NAMPT
La nicotinamide phosphoribosyltransférase (NAMPT) est une enzyme impliquée dans la biosynthèse du nicotinamide adénine dinucléotide (NAD+), un coenzyme essentiel au métabolisme cellulaire et à la production d'énergie. Les inhibiteurs de la NAMPT suscitent un intérêt particulier en recherche sur le cancer, en raison de leur capacité à perturber le métabolisme du NAD+ et à induire la mort des cellules cancéreuses. Ces inhibiteurs sont également étudiés dans le contexte des troubles métaboliques et du vieillissement. Chez CymitQuimica, nous proposons des inhibiteurs de la NAMPT pour soutenir vos recherches en biologie du cancer, métabolisme et vieillissement.
36 produits trouvés pour "NAMPT"
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SBI-797812
CAS :<p>SBI-797812 is structurally similar to active-site directed inhibitor of NAMPT(NAMPT with EC50 of 0.37 μM).</p>Formule :C19H22N4O4SDegré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :402.47Nampt-IN-5
CAS :<p>Nampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) .</p>Formule :C25H25N5O2Degré de pureté :99.30%Couleur et forme :SolidMasse moléculaire :427.5Nampt activator-1
CAS :<p>NAMPT Activator-1, EC50: 3.3-3.7 µM, specific niacinamide phosphotransferase stimulant, shields cells, potential neuroprotectant.</p>Formule :C16H17N3O3Degré de pureté :99.84% - 99.98%Couleur et forme :SoildMasse moléculaire :299.32CB 300919
CAS :<p>CB 300919, a quinazoline antitumor, inhibits CH1 ovarian tumor growth (IC50: 2 nM) over 96h.</p>Formule :C32H34ClN7O2Couleur et forme :SolidMasse moléculaire :584.11NAMPT degrader-3
<p>NAMPT Degrader-3 (compound C5) is a NAMPT degrader that functions through a VHL- and proteasome-dependent mechanism.</p>Formule :C56H74N8O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1003.3Nampt degrader-2
<p>Nampt degrader-2: a fluorescent PROTAC that degrades NAMPT at IC50 41.9 nM, reducing NAD+ and having anti-tumor effects.</p>Formule :C59H73N9O7SCouleur et forme :SolidMasse moléculaire :1052.33NAMPT activator-7
<p>NAMPTactivator-7 (Compound 232) is an activator of nicotinamide phosphoribosyltransferase (NAMPT) with an EC50 of less than 0.5 μM. It effectively stimulates NAMPT in U2OS cells, demonstrating a cellular EC50 of less than 0.5 μM.</p>Formule :C21H17ClN4O3Masse moléculaire :408.09892Nampt-IN-10 trihydrochloride
<p>Nampt-IN-10 trihydrochloride, a NAMPT inhibitor, is effective on A2780 & CORL23 cells (IC50: 5/19 nM); potential ADC payload.</p>Formule :C27H31Cl3FN5O2Couleur et forme :SolidMasse moléculaire :582.92LYP-8
<p>LYP-8 is a potent NAMPT degrader that achieves a maximum degradation rate of 97% in NAMPT within SKOV-3 cells at a concentration of 0.5 μM. LYP-8 also demonstrates anticancer activity both in vitro and in vivo.</p>Formule :C56H74N8O10SMasse moléculaire :1050.52486PROTAC NAMPT Degrader-1
<p>PROTACNAMPT Degrader-1 is an effective NAMPT-targeting PROTAC with a DC50 value of 217 nM. It exhibits antiproliferative activity, with an IC50 value of 0.12 μM against A2780 cells.</p>Formule :C57H69N13O8S2Masse moléculaire :1127.48335ALT-100 (Human IgG1)
