Ras
Les protéines Ras sont de petites GTPases qui agissent comme des commutateurs moléculaires dans la voie de signalisation MAPK, contrôlant la croissance, la différenciation et la survie cellulaires. Ras activé initie une cascade de signalisation qui inclut Raf, MEK et ERK, conduisant à diverses réponses cellulaires. Les mutations des gènes Ras sont courantes dans les cancers, faisant de Ras un point focal important de la recherche sur le cancer. Chez CymitQuimica, nous offrons une gamme de modulateurs de Ras pour soutenir vos recherches en biologie du cancer, transduction de signaux et développement thérapeutique.
167 produits trouvés pour "Ras".
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INCB159020
CAS :INCB159020 is an orally active inhibitor of KRAS G12D, exhibiting a KRAS G12D SPR value of 2.2 nM. It demonstrates anti-tumor activity.Formule :C37H35ClFN7O2Couleur et forme :SolidMasse moléculaire :664.171XMU-MP-9
CAS :XMU-MP-9, a bifunctional compound, targets the C2 domain of Nedd4-1 and the allosteric site of K-Ras. It enhances the interaction and induces conformational changes within the Nedd4-1/K-Ras complex. Furthermore, XMU-MP-9 facilitates the ubiquitination and degradation of various K-Ras mutants and inhibits the proliferation of cells with these mutants. This compound is useful in cancer research.Formule :C19H13ClFN3OSCouleur et forme :SolidMasse moléculaire :385.84AH001
CAS :AH001 is an orally active compound that binds to a concealed pocket near GDP within RhoA, exhibiting a binding affinity of 73.16 nM. By interacting with GDP, AH001 stabilizes the interaction between RhoA and its endogenous inhibitor, RhoGDIα. This compound reduces nuclear translocation of downstream MRTFA and downregulates fibrosis/hypertrophy-related proteins. AH001 alleviates myocardial remodeling in various heart failure animal models and 3D cardiac tissue models. Its cardioprotective effects are mediated through the RhoA-RhoGDIα axis, effectively inhibiting downstream RhoA activation signals.Formule :C10H14O2Masse moléculaire :166.22SOS2 ligand 1
CAS :SOS2 ligand 1 (compound 2) is a selective ligand for son of sevenless 2 (SOS2), exhibiting a KD value of 4.6 µM.Formule :C19H21N5OCouleur et forme :SolidMasse moléculaire :335.403pan-KRAS-IN-17
CAS :pan-KRAS-IN-17 (Example 34) is an inhibitor that targets multiple forms of the KRAS protein.Formule :C34H33F3N5O8PCouleur et forme :SolidMasse moléculaire :727.623BMS-214662
CAS :BMS-214662 is a selective farnesyl transferase inhibitor with anti-tumor activity, used in research on pancreatic cancer, head and neck cancer, and lung cancer.Formule :C25H23N5O2S2Degré de pureté :99.58% - 99.58%Couleur et forme :Yellow ViscousMasse moléculaire :489.61KRas G12C inhibitor 2
CAS :KRas G12C inhibitor 2 is a compound that inhibits KRas G12C.Formule :C32H37N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :567.68
