Microbiologie/Virologie

<p>Influenza HA (518-526) is an immunodominant epitope in H2d mice after flu virus infection.</p>

<p>HIV-1 inhibitor-11, a fused pyridine ring derivative, is a HIV-1 inhibitor.</p>

<p>EFdA-TP: potent HIV-1 RT inhibitor; acts via immediate/delayed chain termination (ICT/DCT) and multiple pathways.</p>

<p>Cefonicid sodium is a broad-spectrum cephalosporin antibiotic that inhibits bacterial cell wall formation.Cost-effective and quality-assured.</p>

<p>XT-4, an antimicrobial peptide originating from the skin secretions of Xenopus tropicalis, exhibits potent activity against E.</p>

<p>Eprinomectin B1b is a minor component and belongs to the avermectin family of insecticides and anthelmintics.</p>

<p>PT-129 is a RPOTAC degrader that targets the G3BP1/2NTF2 domain (protein-RNA interaction site), facilitating the breakdown of intracellular stress granules. It prevents the formation of stress granules in stressed cells and deconstructs existing ones, thereby disrupting ATF4 transmission and inhibiting cancer cell proliferation. Stress granules (SGs) are membraneless cytoplasmic compartments formed under stress, which aid in the transfer of ATF4 from fibroblasts to tumor cells, promoting fibroblast-related tumor growth. G3BP1/2 serve as central proteins in the SG network, and inhibiting them may reduce the stress resilience of cancer cells within the tumor microenvironment. PT-129 consists of a target protein ligand (red part) G3BP1/2-Targeting ligand-1, an E3 ligase ligand (blue part) Thalidomide 4-fluoride, and a PROTAC linker (black part) Amino-PEG3-C2-acid; the E3 ligase ligand and linker form the complex Thalidomide-NH-PEG3-propionic acid.</p>

<p>Propargylcholine, an alkyne-modified choline, blocks Dgc-catalyzed demethylation in P. aeruginosa.</p>

<p>HA5 hinders S. mutans biofilm and dextran production, and reduces eDNA, with an IC50 of 6.42 μM, yet doesn't stop its growth.</p>

<p>SpdSyn binder-1 weakly inhibits malaria by binding to Plasmodium falciparum's spermidine synthase. Used for research.</p>

<p>Ochratoxin C is a toxic metabolite from Aspergillus orchraceus.</p>

<p>Bulevirtide (Myrcludex B) inhibits HBV/HDV entry into hepatocytes, treating chronic hepatitis D.</p>

<p>UCM53 has a wide range of applications in life science related research.</p>

<p>Phen-DC3 Trifluoromethanesulfonate targets G-quadruplexes and inhibits FANCJ/DinG helicases; IC50s: 65±6/50±10 nM.</p>

<p>MK-6186 is a novel non-nucleoside reverse transcriptase inhibitor with antiviral activity for the study of viral infections.</p>

<p>PD 116152: phenazine from Streptomyces with antitumor effects on P388 leukemia (T/C 149) and potent against Streptococcus pneumoniae (MIC &lt; 0.46 µg/ml).</p>

<p>Melarsomine is a trivalent arsenic drug used to treat canine heartworm and other worms. It's key in related research.</p>

<p>(R)-Dinotefuran, a neonicotinoid, is 1.7-2.4x more effective against pests like Aphis gossypii and safer for bees.</p>

<p>Cefazolin is a novel cephalosporin with anti-inflammatory activity and may be used in studies of respiratory tract infections and hepatobiliary infections.</p>

<p>1-Phenylhexane exhibits antibacterial and antioxidant activity, inhibiting S. aureus, Pseudomonas aeruginosa, Proteus mirabilis, E. coli, and Bacillus cereus</p>

<p>(S)-1-(4-Hydroxyphenyl)ethane-1,2-diol, from Angelica sinensis, inhibits Aeromonas hydrophila and acts as an anticoagulant and antibiotic.</p>

