ERK
ERK est une protéine clé de la voie de signalisation MAPK (Mitogen-Activated Protein Kinase), qui est impliquée dans la transmission des signaux des récepteurs de surface cellulaire à l'ADN dans le noyau de la cellule. ERK joue un rôle crucial dans la régulation de divers processus cellulaires, y compris la prolifération, la différenciation et la survie. La dérégulation de la signalisation ERK est associée au développement du cancer et d'autres maladies, ce qui en fait une cible importante pour les interventions thérapeutiques. Chez CymitQuimica, nous offrons une sélection d'inhibiteurs et de modulateurs d'ERK de haute qualité pour soutenir vos recherches en signalisation cellulaire, oncologie et développement thérapeutique.
194 produits trouvés pour "ERK"
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ERK5-IN-1
CAS :<p>ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM).</p>Formule :C25H29N7O2Degré de pureté :97.70%Couleur et forme :SolidMasse moléculaire :459.54Tauroursodeoxycholate
CAS :<p>Tauroursodeoxycholate (UR 906), a hydrophilic bile acid, low in humans, may treat PBC, insulin resistance, and ALS.</p>Formule :C26H45NO6SDegré de pureté :98.77% - 99.93%Couleur et forme :White SolidMasse moléculaire :499.7Loureirin B
CAS :<p>Loureirin B suppresses fibrosis by modulating MMPs/TIMPs, hindering fibroblast growth, and targeting TGF-β1/Smad2/3 pathway.</p>Formule :C18H20O5Degré de pureté :99.33% - 99.86%Couleur et forme :SolidMasse moléculaire :316.35UNC569
CAS :<p>UNC569 selectively inhibits kidney URAT1, regulating uric acid excretion and aiding gout patient's uric balance.</p>Formule :C22H29FN6Degré de pureté :98.91% - 99.67%Couleur et forme :SolidMasse moléculaire :396.5DEL-22379
CAS :<p>DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ～0.5 μM.</p>Formule :C26H28N4O3Degré de pureté :99.3% - 99.53%Couleur et forme :SolidMasse moléculaire :444.532,5-Dihydroxyacetophenone
CAS :<p>2,5-Dihydroxyacetophenone has anti-anxiety, neuroprotective, anti-inflammatory properties, and modulates cell signaling and melanogenesis.</p>Formule :C8H8O3Degré de pureté :99.75%Couleur et forme :Yellow PowderMasse moléculaire :152.15Butein
CAS :<p>Butein is a cAMP-specific PDE inhibitor, protein tyrosine kinase inhibitor, and SIRT1 activator.Cost-effective and quality-assured.</p>Formule :C15H12O5Degré de pureté :98.76% - >99.99%Couleur et forme :SolidMasse moléculaire :272.25Pachymic acid
CAS :<p>Pachymic acid (3-O-Acetyltumulosic acid) is a natural product, and inhibits Akt and ERK signaling pathways.</p>Formule :C33H52O5Degré de pureté :99.43% - >99.99%Couleur et forme :White PowderMasse moléculaire :528.76β-Neoendorphin acetate(77739-21-0 free base)
CAS :<p>beta-Neoendorphin acetate is an agonist of κ-opioid receptor</p>Formule :C56H81N13O14Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :1160.34GRK5-IN-2
CAS :<p>GRK5-IN-2, a pyridine-based bicyclic compound, is a potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor.</p>Formule :C20H20N4O4Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :380.46-OAU
CAS :<p>6-OAU is a GPR84 agonist, activates it in HEK293 cells with a 105 nM EC50.</p>Formule :C12H21N3O2Degré de pureté :98.14% - 99.01%Couleur et forme :SolidMasse moléculaire :239.31Nitidine chloride
