PDE
Les phosphodiestérases (PDE) sont des enzymes qui hydrolysent les nucléotides cycliques, tels que l'AMPc et le GMPc, en leurs formes inactives, jouant un rôle clé dans la régulation des voies de signalisation intracellulaire. Les inhibiteurs de PDE sont utilisés dans le traitement de diverses affections, notamment les maladies cardiovasculaires, la dysfonction érectile et les troubles respiratoires, en raison de leur capacité à moduler les niveaux de nucléotides cycliques. Chez CymitQuimica, nous proposons une gamme d'inhibiteurs de PDE pour soutenir vos recherches en signalisation cellulaire, pharmacologie et développement thérapeutique.
202 produits trouvés pour "PDE".
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PDE4-IN-21
PDE4-IN-21 (Compound L19) is an effective PDE4 inhibitor with an IC50 of 0.48 μM. It demonstrates substantial inhibitory activity and notable metabolic stability in rat liver microsomes.Formule :C15H10Cl2N6SCouleur et forme :SolidMasse moléculaire :377.25Menabitan dihydrochloride
CAS :Menabitan dihydrochloride (SP-204 dihydrochloride), the dihydrochloride salt of Menabitan, serves as a non-opioid analgesic agent by inhibiting phosphodiesterase 9 (PDE 9). Additionally, it has been shown to reduce intraocular pressure in a rabbit model .Formule :C37H58Cl2N2O3Couleur et forme :SolidMasse moléculaire :649.77PDE4-IN-17
PDE4-IN-17 (compound 4e) is a potent PDE4 inhibitor. It effectively inhibits PDE4B and PDE4D with IC50 values of 10.0 nM and 15.2 nM, respectively. In SD rats, PDE4-IN-17 demonstrates good oral bioavailability (F=66%) and a relatively long half-life (t1/2=2.0 h).Formule :C17H16N2O3Couleur et forme :SolidMasse moléculaire :296.11609UK 227786
CAS :UK 227786 is an inhibitor of phosphodiesterase 5 (PDE5), used for treatment of prostatic diseases.Formule :C22H22Cl2N4O4Degré de pureté :99.9%Couleur et forme :White SolidMasse moléculaire :477.34PDE4B-IN-6
PDE4B-IN-6 is a highly selective PDE4B inhibitor (IC50=7.42 nM) that exerts anti-inflammatory effects by elevating cAMP and inhibiting TNF-α, used in COPD research.Formule :C22H24F2N2O7Degré de pureté :99.20%Masse moléculaire :466.43ONO-8430506
CAS :ONO-8430506 is an orally available, potent autotaxin (ATX)/ENPP2 inhibitor (IC90: 100 nM) that inhibits ATX activity in mouse plasma.Formule :C27H28FN3O3Degré de pureté :98.34%Couleur et forme :SolidMasse moléculaire :461.5279Oglemilast
CAS :Oglemilast (GRC 3886) suppresses pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo.Formule :C20H13Cl2F2N3O5SDegré de pureté :99.82%Couleur et forme :Yellow SolidMasse moléculaire :516.302Acetildenafil
CAS :Acetildenafil is an analog of the phosphodiesterase inhibitor sildenafil.Formule :C25H34N6O3Couleur et forme :Off-White To Pale Yelow SolidMasse moléculaire :466.5759Arofylline
CAS :Arofylline (LAS 31025) is a PDE4 inhibitor and can be used for asthma studies.Formule :C14H13ClN4O2Degré de pureté :98.19%Couleur et forme :SolidMasse moléculaire :304.732(1R,2R)-MK-8189
CAS :(1R,2R)-MK-8189 is an isomer of MK-8189, a potent and selective pyrimidine PDE10A inhibitor.Formule :C19H22N6OSDegré de pureté :>99.99% - >99.99%Couleur et forme :SoildMasse moléculaire :382.48FCPR03
CAS :FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively.Formule :C15H19F2NO3Degré de pureté :99.94%Couleur et forme :White SolidMasse moléculaire :299.3131Dazonone
CAS :Dazonone (Imidazo[2,1-b]quinazolin-2(3H)-one, 6-chloro-1,5-dihydro-3-methyl-) is a specific PDE III inhibitors.Formule :C11H10ClN3ODegré de pureté :99.54% - 99.73%Couleur et forme :SolidMasse moléculaire :235.67PDE5-IN-9
CAS :WAY-639921 treats cardiovascular and respiratory conditions by inhibiting PDE1c.Formule :C18H14N4SDegré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :318.396JNJ 42396302
CAS :JNJ 42396302 is an effective PDE10A inhibitor that enhances motility and viability in human sperm cells.Formule :C19H23N5O2Degré de pureté :99.36%Couleur et forme :Yellow SolidMasse moléculaire :353.42PDE10A-IN-5
PDE10A-IN-5 (Compound A30) is an orally active inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 value of 3.5 nM. By inhibiting PDE10A, it activates the cyclic adenosine monophosphate (cAMP)-related signaling pathway, exhibiting activity against pulmonary vascular remodeling. This compound is applicable to research in the field of pulmonary arterial hypertension.Couleur et forme :Odour SolidPDE3/4-IN-2
CAS :PDE3/4-IN-2 is a potent dual PDE3/PDE4 inhibitor with IC50 values of 0.13 nM for PDE3A and 50 nM for PDE4B1. It is used to investigate PDE-related diseases such as asthma, COPD, sepsis, and nephritis. the dual-target activity of PDE3/4-IN-2 provides a mechanistic basis for dissecting cAMP regulation and inflammatory signaling pathways.Formule :C28H33N5O4Degré de pureté :99.99%Masse moléculaire :503.59BC 11-38
CAS :BC 11-38 is a potent, selective PDE biodepressant which is mainly effective against PDE11 (IC50 : 0.28 μM).Formule :C15H16N2OS2Degré de pureté :98.95% - 99.28%Couleur et forme :SolidMasse moléculaire :304.43Phyllodulcin
CAS :Phyllodulcin, an orally active sweetener discovered in Hydrangea macrophylla var. thunbergii, functions as a non-selective phosphodiesterase inhibitor that mitigates allergic reactions by suppressing the activation of lymphocytes. Additionally, it combats obesity through the regulation of leptin levels, genes associated with fat browning, and the hypothalamic BDNF-TrkB signaling pathway.Formule :C16H14O5Masse moléculaire :286.2794Nerandomilast
CAS :Nerandomilast (BI 1015550) is an orally active PDE4B inhibitor with IC50 of 7.2 nM.Cost-effective and quality-assured.Formule :C20H25ClN6O2SDegré de pureté :98.06% - 99.96%Couleur et forme :SoildMasse moléculaire :448.97OPC18750 HCl
CAS :OPC18750 HCl is a phosphodiesterase inhibitor with positive inotropic effects that can be used to study asthma, cancer, diabetes, and psychiatric disorders.Formule :C20H23ClN2O4Degré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :390.86
