ERK
ERK est une protéine clé de la voie de signalisation MAPK (Mitogen-Activated Protein Kinase), qui est impliquée dans la transmission des signaux des récepteurs de surface cellulaire à l'ADN dans le noyau de la cellule. ERK joue un rôle crucial dans la régulation de divers processus cellulaires, y compris la prolifération, la différenciation et la survie. La dérégulation de la signalisation ERK est associée au développement du cancer et d'autres maladies, ce qui en fait une cible importante pour les interventions thérapeutiques. Chez CymitQuimica, nous offrons une sélection d'inhibiteurs et de modulateurs d'ERK de haute qualité pour soutenir vos recherches en signalisation cellulaire, oncologie et développement thérapeutique.
194 produits trouvés pour "ERK"
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TAT-DEF-Elk-1
CAS :<p>TAT-DEF-Elk-1 is a cell-penetrating peptide Elk-1 inhibitor.</p>Formule :C155H259N57O40Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3561.1364-P-PDOT
CAS :<p>4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist.</p>Formule :C19H21NODegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :279.38ROCK-IN-5
CAS :<p>ROCK-IN-5 (I-B-37) inhibits kinases like ROCK/ERK/GSK; may aid in cardiac and neuro disease studies.</p>Formule :C16H11ClFN3OSDegré de pureté :99.72% - 99.83%Couleur et forme :SolidMasse moléculaire :347.79PROTAC MEK1 Degrader-1
CAS :<p>PROTAC MEK1 Degrader-1, a targeted protein degradation agent, combines a MEK1 inhibitor with a von Hippel-Lindau ligand to effectively inhibit ERK1/2</p>Formule :C53H66FIN8O11S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1201.17Emodic acid
CAS :<p>Emodic acid is a useful organic compound for research related to life sciences. The catalog number is T124807 and the CAS number is 478-45-5.</p>Formule :C15H8O7Couleur et forme :SolidMasse moléculaire :300.222ERK1/2 inhibitor 3
CAS :<p>ERK1/2 inhibitor 3, a strong ERK1/2 blocker, may aid in cancer and inflammation research.</p>Formule :C28H31ClFN5O6SCouleur et forme :SolidMasse moléculaire :620.09Anti-inflammatory agent 31
Andrographolide derivative 31 is an anti-inflammatory that blocks NF-κB, PI3K/Akt, and ERK1/2 MAPK, and restores GSH levels to protect the liver.Formule :C19H30O3Couleur et forme :SolidMasse moléculaire :306.44Olomoucine
CAS :<p>Olomoucine hinders Cdk2, Cdc2, CDK5, ERK1, regulates the cell cycle, and fights melanoma; IC50s: 3-25 µM.</p>Formule :C15H18N6ODegré de pureté :99.77%Couleur et forme :White Crystalline PowderMasse moléculaire :298.344′-Demethylnobiletin
CAS :<p>4′-Demethylnobiletin, a bioactive metabolite, activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, and</p>Formule :C20H20O8Couleur et forme :SolidMasse moléculaire :388.37Edaxeterkib
CAS :<p>Edaxeterkib is a potent extracellular signal- regulated kinase (ERK) inhibitor for the research of cancer.</p>Formule :C26H27N7O2Couleur et forme :SolidMasse moléculaire :469.549PD 198306
CAS :<p>PD 198306: a MEK inhibitor with antihyperalgesic properties, reduces Streptozocin-boosted active ERK1.</p>Formule :C18H16F3IN2O2Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :476.23Anti-inflammatory agent 35
CAS :<p>Anti-inflammatory agent 35 is a potent anti-inflammatory agent.</p>Formule :C27H29NO8Degré de pureté :99.98%Couleur et forme :SoildMasse moléculaire :495.52SOS1-IN-18
<p>SOS1-IN-18 (Compound 8) is an inhibitor of the Son of Sevenless 1 protein (SOS1) with a dissociation constant (KD) of 2.6 nM. It disrupts the SOS1-KRAS G12C interaction with an IC50 of 3.4 nM, inhibits ERK phosphorylation in H358 cells with an IC50 of 31 nM, and curtails the proliferation of H358 cells with an IC50 of 5 nM.</p>Formule :C26H29F3N4O2Couleur et forme :SolidMasse moléculaire :486.53MAPK Inhibitor Library
<p>A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;</p>Couleur et forme :Odour SolidRineterkib hydrochloride
CAS :<p>Rineterkib hydrochloride (B) is an oral RAF/ERK1/2 inhibitor for MAPK-driven cancers, including KRAS/BRAF-mutant NSCLC and CRC.</p>Formule :C26H28BrClF3N5O2Couleur et forme :SolidMasse moléculaire :614.89VSLRGDTRG
CAS :<p>VSLRGDTRG is a synthetic peptide derived from the RGD motif in cadherin17 (CDH17) that binds to the α2β1 integrin, activating its signaling pathways. By promoting high-affinity conformational changes in β1 integrins through the RGD motif, VSLRGDTRG enhances cell adhesion and the phosphorylation of FAK and ERK1/2, thereby driving tumor proliferation and metastasis. This peptide is useful for research on cancers expressing CDH17, such as colorectal and pancreatic cancer.</p>Formule :C38H69N15O14Couleur et forme :SolidMasse moléculaire :960.047LC-SF-14
<p>LC-SF-14 is a selective dual inhibitor of SHP2 and FGFR, with IC50 values of 71.6 nM and 8.9 nM, respectively. It blocks FGFR2-FRS2α-SHP2-MAPK signaling and ERK phosphorylation, and also inhibits the proliferation of KATOIII cancer cells (IC50: 9.2 nM). Furthermore, LC-SF-14 exhibits antitumor activity in SNU-16 xenograft mouse models, making it suitable for research on FGFR2-driven gastric cancer.</p>Formule :C44H50Cl3N13O5SCouleur et forme :SolidMasse moléculaire :977.28442GSK143
CAS :<p>GSK143: Oral SYK inhibitor, pIC50=7.5, curbs pErk, anti-inflammatory, hinders immune cells in mice.</p>Formule :C17H22N6O2Couleur et forme :SolidMasse moléculaire :342.403Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Couleur et forme :Odour SolidFulipiftide
CAS :<p>Fulipiftide is a short peptide derived from pigment epithelium-derived factor (PEDF). It stimulates the amplification of nuclear stem cell factor+TSPC by activating the ERK2 and STAT3 signaling pathways. Fulipiftide also exhibits anti-inflammatory properties and is applicable in research on acute tendon injuries.</p>Formule :C144H227N41O47Couleur et forme :SolidMasse moléculaire :3284.59