CAS :<p>1.</p>Formule :C21H18ClNO4Degré de pureté :96.59% - 98.91%Couleur et forme :SolidMasse moléculaire :383.82XMD17-109
CAS :<p>XMD17-109 (ERK5-IN-1) is a new selective ERK-5 inhibitor (EC50: 4.2 uM, HEK293 cells).</p>Formule :C36H46N8O3Degré de pureté :98.75% - 99.7%Couleur et forme :SolidMasse moléculaire :638.8A-674563 2HCl(552325-73-2(fb-2hcl))
<p>A-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.</p>Formule :C22H24Cl2N4ODegré de pureté :94.66%Couleur et forme :SolidMasse moléculaire :431.36DCLK1-IN-1
CAS :<p>DCLK1-IN-1 is a selective, in vivo compatible chemical probe of the kinase domain of doublecortin-like kinase 1 (DCLK1).Cost-effective and quality-assured.</p>Formule :C26H28F3N7O2Degré de pureté :98.55% - 99.28%Couleur et forme :SolidMasse moléculaire :527.54AG126
CAS :<p>AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42). AG-126 weakly inhibits epidermal GFRK and platelet-derived GFRK.</p>Formule :C10H5N3O3Degré de pureté :97.35%Couleur et forme :SolidMasse moléculaire :215.16Epieriocalyxin A
CAS :<p>Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.</p>Formule :C20H24O5Degré de pureté :97.00%Couleur et forme :SolidMasse moléculaire :344.4DMU-212
CAS :<p>DMU-212, a Resveratrol derivative, has antimitotic, antiproliferative, antioxidant properties; induces apoptosis via ERK1/2.</p>Formule :C18H20O4Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :300.35SUN11602
CAS :<p>SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor.</p>Formule :C26H37N5O2Degré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :451.6RU-301
CAS :<p>RU-301 is a novel pan-tam inhibitor</p>Formule :C21H19F3N4O4SDegré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :480.46ERK-IN-3
CAS :<p>ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK.</p>Formule :C22H25ClFN7O2Degré de pureté :99.55% - 99.76%Couleur et forme :SolidMasse moléculaire :473.93Methylnissolin
CAS :<p>Methylnissolin (3-Hydroxy-9,10-dimethoxyptercarpan) is derived from Astragalus and has antibacterial and anti-cancer effects.</p>Formule :C17H16O5Degré de pureté :99.68% - 99.98%Couleur et forme :SolidMasse moléculaire :300.31EF24
CAS :<p>EF24 treatment boosts caspase 3/9 activity, hinders MEK1/ERK phosphorylation, and exhibits strong anti-tumor effects in OSCC by deactivating MAPK/ERK.</p>Formule :C19H15F2NODegré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :311.33Deltonin
CAS :<p>Deltonin inhibits ERK1/2 & AKT; toxic to HepG2 (IC50: 7.66μM), C26 (IC50: 1.22μM), MDA-MB-231 cells (IC50: 1.58μM).</p>Formule :C45H72O17Degré de pureté :98.77% - 99.79%Couleur et forme :SolidMasse moléculaire :885.04trans-Zeatin
CAS :<p>trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient</p>Formule :C10H13N5ODegré de pureté :97.13% - 98.96%Couleur et forme :White To Light Yellow Crystal PowderMasse moléculaire :219.24Ravoxertinib
CAS :<p>Ravoxertinib (GDC-0994) is an effective and orally available ERK1/2 inhibitor (IC50: 1.1/0.3 nM).</p>Formule :C21H18ClFN6O2Degré de pureté :98% - 99.87%Couleur et forme :SolidMasse moléculaire :440.86Bohemine
CAS :<p>Bohemine is a cyclin-dependent kinase inhibitor.</p>Formule :C18H24N6ODegré de pureté :99.09% - 99.53%Couleur et forme :SolidMasse moléculaire :340.42Prosaptide TX14(A) acetate
