MAPK
Les MAPK sont une famille de kinases protéiques impliquées dans une variété de processus cellulaires, y compris la croissance, la prolifération, la différenciation et les réponses au stress. La voie de signalisation MAPK comprend plusieurs niveaux, y compris ERK, JNK et p38 MAPK, chacun jouant des rôles distincts dans la fonction cellulaire. La dérégulation de la signalisation MAPK est liée au cancer, aux maladies inflammatoires et aux troubles métaboliques. Chez CymitQuimica, nous offrons un large éventail d'inhibiteurs et d'activateurs de MAPK pour soutenir vos recherches en biologie cellulaire, transduction de signaux et mécanismes des maladies.
890 produits trouvés pour "MAPK".
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KAI-11101
KAI-11101 is an inhibitor of dual leucine zipper kinase (DLK, MAP3K12) with a Ki of 0.7 nM. It effectively suppresses paclitaxel-induced cJun phosphorylation (IC50=95 nM), thereby inhibiting the activation of the MAPK pathway. KAI-11101 exhibits blood-brain barrier permeability, allowing for further exploration of its neuroprotective properties.Formule :C21H23F4N5O3Couleur et forme :SolidMasse moléculaire :469.433MRTF-A-IN-2
MRTF-A-IN-2 (compound 16) is an inhibitor of MRTF-A. It effectively suppresses cell proliferation and induces senescence in HCC cells.Couleur et forme :Odour SolidSetidegrasib
CAS :KRAS G12D inhibitor 17, a quinazoline-linked prolinamide, degrades mutant KRAS protein; a PROTAC.Formule :C60H65FN12O7SCouleur et forme :White SolidMasse moléculaire :1117.3PROTAC SOS1 degrader-2
CAS :PROTAC SOS1 degrader-2 reduces pERK & RAS-GTP, inhibiting tumor growth dose-dependently in vivo.Formule :C57H76ClFN10O4SCouleur et forme :SolidMasse moléculaire :1051.79Ras Inhibitory Peptide
CAS :Sos1, a GEF, activates ERK by converting Ras-GDP to Ras-GTP via Grb2. The PVPPR peptide inhibits this by blocking Sos1/Grb2 binding.Formule :C53H91N19O11Couleur et forme :SolidMasse moléculaire :1170.433Ras Inhibitory Peptide acetate
Ras Inhibitory Peptide acetate, involved in cancer-related Ras signaling.Formule :C55H95N19O13Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :1230.46KRASG12C IN-14
KRASG12C IN-14 (compound 15), a potent inhibitor specifically designed for the KRAS G12C mutation, exhibits impressive efficacy in impeding CYPA-dependent KRAS-BRAF interaction and ERK phosphorylation in NCI-H358 cells, both with an IC 50 of 0.002 μM.Formule :C51H65F4N9O9S2Couleur et forme :SolidMasse moléculaire :1088.24Divarasib adipate
CAS :Divarasib (GDC-6036) adipate is a selective and highly potent KRAS G12C inhibitor with an impressively low IC 50 value of <0.01 μM, designed for oral administration. It covalently attaches to the switch II (SW-II) pocket in KRAS G12C, irreversibly maintaining the protein in its inactive GDP-bound state [1] [2].Formule :C35H42ClF4N7O6Couleur et forme :SolidMasse moléculaire :768.2PROTAC SOS1 degrader-8
CAS :PROTA CSOS1 degrader-8 (Compd 1) acts as a PROTAC degrader targeting SOS1.Formule :C50H60ClN11O4Couleur et forme :SolidMasse moléculaire :914.54NK7-902
