Canal sodique
Les canaux sodiques sont des protéines membranaires essentielles qui permettent le passage des ions sodium (Na+) à travers la membrane cellulaire, générant et propageant des signaux électriques dans les neurones, les cellules musculaires et d'autres tissus excitables. Ces canaux sont vitaux pour l'initiation et la conduction des potentiels d'action, ce qui les rend cruciaux dans des processus tels que la transmission de l'influx nerveux, la contraction musculaire et la fonction cardiaque. La dysrégulation des canaux sodiques peut entraîner des troubles neurologiques, des arythmies et des conditions de douleur chronique. Chez CymitQuimica, nous proposons une variété de modulateurs de canaux sodiques pour soutenir vos recherches en neurobiologie, cardiologie et gestion de la douleur.
202 produits trouvés pour "Canal sodique"
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λ-Cyhalothrin
CAS :<p>λ-Cyhalothrin (Icon) is a type II synthetic pyrethroid insecticide featuring a high-efficiency, broad-spectrum formula with an α-cyano group.</p>Formule :C23H19ClF3NO3Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :449.85Rimeporide
CAS :<p>Rimeporide (EMD-87580) (EMD-87580) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.</p>Formule :C11H15N3O5S2Degré de pureté :97.66%Couleur et forme :SolidMasse moléculaire :333.38Flecainide hydrochloride
CAS :<p>Flecainide is a medication used to prevent and treat abnormally fast heart rates. This includes ventricular and supraventricular tachycardias.</p>Formule :C17H21ClF6N2O3Degré de pureté :97.79%Couleur et forme :SolidMasse moléculaire :450.81Raxatrigine
CAS :<p>Raxatrigine (CNV 1014802) has been investigated for the treatment of Bipolar Disorder and Bipolar Depression.</p>Formule :C18H19FN2O2Degré de pureté :98% - 99.43%Couleur et forme :SolidMasse moléculaire :314.35N-Me-aminopyrimidinone9
CAS :<p>N-Me-aminopyrimidinone9 is a sodium channel antagonist</p>Formule :C16H21N3OSDegré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :303.42Levobupivacaine
CAS :<p>Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide.</p>Formule :C18H28N2ODegré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :288.43Propafenone hydrochloride
CAS :<p>Propafenone hydrochloride (Arythmol8) is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial.</p>Formule :C21H27NO3·HClDegré de pureté :99.67%Couleur et forme :White SolidMasse moléculaire :377.9Benzocaine xHCl(94-09-7(free base))
<p>Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na+ channel(IC50 of 0.8 mM tested with a potential of +30 mV).</p>Formule :C9H11NO2·xHClDegré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :N/AVX-150
CAS :<p>VX-150 is a highly selective NaV1.8 inhibitor relative to the other sodium channel subtypes (>400-fold).</p>Formule :C21H17F4N2O7PDegré de pureté :97.58%Couleur et forme :SolidMasse moléculaire :516.34PF-01247324
CAS :<p>PF-01247324 is a selective and orally bioavailable Nav1.8 channel blocker (IC50: 196 nM).</p>Formule :C13H10Cl3N3ODegré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :330.6PF 05089771
CAS :<p>PF 05089771 is a Selective inhibitor of Nav1.7 (IC50 = 11 nM) that interacts with the voltage-sensor domain of domain IV.</p>Formule :C18H12Cl2FN5O3S2Degré de pureté :99.03% - 99.42%Couleur et forme :SolidMasse moléculaire :500.35PF-05186462
CAS :<p>PF-05186462 (PF-05150122) is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.</p>Formule :C19H10ClF4N5O3S2Degré de pureté :99.10% - 99.37%Couleur et forme :SolidMasse moléculaire :531.89Ralfinamide mesylate
CAS :<p>Ralfinamide mesylate (FCE-26742A (mesylate)) is an orally available Na+ channel blocker.</p>Formule :C18H23FN2O5SDegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :398.45Ajmaline
CAS :<p>Ajmaline, a class Ia anti-arrhythmic, diagnoses Brugada syndrome and treats tachycardia; inhibits cardiac Kv1.5/Kv4.3 channels.</p>Formule :C20H26N2O2Degré de pureté :99.67% - 99.87%Couleur et forme :SolidMasse moléculaire :326.43ICA-121431
CAS :<p>ICA-121431: a potent Nav1.7 inhibitor (IC50=19 nM for rat), minimal effect on human Nav1.5/Nav1.7.</p>Formule :C23H19N3O3S2Degré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :449.55(+)-Kavain
CAS :<p>(+)-Kavain ((R)-KAWAIN) is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B.</p>Formule :C14H14O3Degré de pureté :97% - ≥95%Couleur et forme :White Fine PowderMasse moléculaire :230.26Benzamil
