Canal TRP/TRPV
Les canaux TRP (récepteur potentiel transitoire), y compris la sous-famille TRPV, sont un groupe de canaux ioniques impliqués dans divers processus sensoriels, tels que la sensation de température, la perception de la douleur et l'osmorégulation. Les canaux TRP sont largement exprimés dans différents tissus et jouent un rôle dans les réponses physiologiques aux stimuli environnementaux. Les canaux TRPV, en particulier, sont impliqués dans la détection des changements de température et sont associés à des conditions telles que la douleur chronique, l'inflammation et le cancer. Chez CymitQuimica, nous proposons une gamme complète de modulateurs de canaux TRP/TRPV pour soutenir vos recherches en biologie sensorielle, gestion de la douleur et transduction du signal.
95 produits trouvés pour "Canal TRP/TRPV"
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AMG 333
CAS :AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine.Formule :C20H12F5N3O4Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :453.32AMG 517
CAS :AMG 517 is an effective and specific TRPV1 antagonist, antagonizes proton (IC50: 0.76 nM), capsaicin (IC50: 0.62 nM) and heat activation (IC50: 1.3 nM) of TRPV1Formule :C20H13F3N4O2SDegré de pureté :99.77% - 99.85%Couleur et forme :SolidMasse moléculaire :430.4cim0216
CAS :CIM0216 is a synthetic TRPM3 activator whose potency and apparent affinity greatly exceeds that of the canonical TRPM3 agonist.Formule :C21H21N3O2Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :347.41Ref: TM-T9263
1mg44,00€2mg56,00€5mg87,00€1mL*10mM (DMSO)96,00€10mg138,00€25mg281,00€50mg442,00€100mg665,00€500mg1.378,00€Chembridge-5861528
CAS :Chembridge-5861528 (TCS 5861528) is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 values of 14.3 and 18.7 μM.Formule :C19H23N5O3Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :369.42ASP7663
CAS :ASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo.Formule :C14H14FNO3Degré de pureté :98.61%Couleur et forme :SolidMasse moléculaire :263.26RQ-00203078
CAS :RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist.Formule :C21H13ClF6N2O5SDegré de pureté :98% - 99.6%Couleur et forme :SolidMasse moléculaire :554.85A-967079
CAS :A 967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively
Formule :C12H14FNODegré de pureté :98.34% - 99.75%Couleur et forme :SolidMasse moléculaire :207.24SB-705498
CAS :SB705498 is a TRPV1 antagonist for hTRPV1. SB-705498 has been investigated for the treatment of Rhinitis, Chronic Cough, and Non-allergic Rhinitis.Formule :C17H16BrF3N4ODegré de pureté :99.57% - ≥95%Couleur et forme :SolidMasse moléculaire :429.23MDR-652
CAS :MDR-652 is a highly specific and efficacious agonist of nonpungent transient receptor potential vanilloid 1 (TRPV1) with Ki value of 11.4 nM and 23.8 nM forFormule :C22H23ClFN3O2SDegré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :447.95Ref: TM-T22360
1mg60,00€2mg87,00€5mg130,00€1mL*10mM (DMSO)142,00€10mg178,00€25mg331,00€50mg512,00€100mg707,00€200mg973,00€RN-1747
CAS :RN-1747: TRPV4 agonist (EC50: human 0.77 μM, mouse 4.0 μM, rat 4.1 μM), TRPM8 antagonist (IC50: 4 μM).Formule :C17H18ClN3O4SDegré de pureté :99.29%Couleur et forme :SolidMasse moléculaire :395.86JNJ-28583113
CAS :JNJ-28583113 is a TRPM2 antagonist, inducing phosphorylation of GSK3α and β subunits, protecting cells from oxidative stress-induced cell death.Formule :C19H21F3N2O2Degré de pureté :98.57%Couleur et forme :SolidMasse moléculaire :366.38Ref: TM-T74779
1mg94,00€5mg193,00€1mL*10mM (DMSO)213,00€10mg241,00€25mg387,00€50mg591,00€100mg754,00€200mg1.046,00€SAR7334
CAS :SAR7334 (TRCP6-IN-1) is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM).Formule :C21H22ClN3ODegré de pureté :99.62% - 99.71%Couleur et forme :SolidMasse moléculaire :367.87Ref: TM-T12849
1mg67,00€2mg88,00€5mg152,00€1mL*10mM (DMSO)166,00€10mg236,00€25mg295,00€50mg349,00€100mg439,00€200mg628,00€AM12
CAS :AM12 inhibits Lanthanide-evoked TRPC5 activity (IC50: 0.28 μM).Formule :C15H9BrO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :349.13Asivatrep
CAS :Asivatrep (PAC14028) is a selective and potent antagonist of transient receptor potential vanilloid subtype 1 (TRPV1) for the study of atopic dermatitis.Formule :C21H22F5N3O3SDegré de pureté :95.13%Couleur et forme :SolidMasse moléculaire :491.48GSK1702934A
CAS :GSK1702934A is a TRPC3 agonist with pro-arrhythmic and positive inotropic effects and is used in the study of diabetes mellitus.Formule :C22H25N3O2SDegré de pureté :98.15%Couleur et forme :SolidMasse moléculaire :395.52N-Oleoyl Valine
CAS :N-Oleoyl valine, an N-acyl amine, antagonizes TRPV3 for thermoregulation; rises post-cold exposure; elevates in mouse lung injury.Formule :C23H43NO3Masse moléculaire :381.59TRPC6-PAM-C20
CAS :TRPC6-PAM-C20, a selective enhancer for TRPC6, boosts calcium in HEK cells and OAG-related platelet clumping, EC50: 2.37μM.Formule :C22H21NO4Degré de pureté :98.16%Couleur et forme :SolidMasse moléculaire :363.41D-3263 hydrochloride
CAS :D-3263 hydrochloride (D3263 HCl salt) is enteric-coated, orally bioavailable transient receptor potential melatonin member 8 (TRPM8) agonist.
