ERK
ERK est une protéine clé de la voie de signalisation MAPK (Mitogen-Activated Protein Kinase), qui est impliquée dans la transmission des signaux des récepteurs de surface cellulaire à l'ADN dans le noyau de la cellule. ERK joue un rôle crucial dans la régulation de divers processus cellulaires, y compris la prolifération, la différenciation et la survie. La dérégulation de la signalisation ERK est associée au développement du cancer et d'autres maladies, ce qui en fait une cible importante pour les interventions thérapeutiques. Chez CymitQuimica, nous offrons une sélection d'inhibiteurs et de modulateurs d'ERK de haute qualité pour soutenir vos recherches en signalisation cellulaire, oncologie et développement thérapeutique.
205 produits trouvés pour "ERK"
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I-287
CAS :I-287 is a selective, orally active PAR2 inhibitor that functions as a negative allosteric modulator of Gαq and Gα12/13 activity and their downstream effectors.Formule :C30H30ClFN4O4Couleur et forme :SolidMasse moléculaire :565.04CXJ-2
CAS :CXJ-2, a cyclic peptide, binds EDPs, inhibits PI3K/ERK, and reduces hepatic cell growth/migration, offering antifibrotic effects.Formule :C55H87N15O22Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1310.37SKI2496
CAS :SKI2496: potent, oral GnRH receptor antagonist, hGnRHR IC50=0.46nM, 84% LH inhibition at 12h, 76% at 24h, selective for humans over monkeys/rats.Formule :C35H36F7N5O5Couleur et forme :SolidMasse moléculaire :739.68ERK1/2 inhibitor 7
CAS :ERK1/2 inhibitor 7 is a potent inhibitor of ERK, acting on ERK2 (IC50: 0.94 nM).Formule :C23H22FN7OSCouleur et forme :SolidMasse moléculaire :463.53EVT801
CAS :EVT801 is a highly selective and low-toxic VEGFR-3 inhibitor that inhibits VEGF-C-induced tumor lymphoid and angiogenesis and reduces CCL4, CCL5 and MDSC.Formule :C19H21N5O3Degré de pureté :97.4%Couleur et forme :SolidMasse moléculaire :367.4Ref: TM-T73516
1mg154,00€5mg371,00€10mg595,00€25mg1.251,00€50mg1.963,00€100mg3.132,00€1mL*10mM (DMSO)409,00€MK-8353
CAS :MK-8353 (SCH900353) is a potent, selective and orally available inhibitor of ERK1/2 (IC50s of 23.0 nM and 8.8 nM, respectively)Formule :C37H41N9O3SDegré de pureté :96.15% - 97.19%Couleur et forme :SolidMasse moléculaire :691.84Ref: TM-T12069
1mg77,00€2mg92,00€5mg147,00€10mg258,00€25mg557,00€50mg888,00€100mg1.341,00€1mL*10mM (DMSO)217,00€ERK2 IN-1
CAS :ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM.Formule :C36H34FN7O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :647.76MAP855
CAS :MAP855: potent, selective, oral MEK1/2 inhibitor; IC50=3 nM, pERKEC50=5 nM; effective on wild-type/mutant MEK1/2.Formule :C28H23ClF2N6O3Couleur et forme :SolidMasse moléculaire :564.97SHR2415
SHR2415: Potent, selective ERK1/2 inhibitor, oral; ERK1 IC50: 2.8 nM, ERK2 IC50: 5.9 nM; effective in Colo205 (IC50: 44.6 nM), for cancer research.Formule :C23H22ClN7O2Couleur et forme :SolidMasse moléculaire :463.92Hypothemycin
CAS :Hypothemycin, a fungal polyketide, inhibits multiple kinases (VEGFR, MEK, FLT-3, PDGFR, ERK) with Kis ranging from 10 nM to 2.4 μM.Formule :C19H22O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :378.37ATX inhibitor 26
