P-gp
La P-glycoprotéine est une pompe d'efflux dépendante de l'ATP qui transporte une grande variété de substrats, y compris des médicaments, des toxines et des lipides, hors des cellules. Elle joue un rôle crucial dans la résistance aux médicaments, en particulier dans le cancer, en réduisant la concentration intracellulaire des agents chimiothérapeutiques. La P-gp est également impliquée dans la barrière hémato-encéphalique, influençant l'exposition du système nerveux central à divers composés. Chez CymitQuimica, nous proposons une gamme de modulateurs de la P-gp pour soutenir vos recherches en résistance aux médicaments, pharmacocinétique et développement thérapeutique.
55 produits trouvés pour "P-gp"
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Norverapamil hydrochloride
CAS :Norverapamil HCl, a Verapamil metabolite, blocks L-type calcium channels and inhibits P-gp function.Formule :C26H37ClN2O4Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :477.04Ref: TM-T16339
1mg34,00€5mg105,00€1mL*10mM (DMSO)110,00€10mg177,00€25mg299,00€50mg447,00€100mg602,00€200mg842,00€Zamicastat
CAS :Zamicastat (BIA 5-1058) inhibits DBH, P-gp (IC50=73.8μM), and BCRP (IC50=17.0μM).Formule :C21H21F2N3OSDegré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :401.47Ref: TM-T13383
1mg92,00€5mg193,00€1mL*10mM (DMSO)210,00€10mg293,00€25mg528,00€50mg795,00€100mg1.153,00€Risperidone
CAS :Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.Formule :C23H27FN4O2Degré de pureté :99.73%Couleur et forme :Crystalline SolidMasse moléculaire :410.48Ref: TM-T0351
10mg48,00€1mL*10mM (DMSO)50,00€25mg56,00€50mg88,00€100mg122,00€200mg192,00€500mg323,00€Glibenclamide
CAS :Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.Formule :C23H28ClN3O5SDegré de pureté :99.05% - 99.75%Couleur et forme :SolidMasse moléculaire :494.00Trifluoperazine dihydrochloride
CAS :Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.Formule :C21H26Cl2F3N3SDegré de pureté :99.57% - 99.96%Couleur et forme :Cream Fine PowderMasse moléculaire :480.43Piperine
CAS :Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.
Formule :C17H19NO3Degré de pureté :98.41% - 98.51%Couleur et forme :SolidMasse moléculaire :285.34Dofequidar fumarate
CAS :Dofequidar fumarate (MS-209)(MS-209 fumarate), a quinoline-based compound administered orally, is known for counteracting multidrug resistance (MDR) through the
Formule :C34H35N3O7Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :597.66Ref: TM-T11071
1mg39,00€2mg50,00€5mg85,00€10mg125,00€25mg245,00€50mg472,00€100mg687,00€500mg1.444,00€Encequidar mesylate
CAS :Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor.
