Canal calcique
Les canaux calciques sont des protéines membranaires qui régulent le flux d'ions calcium dans et hors des cellules, ce qui est essentiel pour diverses fonctions cellulaires, y compris la contraction musculaire, la libération de neurotransmetteurs et l'expression génique. La dysrégulation de l'activité des canaux calciques est associée à des conditions telles que l'hypertension, les arythmies cardiaques et les troubles neurologiques. Chez CymitQuimica, nous proposons une large sélection de modulateurs des canaux calciques pour soutenir vos recherches en santé cardiovasculaire, neurobiologie et transduction du signal.
573 produits trouvés pour "Canal calcique"
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Nicardipine
CAS :Nicardipine (Cardene), a calcium channel blockers belonging to the dihydropyridine class, is a drug used to treat angina and high blood pressure.Formule :C26H29N3O6Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :479.52Zegocractin
CAS :Zegocractin (CM-4620) is a calcium-release activated calcium-channel (CRAC channel) inhibitor.Formule :C19H11ClF3N3O3Degré de pureté :98.82%Couleur et forme :SolidMasse moléculaire :421.76Ref: TM-TQ0033
1mg119,00€5mg245,00€10mg409,00€25mg677,00€50mg945,00€100mg1.279,00€1mL*10mM (DMSO)268,00€MDK-4025
CAS :MDK-4025 is an inhibitor of the high voltage-activated (HVA) Ca2+ current in pyramidal neurons.Formule :C19H15ClODegré de pureté :98.65%Couleur et forme :SolidMasse moléculaire :294.77Bevantolol hydrochloride
CAS :Bevantolol hydrochloride (NC-1400 hydrochloride) is a β1-adrenoceptor antagonist that treatment angina pectoris and hypertension.Formule :C20H28ClNO4Degré de pureté :99.49%Couleur et forme :SolidMasse moléculaire :381.9L-Ascorbic acid sodium salt
CAS :L-Ascorbic acid sodium salt (Vitamin C sodium salt) is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.Formule :C6H7NaO6Degré de pureté :98.73% - 99.75%Couleur et forme :Less Solid PowderMasse moléculaire :198.11SN 6
CAS :SN 6 (SN6) is a selective Na+/Ca2+ exchanger (NCX) inhibitor (IC50s of NCX1: 2.9 μM , NCX2: 16 μM ,NCX3: 8.6 μM)Formule :C20H22N2O5SDegré de pureté :97.28%Couleur et forme :SolidMasse moléculaire :402.46ZSET1446
CAS :ZSET1446 (ST-101) is a T-type calcium channel activator potentially for the treatment of learning deficits in various types of Alzheimer disease (AD) models.Formule :C15H12N2ODegré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :236.27Ref: TM-T8448
1mg50,00€5mg103,00€10mg144,00€25mg281,00€50mg409,00€100mg572,00€200mg772,00€1mL*10mM (DMSO)119,00€Menthol
CAS :Menthol (DL-Menthol) is an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties.Formule :C10H20ODegré de pureté :99.84% - 99.88%Couleur et forme :White Crystals /89-78-1/ Physical Description White Crystalline Solid With A Peppermint Odor And Taste (Ntp 1992)Masse moléculaire :156.2614-Deoxyandrographolide
CAS :14-Deoxyandrographolide is a bioactive compound of Andrographis paniculata with hepatoprotective efficacy.Formule :C20H30O4Degré de pureté :99.89% - 99.98%Couleur et forme :SolidMasse moléculaire :334.45Cinacalcet metabolite M4
CAS :Cinacalcet metabolite M4 (Rarechem AL BW 1078) is a metabolite of Cinacalcet. Cinacalcet is an allosteric agonist of Ca receptor.Formule :C10H12F3NDegré de pureté :97.13%Couleur et forme :SolidMasse moléculaire :203.2Ref: TM-T10814
5mg55,00€10mg74,00€25mg96,00€50mg137,00€100mg170,00€200mg244,00€500mg364,00€1mL*10mM (DMSO)51,00€Tetrandrine
CAS :Tetrandrine (Sinomenine A) is a naturally occurring biphenylisoquinoline alkaloid, a calcium channel inhibitor. Cost-effective and quality-assured.Formule :C38H42N2O6Degré de pureté :99.61% - 99.94%Couleur et forme :White SolidMasse moléculaire :622.75(±)-Bay K 8644
