mAPK p38
Les p38 MAPK sont un sous-groupe de MAPK qui répondent aux signaux de stress et sont impliqués dans la régulation de l'inflammation, de la différenciation cellulaire, de l'apoptose et de l'autophagie. La signalisation p38 MAPK est cruciale dans les réponses immunitaires et est impliquée dans diverses maladies, y compris les affections inflammatoires chroniques, le cancer et les troubles neurodégénératifs. Chez CymitQuimica, nous proposons une gamme complète d'inhibiteurs et de modulateurs de p38 MAPK pour soutenir vos recherches sur l'inflammation, la réponse au stress et le développement thérapeutique.
117 produits trouvés pour "mAPK p38"
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Dihydrocaffeic acid
CAS :<p>Dihydrocaffeic acid, a chlorogenic acid metabolite, has antioxidant, anti-Alzheimer's, neuroprotective, and lipid-lowering properties.</p>Formule :C9H10O4Degré de pureté :98.63%Couleur et forme :SolidMasse moléculaire :182.17Aspirin
CAS :<p>Aspirin (Acetylsalicylic Acid) is a COX inhibitor. Aspirin has anti-inflammatory, antipyretic and analgesic activities. Cost-effective and quality-assured.</p>Formule :C9H8O4Degré de pureté :99.78% - 99.91%Couleur et forme :White Solid CrystallineMasse moléculaire :180.16PF-3644022
CAS :<p>PF-3644022 is a selective MK2 inhibitor, effective against TNFα (IC50: 5.2 nM, Ki: 3 nM), with anti-inflammatory properties. Also blocks MK3 and PRAK.</p>Formule :C21H18N4OSDegré de pureté :98.13%Couleur et forme :SolidMasse moléculaire :374.46Hesperetin
CAS :<p>Hesperetin belongs to the flavanone class of flavonoids.</p>Formule :C16H14O6Degré de pureté :98.45% - 99.27%Couleur et forme :SolidMasse moléculaire :302.28Oxidopamine hydrochloride
CAS :<p>Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist.</p>Formule :C8H12ClNO3Degré de pureté :98.34% - 99.85%Couleur et forme :Physical Description Beige Solid (Ntp 1992)Masse moléculaire :205.64LXH254
CAS :<p>LXH254 is a B/C RAF inhibitor with IC50 values of 0.2 nM and 0.07 nM for inhibiting BRAF and CRAF.Cost-effective and quality-assured.</p>Formule :C25H25F3N4O4Degré de pureté :98.3% - 99.92%Couleur et forme :SolidMasse moléculaire :502.49Carbimazole
CAS :<p>Carbimazole, an imidazolium-based thyroid blocker, turns to MMI in the body. Used in Graves' disease research.</p>Formule :C7H10N2O2SDegré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :186.23AZD7624
CAS :<p>AZD7624 is an p38 inhibitor. It has potent anti-inflammatory activity.</p>Formule :C27H30FN5O3Degré de pureté :98.82%Couleur et forme :SolidMasse moléculaire :491.56Oxidopamine hydrobromide
CAS :<p>Oxidopamine hydrobromide (6-OHDA hydrobromide) is a neurotransmitter dopamine antagonist.</p>Formule :C8H12BrNO3Degré de pureté :98.22% - 99.88%Couleur et forme :Beige To Brown Fine Crystalline PowderMasse moléculaire :250.09Dilmapimod
CAS :<p>Dilmapimod (SB-681323) is a potent inhibitor of p38 MAPK ,it potentially suppresses inflammation in chronic obstructive pulmonary disease.</p>Formule :C23H19F3N4O3Degré de pureté :97.53%Couleur et forme :SolidMasse moléculaire :456.42Dehydrocorydaline chloride
CAS :<p>Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK.</p>Formule :C22H24ClNO4Degré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :401.88BI-3406
CAS :<p>BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.</p>Formule :C23H25F3N4O3Degré de pureté :99.2% - 99.66%Couleur et forme :SolidMasse moléculaire :462.46SB220025
CAS :<p>SB220025 is a P38 mitogen-activated protein kinase inhibitor that inhibits p56Lck and PKC, and inhibits angiogenesis.</p>Formule :C18H19FN6Degré de pureté :99.44%Couleur et forme :SolidMasse moléculaire :338.38p38α inhibitor 3
