Caséine Kinase
Les caséine kinases sont une famille de kinases protéiques sérine/thréonine qui régulent divers processus cellulaires, y compris la réparation de l'ADN, les rythmes circadiens et la transduction du signal. Ces kinases sont impliquées dans la phosphorylation de nombreuses protéines et sont associées à des maladies telles que le cancer, les troubles neurodégénératifs et les syndromes métaboliques. Chez CymitQuimica, nous proposons une sélection d'inhibiteurs de la caséine kinase pour soutenir vos recherches sur la transduction du signal, la régulation du cycle cellulaire et le développement thérapeutique.
130 produits trouvés pour "Caséine Kinase"
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Emodin
CAS :<p>Emodin (Frangula emodin) is a selective 11β-HSD1 inhibitor,IC50 of 186 and 86 nM against 11β-HSD1 in humans and mice. High-Quality, Low-Cost!</p>Formule :C15H10O5Degré de pureté :98.37% - 99.53%Couleur et forme :Physical Description Orange Needles Or Powder (Ntp 1992)Masse moléculaire :270.24Ellagic acid
CAS :<p>Ellagic acid (Gallogen), a thickened tetracyclic natural product, is a potent CK2 inhibitor. Ellagic acid is an antioxidant. Cost-effective and quality-assured.</p>Formule :C14H6O8Degré de pureté :97.11% - 99.75%Couleur et forme :Cream Colored Needles From Pyridine 1992)Masse moléculaire :302.19A-3 hydrochloride
CAS :<p>A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 μM.</p>Formule :C12H14Cl2N2O2SDegré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :321.22Silmitasertib sodium salt
CAS :<p>Silmitasertib sodium salt (CX-4945 sodium salt) is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).</p>Formule :C19H11ClN3NaO2Degré de pureté :99.49% - 99.62%Couleur et forme :SolidMasse moléculaire :371.75NMS-P715
CAS :<p>NMS-P715 is a highly selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).</p>Formule :C35H39F3N8O3Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :676.73GSK-3β/CK-1δ-IN-1
<p>GSK-3β/CK-1δ-IN-1 (8d) is a dual inhibitor of GSK-3β and CK-1δ that can cross the blood-brain barrier, with IC50 values of 0.77 μM and 0.57 μM, respectively. GSK-3β/CK-1δ-IN-1 (8d) is applicable in neuroblastoma research.</p>Formule :C22H17F3N4OCouleur et forme :SolidMasse moléculaire :410.39MU1742
<p>MU1742 is a probe for CK1δ and CK1ε protein kinases [1] .</p>Formule :C22H22F2N6Couleur et forme :SolidMasse moléculaire :408.45Casein kinase 1δ-IN-6
CAS :<p>CK1δ-IN-6: potent, selective CK-1δ inhibitor, IC50 23 nM, neuroprotective, anti-inflammatory, for neurodegenerative research.</p>Formule :C16H10ClF3N2OSDegré de pureté :99%Couleur et forme :SoildMasse moléculaire :370.78CSNK2-IN-2
<p>CSNK2-IN-2 (compound 2) is an orally active inhibitor of CSNK2. It is utilized in antiviral research.</p>Formule :C25H30FN9OCouleur et forme :SolidMasse moléculaire :491.56CK2-IN-14
<p>CK2-IN-14 (Compound 10b) is an inhibitor of cyclin-dependent kinase 2α with an IC50 of 36.7 nM. It effectively hinders the growth of cancer cell lines 786-O and U937, with GI50 values of 7.3 μM and 7.5 μM, respectively.</p>Formule :C19H20ClN5SCouleur et forme :SolidMasse moléculaire :385.91Casein Kinase 2 Substrate Peptide
CAS :<p>CK2 Substrate Peptide, C-terminus linked to EDANS, used for CK2 activity assays.</p>Formule :C45H73N19O24Couleur et forme :SolidMasse moléculaire :1264.17WAY-297174
CAS :<p>WAY-297174 is a human protein kinase CK2 inhibitor with IC50 of > 33 μM.</p>Formule :C11H12N2O2S2Degré de pureté :99.53%Couleur et forme :SoildMasse moléculaire :268.36Casein kinase 1δ-IN-15
CAS :<p>Casein kinase 1δ-IN-15, an inhibitor for casein kinase 1 (CK1δ), exhibits an IC50 of 0.045 μM [1].</p>Formule :C19H17FN6OCouleur et forme :SolidMasse moléculaire :364.38QXG-6442
<p>QXG-6442 is a molecular glue degrader targeting CK1α, demonstrating a degradation potency with a DC50 of 5.7 nM and a Dmax of 90%. In the MOLM-14 cell line, QXG-6442 induces antiproliferative effects.</p>Formule :C21H17N5O4Couleur et forme :SolidMasse moléculaire :403.39CK1-IN-3
