CFTR
Le CFTR est une protéine canal chlorure qui régule le transport des ions chlorure et bicarbonate à travers les membranes des cellules épithéliales, jouant un rôle crucial dans le maintien de l'équilibre hydrique dans les tissus. Les mutations du gène CFTR entraînent la mucoviscidose, une maladie génétique caractérisée par la production de mucus épais pouvant obstruer les voies respiratoires et causer de graves problèmes respiratoires et digestifs. Chez CymitQuimica, nous proposons une sélection de modulateurs CFTR pour soutenir vos recherches sur la mucoviscidose, le transport des ions et les troubles génétiques.
64 produits trouvés pour "CFTR"
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Elexacaftor
CAS :<p>Elexacaftor (VX-445) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector.Cost-effective and quality-assured.</p>Formule :C26H34F3N7O4SDegré de pureté :98.87% - 99.87%Couleur et forme :SolidMasse moléculaire :597.65Glibenclamide
CAS :<p>Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.</p>Formule :C23H28ClN3O5SDegré de pureté :99.05% - 99.75%Couleur et forme :SolidMasse moléculaire :494.00Vanzacaftor
CAS :<p>Vanzacaftor is a CFTR modulator improving protein processing and surface trafficking, restoring chloride transport and aiding cystic fibrosis therapy research.</p>Formule :C32H39N7O4SDegré de pureté :99.14%Couleur et forme :SolidMasse moléculaire :617.76Astressin 2B
CAS :<p>CRF2 antagonist with IC50 of 1.3 nM; >500 nM for CRF1. Aids gastric emptying.</p>Formule :C183H307N49O53Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4041.69CFTR activator 2
CAS :<p>CFTR activator 2 (WAY-326769) is an activator of mutant CFTR (cystic fibrosis transmembrane conductance regulator), which increases ion transport activity and can be used for research into cystic fibrosis (CF).</p>Formule :C27H27N3O3Degré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :441.52(Rac)-Tezacaftor
CAS :<p>(Rac)-Tezacaftor, a racemate, corrects F508del CFTR for cystic fibrosis research.</p>Formule :C26H27F3N2O6Couleur et forme :SolidMasse moléculaire :520.5Crofelemer
CAS :<p>Crofelemer (Provir) is an orally active antidiarrheal agent. It targets the cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-activated chloride channels (CACC), which are responsible for chloride and fluid secretion in the gastrointestinal tract. Crofelemer is applicable for research in diarrhea-related conditions.</p>Couleur et forme :SolidCP-628006
CAS :<p>CP-628006 is a small molecule CFTR potentiator that effectively restores ATP-dependent channel gating to G551D-CFTR, the mutant form found in cystic fibrosis.</p>Formule :C32H35F3N2O2Couleur et forme :SolidMasse moléculaire :536.639H2-Gamendazole
CAS :<p>H2-Gamendazole: inhibits spermatogenesis, cancer therapy, targets heat shock proteins & EF1α, regulates Hsp90.</p>Formule :C18H13Cl2F3N2O2Degré de pureté :97.36%Couleur et forme :SolidMasse moléculaire :417.21Zatonacaftor
CAS :<p>Zatonacaftor, a cystic fibrosis transmembrane regulator (CFTR) modulator, is utilized in the research of cystic fibrosis [1] [2].</p>Formule :C24H27N3O4SCouleur et forme :SolidMasse moléculaire :453.554-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-2-thiazolamine
CAS :<p>4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-2-thiazolamine is an enantiomeric</p>Formule :C27H28ClFN2OSDegré de pureté :99.02%Couleur et forme :SoildMasse moléculaire :483.04WAY-326766
CAS :<p>WAY-326766 increases ion transport through mutant CFTR and can be used to alter the lifespan of eukaryotes.WAY-326766 can be used to treat cystic fibrosis (CF).</p>Formule :C21H23N3O5Degré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :397.42Crinecerfont hydrochloride
CAS :<p>SSR-125543, a potent CRF1 receptor non-peptide antagonist, effective in CAH research, taken orally.</p>Formule :C27H29Cl2FN2OSCouleur et forme :SolidMasse moléculaire :519.5(R)-BPO-27
