ERK
ERK est une protéine clé de la voie de signalisation MAPK (Mitogen-Activated Protein Kinase), qui est impliquée dans la transmission des signaux des récepteurs de surface cellulaire à l'ADN dans le noyau de la cellule. ERK joue un rôle crucial dans la régulation de divers processus cellulaires, y compris la prolifération, la différenciation et la survie. La dérégulation de la signalisation ERK est associée au développement du cancer et d'autres maladies, ce qui en fait une cible importante pour les interventions thérapeutiques. Chez CymitQuimica, nous offrons une sélection d'inhibiteurs et de modulateurs d'ERK de haute qualité pour soutenir vos recherches en signalisation cellulaire, oncologie et développement thérapeutique.
194 produits trouvés pour "ERK"
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EphB2 Protein, Human, Recombinant (His)
EphB2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Couleur et forme :Lyophilized PowderMasse moléculaire :59.2 kDa (predicted); 65-75 kDa (reducing condition, due to glycosylation)ERK2 Protein, Mouse, Recombinant (His & GST)
<p>ERK2 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :69.1 kDa (predicted); 60 kDa (reducing conditions)EphB2 Protein, Mouse, Recombinant (hFc)
EphB2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.Couleur et forme :Lyophilized PowderMasse moléculaire :84.6 kDa (predicted); 96.6 kDa (reducing conditions)EphB2 Protein, Human, Recombinant (aa 570-987, His & GST)
<p>EphB2 Protein, Human, Recombinant (aa 570-987, His & GST) is expressed in Baculovirus insect cells with His and GST tag.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :75.2 kDa (predicted); 65 kDa (reducing conditions)EPHB2 Protein, Cynomolgus, Recombinant (His)
<p>EphB2, a receptor tyrosine kinase for ephrin ligands, is overexpressed in various cancers and plays an important role in tumor progression.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :59.09 kDa (predicted). Due to glycosylation, the protein migrates to 65-75 kDa based on Tris-Bis PAGE result.EM127
CAS :<p>EM127: covalent SMYD3 inhibitor, KD 13μM, impedes ERK1/2, hinders SMYD3 gene regulation, long-term methyltransferase reduction, potential in cancer study.</p>Formule :C14H18ClN3O3Degré de pureté :97.61%Couleur et forme :SolidMasse moléculaire :311.76ERα degrader-2
CAS :ERα degrader-2 is an estrogen receptor (SERD) degrader with anticancer activity that inhibits ERα for the prevention and treatment of HER-positive breast cancFormule :C29H27F3N2O2Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :492.53PERK-IN-2
CAS :<p>PERK-IN-2 is a potent inhibitor of PERK(IC50 of 0.2 nM).</p>Formule :C23H18F3N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :437.42EphB2 Protein, Mouse, Recombinant (His)
<p>EphB2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :59.3 kDa (predicted); 65 kDa (reducing conditions)EphB2 Protein, Human, Recombinant (His & hFc)
<p>EphB2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :86 kDa (predicted); 90-100 kDa (reducing condition, due to glycosylation)Pamoic acid disodium
CAS :Pamoic acid disodium is a GPR35 agonist.Formule :C23H16NaO6Degré de pureté :99.73%Couleur et forme :Yellow PowderMasse moléculaire :411.36ERK2 Protein, Human, Recombinant (GST)
<p>ERK2 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :67 kDa (predicted); 67 kDa (reducing conditions)(E/Z)-BIX02188
CAS :<p>BIX02188 inhibits MEK5 (IC50: 4.3 nM) and ERK5 (810 nM) but not MEK1/2, JNK2, or ERK2.</p>Formule :C25H24N4O2Degré de pureté :97.39% - 98.38%Couleur et forme :SolidMasse moléculaire :412.48Avicularin
CAS :<p>Avicularin reduces inflammation via ERK pathway in RAW 264.7 cells and hinders lipid buildup in adipocytes by limiting glucose uptake and fatty acid synthesis.</p>Formule :C20H18O11Degré de pureté :97.02% - 99.94%Couleur et forme :White PowderMasse moléculaire :434.35Corynoxeine
