Anhydrase carbonique
L'anhydrase carbonique est une enzyme qui catalyse la conversion réversible du dioxyde de carbone et de l'eau en bicarbonate et protons. Cette enzyme joue un rôle crucial dans le maintien de l'équilibre acido-basique, la respiration et le transport du dioxyde de carbone dans le sang. Les inhibiteurs de l'anhydrase carbonique sont utilisés dans le traitement du glaucome, de l'épilepsie et du mal des montagnes, ainsi que dans la recherche sur l'homéostasie acido-basique et les échanges gazeux. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de l'anhydrase carbonique et de réactifs de haute qualité pour soutenir vos recherches en enzymologie, physiologie respiratoire et développement thérapeutique.
197 produits trouvés pour "Anhydrase carbonique"
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Zonisamide
CAS :Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures.Formule :C8H8N2O3SDegré de pureté :99.05% - 99.9%Couleur et forme :Off-White PowderMasse moléculaire :212.23Tioxolone
CAS :Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor.Formule :C7H4O3SDegré de pureté :97.79%Couleur et forme :Light Yellow To Beige PowderMasse moléculaire :168.17Benzthiazide
CAS :Benzthiazide treats edema and hypertension by promoting diuresis and inhibiting kidney Na+/Cl- reuptake, but may reduce potassium and raise uric acid.
Formule :C15H14ClN3O4S3Degré de pureté :99.34% - 99.79%Couleur et forme :Crystals From Acetone SolidMasse moléculaire :431.94Hydrochlorothiazide
CAS :Hydrochlorothiazide (HCTZ) 是一种口服有效的噻嗪类的利尿药，可抑制转化 TGF-β/Smad 信号通路。它通过打开钙激活钾 (KCA) 通道发挥直接的血管松弛作用。它改善心脏功能，减少纤维化并具有降压作用。Formule :C7H8ClN3O4S2Degré de pureté :99.43% - 99.50%Couleur et forme :Crystals Physical Description Crystals Or White Powder (Ntp 1992)Masse moléculaire :297.74Actarit
CAS :Actarit (4-acetylaminophenylacetic acid) is an anti-inflammatory drug.Formule :C10H11NO3Degré de pureté :99.64% - 99.74%Couleur et forme :White Or Off-White Crystal Or Crystalline SolidMasse moléculaire :193.2Topiramate
CAS :Topiramate (RWJ 17021) is a unique antiseizure medication that is used in the treatment of partial and generalized seizures.Formule :C12H21NO8SDegré de pureté :99.79% - 99.92%Couleur et forme :White To Off-White Crystalline PowderMasse moléculaire :339.36Acipimox
CAS :Acipimox (K-9321), a niacin derivative, treats hyperlipidemia in type 2 diabetics.Formule :C6H6N2O3Degré de pureté :98.98%Couleur et forme :Low Yellow Liquid Or CrystallineMasse moléculaire :154.12Brinzolamide
CAS :Brinzolamide (AL-4862) is a Carbonic Anhydrase Inhibitor. The mechanism of action of brinzolamide is as a Carbonic Anhydrase Inhibitor.Formule :C12H21N3O5S3Degré de pureté :99.84% - >99.99%Couleur et forme :Crystalline SolidMasse moléculaire :383.51Methazolamide
CAS :Methazolamide (CL 8490) is a carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.Formule :C5H8N4O3S2Degré de pureté :99.31% - 99.77%Couleur et forme :Crystals From Water SolidMasse moléculaire :236.27pNNP
CAS :pNNP is a substrate for PP2C assays and inhibits β-carbonic anhydrase, α-carbonate dehydrogenase, and H. pylori.Formule :C6H6NO6PDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :219.09Methocarbamol
CAS :Methocarbamol (AHR 85) is a centrally acting muscle relaxant whose mode of action has not been established.Formule :C11H15NO5Degré de pureté :99.96%Couleur et forme :Crystals From Benzene SolidMasse moléculaire :241.24Acesulfame
