PKM
La Pyruvate Kinase M2 (PKM2) est une isoforme de la pyruvate kinase qui joue un rôle crucial dans la glycolyse, en convertissant le phosphoénolpyruvate en pyruvate. PKM2 est impliquée dans la régulation du reprogrammation métabolique dans les cellules cancéreuses, ce qui en fait une cible potentielle pour la thérapie contre le cancer. Les inhibiteurs de PKM2 peuvent altérer les voies métaboliques, réduire la croissance tumorale et induire la mort cellulaire dans les cellules cancéreuses. Chez CymitQuimica, nous proposons des inhibiteurs de PKM2 pour soutenir vos recherches en métabolisme du cancer, oncologie et développement thérapeutique.
17 produits trouvés pour "PKM"
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PKR-IN-2
CAS :PKR-IN-2 is a activator of pyruvate kinase (PKR).Formule :C24H28N4O4SDegré de pureté :99.14%Couleur et forme :SolidMasse moléculaire :468.57Ref: TM-T12499
1mg81,00€5mg145,00€10mg207,00€25mg334,00€50mg467,00€100mg655,00€200mg883,00€1mL*10mM (DMSO)149,00€Dimethylaminomicheliolide HCl
CAS :Dimethylaminomicheliolide HCl has potential anti-inflammatory and anti-tumor activity and inhibits the proliferation of glioblastoma cells by targeting pyruvateFormule :C17H28ClNO3Degré de pureté :99.91%Couleur et forme :SoildMasse moléculaire :329.86PKM2 inhibitor G
CAS :PKM2 inhibitor G is a inhibitor of pyruvate kinase.Formule :C16H15NO3SDegré de pureté :99.89%Couleur et forme :SoildMasse moléculaire :301.36Ref: TM-T67900
1mg109,00€5mg243,00€10mg355,00€25mg532,00€50mg745,00€100mg1.018,00€1mL*10mM (DMSO)230,00€PKM2 activator 7
PKM2 activator 7 (Compd B4) is a PKM2 activator with an AC50 value of 0.144 μM. It functions by inhibiting the growth of T cells, thereby alleviating DSS-induced colitis in mice.Formule :C16H19F3O4Masse moléculaire :332.12354PKM2-IN-10
PKM2-IN-10 is a PKM2 inhibitor. It effectively suppresses the proliferation of A549 and HCC1833 cell lines with IC50 values of 3.36 μM and 9.20 μM, respectively. PKM2-IN-10 demonstrates antitumor activity in human non-small cell lung cancer (NSCLC) and mouse lung adenocarcinoma models. It is applicable for research in lung cancer.Formule :C21H15F4N5Couleur et forme :SolidMasse moléculaire :413.12636PKCζ/ι pseudosubstrate inhibitor
CAS :PKCζ/ι pseudosubstrate inhibitor demonstrates comprehensive inhibitory activity across the protein kinase C (PKC) family and is associated with the induction ofFormule :C76H128N30O16Couleur et forme :SolidMasse moléculaire :1718.02Mitapivat sulfate hydrate
CAS :Mitapivat sulfate hydrate (AG 348 sulfate hydrate) is a pyruvate kinase (PK) allosteric activator, used to study pyruvate kinase deficiency.Formule :C24H26N4O3S1H2SO43H2ODegré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :526.6DASA-58
CAS :DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.Formule :C19H23N3O6S2Degré de pureté :96.96% - 99.28%Couleur et forme :SolidMasse moléculaire :453.53Mitapivat
CAS :Mitapivat (PKR-IN-1), also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.Formule :C24H26N4O3SDegré de pureté :99.47% - 99.83%Couleur et forme :SolidMasse moléculaire :450.55PKM2-IN-1
CAS :PKM2-IN-1 (compound 3k) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.Formule :C18H19NO2S2Degré de pureté :99.49% - 99.68%Couleur et forme :SolidMasse moléculaire :345.48TEPP-46
CAS :TEPP-46 (ML265) is an activator of pyruvate kinase M2 (PKM2), selective for PKM1, PKL and PKR. TEPP-46 has antitumor activity. Cost-effective and quality-assured.Formule :C17H16N4O2S2Degré de pureté :98.21% - 99.65%Couleur et forme :SolidMasse moléculaire :372.46Ref: TM-T7214
1mg46,00€5mg90,00€10mg137,00€25mg224,00€50mg335,00€100mg500,00€500mg1.099,00€1mL*10mM (DMSO)90,00€PKM2 activator 5
CAS :PKM2 activator 5 is a novel and potent PKM2 activator (AC50: 0.316 µM) with potential anticancer activity for the study of cancer metabolism-related diseases.Formule :C18H19FN2O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :442.48PKM2 activator 2
CAS :PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activator with an AC 50 value of 66 nM.PKM2 activator 2 has anti-tumor proliferative properties and attenuates
Formule :C20H18F2N2O4S2Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :452.49NPD10084
CAS :NPD10084 is an inhibitor of pyruvate kinase PKM2 that blocks non-glycolytic signaling in cancer cells by disrupting PKM2's interaction with β-catenin or STAT3, thus inhibiting downstream pathways. It demonstrates antiproliferative effects against colorectal cancer cells both in vitro and in vivo [1].Formule :C21H19N3O2Couleur et forme :SolidMasse moléculaire :345.39Mitapivat hydrochloride
CAS :Mitapivat (AG-348) hydrochloride is an orally active and selective allosteric activator of pyruvate kinase R (PK-R). It enhances the PK-R-catalyzed conversion of phosphoenolpyruvate to pyruvate, thereby promoting the glycolysis pathway, increasing ATP production in red blood cells, and decreasing 2,3-diphosphoglycerate (2,3-DPG) levels. Mitapivat hydrochloride is being investigated for potential use in the study of pyruvate kinase deficiency and other anemia-related disorders.Formule :C24H27ClN4O3SCouleur et forme :SolidMasse moléculaire :487.014PKM2-IN-9
CAS :PKM2-IN-9 (compound C1) is a potent inhibitor of PKM2, demonstrating a 75% inhibition rate at 50 μM. It plays a significant role in cancer research.Formule :C24H22N4O2Couleur et forme :SolidMasse moléculaire :398.457PKR Inhibitor, negative control
CAS :The PKR Inhibitor, negative control, is an inactive structural analog of RNA-dependent protein kinase (PKR) inhibitors, serving as a negative control. Additionally, it can inhibit LK-induced neuronal death, demonstrating significant neuroprotective properties.Formule :C15H8Cl3NO2Masse moléculaire :340.59
