Canal sodique
Les canaux sodiques sont des protéines membranaires essentielles qui permettent le passage des ions sodium (Na+) à travers la membrane cellulaire, générant et propageant des signaux électriques dans les neurones, les cellules musculaires et d'autres tissus excitables. Ces canaux sont vitaux pour l'initiation et la conduction des potentiels d'action, ce qui les rend cruciaux dans des processus tels que la transmission de l'influx nerveux, la contraction musculaire et la fonction cardiaque. La dysrégulation des canaux sodiques peut entraîner des troubles neurologiques, des arythmies et des conditions de douleur chronique. Chez CymitQuimica, nous proposons une variété de modulateurs de canaux sodiques pour soutenir vos recherches en neurobiologie, cardiologie et gestion de la douleur.
202 produits trouvés pour "Canal sodique"
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3-Deoxyyunaconitine
CAS :Produit contrôlé<p>Applications 3-Deoxyyunaconitine is a metabolite of Aconitine (A189875), a neurotoxin that binds, activates tetrodotoxin-sensitive Na+ channels and prolongs the opening of the sodium-ion channel by suppressing conformational changes.<br>References Derbre, S., et al.: Anal. Bioanal. Chem., 398, 1747 (2010), Li, M., et al.: J. Pharm. Biomed. Anal., 53, 1063 (2010),<br></p>Formule :C35H49NO10Couleur et forme :NeatMasse moléculaire :643.761,2,4-Oxadiazol-3-amine
CAS :Produit contrôlé<p>Applications 1,2,4-oxadiazol-3-amine (cas# 39512-64-6) is a useful research chemical.<br></p>Formule :C2H3N3OCouleur et forme :NeatMasse moléculaire :85.066-(Propylamino)-2-hydroxy-N-(2,6-dimethylphenyl)hexanamide
Produit contrôlé<p>Applications 6-(Propylamino)-2-hydroxy-N-(2,6-dimethylphenyl)-hexanamide is a derivative of Bupivacaine (B689560), a sodium channel blocker, local anesthetic.<br>References Wilson, T.D., et al.: Anal. Profiles Drug Subs., 19, 59 (1990), McClellan, K.J., et al.: Drugs, 56, 355 (1998),<br></p>Formule :C17H28N2O2Couleur et forme :NeatMasse moléculaire :292.416Halofuginone
CAS :<p>Halofuginone (RU-19110) inhibits prolyl-tRNA synthetase (Ki=18.3 nM), down-regulates Smad3, and blocks TGF-β at 10 ng/ml.</p>Formule :C16H17BrClN3O3Degré de pureté :99.53%Couleur et forme :Off-White SolidMasse moléculaire :414.68Clopamide
CAS :<p>Clopamide (Brinaldix) is a piperidine and sulfamoylbenzamide-based diuretic with thiazide-like diuretic activity.</p>Formule :C14H20ClN3O3SDegré de pureté :99.71%Couleur et forme :White To Yellowish Crystalline PowderMasse moléculaire :345.84Nav1.7 inhibitor
CAS :<p>Nav1.7 inhibitor is a Nav1.7 inhibitor for research in the field of pain and anesthesia.</p>Formule :C15H11Cl3FNO4SDegré de pureté :97.52%Couleur et forme :SolidMasse moléculaire :426.68GX-585
CAS :<p>GX-585 is a novel potent inhibitor of NaV1.7 and highly selective against NaV1.5, having limited selectivity against NaV1.1 and NaV1.2.</p>Formule :C24H25Cl2FN4O3SDegré de pureté :99.02% - 99.03%Couleur et forme :SolidMasse moléculaire :539.45(5R)-BW-4030W92
CAS :<p>(5R)-BW-4030W92 is the R-type of BW-4030W92, the active enantiomer.</p>Formule :C11H9Cl2FN4Degré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :287.12Sodium Channel inhibitor 2
CAS :<p>Sodium Channel inhibitor 2 is a blocker of sodium channel.</p>Formule :C26H25Cl2N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :466.4GNE-0439