<p>ALT-100 (HumanIgG1) is a human-derived IgG1 monoclonal antibody that targets NAMPT. For its isotype control, please refer to HumanIgG1kappa, Isotype Control.</p>Couleur et forme :Odour LiquidNAMPT Protein, Human, Recombinant (His)
<p>Pre-B cell colony enhancing factor (PBEF) was originally identified as a cytokine that potentiated the clonal expansion and differentiation of pre-B cells, but</p>Degré de pureté :94% - 94%Couleur et forme :Lyophilized PowderMasse moléculaire :55 KDa (reducing condition)NAT
CAS :<p>NAT is a nicotinamide phosphoribosyltransferase (NAMPT) activator that increases intracellular NAD levels.</p>Formule :C18H21NO3Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :299.36CHS-828
CAS :<p>CHS-828 (GMX1778), a pyridyl cyanoguanidine, is an effective inhibitor of NAD+ biosynthesis enzyme NAMPT (IC50 <25 nM).</p>Formule :C19H22ClN5ODegré de pureté :98% - 99.9%Couleur et forme :SolidMasse moléculaire :371.86STF-118804
CAS :<p>STF-118804 is a highly specific NAMPT inhibitor; reduces the viability of most B-ALL cell lines with IC50 <10 nM.</p>Formule :C25H23N3O4SDegré de pureté :98.66%Couleur et forme :SolidMasse moléculaire :461.53GNE-617
CAS :<p>GNE-617, a specific NAMPT inhibitor(IC50=5 nM), shows potency in xenograft models of cancer.</p>Formule :C21H15F2N3O3SDegré de pureté :99.28% - 99.71%Couleur et forme :SolidMasse moléculaire :427.42LB-60-OF61 hydrochloride
CAS :<p>LB-60-OF61 hydrochloride is a potent NAMPT enzyme inhibitor with cytotoxic effects, targeting MYC-overexpressing cell lines.</p>Formule :C29H31ClN6O2Couleur et forme :SolidMasse moléculaire :531.06KPT9274
CAS :<p>KPT9274 (PAK4-IN-1) is a non-competitive dual inhibitor of PAK4 and NAMPT(IC50= ~120 nM). It is an orally bioavailable small molecule.</p>Formule :C35H29F3N4O3Degré de pureté :99.75% - 99.93%Couleur et forme :SolidMasse moléculaire :610.62GNE-617 hydrochloride
CAS :<p>GNE-617 hydrochloride is a specific inhibitor of NAMPT and inhibits NAMPT activity (IC50: 5 nM).</p>Formule :C21H16ClF2N3O3SCouleur et forme :SolidMasse moléculaire :463.88Nampt-IN-1
CAS :<p>Nampt-IN-1 (LSN3154567) (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM.</p>Formule :C20H25N3O5SDegré de pureté :99.28% - 99.4%Couleur et forme :SolidMasse moléculaire :419.49(E)-Daporinad
CAS :<p>(E)-Daporinad (FK866) is a highly specific, non-competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT） .Cost-effective and quality-assured.</p>Formule :C24H29N3O2Degré de pureté :98.44% - >99.99%Couleur et forme :SolidMasse moléculaire :391.51Nampt-IN-9
CAS :<p>Nampt-IN-9 (Compound 8) is a potent inhibitor of NAMPT with anticancer properties.Nampt-IN-9 can be used to study ductal adenocarcinoma of the pancreas.</p>Formule :C26H33N3O4Couleur et forme :SolidMasse moléculaire :451.56Nampt-IN-7
CAS :<p>Nampt-IN-7 (GF8) inhibits NAMPT (IC50: 7.31 μM) and kills HepG2 cells (IC50: 24.28 μM).</p>Formule :C20H21N5O3Couleur et forme :SolidMasse moléculaire :379.41Nampt activator-3
CAS :<p>NAMPT activator-3: a NAT derivative, EC50 of 2.6 μM, KD 132 nM, protects cells, prevents FK866 toxicity, and is neuroprotective in CIPN mice.</p>Formule :C19H20N2O3Couleur et forme :SolidMasse moléculaire :324.37A-1293201
CAS :<p>A-1293201 is a potent and selective NAMPT inhibitor.</p>Formule :C21H23N3O3Couleur et forme :SolidMasse moléculaire :365.43Teglarinad chloride