CAS :<p>p38α inhibitor 3 is a inhibitor of the mitogen-activated protein kinase p38α that can block the effectiveness of myoblast differentiation.</p>Formule :C19H20FNODegré de pureté :99.94%Couleur et forme :SoildMasse moléculaire :297.37p38 MAP Kinase Inhibitor Ⅵ
CAS :<p>p38 MAP Kinase Inhibitor Ⅵ is a potent p38 MAP Kinase inhibitor with anti-inflammatory activity.</p>Formule :C16H13FN2OS2Degré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :332.42p38α inhibitor 5
CAS :<p>The compound p38α inhibitor5 (compound 1) is a PROTAC-type ligand that targets p38 and is utilized in the synthesis of NR-11c.</p>Formule :C26H23BrF2N2O3Couleur et forme :SolidMasse moléculaire :529.37WYE-687
CAS :<p>WYE-687 is a selective mTOR inhibitor (IC50: 7 nM), over 100x more selective for mTOR than PI3Kα/γ, affecting mTORC1/pS6K and mTORC2/P-AKT(S473).</p>Formule :C28H32N8O3Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :528.61Z16078526
CAS :<p>Z16078526 promotes Ucp1, p38 MAPK, lipolysis, thermogenic genes, and mitochondrial activity in mouse brown adipocytes.</p>Formule :C18H17N3O4SDegré de pureté :98.93%Couleur et forme :SolidMasse moléculaire :371.41Talmapimod hydrochloride
CAS :<p>Talmapimod hydrochloride: selective p38α inhibitor, 9 nM IC50, 10x less effective on p38β, >2000-fold selective vs 20+ kinases.</p>Formule :C27H31Cl2FN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :549.46PDE4-IN-26
<p>PDE4-IN-26 (Compound A5) is an orally active, highly selective inhibitor of PDE4. It exhibits anti-inflammatory properties by inhibiting p38 MAPK phosphorylation. In mouse models of acute lung injury and chronic obstructive pulmonary disease, PDE4-IN-26 reduces lung inflammation, damage, and fibrosis, while promoting sputum secretion and alleviating cough. It is useful for researching lung injury-related diseases.</p>Formule :C22H18F2N4O3SCouleur et forme :SolidMasse moléculaire :456.47Ro-3201195
CAS :<p>Ro-3201195 is a novel orally available p38 MAPK inhibitor with high selectivity.</p>Formule :C19H18FN3O4Degré de pureté :99.15%Couleur et forme :SolidMasse moléculaire :371.36Cyclotraxin B
CAS :<p>TrkB receptor antagonist; inhibits BDNF-TrkB signaling (IC50 = 0.30 nM); alters receptor shape; may reduce anxiety in mice.</p>Formule :C48H73N13O17S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1200.36Esculin sesquihydrate
CAS :<p>Esculin sesquihydrate, a coumarin glucoside with fluorescent properties and a constituent of ash bark, improves cognitive deficits associated with experimental</p>Formule :C15H16O9H2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :367.31MAP3K5-IN-1
CAS :<p>Compound 7, also known as 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine, serves as an inhibitor of protein kinases, displaying IC50 values of 0.092 μM for PKC-α, 0.26 μM for ROCK, and 0.77 μM for ASK1. Additionally, this compound exhibits significant cytotoxicity towards PC-3 cancer cells, with an IC50 of 0.16 μM [1].</p>Formule :C28H24N4O4Couleur et forme :SolidMasse moléculaire :480.51DB-10
<p>DB-10 serves as a precursor to 3-nbutylphthalide (NBP). It is absorbed by cells in a temperature and energy-dependent manner through the pyrilamine cation transporter. DB-10 enhances cell survival and rapidly converts into an active form in vivo, increasing accumulation within the brain. This compound is applicable in ischemic stroke research.</p>Couleur et forme :Odour SolidOVA-E1 peptide TFA
