Déshydrogénase
Les déshydrogénases sont des enzymes impliquées dans les réactions d'oxydoréduction des voies métaboliques, jouant un rôle central dans la production d'énergie et la respiration cellulaire. Ces enzymes sont cruciales pour des processus tels que le cycle de l'acide citrique, la glycolyse et l'oxydation des acides gras. Les inhibiteurs de déshydrogénases sont des outils importants dans l'étude des maladies métaboliques, du cancer et du stress oxydatif. Chez CymitQuimica, nous proposons une sélection complète d'inhibiteurs de déshydrogénases pour soutenir vos recherches en métabolisme, biologie du cancer et biochimie.
267 produits trouvés pour "Déshydrogénase"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
PTC299
CAS :<p>PTC299 ((4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate) is an orally active inhibitor of VEGFA mRNA</p>Formule :C25H20Cl2N2O3Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :467.34XEN723
CAS :<p>XEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor(IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively).</p>Formule :C21H20FN5O2SDegré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :425.48BAY-2402234
CAS :<p>BAY-2402234: a selective DHODH inhibitor targeting myeloid cancers with low-nanomolar potency.</p>Formule :C21H18ClF5N4O4Degré de pureté :98.9%Couleur et forme :SolidMasse moléculaire :520.84IDH-305
CAS :<p>IDH-305: Oral, mutation-specific IDH1 inhibitor, 200x selective for R132 mutants; IC50: 27/28/6.14 nM for R132H/C/WT.</p>Formule :C23H22F4N6O2Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :490.45LDH-IN-1
CAS :<p>LDH-IN-1 is a pyrazole-based human lactate dehydrogenase (LDH) inhibitor(IC50s of 32 and 27 nM for LDHA and LDHB, respectively).</p>Formule :C30H26N4O4S2Degré de pureté :99.6%Couleur et forme :SolidMasse moléculaire :570.68RS 61443
CAS :<p>RS 61443 (Mycophenolate mofetil) is an immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH)</p>Formule :C23H31NO7Degré de pureté :99.37% - 99.91%Couleur et forme :SolidMasse moléculaire :433.5SCD1 inhibitor-4
CAS :<p>SCD1 inhibitor-4 is stearoylCoA desaturase-1 (SCD1) inhibitor. SCD1 inhibitor-4 can be used for the research of diabetes.</p>Formule :C17H16F3N5ODegré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :363.34NCT-502
CAS :<p>NCT-502 (N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide) is a human phosphoglycerate dehydrogenase inhibitor,</p>Formule :C18H20F3N5SDegré de pureté :99.60%Couleur et forme :SolidMasse moléculaire :395.454-Diethylaminobenzaldehyde
CAS :<p>4-Diethylaminobenzaldehyde: reversible ALDH1 inhibitor (Ki: 4 nM), potent anti-androgen (IC50: 1.71μM).</p>Formule :C11H15NODegré de pureté :99.6%Couleur et forme :Brown-Black CrystalsMasse moléculaire :177.24Adrenosterone
CAS :<p>Adrenosterone (11-ketoandrostenedione) is a steroid hormone isolated from the adrenal cortex.</p>Formule :C19H24O3Degré de pureté :98.13% - 98.29%Couleur et forme :SolidMasse moléculaire :300.39Trilostane
CAS :<p>Trilostane (Win 24540) is a synthetic derivative of androstane with adrenocortical suppressive properties.</p>Formule :C20H27NO3Degré de pureté :99.46% - >99.99%Couleur et forme :Tan CrystalsMasse moléculaire :329.43Mycophenolic acid
CAS :<p>Mycophenolic acid (Mycophenolate) is an inosine monophosphate dehydrogenase(IMPDH) inhibitor with anti-proliferative activity.</p>Formule :C17H20O6Degré de pureté :98.79% - 99.77%Couleur et forme :SolidMasse moléculaire :320.34CVT-10216
CAS :<p>CVT-10216 inhibits ALDH2 (IC50: 29 nM) and ALDH-1 (IC50: 1.3 μM), reducing alcohol intake and anxiety in rats.</p>Formule :C24H19NO7SDegré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :465.48LY 345899
CAS :<p>LY 345899 is a Folate analog and is a methylenetetrahydrofolate dehydrogenase and MTHFD2 inhibitor (IC50: 96 nM and 663 nM, respectively and a Ki: 18 nM for</p>Formule :C20H21N7O7Degré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :471.42CBR-5884
