PPAR
Les récepteurs activés par les proliférateurs des peroxysomes (PPARs) sont un groupe de protéines réceptrices nucléaires qui fonctionnent comme des facteurs de transcription régulant l'expression des gènes impliqués dans le métabolisme, en particulier le stockage des acides gras et le métabolisme du glucose. Les inhibiteurs des PPARs sont des outils importants pour étudier les troubles métaboliques tels que le diabète, l'obésité et les maladies cardiovasculaires. Ces inhibiteurs peuvent moduler le métabolisme des lipides, la sensibilité à l'insuline et l'inflammation, ce qui les rend précieux dans la recherche thérapeutique. Chez CymitQuimica, nous proposons une gamme d'inhibiteurs de PPARs pour soutenir vos recherches sur les maladies métaboliques, l'endocrinologie et le développement de médicaments.
170 produits trouvés pour "PPAR"
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Mifobate
CAS :Mifobate (SR-202) 是一种有效且特异性的 PPARγ拮抗剂，可选择性抑制噻唑烷二酮 (TZD) 诱导的 PPARγ 转录活性，IC50为140 μM，具有抗肥胖和抗糖尿病作用。Formule :C11H17ClO7P2Degré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :358.65Fenofibrate
CAS :Fenofibrate (Lipanthyl) is a PPARα agonist. Fenofibrate inhibits cytochrome P450 isoforms. Fenofibrate exhibits antihyperlipidemic activity. Cost-effective and quality-assured.Formule :C20H21ClO4Degré de pureté :99.13% - 99.95%Couleur et forme :Crystals From Isopropanol SolidMasse moléculaire :360.83NSC-87877
CAS :NSC-87877 inhibits Shp2 (IC50=0.318μM), Shp1 (IC50=0.355μM), and DUSP26 phosphatases.Formule :C19H13N3O7S2Degré de pureté :97.35%Couleur et forme :SolidMasse moléculaire :459.45Clofibric acid
CAS :Clofibric acid (Chlorofibrinic acid) is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.Formule :C10H11ClO3Degré de pureté :99.47% - 99.8%Couleur et forme :Pale Yellow SolidMasse moléculaire :214.65EHP-101
CAS :EHP-101 is a PPARγ/CB2 dual agonist with anti-inflammatory properties, inhibits fat formation, and combats diet-related obesity.Formule :C28H35NO3Degré de pureté :98.36%Couleur et forme :SolidMasse moléculaire :433.58Ref: TM-T13289
1mg107,00€5mg227,00€10mg378,00€25mg620,00€50mg868,00€100mg1.169,00€1mL*10mM (DMSO)250,00€Retinoic acid
CAS :Retinoic acid (Tretinoin) binds to and activates RARs, thereby inducing changes in gene expression that lead to inhibition of tumorigenesis.Formule :C20H28O2Degré de pureté :97.21% - 99.60%Couleur et forme :Yellow-Orange PowderMasse moléculaire :300.44MA-0204
CAS :MA-0204 is a highly selective and orally available peroxisome proliferator-activated receptor δ (PPARδ) modulator (EC50s: 0.4 nM, 7.9 nM and 10 nM for human,Formule :C25H27F3N2O4Degré de pureté :97.8%Couleur et forme :SolidMasse moléculaire :476.49Ref: TM-T15945
1mg96,00€5mg178,00€10mg301,00€25mg490,00€50mg677,00€100mg900,00€200mg1.206,00€1mL*10mM (DMSO)187,00€Fenofibric acid
CAS :Fenofibric acid (FNF acid) is the active form of fenofibrate, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity.Formule :C17H15ClO4Degré de pureté :99.36%Couleur et forme :White Or Almost White Crystalline PowderMasse moléculaire :318.75Bezafibrate
CAS :Bezafibrate (BM15075) is an antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES.Formule :C19H20ClNO4Degré de pureté :99.56% - 99.82%Couleur et forme :SolidMasse moléculaire :361.82Anandamide
CAS :Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide), an immune modulator, acts via not only cannabinoid receptors (CB1 and CB2) but alsoFormule :C22H37NO2Degré de pureté :95.037% - 99.22%Couleur et forme :Light Yellow OilMasse moléculaire :347.53Ref: TM-T14046
1mg34,00€2mg46,00€5mg67,00€10mg117,00€25mg221,00€50mg330,00€100mg485,00€200mg675,00€1mL*10mM (DMSO)73,00€Candesartan
CAS :Candesartan (CV 11974) is an angiotensin II receptor blocker used widely in the therapy of hypertension and heart failure.Formule :C24H20N6O3Degré de pureté :98.3% - 99.55%Couleur et forme :Colorless Solid CrystallineMasse moléculaire :440.47Muraglitazar