CAS :<p>(R)-BPO-27 is an orally active and potent ATP-competitive CFTR inhibitor (IC50: 4 nM) for the study of diarrhoea and polycystic kidney.</p>Formule :C26H18BrN3O6Degré de pureté :99.1%Couleur et forme :SolidMasse moléculaire :548.34Ataluren
CAS :<p>Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations.</p>Formule :C15H9FN2O3Degré de pureté :99.16% - 99.84%Couleur et forme :SolidMasse moléculaire :284.24PPQ-102
CAS :<p>PPQ-102 (CFTR Inhibitor), an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).</p>Formule :C26H22N4O3Degré de pureté :99.7% - ≥95%Couleur et forme :SolidMasse moléculaire :438.48GlyH-101
CAS :<p>GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.</p>Formule :C19H15Br2N3O3Degré de pureté :98.71% - 98.78%Couleur et forme :SolidMasse moléculaire :493.15Ivacaftor
CAS :<p>Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells,</p>Formule :C24H28N2O3Degré de pureté :99% - 99.98%Couleur et forme :SolidMasse moléculaire :392.49GLPG1837
CAS :<p>GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.</p>Formule :C16H20N4O3SDegré de pureté :99.64% - 99.91%Couleur et forme :SolidMasse moléculaire :348.42Lumacaftor
CAS :<p>Lumacaftor (VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein.</p>Formule :C24H18F2N2O5Degré de pureté :99.48% - 99.68%Couleur et forme :SolidMasse moléculaire :452.41Glibenclamide potassium
CAS :<p>Glibenclamide potassium, a more soluble form of Glibenclamide, exists as anhydrous and hydrate salts.</p>Formule :C23H27ClKN3O5SCouleur et forme :SolidMasse moléculaire :532.09CFTR corrector 2
CAS :<p>CFTR corrector 2 (FDL169) is a novel and potent CFTR corrector for treating cystic fibrosis (CF) patients who carry the F508del mutation.</p>Formule :C27H23FN4O4Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :486.49Lubiprostone
CAS :<p>Lubiprostone (RU-0211), an activator of ClC-2 chloride channels, is used in the therapy of idiopathic chronic constipation.</p>Formule :C20H32F2O5Degré de pureté :97.31% - 98.54%Couleur et forme :White Odorless Crystals Or Crystalline PowderMasse moléculaire :390.46IOWH-032
CAS :<p>IOWH-032 (IOWH032) , a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.</p>Formule :C22H15Br2N3O4Degré de pureté :98.92% - ≥95%Couleur et forme :SolidMasse moléculaire :545.18KM11060
CAS :<p>KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma</p>Formule :C19H17Cl2N3O2SDegré de pureté :98.86%Couleur et forme :SolidMasse moléculaire :422.33Icenticaftor
CAS :<p>Icenticaftor (QBW251) is an orally active potentiator of CFTR channel.</p>Formule :C12H13F6N3O3Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :361.24CFTR(inh)-172
CAS :<p>CFTR(inh)-172 (CFTR Inhibitor-172) is a voltage-independent, selective CFTR inhibitor.</p>Formule :C18H10F3NO3S2Degré de pureté :98% - 99.72%Couleur et forme :SolidMasse moléculaire :409.4Nesolicaftor
CAS :<p>Nesolicaftor (PTI-428) specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis.</p>Formule :C18H18N4O4Degré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :354.36Tezacaftor
CAS :<p>Tezacaftor (VX661) is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.</p>Formule :C26H27F3N2O6Degré de pureté :98.84% - >99.99%Couleur et forme :SolidMasse moléculaire :520.5SRI-41315
CAS :<p>SRI-41315 is an eRF1 degrader that acts as a molecular glue at the ribosomal decoding center.SRI-41315 induces extended pauses at the termination codon.</p>Formule :C22H19N3O2Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :357.41Steviol
CAS :<p>1.</p>Formule :C20H30O3Degré de pureté :98% - 99.92%Couleur et forme :SolidMasse moléculaire :318.45GLPG-3221
CAS :<p>GLPG-3221, a potent oral CFTR corrector for cystic fibrosis treatment, has an EC50 of 105 nM.</p>Formule :C30H37F3N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :578.62CFTR corrector 9