CAS :<p>CBR-5884: active PHGDH inhibitor, IC50=33μM, disrupts serine synthesis, selectively targets high-serine cancers.</p>Formule :C14H12N2O4S2Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :336.39MF-438
CAS :<p>MF-438 is an effective and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor (EC50: 2.3 nM for rSCD1).</p>Formule :C19H18F3N5OSDegré de pureté :98.98% - 99.50%Couleur et forme :SolidMasse moléculaire :421.44GSK2837808A
CAS :<p>GSK2837808A is a potent and selective inhibitor of lactate dehydrogenase A (LDHA) (IC50s: 1.9 and 14 nM for LDHA and LDHB, respectively).</p>Formule :C31H25F2N5O7SDegré de pureté :99.78% - 99.78%Couleur et forme :SolidMasse moléculaire :649.62ML390
CAS :<p>ML390 exerts its potent differentiation effect on multiple leukemia models.</p>Formule :C21H21F3N2O3Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :406.4DHODH-IN-11
CAS :<p>DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.</p>Formule :C15H11N3O2Degré de pureté :98.14%Couleur et forme :SolidMasse moléculaire :265.27Olutasidenib
CAS :<p>Olutasidenib (FT-2102), an IDH1 inhibitor (IC50: 21.2/114 nM), is studied for treating AML/MDS and can cross the blood-brain barrier.</p>Formule :C18H15ClN4O2Degré de pureté :98.57%Couleur et forme :SolidMasse moléculaire :354.79Mutant IDH1 inhibitor
CAS :<p>Mutant IDH1 inhibitor is an effective inhibitor of mutant IDH1 R132H (IC50: < 72 nM).</p>Formule :C25H34N6O3Degré de pureté :98.3%Couleur et forme :SolidMasse moléculaire :466.58CAY10566
CAS :<p>CAY10566 is a potent SCD1 inhibitor, orally bioavailable, with IC50s: HepG2 cells, 7.9nM; mouse, 4.5nM; human, 26nM.</p>Formule :C18H17ClFN5O2Degré de pureté :99.5% - 99.54%Couleur et forme :SolidMasse moléculaire :389.81KPLH1130
CAS :<p>KPLH1130, a PDK inhibitor, boosts glucose tolerance and reduces inflammation in high-fat diet mice.</p>Formule :C15H13N3O3Degré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :283.28WAY-311610
CAS :<p>WAY-311610 is an HSD11B1 inhibitor targeting 11β-HSD1 enzyme with 0.34 μM IC; used for neuropathic and inflammatory pain research.</p>Formule :C16H13F3N4O2Degré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :350.3MTHFD2-IN-3
<p>MTHFD2-IN-3 (compound 10), a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2), demonstrates significant efficacy in obstructing the activity</p>Formule :C22H19NO7SCouleur et forme :SolidMasse moléculaire :441.45LDHA-IN-3
CAS :<p>LDHA-IN-3 is a potent selenobenzene-based LDHA inhibitor with a 145.2 nM IC50, useful in cancer research.</p>Formule :C13H9F3SeDegré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :301.17(Rac)-BMS-816336
<p>(Rac)-BMS-816336 is a racemic 11β-HSD1 inhibitor; IC50: 10 nM (human), 68 nM (mouse), metabolically stable.</p>Formule :C21H27NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :341.44PDK-IN-2
<p>PDK-IN-2 (Compound 1F), with an IC50 of 68 nM, is a potent PDK inhibitor that downregulates the expression of PDK1 and PDK4 in cells.</p>Formule :C17H23AsCl2N2O2S2Couleur et forme :SolidMasse moléculaire :497.33hDHODH-IN-12
<p>hDHODH-IN-12 is a potent inhibitor of dihydroorotate dehydrogenase (DHODH), exhibiting an inhibitory concentration (IC50) of 0.421 μM.</p>Formule :C22H15F3N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :440.37Ascochlorin A
CAS :<p>Ascochlorin A, a compound with a dissociation constant (K D) of 3.29 μM, serves as a novel and potent human dihydroorotate dehydrogenase (hDHODH) inhibitor</p>Formule :C23H31ClO4Couleur et forme :SolidMasse moléculaire :406.95KOTX1
CAS :<p>KOTX1 is an orally active and selective inhibitor of ALDH1A3. In a diabetic mouse model, KOTX1 improves glucose tolerance, insulin secretion, and blood glucose levels.</p>Formule :C17H16FN3O2Couleur et forme :SolidMasse moléculaire :313.3311β-HSD1 inibitor 17
CAS :<p>11β-HSD1 inibitor 17 is an inhibitor of 11β-hydroxysteroid dehydrogenase (11β-HSD1).</p>Formule :C22H20F3N3O2SDegré de pureté :99.26% - 99.72%Couleur et forme :SoildMasse moléculaire :447.47BMS-770767
CAS :<p>BMS-770767 is a novel 11-betahydroxysteroid dehydrogenase type I (11ß-HSD1) inhibitor.</p>Formule :C19H18ClN3O2Couleur et forme :SolidMasse moléculaire :355.82Osmanthuside H
