAPK
Les MAPK sont une famille de kinases protéiques impliquées dans une variété de processus cellulaires, y compris la croissance, la prolifération, la différenciation et les réponses au stress. La voie de signalisation MAPK comprend plusieurs niveaux, y compris ERK, JNK et p38 MAPK, chacun jouant des rôles distincts dans la fonction cellulaire. La dérégulation de la signalisation MAPK est liée au cancer, aux maladies inflammatoires et aux troubles métaboliques. Chez CymitQuimica, nous offrons un large éventail d'inhibiteurs et d'activateurs de MAPK pour soutenir vos recherches en biologie cellulaire, transduction de signaux et mécanismes des maladies.
886 produits trouvés pour "MAPK"
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KRAS G12C inhibitor 45
CAS :<p>KRAS G12C inhibitor 45 is a potent KRAS G12C inhibitor .</p>Formule :C32H33F2N5O5SCouleur et forme :SolidMasse moléculaire :637.7JNK3 inhibitor-4
CAS :<p>JNK3 inhibitor-4: potent, selective JNK3 blocker (IC50=1.0nM), neuroprotective, BBB-permeable.</p>Formule :C28H27N7OCouleur et forme :SolidMasse moléculaire :477.56HPK1-IN-17
CAS :<p>HPK1-IN-17 selectively inhibits HPK1, a MAP4Ks family kinase from blood progenitor cells; useful against HPK1-related diseases like cancer.</p>Formule :C26H28N6OCouleur et forme :SolidMasse moléculaire :440.54KRAS inhibitor-17
CAS :<p>KRAS inhibitor-17 blocks G12C mutation (IC50: 3.37μM) and p-ERK in MIA PaCA-2 (IC50: 9.25μM). Could target pancreatic, colorectal, lung cancers.</p>Formule :C21H18Cl2FN3O2SCouleur et forme :SolidMasse moléculaire :466.36BRAF V600E/CRAF-IN-2
CAS :<p>Potent BRAFV600E/CRAF inhibitor, IC50: 0.888/0.229 μM, induces G0/G1 arrest and apoptosis in HCT-116 cells, potential for cancer research.</p>Formule :C30H30F3N5O2Couleur et forme :SolidMasse moléculaire :549.59KRAS4b-PDEδ stabilizer C19
CAS :<p>KRAS4b-PDEδ stabilizer C19 is a stabilizer of the KRAS4b-PDEδ complex which decreases the proliferation of colorectal cancer cells, and increases apoptosis via</p>Formule :C18H20Cl2N2O3Couleur et forme :SolidMasse moléculaire :383.27SCH 51344
CAS :<p>SCH 51344 inhibits Ras induced malignant transformation. SCH 51344 prevents anchorage-independent growth of oncogene transformed fibroblasts [1].</p>Formule :C16H20N4O3Couleur et forme :SolidMasse moléculaire :316.36LX-3
CAS :<p>LX-3 activates p38 MAPK, enabling expression of genes normally silenced by DNA methylation.</p>Formule :C20H13BrN4OSCouleur et forme :SolidMasse moléculaire :437.31KRAS G12C inhibitor 47
CAS :<p>KRAS G12C inhibitor 47 strongly blocks KRAS G12C (IC50: 0.172 μM) and p-ERK in cells; promising for pancreatic, colorectal, lung cancers.</p>Formule :C30H28ClFN4O3Couleur et forme :SolidMasse moléculaire :547.02SOS1-IN-3
CAS :<p>SOS1-IN-3 is an effective inhibitor of SOS1 (son of sevenless homolog 1) (IC50=5 nM). SOS1-IN-3 shows antitumor activity.</p>Formule :C21H21F3N4OCouleur et forme :SolidMasse moléculaire :402.41SOS1 activator 1
CAS :<p>SOS1 activator 1 enhances SOS1's GDP-GTP exchange on Ras (Kd: 44 nM).</p>Formule :C26H32ClFN6Couleur et forme :SolidMasse moléculaire :483.026-T-GDP
CAS :<p>6-T-GDP (6-Thioguanosine 5'-diphosphate) is a metabolite of thiopurine. It inhibits the activity of Rac1, thereby reducing the transcription of inflammatory factors and the expression of cell adhesion molecules, which ultimately suppresses leukocyte migration and the occurrence of tissue inflammation.</p>Formule :C10H15N5O10P2SCouleur et forme :SolidMasse moléculaire :459.27GDC-0879
CAS :<p>GDC-0879 (AR-00341677) is a novel, potent and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well.</p>Formule :C19H18N4O2Degré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :334.37Tpl2-IN-I
CAS :<p>Tpl2-IN-I is an inhibitor of tumour progression locus 2 (Tpl2) kinase.</p>Formule :C21H14ClFN6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :404.83NSC1011
CAS :<p>NSC1011 is an inhibitor of ras converting enzyme 1 (Rce1).</p>Formule :C23H18N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :370.4AZD6703 free base
