PPAR
Les récepteurs activés par les proliférateurs des peroxysomes (PPARs) sont un groupe de protéines réceptrices nucléaires qui fonctionnent comme des facteurs de transcription régulant l'expression des gènes impliqués dans le métabolisme, en particulier le stockage des acides gras et le métabolisme du glucose. Les inhibiteurs des PPARs sont des outils importants pour étudier les troubles métaboliques tels que le diabète, l'obésité et les maladies cardiovasculaires. Ces inhibiteurs peuvent moduler le métabolisme des lipides, la sensibilité à l'insuline et l'inflammation, ce qui les rend précieux dans la recherche thérapeutique. Chez CymitQuimica, nous proposons une gamme d'inhibiteurs de PPARs pour soutenir vos recherches sur les maladies métaboliques, l'endocrinologie et le développement de médicaments.
164 produits trouvés pour "PPAR"
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T0070907
CAS :<p>T0070907(IC50=1 nM) , an effective and specific PPARγ inhibitor, with the >800-fold selectivity over PPARα and PPARδ.</p>Formule :C12H8ClN3O3Degré de pureté :98.25% - 99.98%Couleur et forme :SolidMasse moléculaire :277.66Angeloylgomisin H
CAS :<p>Angeloylgomisin H shows moderate cytotoxic activities with IC50 values ranging from 100 to 200 ug/mL against MCF7, HEK293 and CAL27 cell lines.</p>Formule :C28H36O8Degré de pureté :99.84% - 99.95%Couleur et forme :SolidMasse moléculaire :500.58Oleuropein
CAS :<p>Oleuropein is an antioxidant polyphenol isolated from olive leaf.</p>Formule :C25H32O13Degré de pureté :98% - 99.95%Couleur et forme :Brown PowderMasse moléculaire :540.51GSK0660
CAS :<p>GSK0660 is an antagonist and inverse agonist of PPARβ/δ.</p>Formule :C19H18N2O5S2Degré de pureté :99.26% - ≥95%Couleur et forme :SolidMasse moléculaire :418.49Rosiglitazone hydrochloride
CAS :<p>Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.</p>Formule :C18H19N3O3S·HClDegré de pureté :99.63% - 99.79%Couleur et forme :SolidMasse moléculaire :393.89EPI-001
CAS :<p>EPI-001 is an androgen receptor N-terminal domain antagonist with IC50 of ～6 μM and a selective PPAR-gamma modulator.</p>Formule :C21H27ClO5Degré de pureté :99% - 99.67%Couleur et forme :SolidMasse moléculaire :394.89Clofibrate
CAS :<p>Clofibrate (Clofibrato) is an aryloxyisobutyric acid derivate with antihyperlipidemic activity.</p>Formule :C12H15ClO3Degré de pureté :98.77%Couleur et forme :Oil LiquidMasse moléculaire :242.70DG172 dihydrochloride
CAS :<p>DG172 dihydrochloride (DG-172 dihydrochloride) is an antagonist of PPARβ/δ(IC50 : 27 nM).</p>Formule :C20H22BrCl2N3Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :455.2L-165041
CAS :<p>L-165041 is a potent and selective agonist of the nuclear receptor PPARβ and PPARδ(Ki = 9 nM, EC50 = ~500 nM ,respectively)</p>Formule :C22H26O7Degré de pureté :97.97%Couleur et forme :SolidMasse moléculaire :402.44GSK3787
CAS :<p>GSK3787 is a specific and irreversible PPARδ inhibitor（pIC50= 6.6）.</p>Formule :C15H12ClF3N2O3SDegré de pureté :98% - 99.56%Couleur et forme :SolidMasse moléculaire :392.78Oroxin A
CAS :<p>Oroxin A (Baicalein 7-O-glucoside) has antitussive and expectorant effects.</p>Formule :C21H20O10Degré de pureté :98.05% - 99.74%Couleur et forme :SolidMasse moléculaire :432.38AMG131