CAS :<p>GNE-0439 is a Nav1.7-selective inhibitor (IC50 0.34 μM), also targeting Nav1.5 and mutant N1742K channels, valuable for ion channel research.</p>Formule :C21H31NO3Degré de pureté :99.60%Couleur et forme :SolidMasse moléculaire :345.48E 0747
CAS :<p>E 0747 is an antiarrhythmic agent of class 1C type. E-0747 suppresses arrhythmia by inhibiting the Na channels of cardiac cells.</p>Formule :C21H28ClN3O4Degré de pureté :95.17%Couleur et forme :SolidMasse moléculaire :421.92GX-674
CAS :<p>GX-674 is a highly potent and selective voltage-gated sodium channel 1.7 (Nav1.7) antagonist with an IC50 value of 0.1 nM measured at -40 mV for the study of</p>Formule :C21H13ClF2N6O3S2Degré de pureté :98.60%Couleur et forme :SolidMasse moléculaire :534.95DPI 201-106
CAS :<p>DPI 201-106: cardioselective h1 Na channel inhibitor, enhances heart contraction, blocks potassium and calcium currents.</p>Formule :C29H30N4O2Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :466.57PF 05089771 tosylate
CAS :<p>PF-05089771 inhibits Nav1.7 channels (IC50: 11-33 nM), selective over Nav1.1-1.6/1.8, Ca+, K+ channels, TRPV1; 1000x affinity for half-inactivated state.</p>Formule :C18H12Cl2FN5O3S2·C7H8O3SDegré de pureté :98.55%Couleur et forme :SolidMasse moléculaire :672.56NHE3-IN-2
CAS :<p>NHE3-IN-2 is an inhibitor of NHE3 (Na+/H+ exchanger-3), applicable for treating hypertension, thrombosis, and ischaemic diseases.</p>Formule :C15H12ClN5Couleur et forme :SolidMasse moléculaire :297.74Halofuginone hydrobromide
CAS :<p>Halofuginone specifically inhibits collagen type I and MMP-2 gene expression, which may result in the suppression of angiogenesis and tumor cell growth.</p>Formule :C16H17BrClN3O3·HBrDegré de pureté :97.01% - 99.73%Couleur et forme :SolidMasse moléculaire :495.59Phenamil
CAS :<p>Phenamil is an inhibitor of epithelial sodium channels, activates the osteomorphin protein pathway to promote bone repair and induces significant fat formation.</p>Formule :C12H12ClN7ODegré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :305.72GDC-0276
CAS :<p>GDC-0276 is an orally active, selective, and potent NaV1.7 inhibitor that can be used for the study of pain-related diseases.</p>Formule :C24H31FN2O4SDegré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :462.58KR-32568
CAS :<p>KR-32568 is a sodium/hydrogen exchanger 1 (NHE-1) inhibitor (IC50: 230 nM).</p>Formule :C13H12FN3O2Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :261.25Nisoxetine hydrochloride
CAS :<p>Nisoxetine hydrochloride is a noradrenaline transporter (NET) inhibitor</p>Formule :C17H21NO2·HClDegré de pureté :99.21%Couleur et forme :White SolidMasse moléculaire :307.82Silperisone HCl
CAS :<p>Silperisone HCl is a muscle relaxant and vasodilator, treating myoclonus, hypertonia, dystonia, and myospasm by blocking Na+ and Ca2+ channels.</p>Formule :C15H25ClFNSiDegré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :301.9Elpetrigine
CAS :<p>Elpetrigine (GW273293) is a potential sodium channel blocker with antiepileptic activity that can be used to study epilepsy.</p>Formule :C10H7Cl3N4Degré de pureté :99.04% - 99.43%Couleur et forme :SolidMasse moléculaire :289.55NaV1.2/1.6 channel blocker-1
CAS :<p>NaV1.2/1.6 channel blocker-1 is a NaV1.2/1.6 channel blocker that inhibits rNaV1.6 and can be used to study generalised epilepsy and movement disorders.</p>Formule :C14H14N2OSDegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :258.34NHE3-IN-1
