NAMPT
La nicotinamide phosphoribosyltransférase (NAMPT) est une enzyme impliquée dans la biosynthèse du nicotinamide adénine dinucléotide (NAD+), un coenzyme essentiel au métabolisme cellulaire et à la production d'énergie. Les inhibiteurs de la NAMPT suscitent un intérêt particulier en recherche sur le cancer, en raison de leur capacité à perturber le métabolisme du NAD+ et à induire la mort des cellules cancéreuses. Ces inhibiteurs sont également étudiés dans le contexte des troubles métaboliques et du vieillissement. Chez CymitQuimica, nous proposons des inhibiteurs de la NAMPT pour soutenir vos recherches en biologie du cancer, métabolisme et vieillissement.
39 produits trouvés pour "NAMPT".
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SBI-797812
CAS :SBI-797812 is structurally similar to active-site directed inhibitor of NAMPT(NAMPT with EC50 of 0.37 μM).Formule :C19H22N4O4SDegré de pureté :99.31%Couleur et forme :White SolidMasse moléculaire :402.47Nampt-IN-5
CAS :Nampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) .Formule :C25H25N5O2Degré de pureté :99.30%Couleur et forme :SolidMasse moléculaire :427.5Ref: TM-T12171
1mg77,00€5mg147,00€1mL*10mM (DMSO)161,00€10mg250,00€25mg398,00€50mg532,00€100mg735,00€200mg973,00€Nampt activator-1
CAS :NAMPT Activator-1, EC50: 3.3-3.7 µM, specific niacinamide phosphotransferase stimulant, shields cells, potential neuroprotectant.Formule :C16H17N3O3Degré de pureté :99.84% - 99.98%Couleur et forme :SoildMasse moléculaire :299.32ALT-100 (Human IgG1)
ALT-100 (Human IgG1) is a neutralizing mAb targeting eNAMPT used to study the treatment mechanisms of myocardial fibrosis and inflammatory diseases by blocking DAMP signaling.Couleur et forme :Odour LiquidNampt-IN-10 trihydrochloride
Nampt-IN-10 trihydrochloride, a NAMPT inhibitor, is effective on A2780 & CORL23 cells (IC50: 5/19 nM); potential ADC payload.Formule :C27H31Cl3FN5O2Couleur et forme :SolidMasse moléculaire :582.92Nampt degrader-2
Nampt degrader-2: a fluorescent PROTAC that degrades NAMPT at IC50 41.9 nM, reducing NAD+ and having anti-tumor effects.Formule :C59H73N9O7SCouleur et forme :SolidMasse moléculaire :1052.33NAMPT degrader-3
NAMPT Degrader-3 (compound C5) is a NAMPT degrader that functions through a VHL- and proteasome-dependent mechanism.Formule :C56H74N8O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1003.3PROTAC NAMPT Degrader-1
PROTACNAMPT Degrader-1 is an effective NAMPT-targeting PROTAC with a DC50 value of 217 nM. It exhibits antiproliferative activity, with an IC50 value of 0.12 μM against A2780 cells.Formule :C57H69N13O8S2Couleur et forme :SolidMasse moléculaire :1127.48335LYP-8
LYP-8 is a potent NAMPT degrader that achieves a maximum degradation rate of 97% in NAMPT within SKOV-3 cells at a concentration of 0.5 μM. LYP-8 also demonstrates anticancer activity both in vitro and in vivo.Formule :C56H74N8O10SCouleur et forme :SolidMasse moléculaire :1050.52486NAMPT activator-7
NAMPTactivator-7 (Compound 232) is an activator of nicotinamide phosphoribosyltransferase (NAMPT) with an EC50 of less than 0.5 μM. It effectively stimulates NAMPT in U2OS cells, demonstrating a cellular EC50 of less than 0.5 μM.Formule :C21H17ClN4O3Couleur et forme :SolidMasse moléculaire :408.09892Nampt-IN-13 FA
Nampt-IN-13 FA is a NAMPT inhibitor (patent WO2021013693A1) suitable for synthesising antibody-drug conjugates (ADCs).Formule :C25H32N6O4Degré de pureté :99.06% - 99.30%Couleur et forme :Yellow SolidMasse moléculaire :480.56CB 300919
CAS :CB 300919, a quinazoline antitumor, inhibits CH1 ovarian tumor growth (IC50: 2 nM) over 96h.Formule :C32H34ClN7O2Couleur et forme :SolidMasse moléculaire :584.11NAMPT Protein, Human, Recombinant (His)
Pre-B cell colony enhancing factor (PBEF) was originally identified as a cytokine that potentiated the clonal expansion and differentiation of pre-B cells, butDegré de pureté :94% - 94%Couleur et forme :Lyophilized PowderMasse moléculaire :55 KDa (reducing condition)Ref: TM-TMPJ-00968