<p>Prosaptide TX14(A) acetate is a potent GPR37L1 and GPR37 agonist. Prosaptide Tx14(A) TFA increases both ERK1 and ERK2 phosphorylation in Schwann cells.</p>Formule :C71H114N16O28Degré de pureté :95.29%Couleur et forme :SolidMasse moléculaire :1639.76Tauroursodeoxycholate sodium
CAS :<p>Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.</p>Formule :C26H44NNaO6SDegré de pureté :97.90%Couleur et forme :SolidMasse moléculaire :521.69FR 180204
CAS :<p>FR 180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2.</p>Formule :C18H13N7Degré de pureté :98% - 99.74%Couleur et forme :SolidMasse moléculaire :327.34MRTX1133
CAS :<p>View and buy MRTX1133 from TargetMol.MRTX1133 is a potent, selective, and noncovalent inhibitor of KRAS G12D.</p>Formule :C33H31F3N6O2Degré de pureté :97.39% - 99.6%Couleur et forme :SolidMasse moléculaire :600.63KO-947
CAS :<p>KO-947 is a potent and specific inhibitor of ERK1/2 kinases.</p>Formule :C21H17N5ODegré de pureté :97.84%Couleur et forme :SolidMasse moléculaire :355.39LM22B-10
CAS :<p>LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.</p>Formule :C27H33ClN2O4Degré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :485.01AZD8330
CAS :<p>AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.</p>Formule :C16H17FIN3O4Degré de pureté :98.72%Couleur et forme :SolidMasse moléculaire :461.23Tizaterkib
CAS :<p>Tizaterkib (AZD-0364) is a potent and selective ERK2 inhibitor.</p>Formule :C24H24F2N8O2Degré de pureté :99.6% - 99.63%Couleur et forme :SolidMasse moléculaire :494.5ERK-IN-4
CAS :<p>ERK-IN-4 is a cell-permeable ERK inhibitor with potential antiproliferative effects for the study of diseases caused by immune dysfunction.</p>Formule :C14H17ClN2O3SDegré de pureté :98.92% - 99.84%Couleur et forme :SolidMasse moléculaire :328.814Ulixertinib hydrochloride
CAS :<p>Ulixertinib hydrochloride (Ulixertinib HCl) is an ERK1/2 inhibitor with anticancer and antitumor activity that inhibits the NB cell cycle and promotes apoptosis</p>Formule :C21H23Cl3N4O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :469.79CAY10561
CAS :<p>CAY10561: potent, selective ERK2 inhibitor (Ki=2nM); blocks cell proliferation; IC50 in COLO 205 cells: 0.54μM.</p>Formule :C22H17Cl2FN4O2Couleur et forme :SolidMasse moléculaire :459.3GP17
CAS :<p>GP17 is a type II kinase inhibitor of the IRE1α endoribonuclease that acts by targeting the ATP-binding pocket of IRE1α.</p>Formule :C26H21F3N4OCouleur et forme :SolidMasse moléculaire :462.47UC-857993
CAS :<p>UC-857993 is a selective SOS1-Ras inhibitor with a Kd of 14.7 μM that inhibits ERK, Ras, and reduces MEF growth.</p>Formule :C25H22ClNO2Couleur et forme :SolidMasse moléculaire :403.9BNC-1
CAS :<p>BNC-1 reduces amyloid in mice, enhances synapses by activating Elk-1.</p>Formule :C16H14N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :282.29mSIRK
CAS :<p>mSIRK (G-Protein βγ Binding Peptide) is an ERK1 and ERK2 dual activator that promotes alpha-subunit dissociation.</p>Formule :C93H150N20O25Degré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :1948.31Dihydrolipoic acid
CAS :<p>Dihydrolipoic acid (USAF XR-12), a dithiol carboxylic acid, is a potent antioxidant active against various reactive oxygen species at 0.01-0.5 mM.</p>Formule :C8H16O2S2Degré de pureté :97.51%Couleur et forme :Yellow To Orange LiquidMasse moléculaire :208.34ERK5-IN-4
