FXR
Le récepteur X des farnésoïdes (FXR) est un récepteur nucléaire qui joue un rôle clé dans la régulation de l'homéostasie des acides biliaires, du métabolisme des lipides et de la régulation du glucose. FXR est une cible thérapeutique potentielle pour le traitement des maladies du foie, des troubles métaboliques et des maladies cardiovasculaires. Les inhibiteurs de FXR peuvent moduler ces voies, offrant des perspectives sur les mécanismes des maladies et les stratégies thérapeutiques. Chez CymitQuimica, nous proposons une gamme d'inhibiteurs de FXR pour soutenir vos recherches en hépatologie, métabolisme et développement de médicaments.
58 produits trouvés pour "FXR"
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Chenodeoxycholic acid
CAS :<p>Chenodeoxycholic acid (CDCA) is a bile acid that inhibits 11β-HSD2 with an IC50 value of 22 mM. High-Quality, Low-Cost!</p>Formule :C24H40O4Degré de pureté :99.70% - 99.93%Couleur et forme :White - Almost White Solid PowderMasse moléculaire :392.57Ursodeoxycholic acid
CAS :<p>Ursodeoxycholic acid (UDCA) is a potent inhibitor of liver-specific fatty acid transporter 5 (FATP5),inhibits cholesterol absorption. High-Quality, Low-Cost!</p>Formule :C24H40O4Degré de pureté :99.74% - ≥95%Couleur et forme :White - Almost White Solid PowderMasse moléculaire :392.57LY2562175
CAS :<p>LY2562175 is an effective and selective FXR agonist (EC50: 193 nM).</p>Formule :C28H27Cl2N3O4Degré de pureté :99.16% - 99.78%Couleur et forme :SolidMasse moléculaire :540.44Alismanol M
CAS :<p>Alismanol M: FXR agonist, EC50 of 50.25 μM, from Alisma orientale, for cholestasis & NASH research.</p>Formule :C30H48O6Couleur et forme :SolidMasse moléculaire :504.7Nuclear Receptor Compound Library
<p>A unique collection of 531 nuclear receptor signaling targeted compounds for high throughput and high content screening;</p>Couleur et forme :Odour SolidFexarene
CAS :<p>Fexarene is a non-steroidal FXR agonist.</p>Formule :C32H33NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :479.62Tauro-β-muricholic acid sodium
CAS :<p>Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).</p>Formule :C26H44NNaO7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :537.69ZLY28
<p>ZLY28 is a novel, first-in-class compound with specific intestinal restriction and oral activity, serving as a dual modulator of FXR and FABP1.</p>Formule :C29H23Cl2NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :520.4FXR agonist 11
CAS :<p>FXR agonist11 (Compound 14) is an FXR activator with an EC50 of 1.2 μM and a maximal effect of 73.7%. It significantly increases GSH levels in the liver and is used to study drug-induced liver injury.</p>Formule :C18H16N2O5Couleur et forme :SolidMasse moléculaire :340.33LZ-007
CAS :<p>LZ-007 is an agonist of the Farnesoid X receptor (FXR), with an EC50 of 51 nM as determined by TR-FRET assay, and an EC50 of 76 nM in HepG2 cells. It exhibits favorable pharmacokinetic properties in SD rats and can improve metabolic dysfunction-associated steatohepatitis induced by high-fat diets and CCl4 in mice.</p>Formule :C27H29F3N2O5Couleur et forme :SolidMasse moléculaire :518.53FXR antagonist 2
CAS :<p>Compound A-26, a diarylamide FXR blocker, may aid hyperlipidemia and diabetes type 2 research.</p>Formule :C22H26Cl2N2O2Couleur et forme :SolidMasse moléculaire :421.36FXR/TGR5 agonist 1
CAS :<p>FXR/TGR5 agonist 1 acts as an agonist on both FXR and TGR5 receptors and is utilized for treating fatty liver disease.</p>Formule :C31H32ClN3O3Couleur et forme :SolidMasse moléculaire :530.07LH10
<p>LH10 is an FXR agonist based on fexaramine, with an EC50 of 0.14 μM. It offers hepatoprotective effects, mitigating conditions such as cholestasis induced by alpha naphthylisothiocyanate (ANIT), acute liver injury caused by APAP, and non-alcoholic steatohepatitis (NASH).</p>Formule :C34H33N3O2Couleur et forme :SolidMasse moléculaire :515.64FXR agonist 10