CAS :<p>AZD6703 is a potent, selective and reversible orally bioavailable inhibitor of p38 mitogen-activated protein kinase 14 (MAPK14).</p>Formule :C24H27N5O2Couleur et forme :SolidMasse moléculaire :417.5Kobe2601
CAS :<p>Kobe2601 is a Kobe0065 and Kobe02602 water-soluble analog. It displays inhibitory activity towards Ras-Raf binding.</p>Formule :C13H10FN5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :351.31GSK329
CAS :<p>GSK329 selectively inhibits TNNI3K, showing cardioprotection in ischemic heart models.</p>Formule :C19H14Cl2F3N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :472.25HCI-2184
CAS :<p>HCI-2184 is an inhibitor of AXL kinase and Nek2 that acts by successfully mitigating drug resistance in bortezomib-resistant multiple myeloma.</p>Formule :C23H28ClN7O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :502.03GSK649A
CAS :<p>GSK649A is a novel activator of Satellite Cell Proliferation, it could enhance repair of Damaged Muscle.</p>Formule :C15H12ClFN6OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :378.81RBC6
CAS :<p>RBC6 is an inhibitor of the binding of Ral to its effector RALBP1.</p>Formule :C16H14Cl2N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :365.21CP-944629
CAS :<p>CP-944629 is a novel, potent, and selective inhibitor of p38alpha.</p>Formule :C19H15F3N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :372.34BNC-1
CAS :<p>BNC-1 reduces amyloid in mice, enhances synapses by activating Elk-1.</p>Formule :C16H14N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :282.29(2Z,3Z)-U0126
CAS :U0126 selectively inhibits MEK1/2, blocks MAPK/ERK signaling, and suppresses Ki-ras-induced cell growth, with IC50s of 72 nM and 58 nM for MEK1/2.Formule :C18H16N6S2Couleur et forme :SolidMasse moléculaire :380.49BSJ-04-122
CAS :<p>BSJ-04-122: MKK4/7 inhibitor with IC50s of 4 nM & 181 nM, used in cancer research.</p>Formule :C15H12ClN5ODegré de pureté :97.61%Couleur et forme :SolidMasse moléculaire :313.74CK1-IN-2
CAS :<p>CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor p38a, and is used in DUX4 overexpression-associated diseases, such as muscular dystrophy.</p>Formule :C17H12FN3O2Degré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :309.29SR-3306
CAS :<p>SR-3306 is a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor with IC50 values of 67 nM, 283 nM, 159 nM.Cost-effective and quality-assured.</p>Formule :C28H26N8ODegré de pureté :99.38% - 99.71%Couleur et forme :SolidMasse moléculaire :490.56GNE-1858
CAS :<p>GNE-1858 inhibits HPK1; IC50: 1.9 nM for wild-type, 1.9 nM (HPK1-TSEE), 4.5 nM (HPK1-SA).</p>Formule :C21H26F2N8Degré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :428.48J30-8
CAS :<p>J30-8 is a JNK3 inhibitor (IC50: 40 nM) with neuroprotective activity and can be used to study neurodegenerative diseases such as Alzheimer's disease.</p>Formule :C17H9ClFN3O2SDegré de pureté :99.90%Couleur et forme :SolidMasse moléculaire :373.79TAK1/MAP4K2 inhibitor 1
CAS :<p>TAK1/MAP4K2 inhibitor 1 (compound 5) is a dual kinase inhibitor of TAK1 and MAP4K2 with IC50 values of 41.1 nM and 18.2 nM, respectively.</p>Formule :C29H31F3N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :552.59RMM-46
CAS :<p>RMM-46 is a reversible covalent inhibitor with high ligand efficiency and selectivity for MSK/RSK family kinases.</p>Formule :C24H26N4O5Degré de pureté :98.89%Couleur et forme :SolidMasse moléculaire :450.49LY-2584702 hydrochloride
CAS :<p>Ly-2584702 hydrochloride is a p70S6K selective ATP competitive inhibitor with IC50 of 4 nM.In the S6K1 enzyme assay, the IC50 of LY-2584702 was 2 nM.</p>Formule :C21H20ClF4N7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :481.88MEK inhibitor
CAS :<p>MEK inhibitor is a MEK receptor and cell cycle protein/CDK complex inhibitor with antitumor activity that can be used to study tumor cell proliferation.</p>Formule :C26H26N4O2Degré de pureté :97.48%Couleur et forme :SolidMasse moléculaire :426.51NSC-70220