CAS :Produit contrôléFormule :C16H15F3N2O4Couleur et forme :NeatMasse moléculaire :356.3HUP30
CAS :HUP30 is a potent vasodilating agent. HUP30 can stimulate soluble guanylyl cyclase, activate K+ channels, and block extracellular Ca2+ influx.Formule :C14H15N3O3SDegré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :305.35Ref: TM-TNU0864
5mg35,00€10mg52,00€25mg96,00€50mg156,00€100mg222,00€200mg310,00€1mL*10mM (DMSO)39,00€Apinocaltamide
CAS :Apinocaltamide (ACT-709478) is an orally available and selective T-type calcium channel blocker that cross BBB for Cav3.1, Cav3.2, and Cav3.3,epilepsy.Formule :C22H18F3N5ODegré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :425.41Bupivacaine
CAS :Bupivacaine (AH-250) is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channelsFormule :C18H28N2ODegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :288.43Equilin
CAS :Equilin (7-Dehydroestrone) is a neurotrophic estrogenic steroid with vasodilatory activity used in the study of hypertension.Formule :C18H20O2Degré de pureté :98.57% - 99.72%Masse moléculaire :268.35Diltiazem
CAS :Diltiazem (CRD 401 free base) is an orally available L-type Ca2+ channel blocker with antihypertensive, antiarrhythmic, and cardioprotective properties that prevent post-reperfusion myocardial injury, angina pectoris, and cardiovascular-related diseases.Formule :C22H26N2O4SDegré de pureté :99.51% - 99.83%Couleur et forme :White Crystalline Powder SolidMasse moléculaire :414.52Amlodipine maleate
CAS :Amlodipine maleate (Amvaz) is an oral dihydropyridine calcium blocker for hypertension and cancer studies.Formule :C24H29ClN2O9Degré de pureté :99.94%Couleur et forme :White To Pale Yellow Crystalline PowderMasse moléculaire :524.95Bupivacaine-d9
CAS :Bupivacaine-d9 is a deuterated compound of Bupivacaine. Bupivacaine has a CAS number of 38396-39-3. Bupivacaine is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine can be used for the research of chronic pain.Formule :C18H19D9N2OCouleur et forme :SolidMasse moléculaire :297.48Gabapentin enacarbil
CAS :Gabapentin enacarbil (XP-13512) is a prodrug for the anticonvulsant and analgesic gabapentin, offering sustained dose-proportional exposure and predictable bioavailability.Formule :C16H27NO6Degré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :329.39Ref: TM-T15366
1mg42,00€5mg88,00€10mg127,00€25mg274,00€50mg439,00€100mg705,00€200mg938,00€1mL*10mM (DMSO)87,00€4-(2-Chlorophenyl)-2-methyl-5-oxo-4,4a,5,7,8,10-hexahydro-1H-pyrido[2',3':2,3]azeto[2,1-c][1,4]oxazine-3-carboxylic Acid
Produit contrôléApplications 4-(2-Chlorophenyl)-2-methyl-5-oxo-4,4a,5,7,8,10-hexahydro-1H-pyrido[2',3':2,3]azeto[2,1-c][1,4]oxazine-3-carboxylic Acid is an intermediate in the synthesis of 3-O-Desethyl-5-O-desmethyl Amlodipine (D291305). 3-O-Desethyl-5-O-desmethyl Amlodipine is an impurity of Amlodipine (A633495), which is a dihydropyridine calcium channel blocker.
References Arrowsmith, J.E., et al.: J. Med. Chem., 29, 1696 (1986); Burges, R.A., et al.: J. Cardiovasc. Pharmacol., 9, 110 (1987); Haria, M., et al.: Drugs, 50, 560 (1995)Formule :C17H17ClN2O4Couleur et forme :NeatMasse moléculaire :348.7811-tert-Butyl 3-Ethyl 5-methyl 2-((2-((tert-Butoxycarbonyl)amino)ethoxy)methyl)-4-(2-chlorophenyl)-6-methylpyridine-1,3,5(4H)-tricarboxylate
CAS :Produit contrôléApplications 1-tert-Butyl 3-Ethyl 5-methyl 2-((2-((tert-Butoxycarbonyl)amino)ethoxy)methyl)-4-(2-chlorophenyl)-6-methylpyridine-1,3,5(4H)-tricarboxylate is an intermediate in the synthesis of 3-O-Desethyl-5-O-desmethyl Amlodipine (D291305). 3-O-Desethyl-5-O-desmethyl Amlodipine is an impurity of Amlodipine (A633495), which is a dihydropyridine calcium channel blocker.
