ROR
Les récepteurs orphelins liés à l'acide rétinoïque (RORs) sont des récepteurs nucléaires qui régulent divers processus physiologiques, y compris le rythme circadien, la réponse immunitaire et le métabolisme. Les inhibiteurs des RORs sont d'un grand intérêt dans l'étude des maladies auto-immunes, des troubles métaboliques et du cancer, car ils peuvent moduler l'expression des gènes et influencer les fonctions cellulaires. Chez CymitQuimica, nous proposons des inhibiteurs de RORs pour soutenir vos recherches en immunologie, endocrinologie et oncologie.
42 produits trouvés pour "ROR"
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SR0987
CAS :<p>SR0987 is a RORγt agonist,</p>Formule :C16H10ClF6NO2Degré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :397.7Nobiletin
CAS :<p>Nobiletin: a citrus-derived flavone with anti-inflammatory and anti-cancer properties; water-insoluble, very weak acid.</p>Formule :C21H22O8Degré de pureté :98.65% - 99.76%Couleur et forme :SolidMasse moléculaire :402.39MRL-871
CAS :<p>MRL-871 is a selective RORγt allosteric inhibitor, reducing IL-17a mRNA production in EL4 cells, interacting with PPARgamma in partial agonistic binding modes.</p>Formule :C22H12ClF3N2O3Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :444.79RORγt Inverse agonist 8
CAS :<p>RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist(human RORγt-LBD with an IC50 of 19 nM).</p>Formule :C26H33N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :475.59Methyl-3β-hydroxycholenate
CAS :<p>Methyl-3β-hydroxycholenate (Methyl 3beta-hydroxychol-5-enoate) is a modulator of RORγ.</p>Formule :C25H40O3Degré de pureté :98.78%Couleur et forme :SolidMasse moléculaire :388.58TF-S14
CAS :<p>TF-S14 is an inverse agonist of RORγt. It functions by binding to RORγt and inhibiting its activity, leading to a reduction in Th17 cell-associated cytokine production, including IL-17A, IL-21, and IL-22. TF-S14 is applicable in research related to autoimmune diseases and allogeneic transplant rejection.</p>Formule :C22H27N3O2SCouleur et forme :SolidMasse moléculaire :397.53XY101
CAS :<p>XY101 is a selective, metabolically stable and orally available agonist of RORγ inverse(IC50 of 30 nM and a Kd of 380 nM).</p>Formule :C25H20F7NO4SDegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :563.48AZD-0284
CAS :<p>AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].</p>Formule :C21H18F6N2O5SDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :524.43ML 209
CAS :<p>ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50= 1.1 μM in a reporter assay).1It inhibits RORγt-induced transcription</p>Formule :C25H31NO6Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :441.52SR2211
CAS :<p>SR2211 is a specific modulator and an inverse agonist of RORγ(IC50 = 320 nM, Ki = 105 nM).</p>Formule :C26H24F7N3ODegré de pureté :98.75%Couleur et forme :SolidMasse moléculaire :527.483-Oxo-5β-cholanoic acid
CAS :<p>3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (Dehydrolithocholic acid) is a bile acid metabolite and inhibits the differentiation of TH17 cells by directly</p>Formule :C24H38O3Degré de pureté :98.01% - 99.86%Couleur et forme :SolidMasse moléculaire :374.56RORγt Inverse agonist 6
CAS :<p>RORγt Inverse agonist 6 is an agonist of RORγt inverse. RORγt Inverse agonist 6 can be used in research on Th17-driven autoimmune diseases.</p>Formule :C28H29ClN6O5Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :565.02FM26
CAS :<p>FM26, an isoxazole-based RORγt inverse agonist, cuts EL4 IL-17a mRNA; potent with 264 nM IC50.</p>Formule :C22H15ClF3N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.82TMP780
CAS :<p>TMP780 is an inverse RORγt agonist (IC50: 13 nM). RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders.</p>Formule :C31H30N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :494.58RORγt inverse agonist 14
CAS :<p>RORγt inverse agonist 14 (8e) is a potent, selective, and orally active compound with an EC50 of 2.5 nM, exhibiting anti-inflammatory activity.</p>Formule :C26H26F8N2O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :678.61RORγt inverse agonist 34
CAS :<p>RORγt inverse agonist 34 (compound 5a) is an inverse agonist for RORγt, exhibiting an IC50 of 0.094 μM for the inhibition of RORγt-LBD. This compound is utilized in psoriasis research.</p>Formule :C31H37N3O3SCouleur et forme :SolidMasse moléculaire :531.709RORγt inhibitor 4
CAS :<p>RORγt inhibitor 4 (Compound 9a) is an orally active RORγt inhibitor capable of penetrating the central nervous system. It has been shown to improve experimental autoimmune encephalomyelitis.</p>Formule :C22H16Cl2F3NO4SCouleur et forme :SolidMasse moléculaire :518.333ROR1-IN-1
CAS :<p>ROR1-IN-1 (Compound 19h) is an inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1) with a Ki of 0.10 μM. It inhibits the proliferation of cancer cell lines H1975, A549, and MDA-MB-231, with IC50 values of 0.36 μM, 1.37 μM, and 0.47 μM, respectively. In mice, ROR1-IN-1 demonstrates antitumor efficacy and exhibits favorable pharmacokinetic properties in a rat model.</p>Formule :C33H27N5O3Masse moléculaire :541.60TAK-828F
CAS :<p>TAK-828F: potent, selective RORγt inverse agonist. Oral. IC50=1.9 nM; reporter gene IC50=6.1 nM.</p>Formule :C28H32FN3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :509.57RORγt inverse agonist 32
CAS :<p>RORγt inverse agonist 32 (compound b14) exhibits oral activity and can be utilized in inflammatory research studies.</p>Formule :C24H28F3NO5SCouleur et forme :SolidMasse moléculaire :499.54