CAS :<p>OVA-E1 peptide TFA activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes.</p>Formule :C49H77F3N10O16Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1119.19R1487 Hydrochloride
CAS :<p>R1487 Hydrochloride (R1487 (Hydrochloride)) is an orally bioavailable and highly selective inhibitors of p38α.</p>Formule :C19H19ClF2N4O3Degré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :424.83Kaempferol-3-O-glucorhamnoside
CAS :<p>Kaempferol-3-O-glucorhamnoside (Kaempferol 3-glucorhamnoside), a flavonoid derived from plant Thesium chinense Turcz, inhibits inflammatory responses via MAPK</p>Formule :C27H30O15Degré de pureté :96.96% - 98.17%Couleur et forme :SolidMasse moléculaire :594.5Neflamapimod
CAS :<p>Neflamapimod (VX-745) , a specific and effective inhibitor of p38α(IC50=10 nM), is 22-fold greater specificity against p38β and no inhibition activity to p38γ.</p>Formule :C19H9Cl2F2N3OSDegré de pureté :97.88% - 99.75%Couleur et forme :SolidMasse moléculaire :436.26Sertaconazole nitrate
CAS :<p>Sertaconazole nitrate, a broad-spectrum topical antifungal, treats skin and mucosal infections.</p>Formule :C20H15Cl3N2OS·HNO3Degré de pureté :98.66% - 99.65%Couleur et forme :SolidMasse moléculaire :500.78ASK1-IN-1
CAS :<p>ASK1-IN-1 inhibits apoptosis kinase 1, crucial in cell stress responses, with 21 nM IC50.</p>Formule :C19H19N9O2Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :405.41SB 202190
CAS :<p>SB 202190 (FHPI) is a p38 MAPK inhibitor that inhibits p38α and p38β2 (IC50=50/100 nM) selectively and cell-permeably.</p>Formule :C20H14FN3ODegré de pureté :98% - 99.84%Couleur et forme :Pale YellowMasse moléculaire :331.34CK1-IN-1
CAS :<p>CK1-IN-1, a CK1 inhibitor with IC50: 15nM CK1δ, 16nM CK1ε, 73nM p38σ; patent WO2015119579A1.</p>Formule :C24H15F2N3Degré de pureté :98.79%Couleur et forme :SolidMasse moléculaire :383.39Gypenoside L
CAS :<p>Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.</p>Formule :C42H72O14Degré de pureté :99.42% - 99.65%Couleur et forme :SolidMasse moléculaire :801.01UM-164
CAS :<p>UM-164 (DAS-DFGO-II), a highly potent c-Src inhibitor with a dissociation constant (Kd) of 2.7 nM, also effectively inhibits p38α and p38β.</p>Formule :C30H31F3N8O3SDegré de pureté :98.72% - 99.52%Couleur et forme :SolidMasse moléculaire :640.68Adezmapimod
CAS :<p>Adezmapimod (SB 203580) is a p38 MAPK inhibitor (IC50=0.3-0.5 μM) that is selective and ATP-competitive.</p>Formule :C21H16FN3OSDegré de pureté :99.42% - 99.93%Couleur et forme :White SolidMasse moléculaire :377.435,6,7-TRIMETHOXYFLAVONE
CAS :<p>5,6,7-Trimethoxyflavone, a natural product extracted from Japanese Callicarpa, acts as a p38-α MAPK inhibitor and exhibits anti-inflammatory properties.</p>Formule :C18H16O5Degré de pureté :99.05% - 99.49%Couleur et forme :SolidMasse moléculaire :312.32SD 0006
CAS :<p>SD 0006 (SD-06) is a MAPK p38 alpha inhibitor( IC50 : 110 nM) for the treatment of arthritis.</p>Formule :C20H20ClN5O2Degré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :397.86Nitidine chloride
CAS :<p>1.</p>Formule :C21H18ClNO4Degré de pureté :96.59% - 98.91%Couleur et forme :SolidMasse moléculaire :383.82SB 239063
CAS :<p>SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.</p>Formule :C20H21FN4O2Degré de pureté :99.42% - 99.81%Couleur et forme :SolidMasse moléculaire :368.4Rotundic acid
CAS :<p>Rotundic acid fights various cancers: HepG2, A375, NCI-H446, MCF-7, and HT-29.</p>Formule :C30H48O5Degré de pureté :96.91% - 99.97%Couleur et forme :SolidMasse moléculaire :488.7Cornuside
CAS :<p>Cornuside boosts immunity, reduces inflammation, protects heart and liver, and guards against brain injury by modulating stress responses.</p>Formule :C24H30O14Degré de pureté :99.86% - >99.99%Couleur et forme :SolidMasse moléculaire :542.49Andrograpanin