CAS :<p>SOS1-IN-1 is an inhibitor of SOS1.</p>Formule :C22H15NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :325.36MNK1/2-IN-5
CAS :<p>MNK1/2-IN-5 is a potent and selective MNK1/2 inhibitor with anticancer activity and can be used to study solid tumors and hematological malignancies.</p>Formule :C17H16N4O2Degré de pureté :98.04%Couleur et forme :SolidMasse moléculaire :308.33MEK-IN-4
CAS :<p>MEK-IN-4 is a MEK inhibitor that can be used to study inflammatory diseases and cancer.</p>Formule :C21H18N4OSDegré de pureté :98.35% - 99.16%Couleur et forme :SolidMasse moléculaire :374.46Nek2-IN-5
CAS :<p>Nek2-IN-5 (NCL00017509) is a potent and selective inhibitor of NIMA-related kinase 2 (Nek2).</p>Formule :C15H12N6ODegré de pureté :98.11%Couleur et forme :SolidMasse moléculaire :292.3mSIRK
CAS :<p>mSIRK (G-Protein βγ Binding Peptide) is an ERK1 and ERK2 dual activator that promotes alpha-subunit dissociation.</p>Formule :C93H150N20O25Degré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :1948.31BI-2852
CAS :<p>BI-2852: nanomolar affinity KRAS switch I/II pocket inhibitor; blocks signaling, halts KRAS mutant cell growth.</p>Formule :C31H28N6O2Degré de pureté :98.98%Couleur et forme :SolidMasse moléculaire :516.59RMC-0331
CAS :<p>RMC-0331 (RM-023) is an oral SOS1 inhibitor with potential to block RAS activation and anticancer properties.</p>Formule :C22H25ClF3N5O3Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :499.91DS12881479
CAS :<p>DS12881479 can be used in cancer research which is a potent and selective inhibitor of Mnk1(IC 50 =21 nM) [1].</p>Formule :C16H19N3OSDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :301.41ZINC12409120
CAS :<p>ZINC12409120 (R-4584) is a selective ERK inhibitor.ZINC12409120 inhibits ERK with an IC50 of 5.0 μM.ZINC12409120 inhibits ERK activity by interfering with FGF23</p>Formule :C20H16N4O2Degré de pureté :99.71% - 99.95%Couleur et forme :SolidMasse moléculaire :344.37UR13870
CAS :<p>UR-13870 (Org 48762-0) is a p38 MAPK inhibitor that prevents bone damage in collagen-induced arthritis in mice.</p>Formule :C24H16F2N4Degré de pureté :99.18% - >99.99%Couleur et forme :SolidMasse moléculaire :398.41GSK2008607
CAS :<p>GSK2008607 is a potent B-RafV600E inhibitor with anticancer activity and can be used to study breast, colorectal, melanoma, thyroid, and ovarian cancers.</p>Formule :C31H28F3N7O3S2Degré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :667.72SOS1-IN-15
CAS :<p>SOS1-IN-15 is an orally active and potent SOS1 inhibitor with potential antitumor activity.SOS1-IN-15 is used in the study of colon cancer.</p>Formule :C28H27F3N6O2Degré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :536.548JNK-IN-11
CAS :<p>JNK-IN-11 inhibits JNK1/2/3 (IC50: 2.2/21.4/1.8 μM); promising for Alzheimer's/Parkinson's research.</p>Formule :C12H11NO3S2Degré de pureté :98.82%Couleur et forme :SolidMasse moléculaire :281.35MKK7-COV-9
CAS :<p>MKK7-COV-9 is an MKK7 inhibitor that inhibits MKK7-induced protein-protein interactions and interrupts the activation of primary B cells in response to LPS.</p>Formule :C18H16N4O2Degré de pureté :99.07% - 99.73%Couleur et forme :SolidMasse moléculaire :320.35(E)-GABAB receptor antagonist 1
CAS :<p>(E)-GABAB antagonist 1 inhibits GABA IP3 production, with an IC50 of 37.9 μM and acts as a selective negative modulator.</p>Formule :C18H24O4Degré de pureté :98.09%Couleur et forme :SolidMasse moléculaire :304.38EO-1606
CAS :<p>EO-1606 is a p38MAP kinase inhibitor with anti-inflammatory activity and may be used in studies of Alzheimer;s disease and dermatitis.</p>Formule :C21H17ClFNODegré de pureté :98.28% - 98.84%Couleur et forme :SolidMasse moléculaire :353.82p38α inhibitor 4
CAS :<p>p38α inhibitor 4 is a selective MAPK p38α inhibitor, which is used to study diabetes, pain and chronic inflammation.</p>Formule :C14H7F6N3ODegré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :347.215