CAS :<p>Benzamil blocks ENaC, inhibiting sodium transport (IC50=4 nM) and binds with Kd=5 nM to bovine kidney membranes.</p>Formule :C13H14ClN7ODegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :319.7520(S)-Ginsenoside Rg3
CAS :<p>20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells.</p>Formule :C42H72O13Degré de pureté :98.11% - 99.93%Couleur et forme :SolidMasse moléculaire :785.01Dronedarone
CAS :<p>Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.</p>Formule :C31H44N2O5SDegré de pureté :98.85% - 99.58%Couleur et forme :SolidMasse moléculaire :556.76Evenamide
CAS :<p>Evenamide (NW-3509) is a sodium channel blocker. Which shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness.</p>Formule :C16H26N2O2Degré de pureté :96.74% - 99.15%Couleur et forme :SolidMasse moléculaire :278.39Metaflumizone
CAS :<p>Metaflumizone (BAS-320I) is a sodium channel blocker insecticide.</p>Formule :C24H16F6N4O2Degré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :506.40Cyfluthrin
CAS :<p>Cyfluthrin binds to voltage-sensitive sodium channel such as Nav 1.8 sodium channel and modify their gating kinetics, thereby disrupting nerve function of pests</p>Formule :C22H18Cl2FNO3Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :434.29A-803467
CAS :<p>A-803467 is a selective NaV1.8 channel blocker.</p>Formule :C19H16ClNO4Degré de pureté :96.94% - 98%Couleur et forme :SolidMasse moléculaire :357.79Metergoline
CAS :<p>Metergoline (Methergoline) is a dopamine agonist and serotonin antagonist.</p>Formule :C25H29N3O2Degré de pureté :99.83% - 99.97%Couleur et forme :SolidMasse moléculaire :403.52Tenapanor
CAS :<p>Tenapanor (RDX 5791), an NHE3 inhibitor, regulates sodium in the gut and kidney with a strong preclinical safety record and minimal side effects.</p>Formule :C50H66Cl4N8O10S2Degré de pureté :99.49% - 99.85%Couleur et forme :SolidMasse moléculaire :1145.05Dimethyl lithospermate B
CAS :<p>Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist.</p>Formule :C38H34O16Degré de pureté :98.34% - 99.62%Couleur et forme :SolidMasse moléculaire :746.67Eslicarbazepine Acetate
CAS :<p>Eslicarbazepine Acetate (Zebinix) is an anticonvulsant medication approved for use as an adjunctive therapy for partial-onset seizures.</p>Formule :C17H16N2O3Degré de pureté :99.58% - >99.99%Couleur et forme :White To Off-White SolidMasse moléculaire :296.32Nicainoprol
CAS :<p>Nicainoprol (RU-42924) is a fast-sodium-channel blocking drug. Nicainoprol is a potent antiarrhythmic agent.</p>Formule :C21H27N3O3Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :369.46Sodium ionophore III
CAS :<p>Sodium ionophore III (ETH2120) is a Na+ ionophore suitable for the test of sodium activity in plasma, serum, and blood.</p>Formule :C34H52N2O4Degré de pureté :99.51% - 99.78%Couleur et forme :SolidMasse moléculaire :552.79BI 01383298
CAS :<p>BI 01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5).</p>Formule :C19H19Cl2FN2O3SDegré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :445.34GS967
CAS :<p>GS967 is a potent, and selective inhibitor of cardiac late sodium current (late INa ).</p>Formule :C14H7F6N3ODegré de pureté :98% - >99.99%Couleur et forme :SolidMasse moléculaire :347.22Ranolazine
CAS :<p>Ranolazine (RS 43285-003) inhibits calcium uptake, treats chronic angina by targeting sodium/calcium channels to modulate intracellular sodium.</p>Formule :C24H33N3O4Degré de pureté :98.13%Couleur et forme :White SolidMasse moléculaire :427.54AZ194
CAS :<p>CRMP2-Ubc9-NaV1.7 inhibitor 194, is a CRMP2-Ubc9-NaV1.7 inhibitor.</p>Formule :C34H31F2N3O3Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :567.62RY785
CAS :<p>RY785 is a potent and selective inhibitor of voltage-gated potassium channel such as KV2.2 (IC50 = 50 nM). RY785 may be used in pain relief studies.</p>Formule :C21H20N4O2SDegré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :392.476-Benzoylheteratisine
CAS :<p>6-Benzoylheteratisine (Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth) is a Aconitum alkaloid.</p>Formule :C29H37NO6Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :495.61Benzonatate
CAS :<p>Benzonatate is an antagonist of sodium channel protein.</p>Formule :C30H53NO11Degré de pureté :99.92%Couleur et forme :Colorless To Faintly Yellow Oil LiquidMasse moléculaire :603.74PF-06869206
