Microbiologie/Virologie
Les inhibiteurs en microbiologie et virologie sont des composés qui ciblent les microorganismes, y compris les bactéries, les virus et les champignons, perturbant leur croissance, leur réplication ou leur survie. Ces inhibiteurs sont essentiels pour étudier la pathogénie microbienne, comprendre les mécanismes de résistance et développer de nouvelles thérapies antimicrobiennes et antivirales. Les inhibiteurs de cette catégorie sont utilisés pour combattre les maladies infectieuses, explorer l'écologie microbienne et étudier les interactions hôte-pathogène. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de haute qualité en microbiologie et virologie pour soutenir vos recherches en maladies infectieuses, microbiologie et virologie.
Sous-catégories appartenant à la catégorie "Microbiologie/Virologie"
- Antibactérien(2.957 produits)
- Antibiotique(920 produits)
- Antifection(23 produits)
- DHFR(33 produits)
- Synthèse ADN/ARN(708 produits)
- VHB(176 produits)
- Protéase du VIH(449 produits)
- HSV(91 produits)
- Intégrase(2 produits)
- Ribosome(13 produits)
Affichez 2 plus de sous-catégories
5842 produits trouvés pour "Microbiologie/Virologie"
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GS-9822
CAS :<p>GS-9822 is a new LEDGIN inhibitor targeting LEDGF/p75 to alter HIV integration, showing a block-and-lock effect in cells.</p>Formule :C36H39ClN4O4SCouleur et forme :SolidMasse moléculaire :659.24GSK_WRN4
CAS :<p>GSK_WRN4 is a WRN helicase inhibitor with anti-cancer activity, inhibiting MSI tumor cell growth by inducing DNA double-strand breaks, useful in cancer research</p>Formule :C16H20N2O4SDegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :336.41PKZ18
CAS :<p>PKZ18 is an antibiotic that inhibits bacterial growth with a MIC value of 32-64 μg/mL against most Gram-positive bacteria. It suppresses the in vivo transcription and translation of glycyl-tRNA synthetase mRNA. PKZ18 selectively targets stem I specifier loops in Gram-positive bacteria, directly reducing T-box transcription readthrough of associated genes. It prevents codon-anticodon pairing necessary for tRNA binding and is less likely to induce resistance.</p>Formule :C22H26N2O3SCouleur et forme :SolidMasse moléculaire :398.518PLpro-IN-6
CAS :<p>PLpro-IN-6 (compound 6) serves as an inhibitor for the papain-like protease (PLpro), demonstrating potent activity with an IC 50 of 0.019 μM against the SARS-CoV-2 PLpro enzyme.</p>Formule :C29H30N6OCouleur et forme :SolidMasse moléculaire :478.59Valopicitabine dihydrochloride
CAS :<p>Valopicitabine, a NS5B inhibitor, is used potentially for the treatment of HCV infection.</p>Formule :C15H25ClN4O6Couleur et forme :SolidMasse moléculaire :392.843HKT-IN-1
CAS :<p>3HKT-IN-1 (Compound 17122279) is an inhibitor of Anopheles gambiae 3-hydroxykynurenine transaminase (3HKT) and is utilized in malaria research.</p>Formule :C12H11BrN2O3Couleur et forme :SolidMasse moléculaire :311.131MsbA-IN-3
<p>MsbA-IN-3 is a potent and highly selective MsbA inhibitor (IC50: 2 nM). MsbA-IN-3 inhibits Escherichia coli activity (MIC: 35 μM).</p>Formule :C24H22Cl2N2O4SCouleur et forme :SolidMasse moléculaire :505.41Tuberculosis inhibitor 4
<p>TB inhibitor 4, a spirothiazolidinone from mandelic acid, blocks 98% of M. tuberculosis H37Rv under 6 μg/mL.</p>Formule :C23H26N2O3SCouleur et forme :SolidMasse moléculaire :410.533-Deazaguanosine
CAS :<p>3-Deazaguanosine (C3Guo) exhibits potent antiviral activity against SARS-CoV-2 with an EC50 of 1.14 μM and a CC50 greater than 200 μM in Vero E6 cells. It has the potential to prevent COVID-19.</p>Formule :C11H14N4O5Couleur et forme :SolidMasse moléculaire :282.25Furametpyr