CAS :<p>NHE3-IN-1 是钠/质子交换剂 3 (NHE-3) 的抑制剂。</p>Formule :C12H10ClN3SDegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :263.75TC-N 1752
CAS :<p>TC-N 1752 is an orally active inhibitor of Nav1.7 channel with IC50 of 0.17 μM. TC-N 1752 shows analgesic activities.</p>Formule :C25H27F3N6O3Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :516.52Ralitoline
CAS :<p>Ralitoline (Ralitolinum) is an anticonvulsant with anticancer activity and sodium channel blocking activity.</p>Formule :C13H13ClN2O2SDegré de pureté :98.45%Couleur et forme :SolidMasse moléculaire :296.77(Rac)-AMG8379
CAS :<p>(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379 which is an orally active and selective sulfonamide NaV1.7 antagonist.</p>Formule :C25H16ClF2N3O5SDegré de pureté :99.6%Couleur et forme :SolidMasse moléculaire :543.93SLC13A5-IN-1
CAS :<p>SLC13A5-IN-1 is a selective inhibitor of sodium-citrate co-transporter (SLC13A5),completely blocks the uptake of 14C-citrate(IC50 : 0.022 μM in HepG2 cells).</p>Formule :C19H19Cl3N2O3SDegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :461.79PF 04531083
CAS :<p>PF 04531083 is a selective blocker of the NaV1.8 channel. PF 04531083 can be used for neuropathic and inflammatory pain studies.</p>Formule :C17H16ClN5O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :357.79Aneratrigine
CAS :<p>Aneratrigine is a blocker of the sodium channel protein type 9 subunit alpha, utilized in research on neuropathic pain diseases [1].</p>Formule :C19H20ClF2N5O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :487.97Sodium Channel inhibitor 4
CAS :<p>Sodium Channel Inhibitor 4 is a compound that functions as a sodium channel inhibitor [1].</p>Formule :C19H18ClN3O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :451.95Co 102862
CAS :<p>Co 102862 is a voltage-gated sodium channel blocker. Co 102862 can be used for anticonvulsant studies.</p>Formule :C14H12FN3O2Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :273.26GDC-0310
CAS :<p>GDC-0310 is a selective, orally available Nav1.7 inhibitor with an IC50 of 0.6 nM for human Nav1.7, suitable for pain research.</p>Formule :C25H29Cl2FN2O4SDegré de pureté :99.877%Couleur et forme :SolidMasse moléculaire :543.486-Iodoamiloride
CAS :<p>6-Iodoamiloride is a potent inhibitor of acid-sensing ion channel 1 (ASIC1), exhibiting an IC50 value of 88 nM.</p>Formule :C6H8IN7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :321.08Aneratrigine hydrochloride
CAS :<p>Aneratrigine hydrochloride is a Nav 1.9 blocker that may be used to prevent or treat sodium channel blocker-related disorders.</p>Formule :C19H21Cl2F2N5O2S2Degré de pureté :98.37% - 99.16%Couleur et forme :SolidMasse moléculaire :524.43VGSCs-IN-1
CAS :<p>VGSCs-IN-1, a VGSC inhibitor and Riluzole analog, exhibits good blocking activity on Nav1.4 and can be used to study cellular excitability disorders.</p>Formule :C12H12F3N3OSDegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :303.3Funapide
CAS :<p>Funapide (TV 45070) is a potent Nav1.7 inhibitor, potentially treating inflammation and various pains.</p>Formule :C22H14F3NO5Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :429.35PF-05661014
CAS :<p>PF-05661014, a demethylated analogue of PF-06526290, selectively inhibits Nav1.3 and Nav1.7 currents by stabilizing the inactivated state through interaction with the D4 VSD. This compound is utilized in research focused on sodium channel modulation.</p>Formule :C17H16N4O3S2Couleur et forme :SolidMasse moléculaire :388.46Olisutrigine bromide