CAS :<p>Andrograpanin (19-HYDROXY-8(17),13-LABDADIEN-16,15-OLIDE) is a bioactive compound from Andrographis paniculata.</p>Formule :C20H30O3Degré de pureté :99.03% - 99.457%Couleur et forme :SolidMasse moléculaire :318.45FERULIC ACID METHYL ESTER
CAS :<p>FERULIC ACID METHYL ESTER (Methyl ferulate) is a hydroxycinnamic acid that is abundant in plants. FERULIC ACID METHYL ESTER has antioxidant activities.</p>Formule :C11H12O4Degré de pureté :99.66% - 99.95%Couleur et forme :SolidMasse moléculaire :208.21BMS-582949 hydrochloride
CAS :<p>The BMS-582949 hydrochloride (BMS-582949 HCl) is a highly specific p38α MAPK inhibitor (IC50: 13 nM).</p>Formule :C22H27ClN6O2Degré de pureté :97.57% - 98.75%Couleur et forme :SolidMasse moléculaire :442.95R1487
CAS :<p>R1487 is an orally bioavailable and highly selective p38α mitogen-activated protein kinase inhibitor.</p>Formule :C19H18F2N4O3Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :388.37SR-318
CAS :<p>SR-318 inhibits TNF-α (IC50=283 nM), selectively targets p38 MAPK: IC50 of 5nM (p38α), 32nM (p38β), 6.11μM (p38α/β).</p>Formule :C27H33N5O2Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :459.58Afatinib Dimaleate
CAS :<p>Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the EGFR family, with antineoplastic activity.</p>Formule :C32H33ClFN5O11Degré de pureté :98.11% - 99.87%Couleur et forme :SolidMasse moléculaire :718.08TA-02
CAS :<p>TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM.TA-02 especially inhibits TGFBR-2.</p>Formule :C20H13F2N3Degré de pureté :99.35% - 99.79%Couleur et forme :SolidMasse moléculaire :333.33TA-01
CAS :<p>TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.</p>Formule :C20H12F3N3Degré de pureté :99.55% - 99.94%Couleur et forme :SolidMasse moléculaire :351.32Ralimetinib dimesylate
CAS :<p>Ralimetinib dimesylate (LY2228820 dimesylate) is a orally available, p38 MAPK inhibitor with potential anti-inflammatory and antineoplastic activities.</p>Formule :C24H29FN6·2CH4O3SDegré de pureté :98% - 99.38%Couleur et forme :SolidMasse moléculaire :612.74Skepinone-L
CAS :<p>Skepinone-L (CBS3830) is a selective p38 mitogen-activated protein kinase inhibitor.</p>Formule :C24H21F2NO4Degré de pureté :99.56% - >99.99%Couleur et forme :SolidMasse moléculaire :425.42SKF-86002
CAS :<p>SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).</p>Formule :C16H12FN3SDegré de pureté :98% - 99.85%Couleur et forme :SolidMasse moléculaire :297.35SB 242235
CAS :<p>SB 242235 is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases.</p>Formule :C19H20FN5ODegré de pureté :99.13% - 99.68%Couleur et forme :SolidMasse moléculaire :353.39Rhoifolin
CAS :<p>Rhoifolin (Apigenin 7-O-neohesperidoside) is extracted from Turpinia arguya Seem dried leaves.</p>Formule :C27H30O14Degré de pureté :98.11% - 98.58%Couleur et forme :SolidMasse moléculaire :578.52TAK-715
CAS :<p>TAK-715 is a p38 MAPK inhibitor for p38α.</p>Formule :C24H21N3OSDegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :399.51PD 169316
CAS :<p>PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor.</p>Formule :C20H13FN4O2Degré de pureté :98.65%Couleur et forme :SolidMasse moléculaire :360.34AMG-47a
CAS :<p>AMG-47a inhibits Lck, T cell growth, and degrades KRAS oncoprotein, affecting EGFP-KRASG12V but not EGFP.</p>Formule :C29H28F3N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :535.56Acumapimod
CAS :<p>Acumapimod (BCT-197) is an orally active inhibitor of p38α MAPK (IC50 <1 μM).</p>Formule :C22H19N5O2Degré de pureté :≥95%Couleur et forme :SolidMasse moléculaire :385.42Skatole