CAS :Acesulfame inhibits CA9/12 and can be used to study inflammation-related diseases.Formule :C4H5NO4SCouleur et forme :SolidMasse moléculaire :163.15hCAII/XII-IN-1
hCAII/XII-IN-1 (compound 4l) is a potent inhibitor of hCAXII and hCAII, with Ki values of 8.4 nM and 9.4 nM, respectively. It plays a significant role in cancer research.Formule :C22H20N4O6S2Couleur et forme :SolidMasse moléculaire :500.547CAII/CAXII-IN-1
CAII/CAXII-IN-1 (compound 8d) is an inhibitor of CAII and CAXII, with IC50 values of 0.38 µM for CAII and 0.61 µM for CAXII.Couleur et forme :Odour SolidhCAII-IN-6
"hCAII-IN-6 (S-13) inhibits hCA II (4.4 nM) and isoforms I, IV, IX (9.2, 480.2, 14.7 nM). For glaucoma research."Formule :C20H25N3O4SCouleur et forme :SolidMasse moléculaire :403.5hCAIX-IN-17
hCA IX-IN-1 inhibits hCA I/II/IX/XII with Ki of 331.4/28.4/9.4/17.8 nM, has anticancer properties.Formule :C19H18N2O3SCouleur et forme :SolidMasse moléculaire :354.42Phenylsulfamide
CAS :Phenylsulfamide (Compound 10), acting as an inhibitor of human carbonic anhydrase-II (hCA-II), exhibits a dissociation constant (Kd) of 45.50 μM and anFormule :C6H8N2O2SCouleur et forme :SolidMasse moléculaire :172.2hCAIX/XII-IN-9
hCAIX/XII-IN-9 (compound 8) is a potent inhibitor of carbonic anhydrase (CA), with Ki values of 1658 nM for hCA I, 184.8 nM for hCA II, 8.9 nM for hCA IX, and 64.8 nM for hCA XII.Formule :C26H25N5O5S2Masse moléculaire :551.12971CAXII-IN-2
CAXII-IN-2 (compound 3j) is a highly effective inhibitor of CAXII. It demonstrates inhibitory activity against CA IX and CAXII, with Ki values of 27.4 nM and 4.0 nM, respectively.Formule :C16H13FNO4PCouleur et forme :SolidMasse moléculaire :333.05662Girentuximab
CAS :Girentuximab (G250) is an anti-carbonic anhydrase IX (CAIX) monoclonal antibody with anti-cancer activity for the study of uroepithelial carcinoma PET (ZiPUP).Couleur et forme :LiquidMasse moléculaire :145.55 kDahCAIX/XII-IN-11
hCAIX/XII-IN-11 (Compound 6c) is an inhibitor of hCA IX and hCA XII, exhibiting Ki values of 0.7 μM for both isoforms. This compound is applicable in cancer research.Formule :C13H10FN3O4Masse moléculaire :291.06553CAIX/CAXII-IN-3
CAIX/CAXII-IN-3 (compound 11) serves as an inhibitor for CAIX/CAXII, exhibiting an IC50 value of less than 65 nM. Additionally, this compound effectively inhibits the proliferation of human melanoma cells.Couleur et forme :Odour Solid(E)-Dehydrodiconiferyl alcohol
CAS :(E)-Dehydrodiconiferyl alcohol inhibits hCA IX/XII enzymes and blocks NF-κB nuclear translocation in healing tissues.Formule :C20H22O6Couleur et forme :SolidMasse moléculaire :358.39hCAII-IN-7
hCAII-IN-7 (R-13) inhibits human CA I, II, IV, IX with K i of 60.7, 320.7, 2298, 35.2 nM respectively.Formule :C20H25N3O4SCouleur et forme :SolidMasse moléculaire :403.5α-Pyrone
CAS :Alpha-Pyrone exhibits inhibitory activity against tyrosinase, carbonic anhydrase 1, and carbonic anhydrase 9Formule :C5H4O2Couleur et forme :SolidMasse moléculaire :96.08Carbonic anhydrase inhibitor 32
Carbonic anhydrase inhibitor32 (compound 5B) is an orally active, selective inhibitor of hCA (carbonic anhydrase) II/VII, with Ki values of 6.3 nM for hCA II, 10.1 nM for hCA VII, and 681 nM for hCA I. It shows potential for neuroprotection and anticonvulsant effects by reducing mTOR activation and increasing hippocampal KCC2 levels.Formule :C17H16N6O3SCouleur et forme :SolidMasse moléculaire :384.41GZ22-4