CAS :<p>Olisutrigine bromide is a sodium channel blocker used as an analgesic.</p>Formule :C25H35BrN2Couleur et forme :SolidMasse moléculaire :443.463N-Depropylpropafenone
CAS :<p>N-Depropylpropafenone, an active metabolite of Propafenone, is produced through the metabolism by the CYP450 enzyme system (primarily CYP2D6). It functions by blocking sodium ion channels, thereby delaying the depolarization process in myocardial cells and exhibiting antiarrhythmic properties.</p>Formule :C18H21NO3Couleur et forme :SolidMasse moléculaire :299.36Vormatrigine
CAS :<p>Vormatrigine effectively inhibits sodium channels (sodium channel).</p>Formule :C16H12F6N4O2Couleur et forme :SolidMasse moléculaire :406.28Tizolemide
CAS :<p>Tizolemide, a sulfonamide diuretic compound with alkaline properties, is cleared through the tubular transport system. It induces changes in the passive transport components across the basolateral membrane of isolated frog skin.</p>Formule :C11H14ClN3O3S2Couleur et forme :SolidMasse moléculaire :335.83Lubeluzole dihydrochloride
CAS :<p>Lubeluzole (dihydrochloride) acts as a neuroprotective agent by blocking neuronal voltage-gated sodium channels and also affects cardiac sodium channels, exhibiting both tonic and blocking effects. This compound is considered promising in the research of antiarrhythmic agents.</p>Formule :C22H27Cl2F2N3O2SCouleur et forme :SolidMasse moléculaire :506.44Quinacainol dihydrochloride
CAS :<p>Quinacainol dihydrochloride (PK 10139 dihydrochloride) is the bis(2 hydrochloride) salt form of Quinacainol. It acts as an inhibitor of the sodium current, with an EC50 of 95 µM. This compound displays antiarrhythmic activity by modulating the electrophysiological properties of the heart.</p>Formule :C21H32Cl2N2OCouleur et forme :SolidMasse moléculaire :399.398Zilvetrigine
CAS :<p>Zilvetrigine is a sodium channel (sodium channel) blocker. It can be used as an analgesic.</p>Formule :C20H20ClN3O2Couleur et forme :SolidMasse moléculaire :369.845(R)-Duloxetine
CAS :<p>(R)-Duloxetine, an isomer of Duloxetine, induces tonic and use-dependent blockade of neuronal Na+ channels. This compound is utilized in pain research.</p>Formule :C18H19NOSCouleur et forme :SolidMasse moléculaire :297.42Olorigliflozin
CAS :<p>Olorigliflozin is a sodium glucose co-transporter (SGLT) inhibitor with antihyperglycemic properties.</p>Formule :C23H27ClO7Couleur et forme :SolidMasse moléculaire :450.909ErSO-TFPy
CAS :<p>ErSO-TFPy activates the sodium ion channel TRPM4, resulting in an imbalance of intracellular calcium and sodium ions. It exhibits low nanomolar-level cytotoxicity (IC50 = 5-25 nM) by inducing necrosis in ERα+ breast cancer cell lines. Additionally, ErSO-TFPy shows antitumor activity in mouse models.</p>Formule :C19H13F7N2O2Couleur et forme :SolidMasse moléculaire :434.307Suzetrigine
CAS :<p>Suzetrigine (VX-548) is an oral NaV1.8 inhibitor with analgesic properties for acute pain research.</p>Formule :C21H20F5N3O4Degré de pureté :98.08% - 99.27%Couleur et forme :SolidMasse moléculaire :473.39SYM2206
CAS :<p>SYM2206 is a low affinity non-competitive AMPA receptor antagonist with an IC50 value of 1.6 μM.SYM2206 exhibits anticancer activity by blocking Nav1.6-mediated</p>Formule :C20H22N4O3Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :366.41