CAS :<p>PF-06869206 is an oral selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1, IC50: 380 nM).</p>Formule :C15H14ClF3N4O2Degré de pureté :99.79% - 99.88%Couleur et forme :SolidMasse moléculaire :374.75Levobupivacaine hydrochloride
CAS :<p>Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) is a reversible neuronal sodium channel inhibitor, used as a long-acting local anesthetic.</p>Formule :C18H28N2O·HClDegré de pureté :99.74%Couleur et forme :White Crystalline PowderMasse moléculaire :324.893-Deoxyaconitine
CAS :<p>3- Deoxyaconitine is a derivative of Aconitine (A189875), which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus</p>Formule :C34H47NO10Degré de pureté :98.31%Couleur et forme :SolidMasse moléculaire :629.74Ralfinamide
CAS :<p>Ralfinamide (Priralfinamide) is an orally available Na-channel blocker for the treatment of neuropathic pain and other pain conditions.</p>Formule :C17H19FN2O2Degré de pureté :99.41%Couleur et forme :SolidMasse moléculaire :302.34Riluzole
CAS :<p>Riluzole (RP-54274) is an anticonvulsant, glutamate antagonist, and prolongs ALS patient survival.</p>Formule :C8H5F3N2OSDegré de pureté :99.71% - 99.88%Couleur et forme :PowderMasse moléculaire :234.2N-Formylguanidine
CAS :Produit contrôléFormule :C2H5N3OCouleur et forme :Off-WhiteMasse moléculaire :87.081Benzocaine N-Glucoside (a/b mixture)
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications The N-Glucoside of Benzocaine (B202970) with anesthetic activity. A potential sun-screening agent.<br>References Rybczynska, B. et al.: Parfum. Kosm., 48, 125 (1967); Nikolin, A. et al.: Glas. Hemi. Tehnol. Bosne Herceg., 16, 93 (1968);<br></p>Formule :C15H21NO7Couleur et forme :NeatMasse moléculaire :327.33Propoxycaine hydrochloride
CAS :<p>Propoxycaine hydrochloride is an ester local anesthetic that inhibits voltage-gated sodium channels, modulates nerve impulses, and induces loss of sensation.</p>Formule :C16H27ClN2O3Degré de pureté :97.25%Couleur et forme :SolidMasse moléculaire :330.85Eleclazine
CAS :<p>Eleclazine (GS-6615) is a novel and selective voltage-gated sodium channel inhibitor with antiarrhythmic properties that reduces peak sodium current (INaP).</p>Formule :C21H16F3N3O3Degré de pureté :98.67%Couleur et forme :SolidMasse moléculaire :415.37Deacetamide Acetonitrile-pentisomide
CAS :Produit contrôlé<p>Applications Deacetamide Acetonitrile-pentisomide is an intermediate in the synthesis of Pentisomide (P275600). Pentisomide is a sodium channel blocker; derivative of disopyramide. Antiarrhythmic (class I).<br>References Kuhlkamp, V., et al.: Int. J. Cardiol., 36, 69 (1992); Yuan, S., et al.: Cardiovasc. Drug Rev., 11, 74 (1993)<br></p>Formule :C19H31N3Couleur et forme :NeatMasse moléculaire :301.47N-(Chloroacetyl)-2,5-dimethylaniline
CAS :Produit contrôlé<p>Applications N-(Chloroacetyl)-2,5-dimethylaniline is an intermediate in the synthesis of impurities of Lidocaine (L397800), an anesthetic local agent and antiarrythmic class IB agent.<br>References Groningsson, K., et al.: Anal. Profiles Drug Subs., 14, 207 (1985), Davies, P.S., et al.: Drugs, 64, 937 (2004),<br></p>Formule :C10H12ClNOCouleur et forme :NeatMasse moléculaire :197.663-(2-Chloropropionyl)amino-4-methyl-2-methoxycarbonylthiophene
CAS :Produit contrôlé<p>Applications 3-(2-Chloropropionyl)amino-4-methyl-2-methoxycarbonylthiophene is an intermediate in the synthesis of Articaine-d7 Hydrochloride which is the labelled form of Articaine Hydrochloride (A777905). Articaine Hydrochloride is the Hydrochloride Salt of Articaine (A777900). Articaine is an amide based short-acting local anesthetic use for regional anaesthesia in day-case settings such arthroscopy, hand, food surgery and in dentistry.<br>References Malamed, S.F., et al.: J. Am. Dent. Assoc., 132, 177 (2001); Luan, F., et al.: Bioorg. Med. Chem., 21, 1870 (2013)<br></p>Formule :C10H12ClNO3SCouleur et forme :NeatMasse moléculaire :261.73Methocarbamol D5
CAS :<p>Methocarbamol is a central muscle relaxant. Methocarbamol D5 is deuterium labeled Methocarbamol.</p>Formule :C11H15NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :246.27Propafenone D7 hydrochloride
CAS :<p>Propafenone D7 hydrochloride is the deuterium labeled Propafenone, and is a classic anti-arrhythmic medication.</p>Formule :C21H28ClNO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :384.95