Formule :C21H32ClN3O3Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :409.95TRPV4 agonist-1
CAS :TRPV4 agonist-1 is an agonist of TRPV4 (EC50: 60 nM in the hTRPV4 Ca2+ assay).Formule :C25H23ClF2N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :484.93TRPM4-IN-2
CAS :NBA, or TRPM4-IN-2, is a potent TRPM4 inhibitor with IC50 of 0.16 μM, used in prostate and colorectal cancer research.Formule :C19H14ClNO4Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :355.77JYL 1421
CAS :JYL 1421 (SC 0030) is an antagonist of TRPV1 receptor (IC50 = 8 nM).Formule :C20H26FN3O2S2Degré de pureté :98.83%Couleur et forme :SolidMasse moléculaire :423.57Ref: TM-T15634
1mg66,00€1mL*10mM (DMSO)170,00€5mg177,00€10mg289,00€25mg580,00€50mg888,00€100mg1.414,00€200mg1.882,00€RN9893
CAS :RN9893 is a selective and potent TRPV4 receptor antagonist with IC50 values of 320, 420 and 660 nM for TRPV4 receptors in mouse, human and rat, respectively.Formule :C21H23F3N4O5SDegré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :500.49TRPV3 antagonist 74a
CAS :TRPV3 antagonist 74a (TRPV3 74a) is a specific TRPV3 antagonist for the study of neurological disorders.Formule :C17H17F3N2O2Degré de pureté :≥98.0%Couleur et forme :SolidMasse moléculaire :338.32Olvanil
CAS :Olvanil (N-Vannilyloleoylamide) is a vanilloid receptor agonist with EC50 of 0.7nM.Formule :C26H43NO3Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :417.62Ref: TM-T23106
2mg34,00€5mg49,00€1mL*10mM (DMSO)50,00€10mg75,00€25mg145,00€50mg236,00€100mg385,00€200mg560,00€SET 2
CAS :SET 2 is an antagonist of transient receptor potential vanilloid type 2(TRPV2) with an IC50 of 0.46 μM. SET 2 shows selectivity over TRPV1, TRPV3 and TRPV4.Formule :C17H21F3N4O2SDegré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :402.43Ref: TM-T37097
500mgÀ demander5mg55,00€1mL*10mM (DMSO)67,00€10mg92,00€25mg168,00€50mg284,00€100mg414,00€Elismetrep
CAS :Elismetrep (MT-8554) is an orally available TRPM8 inhibitor with potential analgesic activity for the study of vasomotor symptoms in postmenopausal women.Formule :C27H21F3N2O5SDegré de pureté :99.37% - 99.93%Couleur et forme :SolidMasse moléculaire :542.53HC-070
CAS :HC-070 is a TRPC5 and TRPC4 antagonist (IC50 = 9.3 nM and 46 nM).Formule :C22H20Cl2N4O4Degré de pureté :98.48%Couleur et forme :SolidMasse moléculaire :475.32Ref: TM-T15465
1mg84,00€5mg160,00€1mL*10mM (DMSO)165,00€10mg236,00€25mg406,00€50mg572,00€100mg772,00€200mg1.035,00€Mavatrep
CAS :Mavatrep (JNJ-39439335) is a selective antagonist of TRPV1 with Ki of 6.5 nM and can be used for studies about inflammatory pain.Formule :C25H21F3N2ODegré de pureté :98.51% - 99.31%Couleur et forme :SolidMasse moléculaire :422.44Ref: TM-T16014
1mg63,00€2mg90,00€5mg137,00€1mL*10mM (DMSO)150,00€10mg215,00€25mg385,00€50mg618,00€100mg888,00€200mg1.243,00€MSP3
CAS :MSP3 is an agonist of TRPV1 (EC50 = 0.87 μM) and shows antinociceptive and neuroprotective effects.Formule :C16H19NO3SDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :305.39Ref: TM-T28118
2mg33,00€5mg50,00€1mL*10mM (DMSO)71,00€10mg80,00€25mg161,00€50mg243,00€100mg358,00€200mg505,00€TC-I 2014
CAS :TC-I 2014 shows antiallodynic properties in pain models.Formule :C23H19F6N3ODegré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :467.41Ref: TM-T17006
1mg57,00€5mg120,00€1mL*10mM (DMSO)126,00€10mg192,00€25mg385,00€50mg620,00€100mg1.018,00€200mg1.378,00€FEMA-4809
CAS :FEMA-4809 activates TRPM8, the ion channel for cold sensation, and is used as a cooling agent.Formule :C17H17N3O2SDegré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :327.4Ref: TM-T27308
1mg34,00€5mg73,00€1mL*10mM (DMSO)84,00€10mg110,00€25mg180,00€50mg255,00€100mg363,00€200mg497,00€Pyr3