References Arrowsmith, J.E., et al.: J. Med. Chem., 29, 1696 (1986); Burges, R.A., et al.: J. Cardiovasc. Pharmacol., 9, 110 (1987); Haria, M., et al.: Drugs, 50, 560 (1995)Formule :C30H41ClN2O9Couleur et forme :NeatMasse moléculaire :609.107Amlodipine besilate impurity G
CAS :Amlodipine besilate impurity G is a Calcium Channel antagonist with potential application in the study of neurological diseases and is an impurity in theFormule :C17H18ClNO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :335.78Amlodipine hydrochloride
CAS :Amlodipine hydrochloride is a salt of Amlodipine --- a medication used to lower blood pressure and prevent chest pain.Formule :C20H26Cl2N2O5Couleur et forme :SolidMasse moléculaire :445.34Cinepazide
CAS :Cinepazide: a vasodilator targeting adenosine A2 receptors, treats various vascular diseases.Formule :C22H31N3O5Couleur et forme :White PowderMasse moléculaire :417.5Topiramate D12
CAS :Topiramate D12 is a deuterium labeled Topiramate. Topiramate is an agent of broad-spectrum antiepileptic. Topiramate is an antagonist of GluR5 receptor.Formule :C12H21NO8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :351.44Nifedipine-d6
CAS :Nifedipine D6 is deuterium labeled nifedipine which is a potent blocker of calcium channel.
Formule :C17H18N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :352.37Maresin 1
CAS :Maresin 1 is biosynthesized by macrophages (MΦ) and possesses significant anti-inflammatory activity that attenuates LPS-induced lung injury in mice.Formule :C22H32O4Couleur et forme :SolidMasse moléculaire :360.49Cinnarizine D8
CAS :Cinnarizine D8 is a deuterium-labeled Cinnarizine which is an antihistamine and a calcium channel blocker.Formule :C26H28N2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :376.573Ionomycin calcium
CAS :Ionomycin calcium (SQ23377 calcium) is an effective and selective calcium ionophore, exhibiting high specificity for calcium ions. Cost-effective and quality-assured.
Formule :C41H70CaO9Degré de pureté :98% - 98.11%Couleur et forme :SolidMasse moléculaire :747.07ORM-10103
CAS :ORM-10103 is a novel potent and selective inhibitor of the Na+/Ca2+ exchanger (NCX).ORM-10103 inhibited NCX currents with estimated IC50 values of 55 and 67 nMFormule :C20H16N2O4Degré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :348.35Ref: TM-T12321
1mg43,00€5mg90,00€10mg135,00€25mg278,00€50mg445,00€100mg605,00€200mg817,00€1mL*10mM (DMSO)90,00€R-(-)-Niguldipine hydrochloride
CAS :R-(-)-Niguldipine HCl: L-type Ca2+ blocker, K+ agonist, α1A antagonist; lowers blood pressure; weaker enantiomer.Formule :C36H40ClN3O6Couleur et forme :SolidMasse moléculaire :646.17(R)-Lercanidipine Hydrochloride
CAS :Produit contrôléFormule :C36H41N3O6·ClHCouleur et forme :NeatMasse moléculaire :648.19(S)-Lercanidipine Hydrochloride
CAS :Produit contrôléFormule :C36H41N3O6·ClHCouleur et forme :NeatMasse moléculaire :648.19Dehydro Azelnidipine
CAS :Produit contrôléFormule :C33H32N4O6Couleur et forme :Light Yellow To Light GreenMasse moléculaire :580.63Dihydrocinnamyl Cilnidipine
Produit contrôléApplications Dihydrocinnamyl Cilnidipine is a metabolite of Cilnidipine (C441375); a dihydropyridine calcium channel blocker.
References Ikeda, K., et al.: Oyo Yakuri, 44, 433 (1992); Hosono, M., et al.: J. Pharmacobio-Dyn., 15, 547, (1992); Ishii, M.: Japan Pharmacol. Ther., 21, 59 (1993)Formule :C27H30N2O7Couleur et forme :NeatMasse moléculaire :494.54Falipamil
CAS :Produit contrôléApplications Falipamil is a specific bradycardic agent and a calcium channel blocker.