CAS :<p>Teglarinad chloride (GMX-1777 chloride) is an inhibitor of NAMPT with antitumor activity that acts by interfering with DNA repair and inhibiting angiogenesis.</p>Formule :C30H43Cl2N5O8Degré de pureté :98.09%Couleur et forme :SolidMasse moléculaire :672.6LB-60-OF61
CAS :<p>LB-60-OF61 is a NAMPT inhibitor, a NAMPT inhibitor that displays antiproliferative activity against MYC oncogene-dependent cancer cell lines.</p>Formule :C29H30N6O2Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :494.59JGB-1-155
CAS :<p>JGB-1-155, serving as a positive allosteric modulator (N-PAMs), effectively enhances the activity of nicotinamide phosphoribosyltransferase (NAMPT) with an EC 50 of 3.29 μM. It mitigates oxidative stress by elevating NAD+ levels in THP-1 human monocytes and reduces TNFα-induced reactive oxygen species (ROS) in HT-22 cells [1].</p>Formule :C26H38N2O3Couleur et forme :SolidMasse moléculaire :426.59Nampt-IN-10 TFA
CAS :<p>Nampt-IN-10 TFA, a NAMPT inhibitor, shows potency in A2780 (IC50: 5 nM) and CORL23 (IC50: 19 nM), suitable for ADC payloads.</p>Formule :C29H29F4N5O4Couleur et forme :SolidMasse moléculaire :587.21557GNE-618
CAS :<p>GNE-618 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (IC50: 6 nM).</p>Formule :C21H15F3N4O3SCouleur et forme :SolidMasse moléculaire :460.43NAMPT activator-6
CAS :<p>NAMPT activator-6, a regulatory molecule for the optical control system of NAMPT and NAD+, can be used to design efficient photoswitchable proteolysis-targeting chimeras (PS-PROTACs) for light-dependent, reversible regulation of NAMPT and NAD+, thereby reducing toxicity associated with inhibitor-based PS-PROTACs. This enables antitumor activity and in vivo modulation of NAMPT and NAD+ through optical manipulation [1].</p>Formule :C17H21N5O3SCouleur et forme :SolidMasse moléculaire :375.45Nampt activator-4
CAS :<p>Nampt activator-4, a positive allosteric modulator (N-PAM) of nicotinamide phosphoribosyltransferase (NAMPT), has an EC50 of 0.058 μM and can enhance nicotinamide adenine dinucleotide (NAD+) levels in cells [1].</p>Formule :C26H22F3N7OSCouleur et forme :SolidMasse moléculaire :537.56CB30865
CAS :<p>CB30865 (ZM 242421) is a selective and highly effective nicotinamide phosphoribosyltransferase (Nampt) inhibitor with potential antitumor activity.</p>Formule :C26H22BrN5O2Degré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :516.39Nampt-IN-15
CAS :Nampt-IN-15 (Example 3) is a Nampt inhibitor that exhibits cytotoxic effects on various cell lines, including BxPC-3, HepG2, L540cy, and MOLM-13. The respective IC50 values for these cell lines are 38.5 nM, 8 nM, 8.5 nM, and 7 nM.Formule :C24H30N4O2Couleur et forme :SolidMasse moléculaire :406.52Nampt-IN-13
CAS :<p>Nampt-IN-13 (example 58m) is an NAMPT inhibitor used in the synthesis of antibody-drug conjugates (ADCs).</p>Formule :C24H30N6O2Couleur et forme :SolidMasse moléculaire :434.53Nampt-IN-14
CAS :<p>Nampt-IN-14 (example 3) is an effective NAMPT inhibitor with an IC50 of 0.2 nM, suited for use in the synthesis of antibody-drug conjugates (ADCs).</p>Formule :C33H35N7O2Couleur et forme :SolidMasse moléculaire :561.68