CAS :ATX inhibitor 26 is an Autotaxin (ATX) inhibitor with an IC50 of 57 nM in human plasma. It effectively inhibits cell migration and collagen gel contraction. Additionally, ATX inhibitor 26 demonstrates significant antifibrotic activity, reducing collagen deposition in a Bleomycin (BLM)-induced pulmonary fibrosis model.Formule :C18H19Cl2N7O3Couleur et forme :SolidMasse moléculaire :452.30ERK1/2 inhibitor 6
CAS :ERK1/2 inhibitor 6 - potent cancer/inflammation treatment from WO2021063335A1.Formule :C27H29ClFN7O5Couleur et forme :SolidMasse moléculaire :586.01KRASG12C IN-15
CAS :KRASG12C IN-15 (Compound 21) is an orally active KRASG12C inhibitor that effectively blocks SOS1-mediated GDP/GTP exchange with an IC50 of 19 nM. It inhibits ERK phosphorylation with an IC50 of 0.051 μM and reduces the viability of KRASG12C mutant MIA PaCa-2 cells with an IC50 of 0.023 μM. Additionally, KRASG12C IN-15 demonstrates antitumor activity in a MIA PaCa-2 xenograft mouse model.Formule :C31H32FN3O2Couleur et forme :SolidMasse moléculaire :497.603DOR agonist 2
CAS :Compound 3 (DOR agonist 2) acts as a Delta Opioid Receptor agonist. It inhibits the expression of TNF-α, obstructs NF-κB transportation to the nucleus, and activates the G protein-mediated ERK1/2 pathway. This compound is useful for research into neurodegenerative diseases.Formule :C29H26N2O3Couleur et forme :SolidMasse moléculaire :450.53SOS1 activator 2
CAS :SOS1 activator 2 (Compound 65) is a benzothiazole derivative and an activator of SOS1. It demonstrates a high binding affinity for SOS1, with a Kd of 9 nM. By modulating the Ras-ERK signaling pathway, SOS1 activator 2 is suitable for tumor research.Formule :C26H28ClFN6Couleur et forme :SolidMasse moléculaire :478.992(rel)-AR234960
CAS :(rel)-AR234960 is an active relative configuration of AR234960. AR234960 is a non-peptide agonist of MAS.Formule :C27H30FN5O5SCouleur et forme :SolidMasse moléculaire :555.63ERK-IN-2
CAS :ERK-IN-2, an ERK2 inhibitor, exhibits an IC50 value of 1.8 nM. At doses greater than 10 μM, it may induce off-target toxicity and/or activity [1].Formule :C16H18ClN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :347.80KU004
CAS :KU004, a potent dual EGFR/HER2 inhibitor, exhibits anticancer properties. It inhibits the proliferation of human breast cancer SKBR3 cells by inducing G1 phase arrest. KU004 blocks the activation of HER2, EGFR, and the downstream Akt and Erk pathways, primarily inducing apoptosis (Apoptosis) through the extrinsic pathway. Additionally, KU004 is a novel quinazoline derivative.
Formule :C29H27ClFN4O2PCouleur et forme :SolidMasse moléculaire :548.98KRAS inhibitor-27
CAS :KRAS inhibitor-27 (Compound 15h) is a KRAS inhibitor that effectively targets KRAS G12D/G12V mutated cells (AsPC-1 and SW620) and wild-type KRAS cells (HT-29), with IC50 values of 378 nM, 0.6 nM, and 3230 nM, respectively. It reduces ERK phosphorylation, with IC50 values of 0.6 nM and 1 nM in AsPC-1 and SW620 cells, respectively, and decreases DUSP4 expression, thereby inhibiting the MAPK signaling pathway.
Formule :C31H28ClF3N6O3SCouleur et forme :SolidMasse moléculaire :657.106AL 8810
CAS :AL-8810 is an 11β-fluoro analog of PGF 2α with selective antagonist effects at the PGF 2α receptor (FP receptor) [1].Formule :C24H31FO4Couleur et forme :SolidMasse moléculaire :402.5