CAS :<p>Furametpyr is a kind of low toxicity pesticides used to control plant diseases caused by various pathogenic microorganisms.</p>Formule :C17H20ClN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :333.81Antibacterial agent 63
CAS :<p>Aztreonam-siderophore conjugate 63 is an antibacterial agent that exhibits efficacy against Gram-negative bacteria through the linkage of aztreonam to a</p>Formule :C35H43N9O14S2Couleur et forme :SolidMasse moléculaire :877.9GC373
CAS :<p>GC373, an effective inhibitor of the SARS-CoV-2 M pro, impedes virus replication, exhibiting an inhibition concentration (IC 50) of 0.4 μM. This compound is valuable for use in anti-COVID-19 research.</p>Formule :C21H29N3O5Couleur et forme :SolidMasse moléculaire :403.47ZK-806450
CAS :<p>ZK-806450 is a compound with antiviral properties. It exhibits high binding potential to the allosteric site of the SARS-CoV-2 3CL protease and is capable of specific and stable interaction with the GAG site of the dengue virus envelope protein.</p>Formule :C31H31N5OCouleur et forme :SolidMasse moléculaire :489.611Antileishmanial agent-6
<p>Antileishmanial agent-6: potent against Leishmania donovani, IC50 0.54μM; cytotoxic IC50 10.2μM.</p>Formule :C24H26O8Couleur et forme :SolidMasse moléculaire :442.46Cyclophilin inhibitor 1
CAS :<p>Cyclophilin inhibitor 1: orally available, Kd 5 nM, potent against HCV, EC50 for HCV 2a is 98 nM.</p>Formule :C31H39N5O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :593.67PLP_Snyder530
<p>PLP_Snyder530, a potent PL pro inhibitor, halts SARS-CoV-2 by triggering protease conformation changes.</p>Formule :C24H24N2O2Couleur et forme :SolidMasse moléculaire :372.46Antibacterial agent 90
<p>Antibacterial agent 90 (6n), a pleuromutilin derivative, targets Gram-positive pathogens and Mycoplasma pneumoniae.</p>Formule :C30H42N2O6Couleur et forme :SolidMasse moléculaire :526.66Antibacterial agent 88
<p>Antibacterial agent 88 is an effective antibacterial agent against B. subtilis (MIC: 4 μg/ml) with MIC values of ≤0.0156 μg/mL for MRSA, MRSE and S. aureus.</p>Formule :C31H44N2O6SCouleur et forme :SolidMasse moléculaire :572.76Squalamine lactate
CAS :<p>Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity.</p>Formule :C37H71N3O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :718.04LN002
CAS :<p>LN002 is an orally active inhibitor of Cryptosporidium oxidase, utilized for research in cryptosporidiosis.</p>Formule :C22H15N7Couleur et forme :SolidMasse moléculaire :377.40UNI418
CAS :<p>UNI418 is a dual inhibitor targeting PIKfyve and PIP5K1C, exhibiting antiviral activity against SARS-CoV-2 (EC50=1.4 μM). It inhibits the endocytosis of the virus mediated by ACE2 by suppressing PIP5K1C (IC50=60.1 nM; Kd=61 nM). Additionally, UNI418 impedes the entry of SARS-CoV-2 into host cells by inhibiting the proteolytic activation regulated by PIKfyve (Kd=0.78 nM).</p>Formule :C22H16N6Couleur et forme :SolidMasse moléculaire :364.40PLpro-IN-5
CAS :<p>PLpro-IN-5 (compound 21), serving as a PLPro protease inhibitor, boasts an IC50 of 91.14 nM. This compound exhibits a broad-spectrum antivirus efficacy, particularly effective against SARS-CoV, MERS-CoV, and SARS-CoV-2.</p>Formule :C26H33N3OCouleur et forme :SolidMasse moléculaire :403.56Anti-Trypanosoma cruzi agent-2
<p>Compd 3b: anti-trypanosomal, IC50 0.51 μM (NINOA), 3.06 μM (INC-5), also combats T. gondii.</p>Formule :C17H10ClNO5Couleur et forme :SolidMasse moléculaire :343.72Anti-MRSA agent 6
<p>Anti-MRSA agent 6 (compound 3q6) is a potent anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) agent with low cytoxicity for MCF-7, A549 cells [1].</p>Formule :C16H11F2N3Couleur et forme :SolidMasse moléculaire :283.28Neocryptolepine-Cl
