MAPK
Les MAPK sont une famille de kinases protéiques impliquées dans une variété de processus cellulaires, y compris la croissance, la prolifération, la différenciation et les réponses au stress. La voie de signalisation MAPK comprend plusieurs niveaux, y compris ERK, JNK et p38 MAPK, chacun jouant des rôles distincts dans la fonction cellulaire. La dérégulation de la signalisation MAPK est liée au cancer, aux maladies inflammatoires et aux troubles métaboliques. Chez CymitQuimica, nous offrons un large éventail d'inhibiteurs et d'activateurs de MAPK pour soutenir vos recherches en biologie cellulaire, transduction de signaux et mécanismes des maladies.
886 produits trouvés pour "MAPK"
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HPK1-IN-16
CAS :<p>HPK1-IN-16, a potent HPK1 inhibitor, useful for cancer research and treatment.</p>Formule :C28H27FN4OCouleur et forme :SolidMasse moléculaire :454.54HPK1-IN-31
<p>HPK1-IN-31 inhibitor with an IC 50 value of 0.8 nM. HPK1-IN-31 has anti-tumour activity and has great potential for immunotherapy .</p>Formule :C30H33N7O3Couleur et forme :SolidMasse moléculaire :539.63AMG-548 dihydrochloride
<p>AMG-548 dihydrochloride, an oral p38α inhibitor (Ki: 0.5 nM), selectively targets p38β, γ, δ, inhibits TNFα (IC50: 3 nM), and suppresses Wnt signaling.</p>Formule :C29H29Cl2N5OCouleur et forme :SolidMasse moléculaire :534.48K-Ras-IN-4
CAS :<p>K-Ras-IN-4 (compound CP163) is an inhibitor of K-Ras.</p>Formule :C31H28F4N6O3SCouleur et forme :SolidMasse moléculaire :640.65ERK2 IN-1
CAS :<p>ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM.</p>Formule :C36H34FN7O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :647.76HPK1-IN-30
CAS :<p>HPK1-IN-30 is a potent inhibitor of HPK1. HPK1-IN-30 has potential for cancer disease research.</p>Formule :C25H23FN6Couleur et forme :SolidMasse moléculaire :426.49ATX inhibitor 26
CAS :<p>ATX inhibitor 26 is an Autotaxin (ATX) inhibitor with an IC50 of 57 nM in human plasma. It effectively inhibits cell migration and collagen gel contraction. Additionally, ATX inhibitor 26 demonstrates significant antifibrotic activity, reducing collagen deposition in a Bleomycin (BLM)-induced pulmonary fibrosis model.</p>Formule :C18H19Cl2N7O3Couleur et forme :SolidMasse moléculaire :452.30VVD-699
CAS :<p>VVD-699 is a covalent inhibitor of RAS-PI3K. It forms a covalent bond with cysteine at position 242 within the RAS-binding domain of PI3Kp110α, thereby obstructing the ability of RAS to activate PI3K. VVD-699 is capable of inhibiting the growth of tumors with RAS mutations and HER2 overexpression. It is applicable in research related to RAS mutation-associated cancers, such as those involving H358 lung cancer cells, A549 cells, and FaDu cells.</p>Formule :C25H30ClFN2O6S2Couleur et forme :SolidMasse moléculaire :573.097MCB-22-174
CAS :MCB-22-174 is a potent agonist of Piezo1 with an EC50 value of 6.28 µM. It activates Ca2+-related extracellular signal-regulated kinase and calcium-calmodulin (CaM)-dependent protein kinase II (CaMKII) pathways, and it promotes mesenchymal stem cell osteogenic differentiation, indicating its potential application in the study of disuse osteoporosis (OP).Formule :C16H14DCl2N5OS2Masse moléculaire :429.37SHR2415
<p>SHR2415: Potent, selective ERK1/2 inhibitor, oral; ERK1 IC50: 2.8 nM, ERK2 IC50: 5.9 nM; effective in Colo205 (IC50: 44.6 nM), for cancer research.</p>Formule :C23H22ClN7O2Couleur et forme :SolidMasse moléculaire :463.92HPK1-IN-55
CAS :<p>HPK1-IN-55 (compound 19) is a selective and orally active inhibitor of hematopoietic progenitor kinase 1 (HPK1) with an IC50 of less than 0.51 nM. It exhibits exceptional kinase selectivity, being over 637 times more selective for HPK1 compared to GCK kinase and over 1022 times compared to LCK. HPK1-IN-55 possesses anti-cancer properties.</p>Formule :C30H34N8O3Couleur et forme :SolidMasse moléculaire :554.643KRAS G12C inhibitor 50
CAS :<p>KRAS G12C inhibitor 50 is a KRAS G12C inhibitor (IC50: 46.7 nM).</p>Formule :C31H34N8O2Couleur et forme :SolidMasse moléculaire :550.65KRAS G12D inhibitor 3
CAS :<p>KRAS G12D Inhibitor 3, a compound targeting the KRAS G12D mutation, demonstrates potent antitumor efficacy with an inhibitory concentration (IC50) of less than</p>Formule :C34H31ClF3N5O2Couleur et forme :SolidMasse moléculaire :634.09Sosimerasib
CAS :<p>Sosimerasib is an inhibitor of the kirsten rat sarcoma viral oncogene homolog (KRAS) and exhibits antitumor activity.</p>Formule :C36H39ClFN7O4Couleur et forme :SolidMasse moléculaire :688.191MRTX849 ethoxypropanoic acid
CAS :<p>MRTX849 is a KRAS G12C ligand and PROTAC linker for creating potent LC-2, degrading KRAS G12C with DC50 of 0.25-0.76 μM.</p>Formule :C37H43ClFN7O5Couleur et forme :SolidMasse moléculaire :720.24KRAS G12D inhibitor 12
<p>KRAS G12D inhibitor 12 targets Ras protein for cancer research. (Patent WO2021108683A1, Compound 134)</p>Formule :C23H21ClFN5O3Couleur et forme :SolidMasse moléculaire :469.9ERK-IN-2
CAS :<p>ERK-IN-2, an ERK2 inhibitor, exhibits an IC50 value of 1.8 nM. At doses greater than 10 μM, it may induce off-target toxicity and/or activity [1].</p>Formule :C16H18ClN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :347.80SML-10-70-1
CAS :<p>SML-10-70-1 is a Novel Active Site Inhibitor of Oncogenic K-Ras G12C.</p>Formule :C25H42ClN7O13P2Couleur et forme :SolidMasse moléculaire :746.04Dorrigocin A
CAS :<p>Dorrigocin A, an analog of Migrastatin, inhibits the carboxymethyltransferase involved in Ras processing, reversing the morphology of Ras-transformed NIH/3T3 cells. Dorrigocin A holds potential for research as an anticancer and anti-arthritis agent.</p>Formule :C27H41NO8Couleur et forme :SolidMasse moléculaire :507.616SOF-436
CAS :<p>SOF-436 is a KRAS inhibitor that can suppress SOS1-mediated KRAS nucleotide exchange (IC50 = 60 μM) and inhibit the interaction between KRAS and the effector protein RAF. SOF-436 is applicable to cancer research.</p>Formule :C15H13F2NO4S2Couleur et forme :SolidMasse moléculaire :373.395