CAS :Pyr3 selectively blocks TRPC3 channels, reducing Ca2+ influx; it's effective at 700 nM.Formule :C16H11Cl3F3N3O3Degré de pureté :98.04%Couleur et forme :SolidMasse moléculaire :456.63Ref: TM-T16687
1mg35,00€2mg52,00€5mg77,00€1mL*10mM (DMSO)86,00€10mg97,00€25mg215,00€50mg363,00€100mg512,00€200mg738,00€500mg1.121,00€ABT 102
CAS :ABT 102 (CHEMBL398338) is a selective antagonist of transient receptor potential vanilloid 1 (TRPV1) receptor.Formule :C21H24N4ODegré de pureté :98.38% - 99.86%Couleur et forme :SolidMasse moléculaire :348.44Ref: TM-T29522
1mg109,00€5mg235,00€1mL*10mM (DMSO)245,00€10mg349,00€25mg532,00€50mg745,00€100mg999,00€200mg1.333,00€JT010
CAS :JT010 is an effective agonist of TRPA1 (EC50 = 0.65 nM).Formule :C16H19ClN2O3SDegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :354.85PF-05105679
CAS :PF-05105679 is a selective TRPM8 antagonist (IC50 = 103 nM). PF-05105679 can be used in research on cold-related pain.Formule :C26H21FN2O3Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :428.45Ref: TM-T16483
1mg44,00€2mg57,00€1mL*10mM (DMSO)90,00€5mg93,00€10mg138,00€25mg264,00€50mg404,00€100mg610,00€200mg848,00€GSK3395879
CAS :GSK3395879 is a selective and orally bioavailable antagonist of transient receptor potential vanilloid-4 (TRPV4) (IC50: 1 nM for hTRPV4).Formule :C20H15F4N3O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :485.41Mesendogen
CAS :Mesendogen is an inhibitor of transient receptor potential cation channel, subfamily M, member 6 (TRPM6) and 7 (TRPM7) and acts by inhibiting TRPM6/TRPM7Formule :C18H16ClF3N2OSDegré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :400.85A-1165442
CAS :A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9 nM.Formule :C22H20ClF2N3O2Couleur et forme :SolidMasse moléculaire :431.86MK-2295
CAS :MK-2295 is a potent TRPV1 antagonist. MK-2295 can be used in studies about the treatment of chronic pain.Formule :C27H31FN6O2Degré de pureté :98.83% - 99.44%Couleur et forme :SolidMasse moléculaire :490.57AMG-0347
CAS :AMG-0347 inhibits TRPA1 ion channels in sensory neurons, blocking pain perception.Formule :C24H26F3N3O2Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :445.48Ref: TM-T29968
1mg215,00€5mg523,00€1mL*10mM (DMSO)537,00€10mg695,00€25mg1.054,00€50mg1.414,00€100mg1.900,00€200mg2.565,00€AMG2850
CAS :AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8).Formule :C19H17F6N3ODegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :417.35Ref: TM-T10300
1mg71,00€5mg161,00€1mL*10mM (DMSO)172,00€10mg235,00€25mg423,00€50mg627,00€100mg803,00€ELP-004
CAS :ELP-004 is a TRPC channel inhibitor that blocks Ca2+ entry mediated by TRPC channels. It serves as an osteoclast inhibitor by preventing osteoclast differentiation. ELP-004 also hinders basal Ca2+ levels and the associated translocation of NFATc1 in inflammatory osteoclastogenesis. Additionally, it reduces bone erosion in mouse models of rheumatoid arthritis.Formule :C10H11Cl2NOCouleur et forme :SolidMasse moléculaire :232.106TRPA1 Antagonist 1
CAS :TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.Formule :C24H20F6N5Na2O7PSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :713.45Apcin A HCL
CAS :Apcin A HCL is an Apcin derivative. Apcin A HCL is an anaphase-promoting complex (APC) inhibitor. Apcin-A HCL interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A HCL can be used to synthesize the PROTAC CP5V [1].
Formule :C10H15Cl4N5O2Degré de pureté :99.30%Couleur et forme :SolidMasse moléculaire :379.07Ref: TM-T001
Produit arrêtéMotugivatrep
CAS :Motugivatrep is a potent and selective TRPV1 antagonist that can be used to study TRPV1-related respiratory diseases.
Formule :C22H20F3NO3Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :403.39