References Boucher, M., et al.: Eur. J. Pharmacol., 306, 93 (1996), Mubagwa, K., et al.: Arch. Int. Pharmacodyn. Ther., 286, 71 (1987), Chaudhry, A., et al.: Development Cardiovascular Medicine, 46, 196 (1985), Ogiwara, Y., et al.: Jpn Heart J., 29, (1988)Formule :C24H32N2O5Couleur et forme :NeatMasse moléculaire :428.523-Desethyl-3-(2-phthalimidoethyl) Phthaloyl Amlodipine
Produit contrôléStability Light and Temperature Sensitive
Applications 3-Desethyl-3-(2-phthalimidoethyl) Phthaloyl Amlodipine is a derivative of Amlodipine (A633495); a dihydropyridine calcium channel blocker where activity mainly resides in the (-)-isomer.
References Arrowsmith, J.E., et al.: J. Med. Chem., 29, 1696 (1986); Burges, R.A., et al.: J. Cardiovasc. Pharmacol., 9, 110 (1987); Haria, M., et al.: Drugs, 50, 560 (1995)Formule :C36H30ClN3O9Couleur et forme :NeatMasse moléculaire :684.091N-Desmethyl-N-acetyl Diltiazem
Produit contrôléApplications N-Desmethyl-N-acetyl Diltiazem is a metabolite of Diltiazem (D460620, HCl); a calcium channel blocker with vasodilating activity. Also anti-anginal, anti-hypertensive, and anti-arrhythmic (class IV).
References Sato, et al.: Arzneim.-Forsch., 21, 1338 (1971); Smirnov, S.R.: Eur. J. Pharmacol., 360, 81 (1998); Hansson, L., et al.: Lancet, 356, 359 (2000)Formule :C23H26N2O5SCouleur et forme :NeatMasse moléculaire :442.53Halofuginone
CAS :Halofuginone (RU-19110) inhibits prolyl-tRNA synthetase (Ki=18.3 nM), down-regulates Smad3, and blocks TGF-β at 10 ng/ml.Formule :C16H17BrClN3O3Degré de pureté :99.53%Couleur et forme :Off-White SolidMasse moléculaire :414.68Ref: TM-T6856
1mg34,00€5mg82,00€10mg116,00€25mg227,00€50mg344,00€100mg517,00€500mg1.134,00€1mL*10mM (DMSO)92,00€Verapamil
CAS :Verapamil (CP-16533-1), an oral calcium channel blocker, inhibits P-gp and CYP3A4, used for hypertension, arrhythmias, and angina research.Formule :C27H38N2O4Degré de pureté :99.61% - 99.93%Couleur et forme :OilMasse moléculaire :454.6Ref: TM-T20656
10mg34,00€25mg49,00€50mg70,00€100mg90,00€200mg136,00€500mg219,00€1mL*10mM (DMSO)52,00€BA 41899
CAS :BA 41899 is a positive inotropic Ca(2+)-sensitizing agent.Formule :C18H16N2O2Couleur et forme :SolidMasse moléculaire :292.33MRS2690
CAS :MRS2690 is a potent P2Y14 receptor agonist (EC50 = 49 nM) that displays 7-fold higher potency than UDP-glucose.Formule :C15H24N2O16P2SCouleur et forme :SolidMasse moléculaire :582.37SIM-6080
CAS :SIM-6080 is a calcium channel antagonist. SIM-6080 inhibits the proliferation of rat aortic myocytes.Formule :C29H36F2N2O3Couleur et forme :SolidMasse moléculaire :498.6RS-93522
CAS :RS-93522: Calcium channel antagonist, inhibits phosphodiesterase (IC50=1.6x10^-5M), like milrinone, and has a negative inotropic effect.Formule :C27H30N2O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :526.54Ethacrynate Sodium
CAS :Ethacrynate Sodium, a sodium salt, blocks chloride, potassium, and sodium transport mainly in Henle's loop.Formule :C13H12Cl2NaO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :326.12A 80b
CAS :A-80b: synthetic pyridazinoindole; potent, lasting antihypertensive; lowers diastolic more; no change in heart rate; inhibits Ca2+-induced contraction.Formule :C16H17N7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :307.35AJG-049 free base
CAS :AJG-049 free base is a calcium channel antagonist that inhibits L-type Ca2+ channels via diltiazem-binding site(s).Formule :C27H30N2O2Couleur et forme :SolidMasse moléculaire :414.54Azelnidipine, (S)-
CAS :Azelnidipine, a selective L-type CCB, improves HF severity and cardiac function in HT and HFpEF compared to N-type CCB cilnidipine.Formule :C33H34N4O6Couleur et forme :SolidMasse moléculaire :582.65UK-52831
CAS :UK-52831, a calcium channel antagonist, is used potentially for the treatment of hypertension and myocardia ischemia.Formule :C22H26Cl2N6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :525.39
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