MAPK
Les MAPK sont une famille de kinases protéiques impliquées dans une variété de processus cellulaires, y compris la croissance, la prolifération, la différenciation et les réponses au stress. La voie de signalisation MAPK comprend plusieurs niveaux, y compris ERK, JNK et p38 MAPK, chacun jouant des rôles distincts dans la fonction cellulaire. La dérégulation de la signalisation MAPK est liée au cancer, aux maladies inflammatoires et aux troubles métaboliques. Chez CymitQuimica, nous offrons un large éventail d'inhibiteurs et d'activateurs de MAPK pour soutenir vos recherches en biologie cellulaire, transduction de signaux et mécanismes des maladies.
886 produits trouvés pour "MAPK"
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B-Raf IN 1
CAS :<p>B-Raf IN 1 is a B-Raf (IC50: 24 nM) and c-Raf (IC50: 25 nM) inhibitor.</p>Formule :C29H24F3N5ODegré de pureté :97.22% - 99.27%Couleur et forme :SolidMasse moléculaire :515.53CAY10404
CAS :<p>CAY10404: potent COX-1/2 inhibitor; blocks PKB/Akt, MAPK pathways; triggers NSC-LC apoptosis; analgesic, anti-inflammatory, anti-cancer.</p>Formule :C17H12F3NO3SDegré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :367.34N-tert-butyl-α-Phenylnitrone
CAS :<p>N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity.</p>Formule :C11H15NODegré de pureté :99.46% - 99.84%Couleur et forme :SolidMasse moléculaire :177.24Refametinib
CAS :<p>Refametinib (RDEA119) (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM).</p>Formule :C19H20F3IN2O5SDegré de pureté :99.53% - >99.99%Couleur et forme :SolidMasse moléculaire :572.34JNK Inhibitor VIII
CAS :<p>JNK Inhibitor VIII (TCS JNK 6o) is an ATP-competitive selective inhibitor of c-Jun N-terminal kinase (JNK)(IC50 values of 45 nM and 160 nM for JNK-1 and -2,</p>Formule :C18H20N4O4Degré de pureté :98.93%Couleur et forme :SolidMasse moléculaire :356.38UM-164
CAS :<p>UM-164 (DAS-DFGO-II), a highly potent c-Src inhibitor with a dissociation constant (Kd) of 2.7 nM, also effectively inhibits p38α and p38β.</p>Formule :C30H31F3N8O3SDegré de pureté :98.72% - 99.52%Couleur et forme :SolidMasse moléculaire :640.68NG25 trihydrochloride
CAS :<p>NG25 trihydrochloride: kinase inhibitor for MAP4K2, TAK1, Src, LYN, Abl, CSK, FER, p38α; blocks TNF-α signals; impedes IFN secretion; anti-cancer properties.</p>Formule :C29H33Cl3F3N5O2Couleur et forme :SolidMasse moléculaire :646.96I-49 free base
<p>I-49 free base (Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-6-(tetrahydro-2H-pyran-4-yl)-) is a novel</p>Formule :C23H26ClF3N4O2Degré de pureté :99.64% - 99.88%Couleur et forme :SolidMasse moléculaire :482.92Ulixertinib
CAS :<p>Ulixertinib (VRT752271) (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2.</p>Formule :C21H22Cl2N4O2Degré de pureté :99.31% - 99.95%Couleur et forme :SolidMasse moléculaire :433.33VX-11e
CAS :<p>VX-11e (TCS ERK 11e) is a potent, selective, and orally bioavailable ERK(Extracellular Signal-Regulated Kinase) inhibitor; antitumor agent.</p>Formule :C24H20Cl2FN5O2Degré de pureté :98.92% - ≥98%Couleur et forme :SolidMasse moléculaire :500.35AD80
CAS :<p>AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.</p>Formule :C22H19F4N7ODegré de pureté :99.49% - 99.75%Couleur et forme :SolidMasse moléculaire :473.43SB 239063
CAS :<p>SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.</p>Formule :C20H21FN4O2Degré de pureté :99.42% - 99.81%Couleur et forme :SolidMasse moléculaire :368.4K-Ras(G12C) inhibitor 6
CAS :<p>Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.</p>Formule :C17H22Cl2N2O3SDegré de pureté :89.07% - 97.09%Couleur et forme :SolidMasse moléculaire :405.34AS601245
CAS :<p>AS601245 is an inhibitor of the c-Jun NH2-terminal kinase (JNK), with neuroprotective properties.</p>Formule :C20H16N6SDegré de pureté :98% - 99.02%Couleur et forme :SolidMasse moléculaire :372.45Talmapimod