CAS :<p>Skatole (3-Methyl-1H-indole), produced by bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.</p>Formule :C9H9NDegré de pureté :99.74%Couleur et forme :Leaves From Petroleum Ether; White-Brown Scales SolidMasse moléculaire :131.17MW-150
CAS :<p>MW-150 (MW01-18-150SRM) is a unique protein kinase inhibitor, is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM.</p>Formule :C24H23N5Degré de pureté :97.35% - 99.27%Couleur et forme :SolidMasse moléculaire :381.47Isoliquiritin apioside
CAS :<p>Isoliquiritin apioside, from Glycyrrhizae radix, inhibits MMP9, MAPK, NF-κB, reduces cancer cell invasion, angiogenesis, and fights oxidative DNA damage.</p>Formule :C26H30O13Degré de pureté :98.84% - 99.27%Couleur et forme :SolidMasse moléculaire :550.51Esculin
CAS :<p>Esculin (Aesculin) is a glucoside found in horse chestnuts.</p>Formule :C15H16O9Degré de pureté :97.93% - 99.83%Couleur et forme :Cream PowderMasse moléculaire :340.28Doramapimod
CAS :<p>Doramapimod (BIRB 796) is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but weakly inhibits c-RAF, Fyn, Lck, ERK-1, SYK, IKK2, and ZAP-70.</p>Formule :C31H37N5O3Degré de pureté :97.14% - 98.80%Couleur et forme :SolidMasse moléculaire :527.66Bakuchiol
CAS :<p>Bakuchiol: anti-tumor, anti-helminthic, DNA polymerase1 inhibitor, cytotoxic, and anti-bacterial, may prevent dental caries.</p>Formule :C18H24ODegré de pureté :98.04% - 99.05%Couleur et forme :Brownish Yellow Liquid ViscousMasse moléculaire :256.38PH-797804
CAS :<p>PH-797804 is a pyridinone inhibitor of p38α (IC50: 26 nM, in a cell-free assay); 4-fold more selective versus p38β and does not inhibit JNK2.</p>Formule :C22H19BrF2N2O3Degré de pureté :97.90% - 98.27%Couleur et forme :SolidMasse moléculaire :477.3Dehydrocorydaline
CAS :<p>1.</p>Formule :C22H24NO4Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :366.43Bisabolangelone
CAS :<p>Bisabolangelone: anti-tumor, anti-inflammatory, anti-microbial, antioxidant, blocks MAPK/NF-κB in dendritic cells.</p>Formule :C15H20O3Degré de pureté :98.91%Couleur et forme :SolidMasse moléculaire :248.32SM-7368
CAS :<p>The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.</p>Formule :C10H5ClN4O5SDegré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :328.69AMG 900
CAS :<p>AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM.</p>Formule :C28H21N7OSDegré de pureté :98.4% - 99.51%Couleur et forme :SolidMasse moléculaire :503.58SD-169
CAS :<p>SD-169 (SD 169) is a selective and ATP competitive the MAP kinases p38α and p38β inhibitor.</p>Formule :C9H8N2ODegré de pureté :98.6%Couleur et forme :SolidMasse moléculaire :160.17Afatinib
CAS :<p>Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.</p>Formule :C24H25ClFN5O3Degré de pureté :98.56% - 99.9%Couleur et forme :Off-White SolidMasse moléculaire :485.94N-Feruloyloctopamine
CAS :<p>N-Feruloyloctopamine is a natural product.</p>Formule :C18H19NO5Degré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :329.35Sesamolin
CAS :<p>Sesamolin and sesamin guard nerves, reduce microglia damage by blocking p38 MAPK and caspase-3, and curb nitric oxide in stimulated cells.</p>Formule :C20H18O7Degré de pureté :98.77% - 99.04%Couleur et forme :SolidMasse moléculaire :370.35Pamapimod
CAS :<p>Pamapimod (R1503) (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase.</p>Formule :C19H20F2N4O4Degré de pureté :99.52% - 99.99%Couleur et forme :SolidMasse moléculaire :406.38Losmapimod