CAS :<p>ERK5-IN-4 (34b) is a potent, specific ERK5 inhibitor; IC50: 77 nM full-length, 300 nM ΔTAD in HEK293 cells.</p>Formule :C16H11Cl2FN4O2Couleur et forme :SolidMasse moléculaire :381.19PERK-IN-3
CAS :<p>PERK-IN-3 is a potent inhibitor of PERK(IC50 of 7.4 nM).</p>Formule :C22H16F2N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.38ADTL-EI1712
CAS :<p>ADTL-EI1712: ERK1/2/5 inhibitor (ERK1 IC50=40.43nM, ERK5=64.5nM), blocks HL-60/MKN74 cell growth, not HeLa; effective in MKN74 mouse model.</p>Formule :C22H18Cl2N4O2S2Couleur et forme :SolidMasse moléculaire :505.44ERK1/2 inhibitor 1
CAS :<p>ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.</p>Formule :C29H32ClN5O4Degré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :550.052,5-Dihydroxybiphenyl
CAS :<p>2,5-Dihydroxybiphenyl: a small molecule that induces trichothiodystrophy A protein dimerization, modulating TFIIH activity.</p>Formule :C12H10O2Degré de pureté :99.66%Couleur et forme :White To Grey-Brownish PowderMasse moléculaire :186.21ERK5-IN-3
CAS :<p>ERK5-IN-3 inhibits ERK5 strongly (IC50: 6 nM) and hampers Hela cell growth (IC50: 31 nM).</p>Formule :C24H23Cl2FN4O2Couleur et forme :SolidMasse moléculaire :489.37GABAB receptor antagonist 1
CAS :<p>(E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.GABAB receptor antagonist 1 is a selective</p>Formule :C18H24O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :304.38Migoprotafib
CAS :Migoprotafib (GDC-1971) is a potent and highly selective SHP2 (Src Homology-2 Domain-Containing Phosphatase 2) inhibitor for advanced solid tumours.Formule :C25H26N8OCouleur et forme :SolidMasse moléculaire :454.53NMDAR/TRPM4-IN-2
CAS :<p>Potent NMDAR/TRPM4-IN-2 blocks NMDAR/TRPM4, protects brain and retinal neurons, and prevents mitochondrial dysfunction with an IC50 of 2.1 μM.</p>Formule :C11H19BrCl2N2Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :330.092(E)-GABAB receptor antagonist 1
CAS :<p>(E)-GABAB antagonist 1 inhibits GABA IP3 production, with an IC50 of 37.9 μM and acts as a selective negative modulator.</p>Formule :C18H24O4Degré de pureté :98.09%Couleur et forme :SolidMasse moléculaire :304.38RLX-33
CAS :<p>RLX-33 blocks RXFP3 and relaxin 3 effects, controls food intake in rats, and may help study metabolic syndrome.</p>Formule :C24H19ClN4O4Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :462.89ZINC12409120
CAS :<p>ZINC12409120 (R-4584) is a selective ERK inhibitor.ZINC12409120 inhibits ERK with an IC50 of 5.0 μM.ZINC12409120 inhibits ERK activity by interfering with FGF23</p>Formule :C20H16N4O2Degré de pureté :99.71% - 99.95%Couleur et forme :SolidMasse moléculaire :344.37ERK1/2 inhibitor 8
CAS :<p>ERK1/2 inhibitor 8 is a potent inhibitor of ERK that acts on ERK2 (IC50: 0.48 nM).</p>Formule :C23H20ClN7O2SCouleur et forme :SolidMasse moléculaire :493.97ERK1/2 inhibitor 5
CAS :ERK1/2 inhibitor 5: potent against ERK1/2, may combat cancer and inflammation.Formule :C28H32ClFN6O5Couleur et forme :SolidMasse moléculaire :587.04ERK1/2 inhibitor 9
CAS :<p>ERK1/2 Inhibitor 9 (Probe 1), a covalent antagonist of ERK1/2, exhibits sub-micromolar efficacy in cellular assays (A375 GI50=0.47 μM) and facilitates the</p>Formule :C31H32ClN7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :586.08ERK Inhibitor II (Negative control)