5µg74,00€10µg108,00€20µg164,00€50µg279,00€100µg479,00€200µg827,00€500µg1.710,00€1mg2.457,00€NAT
CAS :NAT is a nicotinamide phosphoribosyltransferase (NAMPT) activator that increases intracellular NAD levels.Formule :C18H21NO3Degré de pureté :99.65%Couleur et forme :White SolidMasse moléculaire :299.36Ref: TM-T60667
1mg38,00€5mg74,00€10mg92,00€1mL*10mM (DMSO)93,00€25mg157,00€50mg222,00€100mg329,00€200mg487,00€(E)-Daporinad
CAS :(E)-Daporinad (FK866) is a highly specific, non-competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT） .Cost-effective and quality-assured.Formule :C24H29N3O2Degré de pureté :98.44% - >99.99%Couleur et forme :White SolidMasse moléculaire :391.51Ref: TM-T2644
2mg40,00€5mg62,00€1mL*10mM (DMSO)66,00€10mg90,00€25mg178,00€50mg349,00€100mg528,00€500mg1.108,00€Nampt-IN-1
CAS :Nampt-IN-1 (LSN3154567) (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM.Formule :C20H25N3O5SDegré de pureté :99.28% - 99.4%Couleur et forme :SolidMasse moléculaire :419.49Ref: TM-T4376
1mg37,00€2mg49,00€5mg79,00€1mL*10mM (DMSO)87,00€10mg130,00€25mg245,00€50mg409,00€100mg605,00€KPT9274
CAS :KPT9274 (PAK4-IN-1) is a non-competitive dual inhibitor of PAK4 and NAMPT(IC50= ~120 nM). It is an orally bioavailable small molecule.Formule :C35H29F3N4O3Degré de pureté :99.75% - 99.93%Couleur et forme :SolidMasse moléculaire :610.62LB-60-OF61 hydrochloride
CAS :LB-60-OF61 hydrochloride is a potent NAMPT enzyme inhibitor with cytotoxic effects, targeting MYC-overexpressing cell lines.Formule :C29H31ClN6O2Couleur et forme :SolidMasse moléculaire :531.06CHS-828
CAS :CHS-828 (GMX1778), a pyridyl cyanoguanidine, is an effective inhibitor of NAD+ biosynthesis enzyme NAMPT (IC50 <25 nM).Formule :C19H22ClN5ODegré de pureté :98% - 99.9%Couleur et forme :White SolidMasse moléculaire :371.86STF-118804
CAS :STF-118804 is a highly specific NAMPT inhibitor; reduces the viability of most B-ALL cell lines with IC50 <10 nM.Formule :C25H23N3O4SDegré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :461.53GNE-617 hydrochloride
CAS :GNE-617 hydrochloride is a specific inhibitor of NAMPT and inhibits NAMPT activity (IC50: 5 nM).Formule :C21H16ClF2N3O3SCouleur et forme :SolidMasse moléculaire :463.88GNE-617
CAS :GNE-617, a specific NAMPT inhibitor(IC50=5 nM), shows potency in xenograft models of cancer.Formule :C21H15F2N3O3SDegré de pureté :99.38% - 99.71%Couleur et forme :White SolidMasse moléculaire :427.42Ref: TM-T4335
1mg38,00€2mg50,00€5mg80,00€1mL*10mM (DMSO)81,00€10mg117,00€25mg207,00€50mg333,00€100mg495,00€500mg1.071,00€Nampt-IN-12
CAS :Nampt-IN-12 (compound 9), a derivative of N-Pyridinylthiophene carboxamid, exhibits activity against peripheral nerve sheath cancer cells. It is metabolized by the enzymes NAMPT and NMNAT1 within the NAD salvage pathway into an adenine dinucleotide (AD) derivative, an analog of NAD that can inhibit inosine monophosphate dehydrogenase (IMPDH), leading to the accumulation of inosine monophosphate (IMP) within the cells. Nampt-IN-12's effective blood-brain barrier permeability makes it suitable for research into cancers of the central and peripheral nervous system.Formule :C10H8N2OSCouleur et forme :SolidMasse moléculaire :204.25Nampt-IN-7
CAS :Nampt-IN-7 (GF8) inhibits NAMPT (IC50: 7.31 μM) and kills HepG2 cells (IC50: 24.28 μM).Formule :C20H21N5O3Couleur et forme :SolidMasse moléculaire :379.41Teglarinad chloride
CAS :Teglarinad chloride (GMX-1777 chloride) is an inhibitor of NAMPT with antitumor activity that acts by interfering with DNA repair and inhibiting angiogenesis.Formule :C30H43Cl2N5O8Degré de pureté :98.09%Couleur et forme :SolidMasse moléculaire :672.6Nampt-IN-9
CAS :Nampt-IN-9 (Compound 8) is a potent inhibitor of NAMPT with anticancer properties.Nampt-IN-9 can be used to study ductal adenocarcinoma of the pancreas.Formule :C26H33N3O4Couleur et forme :SolidMasse moléculaire :451.56Nampt activator-3