<p>FXR agonist10 (Compound 27) acts as an agonist for FXR with an EC50 of 14.26 μM. It increases the expression of SHP and BSEP proteins while decreasing the expression of NTCP and CYP7A1 proteins. Additionally, FXR agonist10 has been shown to ameliorate ANIT-induced cholestasis in mouse models.</p>Formule :C15H22O4Couleur et forme :SolidMasse moléculaire :266.33FXR agonist 5
CAS :<p>FXR agonist 5 is an FXR agonist used in the study of liver diseases or diseases mediated by metabolic inflammation.</p>Formule :C40H53N5O5Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :683.88NR1H4 Protein, Mouse, Recombinant (His)
<p>NR1H4 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 27.80 kDa.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :27.80 kDa (predicted)NR1H4 Protein, Human, Recombinant (His)
<p>NR1H4 Protein, Human, Recombinant (His) is expressed in E.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :27.83 kDa (predicted)NDB
CAS :<p>NDB is a hFXRα antagonist that inhibits GW4064-stimulated FXR/RXR interactions in primary mouse hepatocytes.NDB is used in the study of diabetes.</p>Formule :C26H28Cl2N2O2Degré de pureté :98.94%Couleur et forme :SolidMasse moléculaire :471.42FXR agonist 3
<p>FXR agonist 3 is an anti NASH compound with anti-fibrotic and active properties that inhibits the expression of COL1A1, TGF-β1, α-SMA and TIMP1.</p>Formule :C28H28BrNO4Degré de pureté :95.04%Couleur et forme :SolidMasse moléculaire :521.12DY268
CAS :<p>DY268 is a compound based on trisubstituted pyrazolamide without any FXR agonist activity and cytotoxicity and can be used as an effective FXR antagonist.</p>Formule :C30H32N4O5SDegré de pureté :99.43% - 99.75%Couleur et forme :SolidMasse moléculaire :560.66Tauro-Obeticholic acid
CAS :<p>Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).</p>Formule :C28H49NO6SDegré de pureté :99.74% - 99.82%Couleur et forme :SolidMasse moléculaire :527.76Ursodeoxycholic acid sodium
CAS :<p>Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities.</p>Formule :C24H40NaO4Degré de pureté :99.66% - 99.96%Couleur et forme :SolidMasse moléculaire :415.56GW 4064
CAS :<p>GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM).</p>Formule :C28H22Cl3NO4Degré de pureté :98% - 99.94%Couleur et forme :SolidMasse moléculaire :542.84Obeticholic Acid
CAS :<p>Obeticholic Acid (6-ECDCA, INT-747) is a high-affinity, semisynthetic, bile acid-derived FXR agonist.Cost-effective and quality-assured.</p>Formule :C26H44O4Degré de pureté :99.88% - 99.97%Couleur et forme :SolidMasse moléculaire :420.63Sevelamer hydrochloride
CAS :<p>Sevelamer hydrochloride (Sevelamer HCl) is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption</p>Formule :(C3H7N·C3H5ClO·HCl)xDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :186.08Tropifexor
CAS :<p>Tropifexor (LJN452) is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.</p>Formule :C29H25F4N3O5SDegré de pureté :99.3% - 99.85%Couleur et forme :SolidMasse moléculaire :603.58Turofexorate Isopropyl
CAS :<p>Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM</p>Formule :C25H24F2N2O3Degré de pureté :98.55% - 99.73%Couleur et forme :SolidMasse moléculaire :438.47BAR 501 impurity
CAS :<p>BAR 501 impurity 在 BAR501 制剂中发现的一种杂质，可作为 G 蛋白偶联胆汁酸激活受体 (GP-BAR1) 的激动剂。 BAR501 杂质 (10 µM) 在 GP-BAR1 报告基因检测中诱导荧光素酶活性增加 150%。</p>Formule :C26H46O3Degré de pureté :98.78%Couleur et forme :SolidMasse moléculaire :406.64BAR502
CAS :<p>BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).</p>Formule :C25H44O3Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :392.62Guggulsterone
CAS :<p>Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.</p>Formule :C21H28O2Degré de pureté :99.4% - 99.8%Couleur et forme :Light Yellow PowderMasse moléculaire :312.45Nidufexor
CAS :<p>Nidufexor is an agonist for the farnesoid X receptor (FXR).</p>Formule :C27H22ClN3O4Degré de pureté :98.67%Couleur et forme :SolidMasse moléculaire :487.93T0901317
CAS :<p>T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).</p>Formule :C17H12F9NO3SDegré de pureté :98% - 99.64%Couleur et forme :SolidMasse moléculaire :481.33Vidofludimus
