ROR
Les récepteurs orphelins liés à l'acide rétinoïque (RORs) sont des récepteurs nucléaires qui régulent divers processus physiologiques, y compris le rythme circadien, la réponse immunitaire et le métabolisme. Les inhibiteurs des RORs sont d'un grand intérêt dans l'étude des maladies auto-immunes, des troubles métaboliques et du cancer, car ils peuvent moduler l'expression des gènes et influencer les fonctions cellulaires. Chez CymitQuimica, nous proposons des inhibiteurs de RORs pour soutenir vos recherches en immunologie, endocrinologie et oncologie.
47 produits trouvés pour "ROR"
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XY039
XY039 (compound 13e) is an RORγ inverse agonist with an IC50 value of 0.55 μM. XY039 induces cell apoptosis and exhibits antiproliferative activity both in vivo and in vitro.Formule :C23H19F5N2O4S2Masse moléculaire :546.07064RORγt inverse agonist 31
RORγt inverse agonist 31 (14g) is a potent antagonist of the retinoic acid receptor-related orphan receptor γt (RORγt), exhibiting an inhibitory concentration (Formule :C23H15Cl2F3N4O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :555.36RORγ antagonist 1
RORγ antagonist 1 (compound 22), a potent derivative of betulinic acid, acts as an antagonist to RORγ with a dissociation constant (K D) of 0.18 μM.Formule :C35H60N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :540.86Bevurogant
CAS :Bevurogant is an antagonist of RORγt receptor and can be used in studies about the treatment of chronic inflammatory diseases.Formule :C26H28N8O3SDegré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :532.62RORγt inverse agonist 33
RORγt inverse agonist 33 (compound (R)-D4) is an orally bioavailable RORγt inverse agonist with an IC50 of 21 nM, playing a significant role in rheumatoid arthritis research.Formule :C27H37NO5SCouleur et forme :SolidMasse moléculaire :487.651ROR1-IN-2
ROR1-IN-2 (compound 9I) is a potent and selective inhibitor of ROR1. It exhibits antiproliferative activity in various cancer cell lines and significantly inhibits tumor growth in vivo.Formule :C30H27N3O4Couleur et forme :SolidMasse moléculaire :493.20016RORγ agonist 2
RORγ agonist2 (Compound 34) is a selective RORγ agonist with an EC50 of 0.03 μM for hRORγ. It significantly inhibits tumor growth in an MC38 tumor mouse model with the same genetic background.Couleur et forme :Odour SolidTMP-778
CAS :TMP-778 is a selective inverse agonist of RORγt.Formule :C31H30N2O4Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :494.58ROR1 ligand-1
ROR1ligand-1 (9-1) serves as the ligand for PROTAC ROR1 degrader-1. By linking with ligands of either the VHL type or CRBN, the first selective and efficient ROR1 PROTAC molecule was designed and synthesized.Formule :C23H30BrN7Couleur et forme :SolidMasse moléculaire :484.44Antitumor agent-127
Antitumor agent-127 (compound 1) is a parent macrocyclic peptide that demonstrates nanomolar binding affinity to ROR1 and shows relatively good internalization in 786-O and MDA-MB-231 tumor cell lines.Formule :C86H107N15O18SMasse moléculaire :1669.76392XY018
CAS :XY018 is a ROR-γ antagonist with anti-tumor activity, inhibits ROR-γ activity, and can be used to study drug-resistant prostate cancer.Formule :C23H15F7N2O4Degré de pureté :99.95% - 99.96%Couleur et forme :SolidMasse moléculaire :516.37TMP920
CAS :TMP920 inhibits RORγt binding to the SRC1 peptide (IC50: 0.03 μM). TMP920 is a highly potent and selective RORγt antagonist.Formule :C29H30N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :454.56Neoruscogenin
CAS :1. Neoruscogenin represents a universal pharmacological tool for RORα research due to its specific selectivity profile versus other nuclear receptors.Formule :C27H40O4Degré de pureté :99.5% - 99.92%Couleur et forme :SolidMasse moléculaire :428.60GSK805
CAS :GSK805 is a potent, orally bioavailable and CNS-penetrant RORγt inhibitor.Cost-effective and quality-assured.Formule :C23H18Cl2F3NO4SDegré de pureté :98% - ≥95%Couleur et forme :SolidMasse moléculaire :532.36Ref: TM-T7388
1mg52,00€2mg74,00€5mg114,00€1mL*10mM (DMSO)136,00€10mg177,00€25mg358,00€50mg437,00€100mg627,00€200mg898,00€Cintirorgon
CAS :Cintirorgon (LYC-55716) is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells.Formule :C27H23F6NO6SDegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :603.53Ref: TM-TQ0007