CAS :NAMPT activator-3: a NAT derivative, EC50 of 2.6 μM, KD 132 nM, protects cells, prevents FK866 toxicity, and is neuroprotective in CIPN mice.Formule :C19H20N2O3Couleur et forme :SolidMasse moléculaire :324.37Nampt activator-2
CAS :Nampt activator-2: Potent NAMPT activator (EC50: 0.023 μM), binds CYP2C9 (0.060 μM), 2D6 (0.41 μM), 2C19 (0.59 μM); useful in metabolic disease research.Formule :C17H15ClN4O3SDegré de pureté :98.59% - 98.88%Couleur et forme :SolidMasse moléculaire :390.84GNE-618
CAS :GNE-618 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (IC50: 6 nM).Formule :C21H15F3N4O3SCouleur et forme :SolidMasse moléculaire :460.43Nampt-IN-10 TFA
CAS :Nampt-IN-10 TFA, a NAMPT inhibitor, shows potency in A2780 (IC50: 5 nM) and CORL23 (IC50: 19 nM), suitable for ADC payloads.Formule :C29H29F4N5O4Couleur et forme :SolidMasse moléculaire :587.21557JGB-1-155
CAS :JGB-1-155 is a positive allosteric modulator of nicotinamide phosphoribosyltransferase that enhances NAMPT enzymatic activity, elevates intracellular NAD⁺ levels in human monocytes, counteracts oxidative stress, and attenuates TNFα-induced reactive oxygen species production, supporting its application in studies of redox balance and inflammatory signaling.Formule :C26H38N2O3Degré de pureté :99.33%Couleur et forme :White SolidMasse moléculaire :426.59LB-60-OF61
CAS :LB-60-OF61 is a NAMPT inhibitor, a NAMPT inhibitor that displays antiproliferative activity against MYC oncogene-dependent cancer cell lines.Formule :C29H30N6O2Degré de pureté :99.47%Couleur et forme :White SolidMasse moléculaire :494.59Ref: TM-T11823
1mg154,00€5mg371,00€1mL*10mM (DMSO)404,00€10mg612,00€25mg1.189,00€50mg2.008,00€100mg3.132,00€NAMPT activator-6
CAS :NAMPT activator-6, a regulatory molecule for the optical control system of NAMPT and NAD+, can be used to design efficient photoswitchable proteolysis-targeting chimeras (PS-PROTACs) for light-dependent, reversible regulation of NAMPT and NAD+, thereby reducing toxicity associated with inhibitor-based PS-PROTACs. This enables antitumor activity and in vivo modulation of NAMPT and NAD+ through optical manipulation [1].Formule :C17H21N5O3SCouleur et forme :SolidMasse moléculaire :375.45Nampt-IN-15
CAS :Nampt-IN-15 (Example 3) is a Nampt inhibitor that exhibits cytotoxic effects on various cell lines, including BxPC-3, HepG2, L540cy, and MOLM-13. The respective IC50 values for these cell lines are 38.5 nM, 8 nM, 8.5 nM, and 7 nM.Formule :C24H30N4O2Couleur et forme :SolidMasse moléculaire :406.52Nampt activator-4
CAS :Nampt activator-4, a positive allosteric modulator (N-PAM) of nicotinamide phosphoribosyltransferase (NAMPT), has an EC50 of 0.058 μM and can enhance nicotinamide adenine dinucleotide (NAD+) levels in cells [1].Formule :C26H22F3N7OSCouleur et forme :SolidMasse moléculaire :537.56Nampt-IN-14
CAS :Nampt-IN-14 (example 3) is an effective NAMPT inhibitor with an IC50 of 0.2 nM, suited for use in the synthesis of antibody-drug conjugates (ADCs).Formule :C33H35N7O2Couleur et forme :SolidMasse moléculaire :561.68Nampt-IN-13
CAS :Nampt-IN-13 (example 58m) is an NAMPT inhibitor used in the synthesis of antibody-drug conjugates (ADCs).Formule :C24H30N6O2Couleur et forme :SolidMasse moléculaire :434.53PD-L1/Nampt-IN-1
CAS :PD-L1/Nampt-IN-1 is an orally active inhibitor that targets both PD-L1 and NAMPT (nicotinamide phosphoribosyltransferase), with IC50 values of 63 nM and 582 nM, respectively. It exhibits cross-species affinity, with KD values of 52.6 nM for hPD-L1 and 49.1 nM for mPD-L1. This compound effectively suppresses tumor growth by activating the tumor immune microenvironment and is applicable in melanoma research.Formule :C28H28N4O2Couleur et forme :SolidMasse moléculaire :452.55CB30865
CAS :CB30865 (ZM 242421) is a selective and highly effective nicotinamide phosphoribosyltransferase (Nampt) inhibitor with potential antitumor activity.Formule :C26H22BrN5O2Degré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :516.39