CAS :<p>WAY-296817 inhibits CK1, potential for circadian rhythm and inflammation research.</p>Formule :C17H16N2O3SDegré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :328.39CK1-IN-4
<p>CK1-IN-4 (Compound 59) is an inhibitor of casein kinase CK1δ with an IC50 of 2.74 μM. It exhibits neuroprotective activity in SH-SY5Y cells treated with Ethacrynic acid.</p>Couleur et forme :Odour SolidCasein kinase 1δ-IN-3
CAS :<p>Casein kinase 1δ-IN-3 (Casein kinase 1δ-IN-3) (Compound 23a) is a casein kinase 1 delta (CK1d) inhibitor with a pIC50 of 6.5376 M.</p>Formule :C17H16N2O2SDegré de pureté :98.94%Couleur et forme :SoildMasse moléculaire :312.39Casein kinase 1δ-IN-9
CAS :<p>Casein kinase 1δ-IN-9 is a Quinone reductase 2 inhibitor with IC50 of 0.6μM.</p>Formule :C15H12ClN3Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :269.73Casein kinase 1δ-IN-7
CAS :<p>Casein kinase 1δ-IN-7 is a Casein kinase 1δ inhibitor for neurodegenerative diseases such as Alzheimer's disease.</p>Formule :C17H14N4O2SDegré de pureté :98.6%Couleur et forme :SolidMasse moléculaire :338.38Casein kinase 1δ-IN-8
CAS :<p>Casein kinase 1δ-IN-8 is an inhibitor of casein kinase 1δ and is used to treat neurodegenerative diseases such as Alzheimer's disease type.</p>Formule :C19H14FN5OSDegré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :379.41CK2-IN-13
<p>CK2-IN-13 (compound 12c) is a potent inhibitor of CK2, with an IC50 value of 5.8 nM, playing a significant role in cancer research.</p>Formule :C19H13Br2NO3Couleur et forme :SolidMasse moléculaire :463.119Casein
CAS :<p>Casein is a milk protein with multiple roles involved in novel drug delivery systems.</p>Degré de pureté :95%Couleur et forme :SoildCasein Kinase Substrates 3
CAS :<p>Casein Kinase Substrates 3 is a substrate of casein kinase.</p>Formule :C85H139N27O35SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :2131.24TBCA
CAS :<p>TBCA: selective CK2 inhibitor, IC50=110 nM, Ki=77 nM, favors CK2 over CK1, DYRK1A, and 27 other kinases.</p>Formule :C9H4Br4O2Degré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :463.74Ellagic acid (hydrate)
CAS :<p>Ellagic acid (hydrate) is a natural antioxidant and acts as a potent and ATP-competitive CK2 inhibitor (IC50:40 nM, Ki: 20 nM).</p>Formule :C14H8O9Degré de pureté :98%Couleur et forme :Green To Beige PowderMasse moléculaire :320.21Casein kinase 1δ-IN-14
CAS :<p>Casein kinase 1δ-IN-14 (WAY-637081) can be used to study atherosclerosis-related cardiovascular disease.</p>Formule :C17H11ClN4O2Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :338.75CIGB-300
CAS :<p>CIGB-300 (P15-Tat) is an anti-casein kinase 2 (CK2) peptide that exhibits anticancer properties by disrupting the phosphorylation activity of protein kinase CK2. The compound induces apoptosis in various tumor cell lines, making it valuable for research in cancer therapy.</p>Formule :C127H215N53O30S3Couleur et forme :SolidMasse moléculaire :3060.6CZP-IN-1
<p>CZP-IN-1 (compound SH-1) is an inhibitor targeting the pathogen Trypanosoma cruzi protease (CZP) without affecting cathepsin L (IC50=28 nM). This compound is applicable in Chagas disease research.</p>Formule :C20H26N4O4SCouleur et forme :SolidMasse moléculaire :418.51CK1δ/CK1ε liagnd-1
<p>CK1δ/CK1ε ligand-1 is a ligand of CK1δ/CK1ε and can serve as a target protein ligand for the synthesis of the CK1 PROTAC degrader AH078.</p>Formule :C21H20F2N6Couleur et forme :SolidMasse moléculaire :394.42AH078
<p>AH078 (compound 37) is a selective PROTAC degrader targeting CK1δ and CK1ε with low selectivity for CK1α. AH078 consists of a PROTAC linker (black part) Monomethyl octanoate, a target protein ligand (red part) CK1δ/CK1ε ligand-1, and an E3 ligase ligand (blue part) E3 Ligase Ligand 58. The E3 ligase ligand combined with the linker forms the conjugate E3 Ligase Ligand-linker Conjugate 163.</p>Formule :C51H60F2N10O5SCouleur et forme :SolidMasse moléculaire :963.15FPFT-2216