NK7-902 is a CRBN molecular glue degrader of NEK7. It fully degrades NEK7 in human primary monocytes and whole blood, yet only partially inhibits NLRP3-dependent IL-1β production. NK7-902 results in profound and lasting degradation of NEK7, but only temporarily blocks NLRP3 inflammasome activation in non-human primates via oral administration. The compound demonstrates activity in mouse systems.Couleur et forme :Odour SolidJNK-IN-15, Cell-Permeable, Negative Control
JNK-IN-15, Cell-Permeable, Negative Control serves as the negative control for JNK-IN-15, Cell-Permeable. JNK-IN-15, Cell-Permeable functions as an inhibitor of JNK.Formule :C191H336N70O48SCouleur et forme :SolidMasse moléculaire :4410.57236PPM-3
PPM-3, a selective PROTAC ERK5 degrader, exhibits a potent inhibitory concentration (IC 50) of 62.4 nM.Formule :C54H69N11O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1000.26LYMTAC-2
LYMTAC-2 is a lysosome-targeting chimera (LYMTAC) developed to degrade membrane-associated proteins through lysosomal membrane proteins (LMP) such as RNF152, LAPTM4a, and LAPTM5. It forms a ternary complex with target proteins like KRASG12D, facilitating their relocation to lysosomes and resulting in ubiquitin-dependent degradation. This compound has potential for studying membrane protein regulation and devising strategies to counter resistance in KRAS-driven signaling pathways.Couleur et forme :SolidMasse moléculaire :1248.44SOS1-IN-11
CAS :SOS1-IN-11 is an effective inhibitor of SOS1 (IC50 = 30 nM).Formule :C22H24F3N5ODegré de pureté :99.4%Couleur et forme :SolidMasse moléculaire :431.45Ref: TM-T60029
1mg72,00€5mg160,00€1mL*10mM (DMSO)172,00€10mg269,00€25mg427,00€50mg610,00€100mg820,00€KRAS G12D inhibitor 5
CAS :KRAS G12D inhibitor 5 is a KRAS G12D inhibitor for the potential treatment of pancreatic cancer.Formule :C31H31ClF2N6O2Couleur et forme :SolidMasse moléculaire :593.08Pan-RAS-IN-6
Pan-RAS-IN-6 (compound 24) serves as a DUSP6 inhibitor, effectively reducing MAPK activation in the NCI-H1373-Luc model (DUSP6). It concurrently exhibits notable tumor growth inhibition and regression in the NSCLC brain metastasis mouse model. The compound displays high selectivity and potent inhibitory effects, particularly on KRAS mutation-associated signaling pathways. It demonstrates varied inhibitory activities against distinct KRAS mutants and their interacting proteins. The IC 50 values for KRAS G12C, G12D, and G12V are 1.3 nM, 4.7 nM, and 0.3 nM, respectively.Formule :C46H60N8O5SCouleur et forme :SolidMasse moléculaire :837.08PROTAC K-Ras Degrader-6
CAS :Pan-KRAS degrader 5 (compound 102) is a cereblon-based PROTAC KRAS degrader with a DC50 value less than 100 nM, exhibiting anticancer activity.Formule :C57H65F2N11O5Couleur et forme :SolidMasse moléculaire :1022.19RM-018
CAS :RM-018 inhibits active KRAS G12C & G12C/Y96D, possibly beating resistance with unique traits.Formule :C56H72N8O8Couleur et forme :SolidMasse moléculaire :985.24NUCC-0200808
NUCC-0200808 (Compound 12g) is an MNK1 inhibitor with an IC50 of 42 nM. It reduces eIF4E phosphorylation and cell viability in AML cells and induces apoptosis. NUCC-0200808 shows potential for research in the field of leukemia.Couleur et forme :Odour SolidPROTAC SOS1 degrader-5
CAS :PROTAC SOS1 degrader-5 (compound 4) serves as an effective degrader of PROTAC SOS1, exhibiting a DC50 of 13 nM. It robustly suppresses the proliferation of NCI-H358 cells, with an IC50 value of 5 nM [1].Formule :C45H51F3N8O7Couleur et forme :SolidMasse moléculaire :872.93