CAS :Muraglitazar (BMS-298585) is a PPAR α/γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia.Formule :C29H28N2O7Degré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :516.54Oleoylethanolamide
CAS :Oleoylethanolamide (N-Oleoylethanolamide) is a high affinity endogenous agonist of PPAR-α.Formule :C20H39NO2Degré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :325.53Ref: TM-T12296
2mg34,00€5mg50,00€10mg75,00€25mg138,00€50mg236,00€100mg356,00€200mg522,00€1mL*10mM (DMSO)55,00€Pioglitazone hydrochloride
CAS :Pioglitazone hydrochloride (AD 4833) is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplasticFormule :C19H20N2O3S·HClDegré de pureté :99.64% - >99.99%Couleur et forme :White Crystals Or Crystalline PowderMasse moléculaire :392.90Cloxiquine
CAS :Cloxiquine (Dermofongin) is a monohalogenated 8-hydroxyquinoline with activity against bacteria, fungi, and protozoa.Formule :C9H6ClNODegré de pureté :99.82% - 99.87%Couleur et forme :Light Yellow CrystalsMasse moléculaire :179.6β-Amyrone
CAS :beta-Amyrone (β-Amyron) has antifungal activity against Chikungunya virus replication with an EC50 of 86 uM.Formule :C30H48ODegré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :424.75-Aminosalicylic Acid
CAS :5-Aminosalicylic Acid (5-ASA) is a specific PPARγ agonist and also inhibits P21-activated kinase 1 (PAK1) and NF-Κb. High-Quality, Low-Cost!Formule :C7H7NO3Degré de pureté :98.88% - 99.49%Couleur et forme :Purplish-Tan Solid PowderMasse moléculaire :153.14Pioglitazone
CAS :Pioglitazone (U 72107) is a selective and oral PPARγ agonist with EC50 of 0.93 and 0.99 μM on human and mouse PPARγ, respectively . High-Quality, Low-Cost!Formule :C19H20N2O3SDegré de pureté :95% - 99.57%Couleur et forme :White PowderMasse moléculaire :356.44LY518674
CAS :LY518674 (LY-674) decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis.Formule :C23H27N3O4Degré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :409.48Ref: TM-T15821
1mg167,00€5mg340,00€10mg505,00€25mg802,00€50mg1.099,00€100mg1.485,00€1mL*10mM (DMSO)376,00€NTP42
CAS :NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM)Formule :C25H23F2N3O5SDegré de pureté :97.55%Couleur et forme :SolidMasse moléculaire :515.53Ref: TM-T12268
1mg59,00€2mg86,00€5mg133,00€10mg203,00€25mg344,00€50mg512,00€100mg735,00€1mL*10mM (DMSO)150,00€GW7647
CAS :GW 7647 is an effective and highly selective PPARα agonist. GW 7647 can reduce the production of nitric oxide in macrophages. Cost-effective and quality-assured.Formule :C29H46N2O3SDegré de pureté :99.3% - 99.34%Couleur et forme :SolidMasse moléculaire :502.75Gemfibrozil
CAS :Gemfibrozil, a fibric acid derivative, stimulates PPARalpha, boosts fatty acid oxidation, LPL, lowers VLDL-C, apoC-III, and raises HDL-C.Formule :C15H22O3Degré de pureté :99.53% - 99.88%Couleur et forme :Crystals From Hexane SolidMasse moléculaire :250.33Rosiglitazone maleate
CAS :Rosiglitazone maleate (BRL 49653) is an oral antidiabetic and potential anticancer agent.Formule :C22H23N3O7SDegré de pureté :99.33% - 99.51%Couleur et forme :Off-White SolidMasse moléculaire :473.50Daidzein
CAS :Daidzein (Isoflavone) is an isoflavone extract from soy, which is an inactive analog of the tyrosine kinase inhibitor genistein.Formule :C15H10O4Degré de pureté :98.08%Couleur et forme :SolidMasse moléculaire :254.24Magnolol
CAS :Magnolol (5,5'-Diallyl-2,2'-biphenyldiol) is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.Formule :C18H18O2Degré de pureté :99.49% - 99.98%Couleur et forme :A Bioactive Compound Found In The Bark Of The Houpu MagnoliaMasse moléculaire :266.33MK-0533
CAS :MK-0533 is a novel PPARγ partial agonist for the prevention of vascular endothelial dysfunction (VED) and VED-related cardiovascular disease.