<p>SARS-CoV-2-IN-109 (compound 50) is an inhibitor targeting SARS-CoV, demonstrating in vivo anti-infection activity. It interferes with the interaction between the SARS-CoV-2 Spike receptor-binding domain (RBD) and the human receptor angiotensin-converting enzyme 2 (ACE2) with an EC50 of 26.5 μM, effectively blocking SARS-CoV-2 entry into VeroE6 cells (ECS50=17.0 μM). The compound has a CC50 greater than 100 μM in VeroE6 cells.</p>

<p>N-0920 is a potent TMPRSS2 inhibitor with an IC50 value of 0.35 nM. It effectively inhibits the entry of SARS-CoV-2 variants [EG.5.1] and [JN.1] into Calu-3 cells, exhibiting EC50 values of 300 pM and 90 pM, respectively.</p>

<p>2,4-Diacetylphloroglucinol is a useful organic compound for research related to life sciences. The catalog number is T21619 and the CAS number is 2161-86-6.</p>

<p>Nafcillin sodium, a penicillin antibiotic, treats Gram-positive, penicillin-resistant staph infections.</p>

<p>AA35 boosts Ceftazidime's efficacy by lowering its MIC.</p>

Ro 41-1879 is a catechol cephalosporin with antimicrobial activity.

<p>Antibacterial Agent 42 boosts Ceftazidime's efficacy by lowering its MIC.</p>

<p>KWR137 is a WRN degrader with an IC50 of 8 nM. It exhibits significant antiproliferative activity against MSI-H cells, with a GI50 of 509 nM for SW48 cells and 824 μM for HCT116. Additionally, KWR137 demonstrates antitumor growth effects in xenograft mouse models. This compound is applicable for cancer research.</p>

<p>Carbomycin B, a precursor in making Carbomycin, is a macrolite antibiotic from Stroptomyces halstedii, akin to Leucomycin and Erythromycin.</p>

<p>Polyoxin D (Polyoxorim), a polyoxin antibiotic fungicide, effectively inhibits chitin synthetase.</p>

<p>Mutanocyclin, a powerful antifungal agent, inhibits the filamentation of Candida albicans (C.</p>

<p>Cefluprenam is a a cephalosporin type antibacterial agent.</p>

<p>Cefovecin Sodium(Convenia) is an antibiotic of the cephalosporin class, licensed for the treatment of skin infections in cats and dogs.</p>

<p>5-Iminodaunorubicin: a quinone-altered anthracycline with antitumor effects, causing DNA breaks in cancer.</p>

<p>N2-Acetylaciclovir (Aciclovir EP Impurity F) is a derivative of the antiviral compound Aciclovir, which has selective T-cell immunotoxicity.</p>

<p>Bacteria use quorum sensing with autoinducers like AHLs to regulate gene expression and behaviors such as biofilm formation.</p>

<p>3-Deaza-2'-deoxyadenosine inhibits lymphocyte cytolysis at 100 μM with low toxicity; aids in studying adenine N3 in DNA.</p>

<p>Cytosporone C, from Diaporthe eucalyptorum fungus, is an antifungal that combats Alternaria solani.</p>

<p>Cefoxitin sodium (Betacef) is a semisynthetic cephamycin antibiotic resistant to beta-lactamase.</p>

<p>Viroxocin, a diterpenoid, is isolated from the roots of Salvia viridis L. cvar. Blue Jeans and exhibits weak antibacterial activity [1].</p>

<p>Ludaconitine, isolated from Aconitum spicatum (Bruhl) Stapf, exhibits antileishmanial activity with an IC50 of 36.10 μg/mL.</p>

<p>Nikkomycin pseudo-J is a nikkomycin isolated from Streptomyces tendae.</p>

<p>Demethyl linezolid, an impurity in linezolid (WO199500721A1, ex. 9), has antimicrobial effects on human and veterinary pathogens.</p>

<p>NCGC00537446 is a dual inhibitor of Nsp14 MTase/ExoN. It is applicable for research on SARS-CoV-2 replication and infection.</p>

<p>Amycolatopsin A, a macrolide from Amycolatopsis, fights M. bovis/tuberculosis and some cancers, not effective on common bacteria.</p>