CAS :<p>Corynoxeine inhibits ERK1/2, curbs VSMC growth induced by PDGF-BB, and may prevent vascular diseases and restenosis post-angioplasty.</p>Formule :C22H26N2O4Degré de pureté :98.61% - 99.73%Couleur et forme :SolidMasse moléculaire :382.45Aurothiomalate sodium
CAS :<p>Sodium aurothiomalate (Miochrysin) inhibits PKC-ι, TrxR; used as an anti-rheumatic and has anti-tumor properties.</p>Formule :C4H3AuNa2O4SDegré de pureté :99.66%Couleur et forme :SoildMasse moléculaire :390.07VX-11e
CAS :VX-11e (TCS ERK 11e) is a potent, selective, and orally bioavailable ERK(Extracellular Signal-Regulated Kinase) inhibitor; antitumor agent.Formule :C24H20Cl2FN5O2Degré de pureté :98.92% - ≥98%Couleur et forme :SolidMasse moléculaire :500.35HS-1793
CAS :<p>HS-1793, resveratrol-like, reduces HIF-1, VEGF in hypoxia, and curbs human breast cancer growth in mouse model.</p>Formule :C16H12O3Degré de pureté :98.16% - 99.82%Couleur et forme :SolidMasse moléculaire :252.26ERK1/2 inhibitor 2
CAS :<p>ERK1/2 inhibitor 2 (ASTX029) is a selective and orally bioavailable ERK 1/2 inhibitor, with potential antineoplastic activity.</p>Formule :C29H31ClFN5O5Degré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :584.04Astragaloside IV
CAS :<p>Astragaloside IV suppresses ERK1/2, JNK, MMP-2/9 in breast cancer; inhibits adenovirus and protects cardiovascular, immune, digestive, nervous systems.</p>Formule :C41H68O14Degré de pureté :99% - 99.84%Couleur et forme :Hydroscopic Brown Or Yellow PowderMasse moléculaire :784.97magnolin
CAS :<p>Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro.</p>Formule :C23H28O7Degré de pureté :98% - 99.77%Couleur et forme :SolidMasse moléculaire :416.46Gypenoside L
CAS :<p>Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.</p>Formule :C42H72O14Degré de pureté :99.42% - 99.65%Couleur et forme :SolidMasse moléculaire :801.01Longdaysin
CAS :Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).Formule :C16H16F3N5Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :335.33A-443654
CAS :<p>A-443654 is a pan-Akt inhibitor. A-443654 has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).</p>Formule :C24H23N5ODegré de pureté :98.04% - 99.51%Couleur et forme :SolidMasse moléculaire :397.47SEW2871
CAS :<p>SEW 2871 is an orally available, highly selective S1P1 agonist. It activates ERK, Akt and Rac signaling pathways and induces S1P1 internalization and recycling.</p>Formule :C20H10F6N2OSDegré de pureté :99.96%Couleur et forme :White SolidMasse moléculaire :440.36BIX02189
CAS :<p>BIX02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM).</p>Formule :C27H28N4O2Degré de pureté :97.84%Couleur et forme :SolidMasse moléculaire :440.54PD98059
CAS :<p>PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive.</p>Formule :C16H13NO3Degré de pureté :98.63% - >99.99%Couleur et forme :Yellow SolidMasse moléculaire :267.28Piperlongumine
CAS :<p>Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L.</p>Formule :C17H19NO5Degré de pureté :97.03% - 99.90%Couleur et forme :SolidMasse moléculaire :317.34TBHQ
CAS :TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.Formule :C10H14O2Degré de pureté :99.17% - 99.53%Couleur et forme :White Solid PowderMasse moléculaire :166.22SCH772984
CAS :<p>SCH772984 is an ERK inhibitor and is highly selective and ATP-competitive. SCH772984 exhibits antitumor activity. Cost-effective and quality-assured.</p>Formule :C33H33N9O2Degré de pureté :97.565% - 98.75%Couleur et forme :SolidMasse moléculaire :587.67Theliatinib
CAS :<p>Theliatinib: potent, selective EGFR inhibitor, anti-tumor; Ki=0.05 nM (EGFR), IC50=3 nM (EGFR), 22 nM (T790M/L858R).</p>Formule :C25H26N6O2Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :442.51Periplocin
CAS :<p>Periplocin fights lung cancer, induces apoptosis, stunts growth via beta-catenin/Tcf, and treats rheumatoid arthritis/traditional ailments.</p>Formule :C36H56O13Degré de pureté :99.66% - 99.74%Couleur et forme :SolidMasse moléculaire :696.82SC99