CAS :<p>ERK Inhibitor II, a control, blocks ERK and insulin receptor activation, aiding diabetes research.</p>Formule :C18H12N6OCouleur et forme :SolidMasse moléculaire :328.33MRS2693 trisodium
CAS :<p>MRS2693 trisodium, a selective P2Y6 agonist with an EC50 of 0.015 μM, demonstrates cytoprotective effects in a mouse hindlimb skeletal muscle ischemia-reperfusion injury model by reducing NF-kappaB activation and stimulating the ERK1/2 pathway [1] [2].</p>Formule :C9H10IN2Na3O12P2Couleur et forme :SolidMasse moléculaire :596Laxiflorin B
CAS :<p>Laxiflorin B, a novel selective inhibitor of ERK 1/2 derived from herbal sources, exhibits antitumor activity [1].</p>Formule :C20H24O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :344.4MEK-IN-6
CAS :<p>MEK-IN-6 (Example 69), a potent MEK inhibitor, effectively inhibits ERK1/2 (Thr202/Tyr204) phosphorylation in A375 cells, with an IC50 of 2 nM, making it</p>Formule :C18H20FN3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :393.43KRAS G12C inhibitor 61
CAS :<p>KRAS G12C inhibitor 61 (Example 3) demonstrates potent activity by inhibiting phospho-ERK 1/2 in MIA PaCa-2 cells, reflected in an IC50 value of 9 nM.</p>Formule :C31H33ClFN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :590.09K145 hydrochloride
CAS :<p>K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM.</p>Formule :C18H25ClN2O3SDegré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :384.92(R)-VX-11e
CAS :<p>(R)-VX-11e is an isomer of VX-11e, a potent and selective ERK2 inhibitor with potential to inhibit tumor growth.</p>Formule :C24H20Cl2FN5O2Degré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :500.35DL-threo dihydrosphingosine
CAS :<p>DL-threo dihydrosphingosine blocks ERK, inhibits smooth muscle proliferation, and works against growth factor/G-protein ERK activation.</p>Formule :C18H39NO2Couleur et forme :SolidMasse moléculaire :301.51Inflachromene
CAS :<p>Inflachromene (ICM) is an inhibitor of HMGB1 and HMGB expression with anti-inflammatory activity.Inflachromene is used in the study of epilepsy.</p>Formule :C21H19N3O4Degré de pureté :97.36% - 99.88%Couleur et forme :SolidMasse moléculaire :377.39CXJ-2
CAS :<p>CXJ-2, a cyclic peptide, binds EDPs, inhibits PI3K/ERK, and reduces hepatic cell growth/migration, offering antifibrotic effects.</p>Formule :C55H87N15O22Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1310.37I-287
CAS :<p>I-287 is a selective, orally active PAR2 inhibitor that functions as a negative allosteric modulator of Gαq and Gα12/13 activity and their downstream effectors.</p>Formule :C30H30ClFN4O4Couleur et forme :SolidMasse moléculaire :565.04ERK1/2 inhibitor 7
CAS :<p>ERK1/2 inhibitor 7 is a potent inhibitor of ERK, acting on ERK2 (IC50: 0.94 nM).</p>Formule :C23H22FN7OSCouleur et forme :SolidMasse moléculaire :463.53EVT801
CAS :<p>EVT801 is a highly selective and low-toxic VEGFR-3 inhibitor that inhibits VEGF-C-induced tumor lymphoid and angiogenesis and reduces CCL4, CCL5 and MDSC.</p>Formule :C19H21N5O3Degré de pureté :97.4%Couleur et forme :SolidMasse moléculaire :367.4ERK-IN-2 free base
CAS :<p>ERK-IN-2 free base inhibits ERK2 (IC50: 1.8 nM); potential off-target effects at >10 μM.</p>Formule :C16H17N5O2Couleur et forme :SolidMasse moléculaire :311.34JWG-071