GZ22-4 is a near-infrared (NIR) fluorescent probe with a high affinity for carbonic anhydrase IX (CAIX), exhibiting a dissociation constant (Kd) of 0.2 nM. It is applicable in studies for visualizing CAIX-positive tumors.Formule :C88H126F3N6NaO24S4Masse moléculaire :1858.755615,6-Dihydro-2H-pyran-2-one
CAS :5,6-Dihydro-2H-pyran-2-one is a carbonic anhydrase 1/9 inhibitor that inhibits KB cell viability.Formule :C5H6O2Couleur et forme :SolidMasse moléculaire :98.1Carbonic anhydrase inhibitor 30
Carbonic anhydrase inhibitor30 (compound 17) is an inhibitor of carbonic anhydrase with Ki values of 2.13 μM for hCA I and 0.161 μM for hCA II[1].Formule :C23H22FN3O5SCouleur et forme :SolidMasse moléculaire :471.12642Chlorothiazide
CAS :Chlorothiazide (Diuril) is a thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE.Formule :C7H6ClN3O4S2Degré de pureté :98.46% - 98.91%Couleur et forme :Crystals Physical Description Crystals; White Powder (Ntp 1992)Masse moléculaire :295.72hCAII/IX-IN-1
hCAII/IX-IN-1 (compound 4o) is a potent inhibitor of hCAII and hCAIX, with Ki values of 7.4 nM and 7.0 nM, respectively. It plays a significant role in cancer research.Formule :C23H22N4O7S2Couleur et forme :SolidMasse moléculaire :530.5732-Methoxy-4-propylphenol
CAS :2-Methoxy-4-propylphenol is an inhibitor of human carbonic anhydrase isoenzymes 1/2/9/12 and has antifungal activity.
Formule :C10H14O2Couleur et forme :SolidMasse moléculaire :166.22TSPO/Carbonic Anhydrase Modulator 1
TSPO/Carbonic Anhydrase Modulator 1 (Compound 3) acts as a dual modulator of mitochondrial translocator protein and carbonic anhydrase, with a TSPOKi of 1.340 μM and a CAVII KA of 10.7 μM. It enhances neurosteroid production, increases BDNF gene expression, and demonstrates neuroprotective activity.Formule :C35H51N3O3Couleur et forme :SolidMasse moléculaire :561.798Pyrocatechol
CAS :Pyrocatechol, often known as catechol or benzene-1,2-diol, is a benzenediol, Pyrocatechol was produced at a large scale industrially, mainly as precursors to pesticides, flavors, and fragrances. Its sulfonic acid is often present in the urine of many mammals.Formule :C6H6O2Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :110.11VM4-037
CAS :VM4-037 is a PET imaging agent used for carbonic anhydrase IX.Formule :C26H29FN6O7S2Couleur et forme :SolidMasse moléculaire :620.67hCA/Wnt/β-catenin-IN-1
hCA/Wnt/β-catenin-IN-1 (Compd 15) serves as an inhibitor with selective affinity for hCA isoforms II, IX, and XII, exhibiting K i values of 33.6, 24.1, and 6.8Couleur et forme :Odour SolidCAIX/CAXII-IN-4
CAIX/CAXII-IN-4 (Compound 7h) is an inhibitor of carbonic anhydrase (CA) that binds to CAIX, CA XII, and CAII with Ki values of 1.324 μM, 0.435 μM, and 3.035 μM, respectively. This compound exhibits broad-spectrum anti-tumor activity and inhibits the proliferation of central nervous system tumor cells U251, with a GI50 of 0.361 μM.Formule :C23H21N5O3SCouleur et forme :SolidMasse moléculaire :447.51hCA/VEGFR-2-IN-2
Compound 8g (hCA/VEGFR-2-IN-2) is an indolinonylbenzenesulfonamide identified as a potential dual inhibitor targeting cancer-associated isozymes hCA IX/XII andFormule :C23H26N6O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.55hCA/VEGFR-2-IN-3