CAS :<p>Talmapimod (SCIO-469): Oral ATP-competitive p38α inhibitor, IC50 = 9 nM (p38α), 90 nM (p38β), >2000-fold selectivity over 20 kinases.</p>Formule :C27H30ClFN4O3Degré de pureté :98% - 99.9%Couleur et forme :SolidMasse moléculaire :513Butein
CAS :<p>Butein is a cAMP-specific PDE inhibitor, protein tyrosine kinase inhibitor, and SIRT1 activator.Cost-effective and quality-assured.</p>Formule :C15H12O5Degré de pureté :98.76% - >99.99%Couleur et forme :SolidMasse moléculaire :272.25D-JNKI-1 acetate
<p>D-JNKI-1 acetate (AM-111 acetate) is a highly potent and cell-permeable peptide inhibitor of JNK.</p>Formule :C166H290N66O42Degré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :3882.5Encorafenib
CAS :<p>Encorafenib (LGX818) is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.</p>Formule :C22H27ClFN7O4SDegré de pureté :99.51% - 99.83%Couleur et forme :SolidMasse moléculaire :540.01CCT196969
CAS :<p>CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. It also inhibits SRC, LCK, and the p38 MAPKs.</p>Formule :C27H24FN7O3Degré de pureté :98.93% - 99.65%Couleur et forme :SolidMasse moléculaire :513.52SD 0006
CAS :<p>SD 0006 (SD-06) is a MAPK p38 alpha inhibitor( IC50 : 110 nM) for the treatment of arthritis.</p>Formule :C20H20ClN5O2Degré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :397.86Cefotetan
CAS :<p>Cefotetan, a cephamycin antibiotic, fights various bacteria by disrupting cell wall synthesis.</p>Formule :C17H17N7O8S4Degré de pureté :95.72% - 99.38%Couleur et forme :SolidMasse moléculaire :575.62ML-098
CAS :<p>ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 (EC50: 77.6 nM).</p>Formule :C19H19NO3Degré de pureté :99.06% - 99.23%Couleur et forme :SolidMasse moléculaire :309.36AZ7550
CAS :<p>AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).</p>Formule :C27H31N7O2Degré de pureté :97.07% - 99.75%Couleur et forme :SolidMasse moléculaire :485.58Deltarasin HCl
CAS :<p>Deltarasin hinders KRAS-PDEδ, impairs cancer cell growth via a PDEδ pocket, disrupting RAS/RAF signaling and autophagy.</p>Formule :C40H37N5O·xHClCouleur et forme :SolidMasse moléculaire :713.144GSK-114
CAS :<p>GSK-114, a TNNI3K inhibitor with a 25 nM IC50, is 40x more selective than B-Raf and good for in vivo studies.</p>Formule :C19H23N5O4SDegré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :417.48JNK-IN-7
CAS :<p>JNK-IN-7 (JNK inhibitor) is a selective JNK1/2/3 inhibitor (IC50: 1.54/1.99/0.75 nM).</p>Formule :C28H27N7O2Degré de pureté :98.02% - 99.53%Couleur et forme :SolidMasse moléculaire :493.56K-Ras(G12C) inhibitor 9
CAS :<p>K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).</p>Formule :C16H21ClIN3O4SDegré de pureté :97.33% - 97.45%Couleur et forme :SolidMasse moléculaire :513.78Pyridoxal 5'-phosphate hydrate
CAS :<p>Pyridoxal 5'-phosphate hydrate (PLP)(1:x), the active form of vitamin B6, is a cofactor for many different enzymes involved in transamination reactions,</p>Formule :C8H10NO6PDegré de pureté :97.52%Couleur et forme :SolidMasse moléculaire :247.14PF-06260933
CAS :<p>PF-06260933 is a highly selective small-molecule MAP4K4 inhibitor with IC50s of 3.7 and 160 nM for kinase and cell, respectively.</p>Formule :C16H13ClN4Degré de pureté :99.63% - 99.97%Couleur et forme :SolidMasse moléculaire :296.75GW284543
CAS :<p>GW284543 (UNC10225170) is a selective inhibitor of MEK5 .</p>Formule :C23H20N2O3Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :372.42ERK-IN-4
CAS :<p>ERK-IN-4 is a cell-permeable ERK inhibitor with potential antiproliferative effects for the study of diseases caused by immune dysfunction.</p>Formule :C14H17ClN2O3SDegré de pureté :98.92% - 99.84%Couleur et forme :SolidMasse moléculaire :328.814Raf inhibitor 1
CAS :<p>B-Raf inhibitor 1 (B-Raf inhibitor 1) is a potent and selective B-Raf inhibitor.</p>Formule :C26H19ClN8Degré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :478.94Cerdulatinib hydrochloride