CAS :<p>AMG131 (CHS 131) , is a novel, non-thiazolidinedione (TZD), selective peroxisome proliferator-activated receptor (PPAR)gamma modulator, which can be used for</p>Formule :C21H12Cl4N2O3SDegré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :514.21Gypenoside XLIX
CAS :<p>Extracted from whole herb of Gynostemsma pentaphyllum(Thunb.)Mak.;Store the product in sealed, cool and dry condition</p>Formule :C52H86O21Degré de pureté :97.05% - 99.78%Couleur et forme :SolidMasse moléculaire :1047.23Elafibranor
CAS :<p>Elafibranor (GFT505) is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ) with</p>Formule :C22H24O4SDegré de pureté :98.42% - 98.78%Couleur et forme :SolidMasse moléculaire :384.49Cinnamyl alcohol
CAS :<p>Cinnamyl alcohol (Styryl Carbinol) readily autoxidizes upon air exposure, and forms strong sensitizers as determined by the local lymph node assay.</p>Formule :C9H10ODegré de pureté :99.00%Couleur et forme :Colourless LiquidMasse moléculaire :134.18Tesaglitazar
CAS :<p>Tesaglitazar is a potent and selective peroxide PPARα / γ receptor dual agonist with a more potent affinity for PPARγ than PPARα, The EC50 values for rat PPARα</p>Formule :C20H24O7SDegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :408.47Pparδ agonist 2
CAS :<p>Pparδ agonist 2 is an agonist of PPARδ.</p>Formule :C20H18F3N3O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :437.44FTX-6746
CAS :<p>FTX-6746 is an orally active and selective PPARG reverse inhibitor with anticancer activity. It can be used in research on urothelial carcinoma.</p>Formule :C16H7ClF2N2ODegré de pureté :98.68%Couleur et forme :SolidMasse moléculaire :316.6913-Oxo-9E,11E-octadecadienoic acid
CAS :<p>13-Oxo-9E,11E-octadecadienoic acid from tomato juice, an isomer of 9-oxo-ODA, activates PPARα and lowers triglycerides in diabetic mice.</p>Formule :C18H30O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :294.43Peliglitazar racemate
CAS :<p>Peliglitazar racemate(BMS 426707-01 racemate) is the racemate of Peliglitazar.Peliglitazar racemate may be used as a potential antidiabetic and anti-obesity</p>Formule :C30H30N2O7Degré de pureté :97.75%Couleur et forme :SolidMasse moléculaire :530.57Daltroban
CAS :<p>Daltroban (SKF 96148) is a specific thromboxane A2 (TXA2) receptor antagonist.</p>Formule :C16H16ClNO4SDegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :353.82GW 9578
CAS :<p>GW 9578 is a PPARα agonist with potent lipid-lowering activity for the study of psoriasis, arthritis, alopecia, asthma and type I diabetes.</p>Formule :C26H34F2N2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :492.62ARH-049020
CAS :<p>ARH-049020, a peroxisome proliferator-activated receptor (PPAR) agonist, is used potentially for the treatment of insulin resistance and type 2 diabetes.</p>Formule :C24H31NO6Degré de pureté :97.19% - 99.82%Couleur et forme :SolidMasse moléculaire :429.51Reglitazar
CAS :<p>Reglitazar, a dual PPARα/γ agonist, enhances insulin signaling, reduces insulin resistance, and lowers hypertriglyceridemia in obese rats.</p>Formule :C22H20N2O5Degré de pureté :97.07% - 98.72%Couleur et forme :SolidMasse moléculaire :392.4THR-0921
CAS :<p>THR-0921 (CLX-0921) is a peroxisome proliferator-activated receptor (PPAR) agonist that can be used to study cardiovascular and metabolic diseases.</p>Formule :C28H25NO7SDegré de pureté :100% - 99.83%Couleur et forme :SolidMasse moléculaire :519.57AVE-8134