<p>Bactobolin is a biochemical.</p>

<p>DprE1-IN-7 (Compound 64) is a DprE1 inhibitor with potent anti-tuberculosis (TB) activity, demonstrating a minimum inhibitory concentration (MIC) of 1 μM</p>

<p>MraY-IN-1 (compound 12a) is a potent inhibitor of MraY, exhibiting an IC50 of 140 µM.</p>

<p>Pseudorabies virus-IN-1 is a potent inhibitor of pseudorabies virus (PRV) with an EC50 of 0.29 nM, acting by targeting PRV deoxyribonucleic acid polymerase (DNA pol) to suppress PRV replication. It effectively inhibits PRV replication even at low concentrations (MIC80: 1.6-8 nM) and is useful for research on PRV infections.</p>

<p>ONX 0801 (BGC 945) trisodium is a targeted thymidylate synthase (TS) inhibitor specifically designed to act against tumors overexpressing the α-folate receptor.</p>

<p>Methyl brevifolincarboxylate is an influenza inhibitor targeting PB2 with IC50s of 27.16μM (H1N1) and 33.41μM (H3N2), and has antioxidant activity.</p>

<p>Cefmetazole is a second-generation semi-synthetic β-lactam cephalosporin antibiotic with antimicrobial activity.</p>

<p>Antibacterial agent 136, an oxadiazolone antibiotic, highly potent against MRSA with MIC 50 at 0.8 μM.</p>

<p>K 41 is a polycyclic polyether antibiotic from Streptomyces hygroscopicus.</p>

<p>(2E,4E)-Decadienoic acid, an aliphatic anti-oomycete agent, is present in the coculture of Bacillus subtilis and Trichoderma asperellum [1].</p>

<p>Tur1A, an antimicrobial peptide sourced from the bottlenose dolphin (Tursiops truncates), impedes bacterial protein synthesis.</p>

<p>Xanthosine-5'-Triphosphate (5'-XTP), a nucleotide derived from the deamination of purine bases, plays a crucial role in various biological processes.</p>

<p>Endosulfan sulfate, a highly toxic, persistent metabolite of the widely-used insecticide Endosulfan, targets multiple crops.</p>

<p>FR901379, an echinocandin-like antifungal, combats various fungi, protects mice from C. albicans, and lessens P. carinii infection symptoms.</p>

<p>FLGFVGQALNALLGKL-NH2, an antimicrobial peptide derived from frogs, exhibits activity against Staphylococcus aureus ATCC 29213 with a minimum inhibitory</p>

<p>N7-Methylguanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium, a dinucleotide cap analog, facilitates in vitro RNA transcription [1].</p>

<p>1,4-Dihydroxynaphthalene A potent HSV-1 protease inhibitor with inhibitory effects on the HCMV protease, which can be used to study herpesviruses.</p>

<p>cis-11-Methyl-2-dodecenoic acid: a QS signal, aids microbial communication, regulates virulence, biofilm in pathogens.</p>

<p>SARS-CoV-2-IN-49 acts as an irreversible covalent inhibitor targeting the main protease of SARS-CoV-2 [1].</p>

<p>Hymeglusin is an HMG-CoA synthase 1 inhibitor with pro-apoptotic and anti-leukemic activity. Hymeglusin decreases the expression level of BCL2 in HL-60 and KG-1 cells.</p>

<p>Antimicrobial agent-26 is a powerful antimicrobial that has demonstrated the ability to counteract antibiotic resistance in vitro [1].</p>

<p>Aureothricin: DTP antibiotic from Streptomyces, broad-spectrum, inhibits HUVEC adhesion to vitronectin.</p>

<p>Antibacterial agent 153 is a broad-spectrum agent that eradicates bacteria by targeting their cell membranes and is employed in research on bacterial infections</p>

<p>Anguinomycin A, an antibiotic from Streptomyces, is like leptomycin B, kills mouse leukemia cells, and fights lung cancer in mice.</p>

<p>ART812 is an orally active inhibitor of DNA polymerase Polθ, possessing an IC50 value of 7.6 nM.</p>

Isosulfazecin is a beta-lactam antibiotic.