CAS :<p>Cerdulatinib hydrochloride is an oral tyrosine kinase inhibitor targeting JAK1/2/3, TYK2, Syk, and 19 others with IC50 < 200 nM.</p>Formule :C20H28ClN7O3SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :482Ulixertinib hydrochloride
CAS :<p>Ulixertinib hydrochloride (Ulixertinib HCl) is an ERK1/2 inhibitor with anticancer and antitumor activity that inhibits the NB cell cycle and promotes apoptosis</p>Formule :C21H23Cl3N4O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :469.79NCB-0846
CAS :<p>NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).</p>Formule :C21H21N5O2Degré de pureté :97.04% - 99.89%Couleur et forme :SolidMasse moléculaire :375.42TBAP-001
CAS :TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.Formule :C27H23F2N7O3Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :531.51VX-702
CAS :<p>VX-702: selective p38α MAPK inhibitor, potent anti-cytokine for rheumatoid arthritis.</p>Formule :C19H12F4N4O2Degré de pureté :99% - >99.99%Couleur et forme :SolidMasse moléculaire :404.32Trametiglue
CAS :<p>Trametiglue, a potent Trametinib derivative, selectively targets KSR-MEK and RAF-MEK through unique binding.</p>Formule :C25H24FIN6O5SCouleur et forme :SolidMasse moléculaire :666.46AZD0022
CAS :<p>AZD0022 is a selective, reversible, and orally active KRAS G12D inhibitor, exhibits tumour marker inhibition in PDAC and NSCLC models.</p>Formule :C34H30F4N6ODegré de pureté :98.73%Couleur et forme :SoildMasse moléculaire :614.64AMG410
CAS :<p>AMG410 is a non-covalent, dual-modality KRAS inhibitor effective against both GDP (OFF) and GTP (ON) binding independently of the cell cycle and other mutants,</p>Formule :C31H32ClF2N7O5Degré de pureté :98.01% - 99.84%Couleur et forme :SoildMasse moléculaire :656.08SC-68376
CAS :<p>SC-68376 is a potent, reversible, cell-permeable, ATP-competitive, and selective inhibitor of p38 MAP kinase.</p>Formule :C15H12N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :236.27Deltarasin
CAS :<p>Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.</p>Formule :C40H37N5ODegré de pureté :99.4%Couleur et forme :SolidMasse moléculaire :603.75Cephradine monohydrate
CAS :<p>Cephradine monohydrate is a β-lactam cephalosporin antibiotic exhibiting broad-spectrum activity against Gram-positive and Gram-negative pathogens.</p>Formule :C16H21N3O5SDegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :367.42ETC-168
CAS :<p>ETC-168 is a selective, orally active MNK inhibitor with IC50 values of 23 nM for MNK1 and 43 nM for MNK2. It demonstrates antiproliferative efficacy both in vivo and in vitro [1].</p>Formule :C24H19N5O2Couleur et forme :SolidMasse moléculaire :409.44FMK
CAS :<p>FMK 是一种不可逆的 RSK2 抑制剂，能够共价修饰 RSK 的 C 末端区域。</p>Formule :C18H19FN4O2Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :342.376H05
CAS :<p>6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).</p>Formule :C20H30ClN3O2S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :476.12Sulindac sulfide
CAS :<p>Sulindac sulfide: NSAID targeting COX-1, inhibits Ras-Raf-1 and gamma-secretase (IC50: 20.2 μM), active sulinic acid metabolite.</p>Formule :C20H17FO2SDegré de pureté :99.35%Couleur et forme :SolidMasse moléculaire :340.41PLX7904
CAS :<p>PLX7904 (PB04), a selective RAF inhibitor, blocks ERK1/2 in mutant BRAF melanoma without activating it in RAS mutants.</p>Formule :C24H22F2N6O3SDegré de pureté :99.51% - 99.66%Couleur et forme :SolidMasse moléculaire :512.53CP-281384
CAS :<p>CP-281384 is a potent, p38alpha-selective inhibitor.</p>Formule :C18H14F2N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :340.33BRAF inhibitor
CAS :<p>BRAF inhibitor is an inhibitor of B-Raf.</p>Formule :C22H18F2N4O3SDegré de pureté :98.2% - 98.41%Couleur et forme :SolidMasse moléculaire :456.47