CAS :<p>Losmapimod (GSK-AHAB) (GW856553X; SB856553; GSK-AHAB) is a specific, potent, and orally active p38 MAPK inhibitor (pKi: 8.1/7.6 for p38α/β).</p>Formule :C22H26FN3O2Degré de pureté :98.35% - 99.89%Couleur et forme :SolidMasse moléculaire :383.46RWJ-67657
CAS :<p>RWJ-67657 is a selective oral p38α/β MAPK inhibitor with IC50s of 1/11μM; inactive on p38γ/δ with cardioprotection.</p>Formule :C27H24FN3ODegré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :425.5Sertaconazole
CAS :<p>Sertaconazole is a broad-spectrum antifungal.</p>Formule :C20H15Cl3N2OSDegré de pureté :99.483%Couleur et forme :SolidMasse moléculaire :437.77Paris saponin VII
CAS :<p>Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.</p>Formule :C51H82O21Degré de pureté :99.51% - 99.63%Couleur et forme :SolidMasse moléculaire :1031.18Talmapimod
CAS :<p>Talmapimod (SCIO-469): Oral ATP-competitive p38α inhibitor, IC50 = 9 nM (p38α), 90 nM (p38β), >2000-fold selectivity over 20 kinases.</p>Formule :C27H30ClFN4O3Degré de pureté :98% - 99.9%Couleur et forme :SolidMasse moléculaire :513BMS582949
CAS :<p>BMS-582949 inhibits p38 MAPK with 13 nM IC50, blocking kinase activity and activation.</p>Formule :C22H26N6O2Degré de pureté :98.11%Couleur et forme :SolidMasse moléculaire :406.48Pexmetinib
CAS :<p>Pexmetinib (ARRY-614) is an orally bioavailable dual p38 MAPK/Tie-2 inhibitor.Cost-effective and quality-assured.</p>Formule :C31H33FN6O3Degré de pureté :99.07% - 99.66%Couleur et forme :SolidMasse moléculaire :556.63Dehydrocorydaline nitrate
CAS :<p>DHC curbs antibody and cell-mediated allergies, inhibits mitochondrial potential in macrophages, and has antinociceptive, anti-inflammatory effects.</p>Formule :C22H24N2O7Degré de pureté :99.79% - 99.92%Couleur et forme :SolidMasse moléculaire :428.44VX-702
CAS :<p>VX-702: selective p38α MAPK inhibitor, potent anti-cytokine for rheumatoid arthritis.</p>Formule :C19H12F4N4O2Degré de pureté :99% - >99.99%Couleur et forme :SolidMasse moléculaire :404.32TLC1566-0618
CAS :<p>TLC1566-0618 shows antitumor activity and targets stat.</p>Formule :C20H15NO3S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :413.53(S)-(-)-PH-797804
CAS :Produit contrôléFormule :C19H38N5O5Couleur et forme :NeatMasse moléculaire :416.536LY 294002 Hydrochloride
CAS :Produit contrôlé<p>Applications LY 294002 Hydrochloride is a highly selective inhibitor of Phosphatidylinositol 3-kinase (PI3K). It is a salt analogue of LY 294002 (L486590).<br>References Lin, C., et. al.: J. Biol. Chem., 286, 10483 (2011); Cao, H., et. al.: J. Biol. Chem., 288, 30399 (2013);<br></p>Formule :C19H17NO3·(HCl)Couleur et forme :NeatMasse moléculaire :343.8SB 706504
CAS :<p>SB 706504 is an effective p38 MAPK inhibitor that suppresses inflammatory gene expression in macrophages and inhibits TNFα production in COPD.</p>Formule :C24H19F3N8ODegré de pureté :98.686%Couleur et forme :SolidMasse moléculaire :492.46AL 8697
CAS :<p>AL 8697 is a selective p38α MAPK inhibitor (IC50 = 6 nM) with 14-fold selectivity over p38β (IC50 = 82 nM) and 300-fold selectivity over a panel of 91 kinases.</p>Formule :C21H21F3N4ODegré de pureté :99.55% - 99.89%Couleur et forme :SolidMasse moléculaire :402.41PF-05381941
CAS :<p>PF-05381941 is a selective and potent dual inhibitor of TAK1 and p38α that inhibits the kinase activity of TAK1 by binding to its active site.</p>Formule :C27H26N6O2Degré de pureté :98.04%Couleur et forme :SolidMasse moléculaire :466.53EO-1606
CAS :<p>EO-1606 is a p38MAP kinase inhibitor with anti-inflammatory activity and may be used in studies of Alzheimer;s disease and dermatitis.</p>Formule :C21H17ClFNODegré de pureté :98.28% - 98.84%Couleur et forme :SolidMasse moléculaire :353.82p38α inhibitor 4