CAS :<p>JWG-071: First ERK5 kinase probe, BET inhibitor, 1 μM BRD4 IC, boosts ERK5 function and BRD4 selectivity.</p>Formule :C34H44N8O3Degré de pureté :98.33%Couleur et forme :SolidMasse moléculaire :612.77MK-8353
CAS :<p>MK-8353 (SCH900353) is a potent, selective and orally available inhibitor of ERK1/2 (IC50s of 23.0 nM and 8.8 nM, respectively)</p>Formule :C37H41N9O3SDegré de pureté :96.15% - 97.19%Couleur et forme :SolidMasse moléculaire :691.84ERK1/2 inhibitor 6
CAS :<p>ERK1/2 inhibitor 6 - potent cancer/inflammation treatment from WO2021063335A1.</p>Formule :C27H29ClFN7O5Couleur et forme :SolidMasse moléculaire :586.01Coelogin
CAS :<p>Coelogin is an orally effective bone-protective agent that activates ER-Erk and Akt-dependent signaling pathways, thereby stimulating osteoblast differentiation. It is utilized in osteoporosis research.</p>Formule :C17H16O5Couleur et forme :SolidMasse moléculaire :300.31ERK2 IN-1
CAS :<p>ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM.</p>Formule :C36H34FN7O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :647.76ATX inhibitor 26
CAS :<p>ATX inhibitor 26 is an Autotaxin (ATX) inhibitor with an IC50 of 57 nM in human plasma. It effectively inhibits cell migration and collagen gel contraction. Additionally, ATX inhibitor 26 demonstrates significant antifibrotic activity, reducing collagen deposition in a Bleomycin (BLM)-induced pulmonary fibrosis model.</p>Formule :C18H19Cl2N7O3Couleur et forme :SolidMasse moléculaire :452.30DOR agonist 2
CAS :<p>Compound 3 (DOR agonist 2) acts as a Delta Opioid Receptor agonist. It inhibits the expression of TNF-α, obstructs NF-κB transportation to the nucleus, and activates the G protein-mediated ERK1/2 pathway. This compound is useful for research into neurodegenerative diseases.</p>Formule :C29H26N2O3Couleur et forme :SolidMasse moléculaire :450.53AL 8810
CAS :<p>AL-8810 is an 11β-fluoro analog of PGF 2α with selective antagonist effects at the PGF 2α receptor (FP receptor) [1].</p>Formule :C24H31FO4Couleur et forme :SolidMasse moléculaire :402.5SOS1 activator 2
CAS :<p>SOS1 activator 2 (Compound 65) is a benzothiazole derivative and an activator of SOS1. It demonstrates a high binding affinity for SOS1, with a Kd of 9 nM. By modulating the Ras-ERK signaling pathway, SOS1 activator 2 is suitable for tumor research.</p>Formule :C26H28ClFN6Couleur et forme :SolidMasse moléculaire :478.992KRASG12C IN-15
CAS :<p>KRASG12C IN-15 (Compound 21) is an orally active KRASG12C inhibitor that effectively blocks SOS1-mediated GDP/GTP exchange with an IC50 of 19 nM. It inhibits ERK phosphorylation with an IC50 of 0.051 μM and reduces the viability of KRASG12C mutant MIA PaCa-2 cells with an IC50 of 0.023 μM. Additionally, KRASG12C IN-15 demonstrates antitumor activity in a MIA PaCa-2 xenograft mouse model.</p>Formule :C31H32FN3O2Couleur et forme :SolidMasse moléculaire :497.603(rel)-AR234960
CAS :(rel)-AR234960 is an active relative configuration of AR234960. AR234960 is a non-peptide agonist of MAS.Formule :C27H30FN5O5SCouleur et forme :SolidMasse moléculaire :555.63ERK-IN-2
CAS :<p>ERK-IN-2, an ERK2 inhibitor, exhibits an IC50 value of 1.8 nM. At doses greater than 10 μM, it may induce off-target toxicity and/or activity [1].</p>Formule :C16H18ClN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :347.80Hypothemycin