CAS :<p>CFTR corrector 9 is a CF modulator used to research cystic fibrosis and related disorders.</p>Formule :C16H14N2O4Degré de pureté :98.24%Couleur et forme :SolidMasse moléculaire :298.29Posenacaftor
CAS :<p>Posenacaftor (PTI-801) regulates CFTR protein for cystic fibrosis research.</p>Formule :C27H27NO5Couleur et forme :SolidMasse moléculaire :445.51Posenacaftor sodium
CAS :<p>Posenacaftor (PTI-801) sodium, a CFTR modulator for CF research, corrects CFTR protein folding and trafficking.</p>Formule :C27H27NNaO5Couleur et forme :SolidMasse moléculaire :468.505Corrector C4
CAS :<p>Corrector C4, a corrector commonly used to study cystic fibrosis mutants, works by alleviating the interaction between CFTR transmembrane domain mutants and</p>Formule :C21H17ClN4O2S2Degré de pureté :98.36%Couleur et forme :SolidMasse moléculaire :456.97Galicaftor
CAS :<p>ABBV-2222 is a CFTR corrector which is studied for the treatment of cystic fibrosis (CF).</p>Formule :C28H21F4NO7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :559.46(R)-Posenacaftor sodium
CAS :<p>(R)-Posenacaftor sodium is a modulator for correcting cystic fibrosis protein folding.</p>Formule :C27H27NNaO5Couleur et forme :SolidMasse moléculaire :468.505(R)-Olacaftor
CAS :<p>(R)-Olacaftor (VX-440) is a CFTR modulator with promise for researching cystic fibrosis.</p>Formule :C29H34FN3O4SCouleur et forme :SolidMasse moléculaire :539.66Ivacaftor-D9
CAS :<p>CTP-656, a cystic fibrosis transmembrane conductance regulator (CFTR) channel activator, is used potentially for the treatment of cystic fibrosis.</p>Formule :C24H19D9N2O3Couleur et forme :SolidMasse moléculaire :401.55AF-2785
CAS :<p>In epididymal epithelial cells, AF-2785 inhibits cystic fibrosis transmembrane conductance regulator Cl(-) channels.</p>Formule :C17H12Cl2N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :347.2SRI-37240
CAS :<p>SRI-37240 suppresses CFTR nonsense mutations, aids in fixing premature termination codons, works with G418.</p>Formule :C24H23N3O2Degré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :385.46VRT-532
CAS :<p>VRT-532 (CFpot-532) is an effective modulator of CFTR and is commonly used in studies of cystic fibrosis (CF) caused by CFTR defects.</p>Formule :C16H14N2ODegré de pureté :99.88% - 99.93%Couleur et forme :SolidMasse moléculaire :250.3Bamocaftor
CAS :<p>Bamocaftor corrects CFTR in CF, restoring F508del-CFTR function, used with tezacaftor and VX-561 for F508del/MF patients.</p>Formule :C28H32F3N5O4SDegré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :591.65Crinecerfont
CAS :<p>Crinecerfont (SSR-125543) is a CRF1 antagonist, useful in congenital adrenal hyperplasia research.</p>Formule :C27H28ClFN2OSDegré de pureté :98.01% - 98.55%Couleur et forme :SolidMasse moléculaire :483.04UCCF-853
CAS :<p>UCCF-853 是一种小分子 CFTR 调节剂，可用于研究囊性纤维化。</p>Formule :C14H8ClF3N2ODegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :312.67PG01
CAS :<p>PG01 is a potent CFTR Cl-channel potentiator, effective against ΔF508 (Ka 0.3 μM), and also against E193K, G970R and G551D (CFTR mutants), with Kd values of 0.</p>Formule :C28H29N3O2Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :439.55CFTR corrector 8
CAS :<p>CFTR corrector 8: potent for cystic fibrosis research, modulates CFTR protein.</p>Formule :C29H27F2NO7Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :539.52CFTR corrector 12
CAS :<p>CFTR corrector 12 is a CFTR corrector that rescues all mutant proteins except M760R ABCA3 and can be used to study cystic fibrosis.</p>Formule :C19H21ClN4O2S2Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :436.98CP 154526
CAS :<p>CRF1 receptor antagonist</p>Formule :C23H33ClN4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :400.99
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