CAS :<p>p38α inhibitor 4 is a selective MAPK p38α inhibitor, which is used to study diabetes, pain and chronic inflammation.</p>Formule :C14H7F6N3ODegré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :347.215UR13870
CAS :<p>UR-13870 (Org 48762-0) is a p38 MAPK inhibitor that prevents bone damage in collagen-induced arthritis in mice.</p>Formule :C24H16F2N4Degré de pureté :99.18% - >99.99%Couleur et forme :SolidMasse moléculaire :398.41AKP-001
CAS :<p>AKP-001 is a selective inhibitor of MAPK of the p38α isoform and is used in the study of immune and digestive disorders.</p>Formule :C21H13ClF2N4O2Degré de pureté :99.50% - 99.92%Couleur et forme :SolidMasse moléculaire :426.8p38 MAPK Inhibitor
CAS :<p>p38 MAPK inhibitor is a potent inhibitor of p38 MAP kinase (IC50 = 35 nM). It inhibits senescence induced by the oncogene RAS.</p>Formule :C20H13ClFN3ODegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :365.79SB-747651A Dihydrochloride
CAS :<p>SB-747651A dihydrochloride, an MSK1 inhibitor (IC50=11 nM), also targets PRK2, RSK1, p70S6K, ROCK-II; potential in inflammation study.</p>Formule :C16H24Cl2N8ODegré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :415.32Org OD 02-0
CAS :<p>10-Ethenyl-19-norprogesterone (Org OD 02-0) is a selective agonist for the membrane progesterone receptor α (mPRα) with an IC50 of 33.9 nM, known to activate</p>Formule :C22H30O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :326.47p38-α MAPK-IN-1
CAS :<p>p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor with IC50 of 2300 nM and 5500 nM in EFC displacement assay and HTRF assay,respectively.</p>Formule :C27H35N5O3Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :477.6PLK1/p38γ-IN-1
CAS :<p>PLK1/p38γ-IN-1 (compound 14) serves as a dual inhibitor targeting both PLK1 and p38γ kinases, effectively suppressing the proliferation of human hepatocellular</p>Formule :C21H26ClN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :387.9AMG-548 dihydrochloride (864249-60-5 free base)
<p>AMG-548 dihydrochloride: oral p38α inhibitor, Ki: 0.5 nM; less so for p38β, Ki: 36 nM; >> p38γ/δ; blocks LPS-induced TNFα, IC50: 3 nM.</p>Formule :C29H29Cl2N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :534.48p38 Kinase inhibitor 4
CAS :<p>Compound 135, also known as p38 Kinase Inhibitor 4, is a potent inhibitor of p38 [1].</p>Formule :C12H9Cl2N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :282.13AMG-548 hydrochloride (864249-60-5 free base)
<p>AMG-548 hydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective</p>Formule :C29H28ClN5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.02p38-α MAPK-IN-9
CAS :<p>p38-α MAPK-IN-9 (Compound 25a) is a p38-α MAPK inhibitor with a Ki value of 0.057 nM. It effectively inhibits LPS-induced TNFα production in hPBMC cells, exhibiting an IC50 of 18 nM.</p>Formule :C19H20N8O2Couleur et forme :SolidMasse moléculaire :392.414PS-166276
CAS :<p>PS-166276 is a potent p38 inhibitor with low cytotoxicity. It exhibits an IC50 value of 28 nM against p38 kinase and an IC50 of 170 nM in the THP-1 TNFα assay.</p>Formule :C20H30N8OCouleur et forme :SolidMasse moléculaire :398.51Anti-osteoporosis agent-11
CAS :<p>Anti-osteoporosis agent-11 (compound 3k) is an anti-osteoporosis compound targeting osteoclasts. It exhibits its most prominent effect by inhibiting osteoclast differentiation, with an IC50 value of 0.36 μM. Additionally, Anti-osteoporosis agent-11 suppresses osteoclast formation, bone resorption, and the expression of osteoclast-specific genes by blocking the RANKL-induced mitogen-activated protein kinase (MAPK) and NF-κB signaling pathways.</p>Formule :C23H17NO2Se2Couleur et forme :SolidMasse moléculaire :497.31p38-α MAPK-IN-10