CAS :SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.Formule :C15H8Cl2FN3ODegré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :336.15Yoda 1
CAS :<p>Yoda 1 is an agonist of the Piezo1 channel that agonizes human- and mouse-derived Piezo1. Yoda 1 is also an inhibitor of GlyT2. Cost-effective, quality assurance.</p>Formule :C13H8Cl2N4S2Degré de pureté :98% - 99.98%Couleur et forme :SolidMasse moléculaire :355.27ERK5-IN-2
CAS :<p>ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively.</p>Formule :C17H11BrFN3O2Degré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :388.19Asperulosidic acid
CAS :<p>Asperulosidic acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related to the inhibition of inflammatory cytokines.</p>Formule :C18H24O12Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :432.38CAFESTOL
CAS :<p>Cafestol, an ERK inhibitor, suppresses PGE2 and COX-2 by blocking NF-kB in LPS-stimulated RAW264.7 cells.</p>Formule :C20H28O3Degré de pureté :97.06% - 99.08%Couleur et forme :SolidMasse moléculaire :316.43Sulforaphene
CAS :<p>Sulforaphene, from radish seeds, aids cancer cell apoptosis and inhibits migration; has an ED50 for velvetleaf at ~2x10^-4 M.</p>Formule :C6H9NOS2Degré de pureté :97.55% - 99.19%Couleur et forme :Slightly Yellowish LiquidMasse moléculaire :175.27Acalabrutinib
CAS :<p>Acalabrutinib (ACP-196), also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity.</p>Formule :C26H23N7O2Degré de pureté :98.94% - 99.64%Couleur et forme :SolidMasse moléculaire :465.51XMD8-92
CAS :<p>XMD8-92 is an effective and specific BMK1/ERK5 inhibitor (Kd: 80 nM).</p>Formule :C26H30N6O3Degré de pureté :98.21%Couleur et forme :SolidMasse moléculaire :474.55Triptonide
CAS :<p>Triptonide treats autoimmune diseases, has antileukemic/tumor effects, is anti-inflammatory, and boosts IL-37.</p>Formule :C20H22O6Degré de pureté :99.11% - 99.64%Couleur et forme :White Crystalline PowderMasse moléculaire :358.39Peramivir Trihydrate
CAS :<p>Peramivir Trihydrate (RWJ-270201) is a neuraminidase inhibitor (IC50: 0.09 nM) which prevents normal processing of virus particles such that virus particles are</p>Formule :C15H28N4O4·3H2ODegré de pureté :99.52% - ≥95%Couleur et forme :SolidMasse moléculaire :382.45Ulixertinib
CAS :<p>Ulixertinib (VRT752271) (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2.</p>Formule :C21H22Cl2N4O2Degré de pureté :99.31% - 99.95%Couleur et forme :SolidMasse moléculaire :433.33N-tert-butyl-α-Phenylnitrone
CAS :N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity.Formule :C11H15NODegré de pureté :99.46% - 99.84%Couleur et forme :SolidMasse moléculaire :177.24(E/Z)-BIX 02189
CAS :<p>BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.</p>Formule :C27H28N4O2Degré de pureté :98% - 99.89%Couleur et forme :SolidMasse moléculaire :440.54Pluripotin
CAS :<p>Pluripotin (SC1) (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and</p>Formule :C27H25F3N8O2Degré de pureté :98.77% - 98.82%Couleur et forme :SolidMasse moléculaire :550.53Tenuifoliside A
CAS :<p>Tenuifoliside A has anti-apoptotic , neuroprotective activity.</p>Formule :C31H38O17Degré de pureté :98.99% - 99.91%Couleur et forme :SolidMasse moléculaire :682.62BAY885
CAS :<p>BAY885 is a new ERK5 inhibitor.</p>Formule :C25H28F3N7O2Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :515.53Mogrol
CAS :<p>Mogrol, a biometabolite of mogrosides, functions by inhibiting the ERK1/2 and STAT3 pathways, diminishing CREB activation, and activating AMPK signaling.</p>Formule :C30H52O4Degré de pureté :99.85% - 99.90%Couleur et forme :SolidMasse moléculaire :476.73Temuterkib
CAS :<p>LY3214996 (Temuterkib) is a potent oral ERK1/2 inhibitor with potential cancer-fighting properties.</p>Formule :C22H27N7O2SDegré de pureté :99.57% - >99.99%Couleur et forme :SolidMasse moléculaire :453.56