Formule :C39H40N6O10SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :784.83Atazanavir sulfate
CAS :Atazanavir sulfate, an azapeptide HIV-protease inhibitor, treats HIV/AIDS alongside other anti-HIV drugs.Formule :C38H52N6O7·H2SO4Degré de pureté :99.31% - 99.40%Couleur et forme :SolidMasse moléculaire :802.93Ref: TM-T0100
5mg44,00€1mL*10mM (DMSO)50,00€10mg58,00€25mg90,00€50mg114,00€100mg170,00€200mg250,00€500mg425,00€(20S)-Protopanaxadiol
CAS :(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-typeFormule :C30H52O3Degré de pureté :97.07% - 98.91%Couleur et forme :SolidMasse moléculaire :460.73Atazanavir
CAS :Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.Formule :C38H52N6O7Degré de pureté :98% - 99.95%Couleur et forme :Crystalline SolidMasse moléculaire :704.86Verapamil hydrochloride
CAS :Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.Formule :C27H39ClN2O4Degré de pureté :98.7% - 99.98%Couleur et forme :White To Off-White PowderMasse moléculaire :491.06P-gp inhibitor 14
CAS :Compound 8a, also known as P-gp inhibitor 14, demonstrates high affinity as a P-gp inhibitor and effectively reverses P-gp-mediated multidrug resistance (EC 50 = 48.74 nM). Additionally, this compound exhibits a weak inhibitory effect on CYP3A4 activity [1].Formule :C37H38N2O8Couleur et forme :SolidMasse moléculaire :638.71P-gp modulator-5
P-gp Modulator-5 (compound 25) serves as a modulator of P-gp, effectively inhibiting the proliferation of multidrug-resistant (MDR) tumors. This compound suppresses the function of drug efflux pumps in MDR cells, which results in significant accumulation of ROS and modifications in cell cycle profiles.Formule :C19H16N2O5Couleur et forme :SolidMasse moléculaire :352.34Evodine
CAS :1. Evodine has antinociceptive activity.Formule :C18H19NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :329.35CPI1
CPI1 is an effective and highly specific inhibitor of multidrug resistance protein 1 (MRP1). It exhibits inhibitory activity against MRP1 at the nanomolar level (Ki: 100 nM) and has minimal effect on P-glycoprotein (Pgp). CPI1 competes with LTC4 for binding to the same site on MRP1, inhibiting ATP hydrolysis and substrate transport. It is useful in research related to drug delivery and addressing cancer chemotherapy resistance.Formule :C111H131N23O30SCouleur et forme :SolidMasse moléculaire :2299.43FM04
CAS :FM04 is a potent oral P-gp inhibitor (EC50: 83 nM), disrupting human P-gp NBD2 to enhance cancer treatment.Formule :C26H25NO4Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :415.48P-gb-IN-1
CAS :P-gb-IN-1 is a potent P-glycoprotein (P-gp) inhibitor that exhibits reverse activity by inhibiting P-gp outflow.Formule :C30H28N2O6Degré de pureté :99.85%Couleur et forme :SoildMasse moléculaire :512.55Tariquidar methanesulfonate hydrate
CAS :m-PEG8-Ms is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC compounds.Formule :C40H58N4O18S2Degré de pureté :98.13%Couleur et forme :SolidMasse moléculaire :947.04YS-370
CAS :YS-370 orally blocks P-gp, moderately inhibits CYP3A4, reverses drug resistance, and enhances paclitaxel's anticancer effects.Formule :C37H35BrN4O3Degré de pureté :98.055%Couleur et forme :SolidMasse moléculaire :663.6Laniquidar TFA
Laniquidar TFA (R101933), a non-competitive P-gp inhibitor, has an IC50 of 0.51 μM; used to study AML and MDS, but with limited bioavailability.Formule :C39H37F3N4O5Degré de pureté :99.85%Couleur et forme :SoildMasse moléculaire :698.73WS-917