1mg66,00€5mg130,00€1mL*10mM (DMSO)167,00€10mg178,00€25mg313,00€50mg447,00€100mg620,00€SR1001
CAS :SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM).Formule :C15H13F6N3O4S2Degré de pureté :98.93%Couleur et forme :SolidMasse moléculaire :477.4GSK2981278
CAS :GSK2981278 (ROR gama modulator 1) is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).Formule :C25H35NO5SDegré de pureté :99.31% - 99.67%Couleur et forme :SolidMasse moléculaire :461.61RORγt inverse agonist 13
CAS :RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist (IC50=63.8 nM), with improved drug-like properties[1].Formule :C23H17Cl2F3N2O4Degré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :513.29Ref: TM-T9623
1mg50,00€5mg110,00€1mL*10mM (DMSO)124,00€10mg170,00€25mg295,00€50mg420,00€100mg572,00€200mg772,00€S18-000003
CAS :S18-000003: Oral retinoic acid receptor gamma-t inhibitor, IC50 29 nM, reduces IL-17 production.Formule :C26H25F3N2O4SDegré de pureté :99.24% - 99.31%Couleur et forme :SolidMasse moléculaire :518.55Ref: TM-T16832
1mg54,00€5mg118,00€1mL*10mM (DMSO)135,00€10mg178,00€25mg318,00€50mg445,00€100mg627,00€500mg1.251,00€SR3335
CAS :SR3335 (ML 176) is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM).Formule :C13H9F6NO3S2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :405.34Ref: TM-T5160
1mg34,00€5mg74,00€1mL*10mM (DMSO)82,00€10mg119,00€25mg233,00€50mg371,00€100mg595,00€200mg833,00€SR1078
CAS :SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ.Formule :C17H10F9NO2Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :431.25Ref: TM-T4594
1mg39,00€2mg52,00€5mg85,00€1mL*10mM (DMSO)87,00€10mg109,00€25mg215,00€50mg349,00€100mg517,00€T0901317
CAS :T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).Formule :C17H12F9NO3SDegré de pureté :98% - 99.64%Couleur et forme :SolidMasse moléculaire :481.33Cedirogant
CAS :Cedirogant (ABBV-157) is an orally active retinoid-related orphan receptor-γt(RORγt) inverse agonist that is used for psoriasis study.Formule :C24H20Cl3F3N2O3Degré de pureté :99.20%Couleur et forme :SolidMasse moléculaire :547.78Ref: TM-T9635
1mg81,00€5mg167,00€1mL*10mM (DMSO)197,00€10mg259,00€25mg470,00€50mg703,00€100mg1.044,00€200mg1.404,00€SR0987
CAS :SR0987 is a RORγt agonist,Formule :C16H10ClF6NO2Degré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :397.7Nobiletin
CAS :Nobiletin: a citrus-derived flavone with anti-inflammatory and anti-cancer properties; water-insoluble, very weak acid.Formule :C21H22O8Degré de pureté :98.65% - 99.76%Couleur et forme :SolidMasse moléculaire :402.39Ref: TM-T2834
5mg54,00€1mL*10mM (DMSO)56,00€10mg84,00€25mg117,00€50mg159,00€100mg251,00€200mg371,00€500mg620,00€TF-S14
CAS :TF-S14 is an inverse agonist of RORγt. It functions by binding to RORγt and inhibiting its activity, leading to a reduction in Th17 cell-associated cytokine production, including IL-17A, IL-21, and IL-22. TF-S14 is applicable in research related to autoimmune diseases and allogeneic transplant rejection.Formule :C22H27N3O2SCouleur et forme :SolidMasse moléculaire :397.53XY101
CAS :XY101 is a selective, metabolically stable and orally available agonist of RORγ inverse(IC50 of 30 nM and a Kd of 380 nM).Formule :C25H20F7NO4SDegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :563.48Ref: TM-T13362
1mg82,00€5mg161,00€1mL*10mM (DMSO)193,00€10mg269,00€25mg427,00€50mg610,00€100mg820,00€500mg1.603,00€RORγt Inverse agonist 8
CAS :RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist(human RORγt-LBD with an IC50 of 19 nM).Formule :C26H33N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :475.59GNE-0946
CAS :GNE-0946 is an effective and selective RORγ/RORc/NR1F3 antagonist (inverse agonist) with an EC50 of 4 nM in HEK-293 cells. autoimmune disease research.Formule :C22H12ClF3N2O4Degré de pureté :98.11%Couleur et forme :SolidMasse moléculaire :460.79MRL-871
CAS :MRL-871 is a selective RORγt allosteric inhibitor, reducing IL-17a mRNA production in EL4 cells, interacting with PPARgamma in partial agonistic binding modes.Formule :C22H12ClF3N2O3Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :444.79Ref: TM-T62622
1mg90,00€5mg215,00€1mL*10mM (DMSO)236,00€10mg356,00€25mg715,00€50mg1.153,00€100mg1.783,00€200mg2.412,00€Methyl-3β-hydroxycholenate
