Caséine Kinase
Les caséine kinases sont une famille de kinases protéiques sérine/thréonine qui régulent divers processus cellulaires, y compris la réparation de l'ADN, les rythmes circadiens et la transduction du signal. Ces kinases sont impliquées dans la phosphorylation de nombreuses protéines et sont associées à des maladies telles que le cancer, les troubles neurodégénératifs et les syndromes métaboliques. Chez CymitQuimica, nous proposons une sélection d'inhibiteurs de la caséine kinase pour soutenir vos recherches sur la transduction du signal, la régulation du cycle cellulaire et le développement thérapeutique.
130 produits trouvés pour "Caséine Kinase"
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CK1δ-IN-5
CAS :<p>CK1δ-IN-5 (Compound 24) is an inhibitor of casein kinase 1δ (CK1δ) and can be used in the study of neurodegenerative diseases.</p>Formule :C22H21N5Couleur et forme :SolidMasse moléculaire :355.436Casein kinase 1δ-IN-27
CAS :<p>Casein kinase1δ-IN-27 (Compound 8) is an inhibitor of casein kinase 1 (CK1), effectively inhibiting CK1α, CK1δ, CK1ε, and p38α with IC50 values of 22, 16.5, 9.41, and 14.8 nM, respectively. It also suppresses DUX4 expression, with an IC50 of 10 nM.</p>Formule :C21H19FN6Couleur et forme :SolidMasse moléculaire :374.414CK1δ-IN-7
CAS :<p>CK1δ-IN-7 (Compound 488) is an inhibitor of casein kinase 1δ (CK1δ).</p>Formule :C23H23N5OCouleur et forme :SolidMasse moléculaire :385.462p38α inhibitor 8
CAS :<p>p38α inhibitor8 (Compound 1) demonstrates inhibitory activity against p38αMAPK and CK1δ, with IC50 values of 0.21 µM and 0.202 µM, respectively.</p>Formule :C17H13FN6Couleur et forme :SolidMasse moléculaire :320.324dCK1α-2
<p>dCK1α-2 is an orally effective CK1α molecular glue (Molecular Glue) degrader that targets p53 pathway-related targets. It demonstrates antitumor efficacy in mouse models by enhancing the expression of p53-related genes.</p>Formule :C24H24ClN5O4Couleur et forme :SolidMasse moléculaire :481.93CK1δ-IN-9
CAS :<p>CK1δ-IN-9 (Compound 8) is an inhibitor of casein kinase 1 (CK1), specifically targeting CK1δ with an IC50 of 1.4 nM. The compound also inhibits p38α and p38β with IC50 values of 0.25 μM and 0.78 μM, respectively. CK1δ-IN-9 exhibits favorable pharmacokinetic properties, including high oral bioavailability (70%) and moderate clearance.</p>Formule :C16H12FN5Couleur et forme :SolidMasse moléculaire :293.298Casein kinase 1δ-IN-31
CAS :<p>Casein kinase1δ-IN-31 (Compound 16) is an inhibitor of casein kinase (CK), specifically targeting CK1α, CK1δ, and p38α, with IC50 values of 196 nM, 17 nM, and 18 nM, respectively. Additionally, Casein kinase1δ-IN-31 inhibits Double Homeobox 4 (DUX4) with an IC50 of 1200 nM.</p>Formule :C17H13FN4Couleur et forme :SolidMasse moléculaire :292.31MGD-28
CAS :<p>MGD-28 is a Cullin-CRBN-dependent IKZF family protein degrader for IKZF1 (Ikaros), IKZF2 (Helios), IKZF3 (Aiolos) ,and CK1α, antiproliferative.</p>Formule :C33H34FN7O3Degré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :595.67CK1δ-IN-10
CAS :<p>CK1δ-IN-10 (Compound 85) is an inhibitor of casein kinase 1 (CK1), specifically targeting CK1δ (CSNKID), with an IC50 value of 0.255 μM.</p>Formule :C17H11F4N5Couleur et forme :SolidMasse moléculaire :361.296Casein kinase 1δ-IN-16
CAS :<p>Casein kinase1δ-IN-16 (compound 506) is an inhibitor of casein kinase 1δ (CK1δ). This compound is applicable in research related to neurodegenerative diseases.</p>Formule :C17H12N4S2Couleur et forme :SolidMasse moléculaire :336.434CK1δ-IN-8
CAS :<p>CK1δ-IN-8 (Compound 429) is a CK1δ inhibitor suitable for Alzheimer's disease research.</p>Formule :C14H9N3O2S2Couleur et forme :SolidMasse moléculaire :315.37Casein kinase 1δ-IN-30
CAS :<p>Casein kinase1δ-IN-30 (Compound 581) is an inhibitor of casein kinase 1δ (CK1δ). It can be utilized in research related to neurodegenerative diseases.</p>Formule :C18H15BrN6O2SCouleur et forme :SolidMasse moléculaire :459.32p38α MAPK/CK1δ inhibitor-1
CAS :<p>p38αMAPK/CK1δ inhibitor-1 (Compound 3) exhibits inhibitory activity against p38αMAPK and CK1δ, with IC50 values of 0.185 µM and 0.089 µM, respectively.</p>Formule :C24H17FN6O2Couleur et forme :SolidMasse moléculaire :440.429Casein kinase 1δ-IN-18
CAS :<p>Casein kinase1δ-IN-18 (compound 660) is an inhibitor of casein kinase 1δ (CK1δ), which can be utilized for research in neurodegenerative diseases.</p>Formule :C16H12ClN3O2S2Couleur et forme :SolidMasse moléculaire :377.868(R,R)-BMS-986397
CAS :<p>(R,R)-BMS-986397 is a CK1α degrader with a DC50 ranging from 0.1 to 0.5 pM. This compound is applicable in leukemia research.</p>Formule :C21H16ClF3N4O4Couleur et forme :SolidMasse moléculaire :480.82DEG-35
CAS :<p>DEG-35 is a CRBN-dependent bifunctional degrader targeting IKZF2 and CK1α, with DC50 values of 1.4 nM and 4.4 nM for CK1α and IKZF2, respectively. It activates the p53 apoptotic pathway and is applicable for research related to acute myeloid leukemia (AML).</p>Formule :C25H21N3O5Couleur et forme :SolidMasse moléculaire :443.45AMG-548 dihydrochloride
<p>AMG-548 dihydrochloride, an oral p38α inhibitor (Ki: 0.5 nM), selectively targets p38β, γ, δ, inhibits TNFα (IC50: 3 nM), and suppresses Wnt signaling.</p>Formule :C29H29Cl2N5OCouleur et forme :SolidMasse moléculaire :534.48Casein kinase 1δ-IN-26
CAS :<p>Casein kinase1δ-IN-26 (compound 505) is a potent inhibitor of casein kinase 1δ. This compound is applicable in research related to neurodegenerative disorders such as Alzheimer’s disease.</p>Formule :C16H13N3O4SCouleur et forme :SolidMasse moléculaire :343.357AMG-548 hydrochloride
<p>AMG-548 hydrochloride: orally active, p38α inhibitor (Ki=0.5 nM), 1000x less for p38γ/δ, also blocks TNFα (IC50=3 nM) & inhibits casein kinase 1 δ/ε.</p>Formule :C29H28ClN5OCouleur et forme :SolidMasse moléculaire :498.02CK2 inhibitor 3
<p>CK2 inhibitor 3: potent CK2 blocker, IC50 of 280 nM, suppresses tumor cell growth, highly selective among 320 kinases.</p>Formule :C13H9BrN4O3SCouleur et forme :SolidMasse moléculaire :381.2