Formule :C28H24F3NO6Degré de pureté :99.03%Couleur et forme :SoildMasse moléculaire :527.49Arhalofenate
CAS :Arhalofenate (JNJ 39659100) is a selective partial agonist of peroxisome proliferator-activated receptor PPARγ. It is used for the treatment of type 2 diabetes.Formule :C19H17ClF3NO4Degré de pureté :98.97%Couleur et forme :SolidMasse moléculaire :415.79Ref: TM-T16022
1mg62,00€5mg205,00€10mg359,00€25mg588,00€50mg825,00€100mg1.111,00€200mg1.501,00€1mL*10mM (DMSO)270,00€Sulotroban potassium
Sulotroban potassium is a small molecule thromboxane A2 receptor (TXA2R) antagonist that can be used to study myocardial infarction and thrombosis.Formule :C16H16KNO5SDegré de pureté :98.02%Couleur et forme :SoildMasse moléculaire :373.46Mavodelpar free acid hydrochloride
Mavodelpar free acid hydrochloride (Pparδ agonist HCl) is a potent PPARδ agonist.
Formule :C31H31ClFNO5Degré de pureté :98.13%Couleur et forme :SoildMasse moléculaire :552.03PPARγ agonist 16
CAS :PPARγ agonist16 (Compound 4G) is a PPARγ agonist that competitively binds to the ligand-binding domain (LBD) of PPARγ with an IC50 of 1790 nM. It reduces ear swelling in mouse models and exhibits antihyperglycemic activity in mice with Streptozotocin-induced diabetes.Formule :C19H14BrNO4SCouleur et forme :SolidMasse moléculaire :432.29Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)-
CAS :Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)- is a dual PPARα/γ agonist with EC50 of 0.358μM and 1.21μM.Formule :C24H23NO5SDegré de pureté :99.59%Couleur et forme :SoildMasse moléculaire :437.51Ref: TM-T63898
1mg175,00€5mg404,00€10mg593,00€25mg888,00€50mg1.251,00€100mg1.693,00€1mL*10mM (DMSO)447,00€PPARγ agonist 15
PPARγ agonist15 (Compound 7c) functions as an agonist of PPARγ, inhibiting the expression of α-amylase (HPA) and α-glucosidase (HLAG) with IC50 values of 28.35 µM and 26.21 µM, respectively. It enhances glucose uptake in L6 myotubes and improves glucose homeostasis, insulin sensitivity, and lipid metabolism in a rat model of Streptozotocin-induced diabetes.Formule :C21H16N4O3S2Couleur et forme :SolidMasse moléculaire :436.51Nuclear Receptor Compound Library
A unique collection of 531 nuclear receptor signaling targeted compounds for high throughput and high content screening;
Couleur et forme :Odour SolidWAY-620472
CAS :WAY-620472 is a PPAR regulator that can be used to alter the lifespan of eukaryotes.Formule :C23H21N5OSDegré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :415.51GQ-16
CAS :GQ-16 is a partial agonist of PPARγ with a Ki of 160 nM. GQ-16 reduces adipogenic actions and promotes insulin Sensitization without weight gain.Formule :C19H16BrNO3SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :418.3Ref: TM-T21955
10mg39,00€25mg80,00€50mg116,00€100mg187,00€200mg280,00€500mg449,00€1mL*10mM (DMSO)35,00€PPAR agonist 6
PPAR agonist6 (compound 5a) acts as an agonist for PPAR, exhibiting EC50 values of 3.6 μM and 2.6 μM for PPARα and PPARβ/δ respectively. Additionally, PPAR agonist6 inhibits the transactivation of a TNFα-dependent NF-κB-driven reporter gene in L929 cells [1].Couleur et forme :Odour SolidGW590735
CAS :GW590735: PPARα agonist, EC50=4 nM, >500x selective over PPARδ/γ, for dyslipidemia research.Formule :C23H21F3N2O4SDegré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :478.48E0924G
