Ras
Les protéines Ras sont de petites GTPases qui agissent comme des commutateurs moléculaires dans la voie de signalisation MAPK, contrôlant la croissance, la différenciation et la survie cellulaires. Ras activé initie une cascade de signalisation qui inclut Raf, MEK et ERK, conduisant à diverses réponses cellulaires. Les mutations des gènes Ras sont courantes dans les cancers, faisant de Ras un point focal important de la recherche sur le cancer. Chez CymitQuimica, nous offrons une gamme de modulateurs de Ras pour soutenir vos recherches en biologie du cancer, transduction de signaux et développement thérapeutique.
173 produits trouvés pour "Ras".
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Palmostatin M
CAS :Palmostatin M is a Ras signaling modulator that targets acyl-protein thioesterase 1 (APT1) and 2 (APT2) within cells, with an IC50 of 2.5 nM for APT1. It disrupts the depalmitoylation cycle of Ras, thus downregulating the overall Ras signaling pathway. Palmostatin M is applicable in cancer research.Formule :C22H43NO4SMasse moléculaire :417.65RGT-018
CAS :RGT-018 is a potent oral SOS1 inhibitor with antitumor properties. It exerts its anticancer activity by inhibiting KRAS activation, thereby hindering cancer cell proliferation.Formule :C27H24F3N7O2Couleur et forme :SolidMasse moléculaire :535.52KRAS-IN-5
CAS :KRAS-IN-5 (Compound Ex 6) is an orally active, selective inhibitor that targets KRAS mutants, including KRASG12D, KRASG12V, and KRASWT, with an impressive GNE IC50 value of 1.3 nM for KRASG12D. By inhibiting KRAS-mediated signaling pathways, such as reducing ERK phosphorylation, KRAS-IN-5 effectively prevents tumor cell proliferation. This compound holds potential for research into cancers associated with KRAS mutations, such as pancreatic cancer, colorectal cancer, and lung cancer.Formule :C35H36F3N7O3Couleur et forme :SolidMasse moléculaire :659.70KRASG12D-IN-5
CAS :KRASG12D-IN-5 (Compound 241) is an orally active KRAS(G12D) inhibitor with an IC50 of 11 nM. It demonstrates potent anticancer activity without significant cytotoxicity to BxPC-3 cells (wild-type), KRAS-mutant AsPC-1 cells (G12D), and MIAPaCa-2 cells (G12C), with CC50 values of 10.37, 0.76, and 0.3 μM, respectively. KRASG12D-IN-5 is applicable in cancer studies, including lung, pancreatic, and colorectal cancers.Formule :C34H31F5N6O2Couleur et forme :SolidMasse moléculaire :650.64KRAS inhibitor-31
CAS :KRAS inhibitor-31 (compound 33), a potent agent targeting KRAS, exhibits K D (SPR) values of 0.019 nM for KRas G12D, 0.019 nM for KRas G12C, and 0.096 nM for KRas G12V, illustrating its efficacy across these variants.Formule :C33H30F3N5O4Couleur et forme :SolidMasse moléculaire :617.62KRAS inhibitor-32
CAS :KRAS inhibitor-32 (compound 139A) is a KRAS inhibitor utilized in cancer research.Formule :C29H35FN10OS2Couleur et forme :SolidMasse moléculaire :622.78BSF-466895
CAS :BSF-466895 (A-422885.66) is a Tie2 inhibitor with an IC50 of 5 nM, also capable of inhibiting Tie1.Formule :C29H32Cl2FN7O2SMasse moléculaire :632.58AH001
CAS :AH001 is an orally active compound that binds to a concealed pocket near GDP within RhoA, exhibiting a binding affinity of 73.16 nM. By interacting with GDP, AH001 stabilizes the interaction between RhoA and its endogenous inhibitor, RhoGDIα. This compound reduces nuclear translocation of downstream MRTFA and downregulates fibrosis/hypertrophy-related proteins. AH001 alleviates myocardial remodeling in various heart failure animal models and 3D cardiac tissue models. Its cardioprotective effects are mediated through the RhoA-RhoGDIα axis, effectively inhibiting downstream RhoA activation signals.Formule :C10H14O2Masse moléculaire :166.22pan-KRAS-IN-17
CAS :pan-KRAS-IN-17 (Example 34) is an inhibitor that targets multiple forms of the KRAS protein.Formule :C34H33F3N5O8PCouleur et forme :SolidMasse moléculaire :727.623ADT-1004
CAS :ADT-1004 is a small-molecule RAS inhibitor that suppresses the growth of mutant RAS tumor cells by blocking RAS-mediated signaling pathways.Formule :C33H36FN3O6Degré de pureté :99.04%Couleur et forme :Yellow SolidMasse moléculaire :589.65Pan-RAS-IN-7
CAS :Pan-RAS-IN-7 (Compound D101) is a broad-spectrum RAS inhibitor used in the synthesis of antibody-drug conjugates (ADCs). It is also applicable in cancer research.Formule :C59H76N8O8Couleur et forme :SolidMasse moléculaire :1025.28pan-KRAS-IN-4
CAS :Pan-KRAS-IN-4 (compound 5) is a potent KRAS inhibitor, demonstrating IC50 values of 0.37 nM for Kras G12C and 0.19 nM for Kras G12V [1].Formule :C36H34F2N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :636.69J-104871
CAS :J-104871 (UNII-6137X5QNJF) is an FTase inhibitor that inhibits tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells.Formule :C38H32N2O12Degré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :708.67