CAS :<p>Hypothemycin, a fungal polyketide, inhibits multiple kinases (VEGFR, MEK, FLT-3, PDGFR, ERK) with Kis ranging from 10 nM to 2.4 μM.</p>Formule :C19H22O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :378.37MAP855
CAS :<p>MAP855: potent, selective, oral MEK1/2 inhibitor; IC50=3 nM, pERKEC50=5 nM; effective on wild-type/mutant MEK1/2.</p>Formule :C28H23ClF2N6O3Couleur et forme :SolidMasse moléculaire :564.97SHR2415
<p>SHR2415: Potent, selective ERK1/2 inhibitor, oral; ERK1 IC50: 2.8 nM, ERK2 IC50: 5.9 nM; effective in Colo205 (IC50: 44.6 nM), for cancer research.</p>Formule :C23H22ClN7O2Couleur et forme :SolidMasse moléculaire :463.92KU004
CAS :<p>KU004, a potent dual EGFR/HER2 inhibitor, exhibits anticancer properties. It inhibits the proliferation of human breast cancer SKBR3 cells by inducing G1 phase arrest. KU004 blocks the activation of HER2, EGFR, and the downstream Akt and Erk pathways, primarily inducing apoptosis (Apoptosis) through the extrinsic pathway. Additionally, KU004 is a novel quinazoline derivative.</p>Formule :C29H27ClFN4O2PCouleur et forme :SolidMasse moléculaire :548.98KRAS inhibitor-27
CAS :<p>KRAS inhibitor-27 (Compound 15h) is a KRAS inhibitor that effectively targets KRAS G12D/G12V mutated cells (AsPC-1 and SW620) and wild-type KRAS cells (HT-29), with IC50 values of 378 nM, 0.6 nM, and 3230 nM, respectively. It reduces ERK phosphorylation, with IC50 values of 0.6 nM and 1 nM in AsPC-1 and SW620 cells, respectively, and decreases DUSP4 expression, thereby inhibiting the MAPK signaling pathway.</p>Formule :C31H28ClF3N6O3SCouleur et forme :SolidMasse moléculaire :657.106Rineterkib
CAS :<p>Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.</p>Formule :C26H27BrF3N5O2Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :578.42Omtriptolide
CAS :<p>Omtriptolide, triptolide purified from the Chinese herb, is a water-soluble derivative prodrug.</p>Formule :C24H28O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :460.479Ravoxertinib hydrochloride
CAS :<p>Ravoxertinib hydrochloride is an orally bioavailable and selective inhibitor for ERK kinase activity (IC50: 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively).</p>Formule :C21H19Cl2FN6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :477.32Pamoic acid
CAS :<p>Pamoic acid is the orphan G protein-coupled receptor GPR35 agonist. Pamoic acid activates ERK and beta-arrestin2 and causes antinociceptive activity.</p>Formule :C23H16O6Degré de pureté :99.99%Couleur et forme :Fine Yellow PowderMasse moléculaire :388.37WQ-C-401
CAS :<p>WQ-C-401 is an orally active inhibitor of the platelet-derived growth factor receptor (PDGFR). It inhibits cell proliferation by blocking PDGFR auto-phosphorylation in a concentration-dependent manner, with EC50 values of 3.5 nM for PDGFRαY849 and 5.8 nM for PDGFRβY1021. Additionally, WQ-C-401 suppresses the proliferation and migration of PASMCs by inhibiting PDGF-BB-induced phosphorylation of ERK1/2, reduces collagen I synthesis, and increases α-SMA expression, thereby preventing pulmonary vascular remodeling. This compound shows promise for research in the field of pulmonary arterial hypertension.</p>Formule :C24H26N4O3Couleur et forme :SolidMasse moléculaire :418.49