<p>Cletoquine hydrochloride, a Hydroxychloroquine metabolite, is a Chloroquine derivative with antimalarial properties and combatting CHIKV.</p>

<p>Cytochalasin R (compound 17), an analogue of cytochalasin, is derived from the endophytic fungus Phomopsis sp.</p>

<p>Sisomicin is a broad-spectrum aminoglycoside antibiotic isolated from Micromonospora inyoensis. It is highly active against staphylococci.</p>

<p>Cafamycin is a bioactive chemical.</p>

<p>RG7800 hydrochloride is an orally active modulator of SMN2 splicing, exhibiting EC50 values of 23 nM for SMN2 splicing and 87 nM for SMN protein production.</p>

<p>Brevianamide M (compound 4), a metabolite of the endophytic fungus Aspergillus versicolor isolated from the marine brown alga Sargassum, exhibits antimicrobial</p>

<p>Bombinin H4 is an antimicrobial peptide originating from the skin of the moth species Bombina variegata.</p>

<p>Chamaejasmenin D is a useful organic compound for research related to life sciences and the catalog number is T124064.</p>

<p>Formycin B is a model nucleoside analog.</p>

<p>Kipukasin D is a naturally derived nucleoside with antibacterial properties, isolated from Aspergillus versicolor.</p>

<p>ARS-CoV-2-IN-53 (Compd 5d) exhibits an inhibitory effect on SARS-CoV-2 replication, with an effective concentration (EC50) value of 14.3 μM, and demonstrates</p>

<p>Antileishmanial agent-21 (compound 4e) functions as an inhibitor of Leishmania pteridine reductase 1 (Lm-PTR1), employing an anti-folate mechanism.</p>

<p>SARS-CoV-2-IN-50 (Compound X77C) is a potent inhibitor of the SARS-CoV-2 main protease (M^pro), exhibiting high affinity for the enzyme's catalytic site [1].</p>

<p>Altromycin D is a new pluramycin-like antibiotic.</p>

<p>Antitrypanosomal agent 16 functions as a potent trypanocide, exhibiting an inhibitory concentration 50 (IC50) of 0.04μM against the T.</p>

<p>Lugdunin is an antibiotic peptide that disrupts membrane potential in bacteria, demonstrating activity against Gram-positive species including S.</p>

<p>RdRP-IN-6 (compound 27) is an inhibitor of RNA-dependent RNA polymerase (RdRp), exhibiting an IC90 value of 14.1 μM.</p>

<p>This peptide is a H2-Db-restricted epitope from Influenza nucleoprotein (147-155).</p>

<p>RFI-641 is a dendrimer-like compound with anti-RSV properties and is effective in vitro and in vivo activity.</p>

<p>Pyrrolnitrin: broad-spectrum antibiotic from Pseudomonas pyrrocinia; effective against fungi, yeast, and gram-positive bacteria.</p>

<p>Massarigenin C from M. flavorosea inhibits neuraminidase (IC50=4.15μM) and α-glucosidase (IC50=1.25mM), reduces blood glucose in mice.</p>

<p>Amicetin, a potent antibiotic, is effective against gram-positive bacteria by inhibiting protein synthesis [1] [2] [3].</p>

<p>Compound A11 is a potent antibacterial, with MIC 0.00191 μg/mL against MRSA, outperforming tiamulin and retapamulin by 162x and 32x.</p>

<p>A 26771B is an antibiotic in the class of macrolide lactone.</p>

<p>Compound 3h, also known as SARS-CoV-2 3CLpro-IN-17, is a selective inhibitor of the SARS-CoV-2 3CL protease, demonstrating an IC50 of 0.322 μM [1].</p>

<p>β-Herpesvirus protease-IN-1 (compound 19) serves as an inhibitor of β-herpesvirus protease, exhibiting IC50 values of 2.5 μM for HCMVPro and 0.33 μM for HHV6Pro</p>

<p>SARS-CoV-2-IN-54 (Compound 2), a SARS-CoV-2 inhibitor, exhibits antiviral activity by impeding the virus in Vero E6 cells with an inhibitory concentration (IC50</p>

<p>Clenpirin is a bio-active chemical.</p>