MAPK
Les MAPK sont une famille de kinases protéiques impliquées dans une variété de processus cellulaires, y compris la croissance, la prolifération, la différenciation et les réponses au stress. La voie de signalisation MAPK comprend plusieurs niveaux, y compris ERK, JNK et p38 MAPK, chacun jouant des rôles distincts dans la fonction cellulaire. La dérégulation de la signalisation MAPK est liée au cancer, aux maladies inflammatoires et aux troubles métaboliques. Chez CymitQuimica, nous offrons un large éventail d'inhibiteurs et d'activateurs de MAPK pour soutenir vos recherches en biologie cellulaire, transduction de signaux et mécanismes des maladies.
886 produits trouvés pour "MAPK"
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KRASG12C IN-13
CAS :KRASG12C IN-13 (LY3499446), a potent inhibitor of KRAS G12C, shows potential in the study of advanced solid tumors, specifically non-small cell lung cancer and colorectal cancer.Formule :C22H17ClF2N6OSCouleur et forme :SolidMasse moléculaire :486.93Refametinib R enantiomer
CAS :<p>Refametinib R enantiomer (RDEA119 R enantiomer) is an MEK inhibitor with an EC50 of 2.0-15 nM.Refametinib (R enantiomer) has anticancer activity and can be used</p>Formule :C19H20F3IN2O5SDegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :572.34KRAS G12C inhibitor 37
CAS :<p>KRAS G12C inhibitor 37 targets a key signaling protein, showing promise for cancer research involving KRAS G12C.</p>Formule :C35H39F3N8O2Couleur et forme :SolidMasse moléculaire :660.73(rel)-AR234960
CAS :(rel)-AR234960 is an active relative configuration of AR234960. AR234960 is a non-peptide agonist of MAS.Formule :C27H30FN5O5SCouleur et forme :SolidMasse moléculaire :555.63p38 MAPK-IN-6
CAS :<p>p38 MAPK-IN-6 (compound c47) is an inhibitor of p38 MAPK, exhibiting a 14% inhibition rate at a concentration of 10 μM.</p>Formule :C16H14BrN3OS2Couleur et forme :SolidMasse moléculaire :408.336Everafenib
<p>Everafenib: potent BRAF inhibitor, crosses blood-brain barrier, hinders MAPK, effective on V600EBRAF cells, outperforms other drugs in trials.</p>Formule :C20H23ClFN5O2S2Couleur et forme :SolidMasse moléculaire :484.01Famlasertib
CAS :<p>Famlasertib is a potent inhibitor of the mitogen-activated protein kinase kinase kinase kinase (MAP4K) family, capable of penetrating the brain. It exhibits an IC50 value of 0.3 nM for HGK (MAP4K4) and 23.7 nM for MLK3.</p>Formule :C26H27ClN4OCouleur et forme :SolidMasse moléculaire :446.97210-Methoxy-canthin-6-one
CAS :<p>10-Methoxy-canthin-6-one (Mtx-C) acts as a DNA damage inducer that embeds into DNA, promoting cell cycle arrest at the G2/M phase. This process triggers myeloid differentiation in acute myeloid leukemia cells (AML) and leukemia stem cells (LSC). Differentiation in AML and LSC cells is characterized by increased expression of myeloperoxidase, CD15, CD11b, and CD14, along with the activation of p38 MAPK. 10-Methoxy-canthin-6-one is utilized in the study of leukemia.</p>Formule :C15H10N2O2Couleur et forme :SolidMasse moléculaire :250.25TH-Z816
CAS :<p>TH-Z816 acts as a reversible inhibitor targeting the KRAS(G12D) mutation, exhibiting an IC50 of 14 µM. This compound is utilized in cancer research [1].</p>Formule :C29H38N6OCouleur et forme :SolidMasse moléculaire :486.65Calderasib
CAS :<p>Calderasib (MK-1084) is a selective KRAS G12C inhibitor (IC50 1.2 nM) with anticancer activity, usable as monotherapy or combined with PD-1 inhibitors</p>Formule :C32H31ClF2N6O4Degré de pureté :98.69%Couleur et forme :SolidMasse moléculaire :637.08G12Si-1
<p>G12Si-1 selectively binds and inhibits K-Ras(G12S) to block oncogenic signaling and nucleotide exchange.</p>Formule :C29H32ClN5O3Couleur et forme :SolidMasse moléculaire :534.05HPK1-IN-41
CAS :<p>HPK1-IN-41 (compound Z389) functions as an HPK1 inhibitor, exhibiting an IC50 value of 0.21 nM [1].</p>Formule :C28H33N5O2Couleur et forme :SolidMasse moléculaire :471.59(+)-Perillyl alcohol
CAS :<p>(+)-Perillyl alcohol (0.25-1 mM) inhibits cell growth in SW480 cells. At a concentration of 1 mM and a duration of 24 hours, (+)-Perillyl alcohol increases the number of cells in the G0/G1 phase and reduces the number in the S phase in SW480 cells.</p>Formule :C10H16OCouleur et forme :SolidMasse moléculaire :152.23MAP855
CAS :<p>MAP855: potent, selective, oral MEK1/2 inhibitor; IC50=3 nM, pERKEC50=5 nM; effective on wild-type/mutant MEK1/2.</p>Formule :C28H23ClF2N6O3Couleur et forme :SolidMasse moléculaire :564.97SOS1-IN-10
<p>SOS1-IN-10 is a potent inhibitor of SOS1 that acts on KRAS G12C-SOS1 (IC50: 13 nM).</p>Formule :C22H19F5N4OCouleur et forme :SolidMasse moléculaire :450.4KRAS G12D inhibitor 1
CAS :<p>KRAS G12D inhibitor 1 (example 243) is an inhibitor of KRAS G12D with an IC 50 of 0.8 nM for KRAS G12D-mediated ERK phosphorylation [1].</p>Formule :C33H32F2N6O2Couleur et forme :SolidMasse moléculaire :582.64p38-α MAPK-IN-5
CAS :<p>p38-α MAPK-IN-5: potent p38α inhibitor, IC50s: 0.1 nM (α), 0.2 nM (β), 944 nM (γ), 4100 nM (δ); anti-inflammatory, promising for asthma/COPD research.</p>Formule :C37H49N11O2Couleur et forme :SolidMasse moléculaire :679.86KRAS ligand 3
CAS :<p>KRAS ligand 3 (compound 1), a BTX-6654 target-binding ligand, exhibits synergistic tumor growth inhibition through its capacity to bind a KRAS inhibitor [1].</p>Formule :C24H28F3N5Couleur et forme :SolidMasse moléculaire :443.51pan-KRAS-IN-17
CAS :<p>pan-KRAS-IN-17 (Example 34) is an inhibitor that targets multiple forms of the KRAS protein.</p>Formule :C34H33F3N5O8PCouleur et forme :SolidMasse moléculaire :727.623COTI-219
CAS :<p>COTI-219 is an oral inhibitor of KRAS with antitumor properties [1].</p>Formule :C17H18N6SCouleur et forme :SolidMasse moléculaire :338.43