WS-917 is an efficacious and orally active regulator of ABCB1. It enhances the ABCB1 ATPase activity and significantly boosts the antitumor efficacy of combined paclitaxel and anti-PD-1 antibody therapy. WS-917 also promotes the activation of CD8+ T cells.Formule :C16H13N5OS2Couleur et forme :SolidMasse moléculaire :355.44Valspodar
CAS :Valspodar (PSC 833) is a specific P-glycoprotein inhibitor and MDR regulator often used as a chemical sensitizer to study advanced epithelial ovarian cancer.Formule :C63H111N11O12Degré de pureté :95% - >99.99%Couleur et forme :SolidMasse moléculaire :1214.62P-gp inhibitor 25
CAS :P-gp Inhibitor 25 (compound 16c) is a P-gp inhibitor that enhances the oral absorption of paclitaxel. It is utilized in cancer research to improve treatment efficacy.Formule :C41H36N4O8Masse moléculaire :712.75Solamargine
CAS :Solamargine, a steroidal alkaloid from Solanum nigrum, inhibits cancer cell growth and induces apoptosis.Formule :C45H73NO15Degré de pureté :99.17% - 99.96%Couleur et forme :SolidMasse moléculaire :868.06Ref: TM-T4034
1mg56,00€2mg78,00€5mg109,00€1mL*10mM (DMSO)158,00€10mg165,00€25mg289,00€50mg434,00€100mg655,00€200mg883,00€Ceefourin 1
CAS :Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.Formule :C11H10N4S3Degré de pureté :99.15%Couleur et forme :SolidMasse moléculaire :294.42Ref: TM-T8596
1mg43,00€1mL*10mM (DMSO)87,00€5mg88,00€10mg119,00€25mg250,00€50mg389,00€100mg550,00€200mg785,00€Paris saponin VII
CAS :Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.Formule :C51H82O21Degré de pureté :99.51% - 99.63%Couleur et forme :SolidMasse moléculaire :1031.18Polyoxyethylene stearate
CAS :Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.Formule :C20H40O3Degré de pureté :n~9-10Couleur et forme :Light Amber SemisolidMasse moléculaire :328.29775Isosinensetin
CAS :1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities.Formule :C20H20O7Degré de pureté :99.98% - ≥95%Couleur et forme :SolidMasse moléculaire :372.37Ref: TM-T2S0223
1mg63,00€5mg135,00€1mL*10mM (DMSO)165,00€10mg195,00€25mg326,00€50mg485,00€100mg700,00€Voacamine
CAS :Voacamine: an indole alkaloid, CB1 antagonist, inhibits P-gp, may affect rhythm.
Formule :C43H52N4O5Degré de pureté :98.54% - 99.82%Couleur et forme :SolidMasse moléculaire :704.9Tariquidar
CAS :Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines.Formule :C38H38N4O6Degré de pureté :98.07% - 99.45%Couleur et forme :SolidMasse moléculaire :646.73Selamectin
CAS :Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening inFormule :C43H63NO11Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :769.96Phellamurin
CAS :Phellamurin blocks intestinal P-glycoprotein dose-dependently and it seriously interacts with cyclosporin; coadministration should be avoided.Formule :C26H30O11Degré de pureté :97.91%Couleur et forme :SolidMasse moléculaire :518.51Ref: TM-TN4761
1mg155,00€5mg304,00€1mL*10mM (DMSO)389,00€10mg447,00€25mg713,00€50mg1.018,00€100mg1.369,00€Sinapine
CAS :Sinapine: an alkaloid with chemo-resistance, antioxidant, and radioprotective properties from cruciferous seeds.Formule :C16H24NO5Degré de pureté :98% - 99.68%Couleur et forme :White Or Light-Tan SolidMasse moléculaire :310.37Convallatoxin
CAS :Convallatoxin is a natural product.Formule :C29H42O10Degré de pureté :99.27% - 99.53%Couleur et forme :Prisms From Methanol + Ether SolidMasse moléculaire :550.64Zosuquidar trihydrochloride
CAS :Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.Formule :C32H31F2N3O2·3HClDegré de pureté :99.49% - >99.99%Couleur et forme :SolidMasse moléculaire :636.99Hypophyllanthin
CAS :Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.Formule :C24H30O7Degré de pureté :98.39%Couleur et forme :SolidMasse moléculaire :430.49Zosuquidar