hCA/VEGFR-2-IN-3 (compound 8j) is an indolinonylbenzenesulfonamide with potential as a dual inhibitor of cancer-associated hCA IX/XII and VEGFR-2.Formule :C24H28N6O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :528.58hCAIX/XII-IN-14
hCAIX/XII-IN-14 (Compound 1i) is an inhibitor of hCAIX and hCAXII, with Ki values of 9.4 nM for hCAII, 5.6 nM for hCAIX, and 6.3 nM for hCAXII.Formule :C16H14F3N3O4SCouleur et forme :SolidMasse moléculaire :401.36DOTA-XYIMSR-01
CAS :DOTA-XYIMSR-01 is a molecular probe targeting CAIX, capable of being labeled with 177Lu for the treatment and localization of malignant gliomas. The uptake of [177Lu]Lu-XYIMSR-01 in U87MG tumors is 6.19% injected dose per gram (% ID/g), with a tumor-to-muscle uptake ratio of 20.14. In an orthotopic glioma model, co-administration with temozolomide significantly enhances survival rates and inhibits tumor growth in mice. DOTA-XYIMSR-01 shows potential for research in the field of cancer treatment.Formule :C61H88N16O22S2Couleur et forme :SolidMasse moléculaire :1461.57DPP IV/hCA II-IN-1
CAS :DPP IV/hCA II-IN-1: strong DPP IV & CA inhibitor, IC50=0.049μM (DPP IV), Ki=0.0361-3.034μM (CA II-IV).Formule :C17H20N2O5SCouleur et forme :SolidMasse moléculaire :364.42Dorzolamide
CAS :Dorzolamide is an anti-glaucoma agent and is a carbonic anhydrase inhibitor.
Formule :C10H16N2O4S3Degré de pureté :98%Couleur et forme :White Or Almost White Crystalline PowderMasse moléculaire :324.44hCAI/II-IN-10
hCAI/II-IN-10 (Compound 5d) is an inhibitor of human carbonic anhydrase I and II (hCA I and hCA II), with IC50 values of 4.32 nM and 3.89 nM, respectively.Formule :C24H17Cl2N3O3S2Couleur et forme :SolidMasse moléculaire :530.446hCAIX-IN-19
hCAIX-IN-19 is a sulfonamide inhibitor with an inhibition constant (KI) of 6.2 nM for hCAIX, exhibiting significant selectivity towards hCAIX over hCAI (hCA I/Couleur et forme :Odour SolidhCA/VEGFR-2-IN-4
hCA/VEGFR-2-IN-4 (compound 15b), an indolinylbenzenesulfonamide, serves as a potential dual inhibitor targeting cancer-related human carbonic anhydrases hCA IX/Formule :C22H23FN6O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :502.52hCAII-IN-8
CAS :Compound CDy9 is a highly selective inhibitor of carbonic anhydrase (CA) with an IC50 value of 0.18 μM for hCA II.Formule :C15H16N2O5SDegré de pureté :99.73%Couleur et forme :SoildMasse moléculaire :336.36Ref: TM-T67774
5mg42,00€1mL*10mM (DMSO)52,00€10mg64,00€25mg116,00€50mg167,00€100mg241,00€200mg339,00€Carbonic anhydrase inhibitor 31
Carbonic anhydrase inhibitor31 is an mtCA2 inhibitor (Ki: 5.2 nM) that can be used in antituberculosis research.Formule :C24H20N6O5SCouleur et forme :SolidMasse moléculaire :504.12159CAIX Inhibitor S4
CAS :CAIX Inhibitor S4 (S4) is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively.Formule :C15H17N3O4SDegré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :335.38Ref: TM-T36758
2mg38,00€5mg57,00€1mL*10mM (DMSO)63,00€10mg90,00€25mg178,00€50mg334,00€100mg500,00€500mg1.099,00€Carbonic anhydrase inhibitor 29
Carbonic anhydrase inhibitor29 (Compound 5d) is an inhibitor targeting carbonic anhydrase IX and XII, with an inhibition constant (Ki) of 26.6 nM for carbonic anhydrase IX and a Ki of 10.9 nM for carbonic anhydrase XII. Carbonic anhydrase inhibitor29 can be used in cancer research.Couleur et forme :Odour Solid