CAS :<p>FPFT-2216 is a "molecular glue" compound with potential anti-tumor activity that degrades IKZF6, IKZF1, DE1D and can be used to study immune system diseases.</p>Formule :C12H12N4O3SDegré de pureté :99.35% - 99.62%Couleur et forme :SolidMasse moléculaire :292.31MRT00033659
CAS :<p>MRT00033659 inhibits CK1 (IC50=0.9 μM), CHK1 (IC50=0.23 μM), activates p53, and destabilizes E2F-1; it's a pyrazolo-pyridine.</p>Formule :C15H14N4OCouleur et forme :SolidMasse moléculaire :266.3SGC-CK2-1
CAS :<p>SGC-CK2-1, a CK2 inhibitor, is a inducer of insulin production and secretion in pancreatic β-cells.</p>Formule :C20H21N7ODegré de pureté :99.41%Couleur et forme :SolidMasse moléculaire :375.43PF-5006739
CAS :<p>PF-5006739: potent, selective CK1δ/ε inhibitor (IC50: 3.9/17.0 nM); may treat psychiatric disorders, improves glucose tolerance, reduces opioid seeking.</p>Formule :C22H22FN7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :419.45TA-01
CAS :<p>TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.</p>Formule :C20H12F3N3Degré de pureté :99.55% - 99.94%Couleur et forme :SolidMasse moléculaire :351.32SR-3029
CAS :<p>SR-3029 is a potent and highly specific CK1δ/CK1ε inhibitor.</p>Formule :C23H19F3N8ODegré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :480.45PF-670462
CAS :<p>PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations.</p>Formule :C19H22Cl2FN5Degré de pureté :99.42% - 99.72%Couleur et forme :SolidMasse moléculaire :410.32CK1-IN-1
CAS :<p>CK1-IN-1, a CK1 inhibitor with IC50: 15nM CK1δ, 16nM CK1ε, 73nM p38σ; patent WO2015119579A1.</p>Formule :C24H15F2N3Degré de pureté :98.79%Couleur et forme :SolidMasse moléculaire :383.39Longdaysin
CAS :<p>Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).</p>Formule :C16H16F3N5Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :335.33TTP 22
CAS :<p>TTP 22: ATP-competitive CK2 inhibitor; IC50/Ki: 0.1 μM/40 nM; >250x selective over JNK3, ROCK1, MET.</p>Formule :C16H14N2O2S2Degré de pureté :97.08% - 97.78%Couleur et forme :SolidMasse moléculaire :330.42TBB
CAS :<p>TBB (NSC-231634)(NSC-231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).</p>Formule :C6HBr4N3Degré de pureté :98.51% - 99.45%Couleur et forme :Off-White SolidMasse moléculaire :434.71NCC007
CAS :<p>NCC007 is a novel CKIα and CKIδ dual inhibitors by structural modification of N9 and C2 position of longdaysin.</p>Formule :C22H28F3N7Degré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :447.5MLN8054
CAS :<p>MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.</p>Formule :C25H15ClF2N4O2Degré de pureté :98.07% - 98.26%Couleur et forme :SolidMasse moléculaire :476.86(E/Z)-GO289
CAS :<p>(E/Z)-GO289, which strongly lengthened circadian period, is a potent and selective inhibitor of CK2.</p>Formule :C17H15BrN4O2SDegré de pureté :98.1%Couleur et forme :SolidMasse moléculaire :419.3AS-252424
CAS :<p>AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα.</p>Formule :C14H8FNO4SDegré de pureté :99.06% - 99.09%Couleur et forme :SolidMasse moléculaire :305.28Umbralisib hydrochloride
CAS :<p>Umbralisib hydrochloride: PI3Kδ inhibitor; IC50=22.2 nM, EC50=24.3 nM; active vs CK1ε, EC50=6.0 μM.</p>Formule :C31H25ClF3N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :608.01CKI-7
CAS :<p>CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor.</p>Formule :C11H14Cl3N3O2SDegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :358.67DMAT
CAS :<p>DMAT (Casein kinase II Inhibitor) is a potent and specific inhibitor of CK2(IC50 value of 130 nM).</p>Formule :C9H7Br4N3Degré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :476.79CK2-IN-1
CAS :<p>CK2 inhibitor</p>Formule :C14H9NO3Degré de pureté :97.28%Couleur et forme :SolidMasse moléculaire :239.23TAK-715
CAS :<p>TAK-715 is a p38 MAPK inhibitor for p38α.</p>Formule :C24H21N3OSDegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :399.51