CAS :Zosuquidar (RS 33295-198) is a potent P-glycoprotein inhibitor with antitumor activity that inhibits tumor growth.Formule :C32H31F2N3O2Degré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :527.6Ref: TM-T6018L
1mg73,00€5mg152,00€1mL*10mM (DMSO)170,00€10mg220,00€25mg358,00€50mg537,00€100mg782,00€200mg1.071,00€HM-30181 mesylate monohydrate
CAS :HM-30181 mesylate monohydrate is an oral P-glycoprotein (P-gp) inhibitor, used to enhance the oral bioavailability of P-gp substrate drugs.Formule :C39H42N6O11SDegré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :802.85Ref: TM-T9173
1mg65,00€2mg94,00€5mg119,00€1mL*10mM (DMSO)177,00€10mg185,00€25mg309,00€50mg442,00€100mg643,00€200mg835,00€500mg1.251,00€Encequidar
CAS :Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.Formule :C38H36N6O7Degré de pureté :98.72% - 99.93%Couleur et forme :SolidMasse moléculaire :688.73Ref: TM-T8426
1mg46,00€2mg62,00€5mg90,00€1mL*10mM (DMSO)127,00€10mg137,00€25mg234,00€50mg360,00€100mg528,00€Trifluoperazine
CAS :Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.Formule :C21H24F3N3SDegré de pureté :98.3% - 99.46%Couleur et forme :White To Yellowish Crystalline PowderMasse moléculaire :407.5γ-Tocotrienol
CAS :γ-Tocotrienol (Plastochromanol) is one of the four types of tocotrienol, a type of vitamin E.Formule :C28H42O2Degré de pureté :97.27% - 98.13%Couleur et forme :SolidMasse moléculaire :410.63Ref: TM-T19768
1mg44,00€2mg58,00€1mL*10mM (DMSO)92,00€5mg96,00€10mg137,00€25mg224,00€50mg333,00€100mg489,00€200mg705,00€Sinapine thiocyanate
CAS :Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds.Formule :C16H24NO5·CNSDegré de pureté :99.79% - ≥95%Couleur et forme :SolidMasse moléculaire :368.45Talinolol
CAS :(±)-Talinolol is a selective β1 adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity.Formule :C20H33N3O3Degré de pureté :98.8%Couleur et forme :SolidMasse moléculaire :363.49Ref: TM-T21640
2mg34,00€5mg52,00€1mL*10mM (DMSO)52,00€10mg92,00€25mg178,00€50mg313,00€100mg535,00€200mg775,00€Elacridar
CAS :Elacridar (GG918) is a potent inhibitor of P-glycoprotein and BCRP.Cost-effective and quality-assured.Formule :C34H33N3O5Degré de pureté :98.12% - >99.99%Couleur et forme :SolidMasse moléculaire :563.64Chrysosplenetin
CAS :Chrysosplenetin is a metabolic inhibitor of artemisinin.Formule :C19H18O8Degré de pureté :97.43% - 98.4%Couleur et forme :SolidMasse moléculaire :374.34Ref: TM-TJS1159
1mg57,00€5mg120,00€10mg178,00€1mL*10mM (DMSO)215,00€25mg329,00€50mg485,00€100mg692,00€500mg1.404,00€HTT-D3
CAS :HTT-D3 is a Huntington splicing regulator that induces HTT mRNA degradation, leading to a reduction in HTT protein levels.
Formule :C23H25FN6Degré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :404.48Verapamil
CAS :Verapamil (CP-16533-1), an oral calcium channel blocker, inhibits P-gp and CYP3A4, used for hypertension, arrhythmias, and angina research.Formule :C27H38N2O4Degré de pureté :99.61% - 99.93%Couleur et forme :OilMasse moléculaire :454.6Ref: TM-T20656
10mg34,00€25mg49,00€1mL*10mM (DMSO)52,00€50mg70,00€100mg90,00€200mg136,00€500mg219,00€P-gp inhibitor 1
CAS :P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 cells).Formule :C32H31N5O2Degré de pureté :98.65%Couleur et forme :SolidMasse moléculaire :517.62Ref: TM-T12341
5mg50,00€1mL*10mM (DMSO)58,00€10mg84,00€25mg150,00€50mg219,00€100mg304,00€200mg419,00€P-gp inhibitor 17
CAS :P-gp Inhibitor 17 (compound 2g), a potent inhibitor, directly interacts with the transmembrane domain of P-gp. This compound is useful for studying P-gp-mediated multidrug resistance in tumor cells [1].Formule :C36H49N3O3Couleur et forme :SolidMasse moléculaire :571.79