CAS :E0924G is an orally active PPARδ agonist with an EC50 of 2.82 μM. It enhances the upregulation of osteoprotegerin (OPG) expression, with an EC50 of 0.29 μM. E0924G reduces RANKL-induced osteoclast differentiation and inhibits F-actin ring formation in RAW264.7 macrophages. Additionally, E0924G modulates bone density and bone loss in models of ovariectomy (OVX) and age-related osteoporosis.Formule :C12H12N2O3Couleur et forme :SolidMasse moléculaire :232.24MCC-555
CAS :MCC-555 (Isaglitazone) is a PPARα and PPARγ agonist exerting antihyperglycemic effects.Formule :C21H16FNO3SDegré de pureté :99.07% - 99.82%Couleur et forme :SolidMasse moléculaire :381.42Ref: TM-T21764
5mg66,00€10mg105,00€25mg215,00€50mg356,00€100mg530,00€500mg1.153,00€1mL*10mM (DMSO)73,00€PPARγ-IN-3
PPARγ-IN-3 (compound 9ga), a potent and orally active PPARγ inhibitor, effectively reduces triglyceride (TG) accumulation and exhibits low cytotoxicity. Additionally, it prevents excessive body weight gain, lessens fat and liver mass, and decreases lipid accumulation in both the liver and blood. PPARγ-IN-3 holds promise for research into diet-induced obesity.Formule :C23H28FN7O3Couleur et forme :SolidMasse moléculaire :469.51Anti-obesity agent 1
Compound 4 (Anti-obesity agent 1) demonstrates potential for enhanced lipolysis, highlighting its anti-obesity characteristics.
Formule :C21H22N2O6Couleur et forme :SolidMasse moléculaire :398.409CUDA
CAS :CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively.
Formule :C19H36N2O3Degré de pureté :97.585%Couleur et forme :SolidMasse moléculaire :340.5CC618
CAS :CC618 is a selective PPARβ/δ antagonist with an IC50 of 10.0 μM.Formule :C20H15F6N3O3S2Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :523.47Ref: TM-T9767
1mg109,00€5mg235,00€10mg349,00€25mg532,00€50mg745,00€100mg999,00€200mg1.333,00€1mL*10mM (DMSO)298,00€AZD-9574
CAS :AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs.Formule :C21H22F2N6O2Degré de pureté :98.46% - 99.39%Couleur et forme :SolidMasse moléculaire :428.44Sulotroban
CAS :sulotroban is a TXA2 receptor antagonist that acts synergistically with iloprost to inhibit TXA2-dependent platelet activation.Formule :C16H17NO5SDegré de pureté :98.86% - 99.98%Couleur et forme :SolidMasse moléculaire :335.378-iso Prostaglandin F1β
CAS :8-iso Prostaglandin F1β,inducet vasoconstrictor effects in (PA), (PV) and (MA) through the activation of TXA2R, tyrosine kinase and Rho kinase.Formule :C20H36O5Couleur et forme :SolidMasse moléculaire :356.5Anti-osteoporosis agent-10
Anti-osteoporosis agent-10 is an inhibitor of osteoporosis that suppresses the formation of osteoclasts with an IC50 of 0.042 μM. It also exhibits antagonistic activity towards PPARγ, with an EC50 value of 0.75 μM.Couleur et forme :Odour SolidLipid Metabolism Compound Library
A unique collection of 492 compounds targeting lipid metabolism, can be used for high-throughput screening (HTS) and high-content screening (HCS).
Couleur et forme :Odour Solid8-iso Prostaglandin F1α
CAS :8-iso Prostaglandin F1α induces vasoconstrictor effects in (PA),(PV) and (MA) through activation of TXA2R, tyrosine kinases and Rho kinases.Formule :C20H36O5Couleur et forme :SolidMasse moléculaire :356.5(±)-CBCQ
CAS :(±)-CBCQ, an oxidation product of cannabidiol, exhibits an EC50 value of 14.7 μM for the activation of peroxisome proliferator-activated receptor γ (PPAR-γ).Formule :C21H28O3Couleur et forme :SolidMasse moléculaire :328.45
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