CAS :<p>AVE-8134 is an agonist of PPARα. For human and rodent PPARα receptor, the EC50 values are 100 and 3000 nM, respectively.</p>Formule :C22H23NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :381.42PPARα-MO-1
CAS :<p>PPARα-MO-1 is a potent modulator of PPARα.</p>Formule :C27H37NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :455.59LG100754
CAS :<p>LG100754 (UVI 2112) is an insulin sensitizer and RXR modulator, antagonizing RXR homodimers while agonizing RXR:PPARα/γ heterodimers.</p>Formule :C26H36O3Couleur et forme :SolidMasse moléculaire :396.56Chiglitazar
CAS :<p>Chiglitazar is a PPAR α/γ/δ agonist and insulin sensitizer used in the treatment of type 2 diabetes mellitus , anti-inflammatory and anti-fibrotic.</p>Formule :C36H29FN2O4Couleur et forme :SolidMasse moléculaire :572.63Inolitazone dihydrochloride
CAS :<p>Inolitazone dihydrochloride is an effective, high-affinity PPARγ agonist; its biological activity is dependent on PPARγ (IC50:0.8 nM) to inhibit cell growth.</p>Formule :C27H28Cl2N4O4SCouleur et forme :SolidMasse moléculaire :575.51Saroglitazar
CAS :<p>Saroglitazar (Lipaglyn) is an agonist of PPAR with EC50 values of 0.65 pM and 3 nM for PPARα and PPARγ.</p>Formule :C25H29NO4SDegré de pureté :98.51%Couleur et forme :SolidMasse moléculaire :439.57GSK376501A
CAS :<p>GSK376501A is a selective and effective modulator of peroxisome proliferator-activated receptor γ (PPARγ) for the study of type 2 diabetes.</p>Formule :C32H37NO6Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :531.64Indeglitazar
CAS :<p>Indeglitazar (PPM 204) is orally available pan-agonist of PPAR (PPAR subtypes alpha (α), delta (δ), and gamma (γ)).</p>Formule :C19H19NO6SDegré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :389.42K-111
CAS :<p>K-111 is a PPAR alpha agonist. K-111 improves insulin resistance, reducing bodyweight, and ameliorating atherogenic dyslipidemia.</p>Formule :C18H25Cl3O2Degré de pureté :99.64% - 99.88%Couleur et forme :SolidMasse moléculaire :379.75Farglitazar
CAS :<p>Farglitazar (GI-262570) is a PPAR-γ agonist and insulin sensitizer used in the study of diabetes.</p>Formule :C34H30N2O5Degré de pureté :99.4% - 99.52%Couleur et forme :SolidMasse moléculaire :546.61Cevoglitazar
CAS :<p>Cevoglitazar (LBM-642) is a PPARɑ agonist and PPARγ agonist. Cevoglitazar potently reduces food intake and body weight in obese mice and cynomolgus monkeys.</p>Formule :C27H21F3N2O6SDegré de pureté :98.75%Couleur et forme :SolidMasse moléculaire :558.53Dazmegrel
CAS :<p>Dazmegrel (UK 38,485) is a thromboxane A2 (TXA2) synthase inhibitor for the prevention of increased whole platelet aggregation in normal pregnancy.</p>Formule :C16H17N3O2Degré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :283.33BAY-0069
CAS :<p>BAY-0069 is a potent and selective PPARγ transactivator that inhibits human PPARγ and murine PPARγ with IC50s of 6.3 nM and 24 nM, respectively.BAY-0069 can be</p>Formule :C22H16BrN3O4Degré de pureté :99.41%Couleur et forme :SoildMasse moléculaire :466.28Linotroban
CAS :<p>Linotroban（CL-871502） is a potent selective thromboxane (TXA2) receptor antagonist with antithrombotic activity.</p>Formule :C14H15NO5S2Degré de pureté :97.95% - >99.99%Couleur et forme :SolidMasse moléculaire :341.4BAY-4931
CAS :<p>BAY-4931 is a powerful, covalent, and selective inverse-agonist of PPARγ, exhibiting an IC50 value of 0.17 nM.</p>Formule :C22H16ClN3O4Degré de pureté :99.47%Couleur et forme :SoildMasse moléculaire :421.83Edaglitazone