CAS :Methyl-3β-hydroxycholenate (Methyl 3beta-hydroxychol-5-enoate) is a modulator of RORγ.Formule :C25H40O3Degré de pureté :98.78%Couleur et forme :SolidMasse moléculaire :388.58AZD-0284
CAS :AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].Formule :C21H18F6N2O5SDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :524.43ML 209
CAS :ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50= 1.1 μM in a reporter assay).1It inhibits RORγt-induced transcriptionFormule :C25H31NO6Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :441.52SR2211
CAS :SR2211 is a specific modulator and an inverse agonist of RORγ(IC50 = 320 nM, Ki = 105 nM).Formule :C26H24F7N3ODegré de pureté :98.75%Couleur et forme :SolidMasse moléculaire :527.48Ref: TM-T16929
1mg49,00€5mg90,00€1mL*10mM (DMSO)114,00€10mg170,00€25mg260,00€50mg356,00€100mg505,00€500mg1.071,00€RORγt inverse agonist 14
CAS :RORγt inverse agonist 14 (8e) is a potent, selective, and orally active compound with an EC50 of 2.5 nM, exhibiting anti-inflammatory activity.Formule :C26H26F8N2O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :678.613-Oxo-5β-cholanoic acid
CAS :3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (Dehydrolithocholic acid) is a bile acid metabolite and inhibits the differentiation of TH17 cells by directlyFormule :C24H38O3Degré de pureté :98.01% - 99.86%Couleur et forme :SolidMasse moléculaire :374.56TMP780
CAS :TMP780 is an inverse RORγt agonist (IC50: 13 nM). RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders.Formule :C31H30N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :494.58RORγt Inverse agonist 6
CAS :RORγt Inverse agonist 6 is an agonist of RORγt inverse. RORγt Inverse agonist 6 can be used in research on Th17-driven autoimmune diseases.Formule :C28H29ClN6O5Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :565.02Ref: TM-T12753
1mg58,00€5mg133,00€1mL*10mM (DMSO)165,00€10mg190,00€25mg306,00€50mg414,00€100mg532,00€200mg705,00€FM26
CAS :FM26, an isoxazole-based RORγt inverse agonist, cuts EL4 IL-17a mRNA; potent with 264 nM IC50.Formule :C22H15ClF3N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.82JTE-151
CAS :JTE-151, a RORγ inhibitor, suppresses the overactive immune response by inhibiting RORγ, which is linked to the activation of Th17 cells. This action positions JTE-151 as a potential candidate for autoimmune disease research [1].Formule :C28H37ClN2O4Masse moléculaire :501.06RORγt inverse agonist 34
CAS :RORγt inverse agonist 34 (compound 5a) is an inverse agonist for RORγt, exhibiting an IC50 of 0.094 μM for the inhibition of RORγt-LBD. This compound is utilized in psoriasis research.Formule :C31H37N3O3SCouleur et forme :SolidMasse moléculaire :531.709RORγ-IN-2
CAS :RORγ-IN-2 (Compound 22) is an inhibitor of RORγ, with a Ki value of 16.6 nM for hRORγ. It is useful for research in IL-17-dependent autoimmune diseases.
Formule :C28H32F3N5O4S2Couleur et forme :SolidMasse moléculaire :623.71RORγt inverse agonist 32
CAS :RORγt inverse agonist 32 (compound b14) exhibits oral activity and can be utilized in inflammatory research studies.Formule :C24H28F3NO5SCouleur et forme :SolidMasse moléculaire :499.54TAK-828F
CAS :TAK-828F: potent, selective RORγt inverse agonist. Oral. IC50=1.9 nM; reporter gene IC50=6.1 nM.Formule :C28H32FN3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :509.57RORγt inhibitor 4
CAS :RORγt inhibitor 4 (Compound 9a) is an orally active RORγt inhibitor capable of penetrating the central nervous system. It has been shown to improve experimental autoimmune encephalomyelitis.Formule :C22H16Cl2F3NO4SCouleur et forme :SolidMasse moléculaire :518.333ROR1-IN-1
CAS :ROR1-IN-1 (Compound 19h) is an inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1) with a Ki of 0.10 μM. It inhibits the proliferation of cancer cell lines H1975, A549, and MDA-MB-231, with IC50 values of 0.36 μM, 1.37 μM, and 0.47 μM, respectively. In mice, ROR1-IN-1 demonstrates antitumor efficacy and exhibits favorable pharmacokinetic properties in a rat model.Formule :C33H27N5O3Masse moléculaire :541.60Vimirogant
CAS :Vimirogant is a RORγ inhibitor (Ki: <100 nM).Formule :C27H35F3N4O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :552.65
