MAPK
Les MAPK sont une famille de kinases protéiques impliquées dans une variété de processus cellulaires, y compris la croissance, la prolifération, la différenciation et les réponses au stress. La voie de signalisation MAPK comprend plusieurs niveaux, y compris ERK, JNK et p38 MAPK, chacun jouant des rôles distincts dans la fonction cellulaire. La dérégulation de la signalisation MAPK est liée au cancer, aux maladies inflammatoires et aux troubles métaboliques. Chez CymitQuimica, nous offrons un large éventail d'inhibiteurs et d'activateurs de MAPK pour soutenir vos recherches en biologie cellulaire, transduction de signaux et mécanismes des maladies.
886 produits trouvés pour "MAPK"
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ARS-1630
CAS :<p>ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.</p>Formule :C21H17ClF2N4O2Degré de pureté :97.78%Couleur et forme :SolidMasse moléculaire :430.84Azelnidipine
CAS :<p>Azelnidipine (UR-12592) is a dihydropyridine used as calcium channel blocker.</p>Formule :C33H34N4O6Degré de pureté :99.78%Couleur et forme :Light Yellowish PowderMasse moléculaire :582.65ERK5-IN-5
CAS :<p>ERK5-IN-5 is extracellular signal-regulated kinase 5 (ERK5) inhibitor with anticancer activity anticonvulsant activity inhibits A549 cell proliferation.</p>Formule :C19H16ClN3ODegré de pureté :99.77%Couleur et forme :SoildMasse moléculaire :337.8Cephradine
CAS :<p>Cephradine (Anspor) is a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity.</p>Formule :C16H19N3O4SDegré de pureté :99.63%Couleur et forme :White Crystalline Powder; Polymorphic SolidMasse moléculaire :349.40Pepinh-TRIF TFA
<p>Pepinh-TRIF TFA is a 30 aa peptide associated with the immune system that blocks TRIF signaling by interfering with TLR-TRIF interaction (TLR-TRIF interaction</p>Formule :C180H279F3N58O40S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4014.09741ERK5-IN-6
CAS :<p>ERK5-IN-6 is an ERK5 kinase inhibitor with antiproliferative, anticonvulsant, and antitumor activity for the study of central nervous system related diseases.</p>Formule :C23H21N3Degré de pureté :98.59%Couleur et forme :SoildMasse moléculaire :339.43CC-90003
CAS :<p>CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.</p>Formule :C22H21F3N6O2Degré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :458.44ETC-206
CAS :<p>ETC-206 is a selective inhibitor of MNK1 and MNK2 (IC50s: 64 nM and 86 nM).</p>Formule :C25H20N4O2Degré de pureté :99.72% - 99.79%Couleur et forme :SolidMasse moléculaire :408.45KRAS G12C inhibitor 19
CAS :<p>KRAS G12C inhibitor 19 is a potent KRAS G12C inhibitor that shows anti-tumor activity in cellular assays, and the family inhibits tumor growth.</p>Formule :C25H19ClF2N4O3SDegré de pureté :97.46%Couleur et forme :SolidMasse moléculaire :528.96MAP4K4-IN-3
CAS :<p>MAP4K4-IN-3 (Compound 17) may be a viable target for antidiabetic agents, a serine/threonine protein kinase.</p>Formule :C15H12ClN5Degré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :297.74MRTX0902
CAS :<p>MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM.</p>Formule :C22H24N6ODegré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :388.47LUT014
CAS :<p>LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.</p>Formule :C27H19F3N8ODegré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :528.49GW806742X
CAS :<p>GW806742X inhibits MLKL with Kd 9.3 μM, preventing necroptosis; also targets VEGFR2.</p>Formule :C25H22F3N7O4SDegré de pureté :98.3%Couleur et forme :SolidMasse moléculaire :573.55HSND80
<p>HSND80 (Compound 1) is an orally active MNK/p70S6K inhibitor, exhibiting a Kd value of 44 nM for MNK1 and 4 nM for MNK2. The residence time of HSND80 on MNK1 and MNK2 is 45 minutes and 58 minutes, respectively. HSND80 effectively inhibits non-small cell lung cancer (NSCLC) both in vitro and in vivo, and suppresses the growth of triple-negative breast cancer (TNBC) cells in vitro.</p>Couleur et forme :Odour SolidMitogen-activated protein kinase 1
CAS :<p>Mitogen-activated protein kinase 1 (MAPK1) activates the p38/NF-κB pathway and regulates cellular processes in sepsis-associated diseases.</p>Degré de pureté :98%Couleur et forme :SolidADT-007
CAS :<p>ADT-007 is a pan-RAS inhibitor with potent anticancer activity.</p>Formule :C26H24FNO5Degré de pureté :97.75%Couleur et forme :SoildMasse moléculaire :449.47RTIL 13
CAS :<p>RTIL 13 inhibits dynamin GTPase (IC50: 2.3 μM), targets its lipid binding domain, and suppresses endocytosis (IC50: 9.3 & 7.1 μM).</p>Formule :C30H55BrN2O3Couleur et forme :SolidMasse moléculaire :571.685KRAS G12C inhibitor 69
<p>KRAS G12C inhibitor 69 (Compound K09) is an inhibitor of the mutant RAS protein KRAS G12C with an IC50 of 4.36 nM. In the cell lines NCI-H358 and MIA-PACA-2, it suppresses ERK phosphorylation with IC50 values of 12 nM and 7 nM, respectively. Additionally, KRAS G12C inhibitor 69 hinders the proliferation of NCI-H358 and MIA-PACA-2 cancer cells, with IC50 values of 3.15 nM and 2.33 nM, respectively.</p>Formule :C29H29ClF3N5O3Couleur et forme :SolidMasse moléculaire :588.02PROTAC MEK1 Degrader-1
CAS :<p>PROTAC MEK1 Degrader-1, a targeted protein degradation agent, combines a MEK1 inhibitor with a von Hippel-Lindau ligand to effectively inhibit ERK1/2</p>Formule :C53H66FIN8O11S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1201.17R18
CAS :<p>14.3.3 protein antagonist, blocks binding to Raf-1/Bad/ASK1/exoenzyme S, competitive, no phosphorylation needed, KD ~80 nM.</p>Formule :C101H157N27O29S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2309.69