CAS :<p>Edaglitazone (R-483) is a PPARγ agonist with antiplatelet activity that can be used in studies of diabetes and obesity.</p>Formule :C24H20N2O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :464.56LCB-2853
CAS :<p>LCB-2853 is a potent thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor antagonist with antiplatelet aggregation, antivasospasm, and antithrombotic effects.</p>Formule :C21H24ClNO4SDegré de pureté :97.15%Couleur et forme :SolidMasse moléculaire :421.94Imiglitazar
CAS :<p>Imiglitazar (TAK559) is a potent PPAR-β/δ receptor agonist with hypoglycemic effects.</p>Formule :C28H26N2O5Degré de pureté :97.33%Couleur et forme :SolidMasse moléculaire :470.52PPAR agonist 1
CAS :<p>PPAR agonist 1 is an agonist of PPAR α/γ, used for reducing blood glucose, lipid levels, reducing body weight, and lowering cholesterol.</p>Formule :C20H25NO6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :407.48U-46619
CAS :<p>U-46619 is an effective thromboxane A2 (TXA2) agonist and a thromboxane A2 analog (endoperoxide), capable of inducing contraction in the aortic smooth muscle (</p>Formule :C21H34O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :350.49KD-3010
CAS :<p>KD-3010 (Kalypsys) is an orally active potent and selective PPARδ agonist for the study of liver injury.</p>Formule :C30H33F3N2O8S2Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :670.72CRX000227
CAS :<p>CRX000227 is a PPAR modulator suitable for researching metabolic and cell proliferative disorders [1].</p>Formule :C25H24N4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :444.55PPARγ agonist 8
CAS :<p>PPARγ agonist 8, a compound that acts on the peroxisome proliferator-activated receptor gamma (PPARγ), has been shown to stimulate peroxisome proliferator</p>Formule :C19H12F4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :380.36Darglitazone
CAS :<p>Darglitazone (CP-86325) is a potent, selective agonist of PPAR-γ with antidiabetic actions.</p>Formule :C23H20N2O4SDegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :420.48PPARδ agonist 9
CAS :<p>PPARδ agonist 9 (compound 21), with an EC50 of 3.6 nM, is effective in vivo, decreasing serum MCP-1 concentrations in mice and markedly reducing atherosclerotic</p>Formule :C26H28ClF3N4O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :569.04Ragaglitazar
CAS :<p>Ragaglitazar(NNC-61-0029) is a potent dual activator of PPARγ and PPARα.Cost-effective and quality-assured.</p>Formule :C25H25NO5Degré de pureté :97.46% - 98.56%Couleur et forme :SolidMasse moléculaire :419.47Inolitazone
CAS :<p>Inolitazone (RS5444) a high-affinity PPARγ agonist. Inolitazone exhibits IC50 for growth inhibition is ~0.8 nM in vitro.</p>Formule :C27H26N4O4SDegré de pureté :99.41% - 99.53%Couleur et forme :SolidMasse moléculaire :502.58Fonadelpar
CAS :<p>Fonadelpar is an agonist of PPARδ. It also is used in the research of neuroparalytic keratopathy.</p>Formule :C25H23F3N2O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :504.52Anti-NASH agent 2
CAS :<p>Anti-NASH agent 2 (compound 21) is an inhibitor of neolipogenesis activity and α-SMA gene expression. It improves hepatic steatosis, edema, inflammatory infiltration, and liver fibrosis in NASH mouse models.</p>Formule :C32H51N3O2Couleur et forme :SolidMasse moléculaire :509.766PPARγ agonist 17