CAS :<p>Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).</p>Formule :C20H18FNO4Degré de pureté :98.33% - 99.58%Couleur et forme :SolidMasse moléculaire :355.36Glyco-Obeticholic acid
CAS :<p>Glyco-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an agonist of the farnesoid X receptor (FXR).</p>Formule :C28H47NO5Degré de pureté :99.77% - 99.95%Couleur et forme :SolidMasse moléculaire :477.68Fexaramine
CAS :<p>Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.</p>Formule :C32H36N2O3Degré de pureté :98.87% - 99.61%Couleur et forme :SolidMasse moléculaire :496.64Forskolin
CAS :<p>Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM).</p>Formule :C22H34O7Degré de pureté :98.83% - 99.96%Couleur et forme :Less Crystalline Solid Colorless Crystalline SolidMasse moléculaire :410.5Cilofexor
CAS :<p>Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.</p>Formule :C28H22Cl3N3O5Degré de pureté :99.86% - ≥95%Couleur et forme :SolidMasse moléculaire :586.85Vonafexor
CAS :<p>Vonafexor (EYP001) is a farnesoid X receptor (FXR, NR1H4) agonist, with anti-HBV effects</p>Formule :C19H15Cl3N2O5SDegré de pureté :98.74%Couleur et forme :SolidMasse moléculaire :489.76Teduglutide
CAS :<p>Teduglutide (ALX-0600) is a glucagon-like peptide-2 analog that increases intestinal absorption and can be used in research on short bowel syndrome (SBS).</p>Formule :C164H252N44O55SDegré de pureté :98.08%Couleur et forme :SolidMasse moléculaire :3752.08EDP-305
CAS :<p>EDP-305, an oral FXR agonist, has EC50s of 34 nM/8 nM in CHO/HEK cells, aids in PBC and NASH research with antifibrotic properties.</p>Formule :C36H58N2O5SCouleur et forme :SolidMasse moléculaire :630.92ST-1892
CAS :<p>ST-1892 is a soluble partial FXR agonist.</p>Formule :C16H12N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :280.28PX20606
CAS :<p>PX20606 is an orally active farnesoid X receptor (FXR) agonist, demonstrating EC50 values of 220 nM (mFXR) and 50 nM (hFXR) in Gal4-FXR assays. It induces the expression of the tumor suppressor gene NDRG2 and inhibits tumor growth and metastasis in a mouse HCC model. Additionally, PX20606 exhibits hepatoprotective properties.</p>Formule :C29H22Cl3NO4Couleur et forme :SolidMasse moléculaire :554.85FXR agonist 4
<p>FXR agonist 4: EC50 of 1.05μM, treats hyperlipidemia, steatosis, insulin resistance, inflammation in DIO mice, for NAFLD research.</p>Formule :C21H28ClN3OCouleur et forme :SolidMasse moléculaire :373.92LY367385
CAS :<p>LY367385 is a highly effective and selective mGluR1a antagonist.</p>Formule :C10H11NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :209.2Fexarine
CAS :<p>Fexarine is a potent, selective agonist of farnesoid X receptor.</p>Formule :C31H31NO5Couleur et forme :SolidMasse moléculaire :497.58GSK-8062
CAS :<p>GSK-8062 is an agonist of farnesoid X receptor (FXR).</p>Formule :C30H23Cl2NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :532.41BMS-986318
CAS :<p>BMS-986318: potent FXR agonist, EC50=53/350 nM, good ADME, effective in liver disease models, for nonalcoholic steatohepatitis research.</p>Formule :C30H23Cl2F3N4O3Couleur et forme :SolidMasse moléculaire :615.43FXR antagonist 1
CAS :<p>"Oral FXR antagonist 1 selectively blocks intestinal FXR, with IC50 of 2.1 μM, aiding in NASH research by improving liver health."</p>Formule :C36H59NO5Couleur et forme :SolidMasse moléculaire :585.86GSK2324
CAS :<p>GSK2324 is a potent FXR agonist for the treatment of NAFLD by controlling hepatic lipids through reduced uptake and selective reduction of fatty acid synthesis.</p>Formule :C29H22Cl2N2O4Degré de pureté :98.09% - 99.02%Couleur et forme :SolidMasse moléculaire :533.4FXR agonist 9
CAS :<p>FXR agonist9 (compound 26) is a selective, orally active partial agonist of FXR with an EC50 of 0.09 µM (maximum efficacy of 75.13%). It ameliorates the pathological features of fatty liver disease in mice induced by HFD and CCl4-related metabolic dysfunction.</p>Formule :C28H30N2O5Couleur et forme :SolidMasse moléculaire :474.55