CAS :<p>p38-α MAPK-IN-10 (Compound 6) is an inhibitor of p38α, with an IC50 value of 4 nM.</p>Formule :C27H34Cl2N6Couleur et forme :SolidMasse moléculaire :513.50510-Methoxy-canthin-6-one
CAS :<p>10-Methoxy-canthin-6-one (Mtx-C) acts as a DNA damage inducer that embeds into DNA, promoting cell cycle arrest at the G2/M phase. This process triggers myeloid differentiation in acute myeloid leukemia cells (AML) and leukemia stem cells (LSC). Differentiation in AML and LSC cells is characterized by increased expression of myeloperoxidase, CD15, CD11b, and CD14, along with the activation of p38 MAPK. 10-Methoxy-canthin-6-one is utilized in the study of leukemia.</p>Formule :C15H10N2O2Couleur et forme :SolidMasse moléculaire :250.25AMC-04
CAS :<p>AMC-04 is a protein response (UPR) activator that initiates the UPR pathway via ROS and p38 MAPK signaling, leading to apoptotic cell death. It is used in cancer research [1].</p>Formule :C26H28N2O3Couleur et forme :SolidMasse moléculaire :416.51p38 MAPK-IN-6
CAS :<p>p38 MAPK-IN-6 (compound c47) is an inhibitor of p38 MAPK, exhibiting a 14% inhibition rate at a concentration of 10 μM.</p>Formule :C16H14BrN3OS2Couleur et forme :SolidMasse moléculaire :408.336RIPK2-IN-6
CAS :<p>RIPK2-IN-6 (Compound 15a) is an inhibitor of RIPK that specifically targets the phosphorylation of RIPK2, thereby suppressing the NF-κB and MAPK signaling pathways. It has demonstrated anti-inflammatory and anti-fibrotic activities in a mouse model of colitis induced by Dextran sodium sulfate.</p>Formule :C26H21NO3Couleur et forme :SolidMasse moléculaire :395.45Lambertellin
CAS :<p>Lambertellin, an effective antibiotic, acts as both a bactericide and fungicide. It exerts anti-inflammatory effects in LPS-stimulated RAW 264.7 macrophages by modulating the activation of MAPK and NF-κB signaling pathways.</p>Formule :C14H8O5Couleur et forme :SolidMasse moléculaire :256.21PF-03715455
CAS :<p>PF-03715455 is a potent p38 MAPK inhibitor, reducing TNFα in blood (IC50=1.7 nM) with selectivity for p38α, and may treat COPD.</p>Formule :C35H34ClN7O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :700.27(R)-STU104-d6
CAS :<p>(R)-STU104-d6 is a deuterium-labeled variant of (R)-STU104. This compound acts as a potent and orally active inhibitor of the interaction between TAK1 and MKK3 proteins, exhibiting IC50 values of 0.58 μM for TNF-α and 4.0 μM for MKK3 phosphorylation. By binding to MKK3, (R)-STU104 hinders TAK1's ability to phosphorylate MKK3, thereby disrupting the TAK1/MKK3/p38/MnK1/MK2/elF4E signaling pathway. It is utilized in research related to ulcerative colitis.</p>Formule :C18H182D6O4Couleur et forme :SolidMasse moléculaire :304.37p38 Kinase inhibitor 7
CAS :<p>p38 Kinase inhibitor 7 (Comp:XXXIX) is an inhibitor of p38α, with an IC50 value of 5.25 nM. It also effectively suppresses TNFα production in THP-1 cells, demonstrating an IC50 of 5.88 nM.</p>Formule :C22H25FN6OCouleur et forme :SolidMasse moléculaire :408.472p38 MAP Kinase-IN-1
CAS :<p>p38 MAP Kinase-IN-1 (Compound 4) is an inhibitor of p38, suitable for studies related to inflammation and autoimmune responses.</p>Formule :C20H19FN6OCouleur et forme :SolidMasse moléculaire :378.403Emprumapimod
CAS :<p>Emprumapimod, an oral p38α MAPK inhibitor, targets RPMI-8226 cells, curbs LPS-induced IL-6; IC50: 100 pM; for cardiomyopathy, acute pain.</p>Formule :C24H29F2N5O3Degré de pureté :99.21% - >99.99%Couleur et forme :SolidMasse moléculaire :473.52