CAS :<p>PPARγ agonist17 (Compound C1) is an orally active PPARγ agonist. It enhances PPARγ activity, arrests the cell cycle of HT-29 cells at the G2/M phase, inhibits cell migration, and induces apoptosis. PPARγ agonist17 exhibits broad-spectrum antiproliferative activity against cancer cells with relatively low toxicity to normal cells and does not cross the blood-brain barrier.</p>Formule :C48H63NO7Couleur et forme :SolidMasse moléculaire :766.016PPARγ modulator-2
CAS :<p>PPARγmodulator-2 (Compound (R)-2n) is a reversible modulator of PPARγ, inhibiting the PPARγ ligand-binding domain (LBD) with an IC50 of 41 nM. It helps lower blood glucose levels, improves glucose tolerance and insulin sensitivity, and demonstrates antidiabetic activity in db/db mouse models.</p>Formule :C26H21NO7S3SeCouleur et forme :SolidMasse moléculaire :634.6Amezalpat
CAS :<p>Amezalpat is a PPARα antagonist with an IC50 of 58 nM [nanomolar]. Amezalpat also exhibits antitumor activity.</p>Formule :C34H41N3O4Couleur et forme :SolidMasse moléculaire :555.707PPARγ-IN-5
CAS :<p>PPARγ-IN-5 (Compound A3) is an inhibitor of PPARγ. In liver cells, it reduces lipid accumulation and shows no significant cytotoxicity in HepG2 cells at a concentration of 400 µM. PPARγ-IN-5 is applicable for research on non-alcoholic fatty liver disease.</p>Formule :C22H23ClO7Couleur et forme :SolidMasse moléculaire :434.867PPARα/δ agonist 3
CAS :<p>PPARα/δ agonist 3 (Compound 8) is an orally active PPAR agonist capable of activating PPARα, PPARδ, and PPARγ, with EC50 values of 5.6 nM, 3.4 nM, and 1278 nM, respectively. It exhibits anti-cholestatic activity in mouse models of cholestatic liver disease induced by ANIT or CDCA.</p>Formule :C23H25F3N2O4Couleur et forme :SolidMasse moléculaire :450.451PPARδ agonist 11
CAS :<p>Compound 11, a selective PPARδ agonist, demonstrates an EC50 of 20 nM, indicating its high affinity for PPARδ receptors. This compound efficiently reduces levels of nitric oxide (NO), as well as the pro-inflammatory cytokines TNFα and IL-6 in LPS-stimulated RAW264.7 cells via the NF-κB pathway, showcasing its anti-inflammatory properties. Additionally, Compound 11 exhibits remarkable stability in human liver microsomes and plasma. It significantly ameliorates foot edema induced by Carrageenan, displaying favorable pharmacokinetic properties with a bioavailability of approximately 100%.</p>Formule :C19H15F3N2O3S2Couleur et forme :SolidMasse moléculaire :440.46Aleglitazar
CAS :<p>Aleglitazar (R1439) (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively.</p>Formule :C24H23NO5SDegré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :437.51Anti-NASH agent 1
CAS :<p>Anti-NASH Agent 1 (Compound 3d), derived from Elafibranor, serves as a strong PPAR-α/δ agonist aimed at treating nonalcoholic steatohepatitis (NASH).</p>Formule :C26H33NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :423.54PPARγ-IN-2
CAS :<p>"PPARγ-IN-2 (Compound 5a), a PPARγ inhibitor, exhibits an EC50 of 0.106 μM in inhibiting TG accumulation in 3T3-L1 preadipocytes.</p>Formule :C19H21N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :335.4Mavodelpar free base
CAS :<p>Mavodelpar free acid (REN001 free acid) is an selective agonist of PPARδ.</p>Formule :C31H30FNO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.57