CAS :<p>Osmanthuside H is a useful organic compound for research related to life sciences. The catalog number is T125796 and the CAS number is 149155-70-4.</p>Formule :C19H28O11Couleur et forme :SolidMasse moléculaire :432.422IGUANA-1 free base
CAS :<p>IGUANA-1: selective ALDH1 B1 inhibitor, IC50=30 nM, hinders SW480 cell growth with IC50=2.46/0.39 μM in adherent/spheroid forms, for cancer research.</p>Formule :C26H24ClN3O2Couleur et forme :SolidMasse moléculaire :445.94DSM705
CAS :<p>DSM705: Pyrrole-based, potent nanomolar Plasmodium DHODH inhibitor with strong antimalarial efficacy; spares mammalian DHODH.</p>Formule :C19H19F3N6OCouleur et forme :SolidMasse moléculaire :404.397D-Lactate dehydrogenase
CAS :<p>D-LDH is an oxidoreductase turning D-lactate into pyruvate, using NAD+/NADP+; prevalent in bacteria and fungi, key for biochemical research.</p>Couleur et forme :SolidOctanoyl Coenzyme A (sodium salt)
<p>Octanoyl Coenzyme A (sodium salt) inhibits citrate synthase and glutamate dehydrogenase with an IC50 of 0.4–1.6 mM.</p>Formule :C29H49N7NaO17P3SCouleur et forme :SolidMasse moléculaire :915.71BVT-2733 hydrochloride
CAS :<p>BVT-2733 hydrochloride is a potent, selective, and orally active non-steroidal 11β-HSD1 inhibitor. It exhibits stronger inhibition on mouse 11β-HSD1 enzyme (IC50=96 nM) compared to the human 11β-HSD1 enzyme (IC50=3341 nM). BVT-2733 hydrochloride shows potential for research in arthritis and obesity-related diseases.</p>Formule :C17H22Cl2N4O3S2Couleur et forme :SolidMasse moléculaire :465.42SCD1 inhibitor-3
CAS :<p>SCD1 inhibitor-3 (ML-270) is a highly effective and orally available compound that inhibits SCD1 with remarkable safety.</p>Formule :C19H16FN7O2Degré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :393.37CM121
CAS :<p>CM121, a reversible ALDH1A2 inhibitor, targets active site with IC50=0.54μM, Kd=1.1μM, using hydrophobic interactions.</p>Formule :C24H17FN4O3SCouleur et forme :SolidMasse moléculaire :460.48Nedosiran sodium
CAS :<p>Nedosiran sodium, a GalNAc-dsRNA conjugate, is engineered to suppress the synthesis of the hepatic lactate dehydrogenase (LDH) enzyme.</p>Couleur et forme :SolidNecroptosis-IN-3
CAS :<p>Necroptosis-IN-3 (Cyclohexanecarboxamide, N-(2-thienylmethyl)-) (Compound 69) is a Necroptosis inhibitor that inhibits TNF-α induced necroptosis.</p>Formule :C12H17NOSDegré de pureté :99.85%Couleur et forme :SoildMasse moléculaire :223.33MTHFD2-IN-4
<p>MTHFD2-IN-4, a tricyclic coumarin derivative, serves as a potent inhibitor of MTHFD2 and has applications in cancer research [1].</p>Formule :C26H21F6N2O5Couleur et forme :SolidMasse moléculaire :555.45MTHFD2-IN-4 sodium
<p>MTHFD2-IN-4 sodium, a potent inhibitor of MTHFD2 and a tricyclic coumarin derivative, is applicable in cancer research [1].</p>Formule :C26H21F6N2NaO5Couleur et forme :SolidMasse moléculaire :578.44DSM1465
<p>DSM1465 (Compound 82) is a potent and selective inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 value of 15 nM. It inhibits P. falciparum 3D7 (Pf3D7) parasites with an EC50 value of 1.4 nM and demonstrates significant in vivo efficacy in humanized P. falciparum mouse models.</p>Formule :C17H12ClF6N5O2Couleur et forme :SolidMasse moléculaire :467.753MTHFD2-IN-2
<p>MTHFD2-IN-2 (compound 13) serves as a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2) [1].</p>Formule :C22H18N4O5Couleur et forme :SolidMasse moléculaire :418.4DHODH-IN-18
CAS :<p>DHODH-IN-18 is a human DHODH inhibitor ( IC 50 = 0.2 nM).</p>Formule :C21H16ClF5N6O4Couleur et forme :SolidMasse moléculaire :546.842,3-Dihydroxybenzaldehyde
CAS :<p>2,3-Dihydroxybenzaldehyde exhibits activity against NADH dehydrogenase (Km = 35 µM) and can be used in biochemical experiments and drug synthesis.</p>Formule :C7H6O3Couleur et forme :SolidMasse moléculaire :138.12hDHODH-IN-13
CAS :<p>hDHODH-IN-13 (compound w2), an inhibitor of human dihydroorotate dehydrogenase (hDHODH), exhibits an IC50 of 173.4 nM and has potential research applications in</p>Couleur et forme :Soild