CAS :<p>Neocryptolepine-Cl (compound Z24) is an inhibitor of Bcthi4, demonstrating excellent antifungal activity against B. cinerea, with an EC50 value of 0.56 μg/mL.</p>Formule :C16H11ClN2Couleur et forme :SolidMasse moléculaire :266.725Antifungal agent 43
<p>Antifungal agent 43 inhibits biofilms with low toxicity to human cancer cells.</p>Formule :C24H26N4Se2Couleur et forme :SolidMasse moléculaire :528.41trans-Clopenthixol
CAS :<p>Trans-Clopenthixol ((E)-Clopenthixol) is an antibiotic without any sedative properties. It can be used in vitro to inhibit Pseudomonas aeruginosa and Plasmodium falciparum.</p>Formule :C22H25ClN2OSCouleur et forme :SolidMasse moléculaire :400.9652-CEES
CAS :<p>2-CEES is a mustard gas analogue that only forms DNA monoadducts. It induces centromere amplification in both human and mouse cells and can lead to chromosome instability.</p>Formule :C4H9ClSCouleur et forme :SolidMasse moléculaire :124.632ATIC-IN-2
CAS :<p>ATIC-IN-2 (Compound 1) is a competitive inhibitor of the bifunctional enzyme AICAR Tfase/IMPCH (ATIC), binding to inosine monophosphate cyclohydrolase (IMPCH) with a Ki of 0.13 μM.</p>Formule :C4H4N4O3SCouleur et forme :SolidMasse moléculaire :188.165Piperacillin hydrate
CAS :<p>Piperacillin hydrate is a semisynthetic broad-spectrum β-lactam antibiotic. It exhibits potent bactericidal activity against Gram-negative bacteria and some Gram-positive bacteria by targeting penicillin-binding proteins. Piperacillin hydrate is frequently combined with the β-lactamase inhibitor Tazobactam for enhanced efficacy.</p>Formule :C23H29N5O8SCouleur et forme :SolidMasse moléculaire :535.57Anti-Trypanosoma cruzi agent-1
<p>Anti-Trypanosoma cruzi agent-1 (Compd E5) has a potent anti-Toxoplasma effect.</p>Formule :C23H29N3O5Couleur et forme :SolidMasse moléculaire :427.49MDL-860
CAS :<p>MDL-860 is a broad-spectrum antiviral compound targeting small RNA viruses and exhibits low cytotoxicity to human cells. MDL-860 is useful for research into viral infections.</p>Formule :C13H6Cl2N2O3Couleur et forme :SolidMasse moléculaire :309.104Saphenamycin
CAS :<p>Saphenamycin is an antibiotic from a strain of Streptomyces.</p>Formule :C23H18N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :402.40ZG297
CAS :<p>ZG297 is an agonist of Staphylococcus aureus ClpP (SaClpP) with an EC50 of 0.26 μM. It degrades SaFtsZ and inhibits bacterial cell division, exhibiting antistaphylococcal activity by inhibiting S. aureus 8325-4 and MRSA strains, with a MIC range of 0.063-256 μg/mL. In mouse models, ZG297 demonstrates anti-infective properties.</p>Formule :C31H35F3N4O3Couleur et forme :SolidMasse moléculaire :568.63RSV-IN-5
CAS :<p>RSV-IN-5: Dual inhibitor for RSV fusion proteins, effective on wild-type A2 and D486N mutant with EC50s of 2.0 nM & 8.1 nM. Potent anti-RSV.</p>Formule :C28H37N7O2Couleur et forme :SolidMasse moléculaire :503.64PCNA-IN-1
CAS :<p>PCNA-IN-1 (Compound 11) is an inhibitor of the PCNA/PIP-box interaction, with an IC50 greater than 50 μM. It is applicable in cancer research.</p>Formule :C19H18I3NO3Couleur et forme :SolidMasse moléculaire :689.065LolCDE-IN-2
CAS :<p>LolCDE-IN-2 is a potent Lol protein (LolCDE) inhibitor. LolCDE-IN-2 shows antibacterial activity with a MIC of 2 μg/ml against E. coli MG1655 [1].</p>Formule :C22H17N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :367.40Doxazosin impurity 12
CAS :<p>Doxazosin impurity 12 acts as an inhibitor of CTX-M β-lactamase (Beta-lactamase) with a Ki value of 0.7 mM against CTX-M.</p>Formule :C10H6O5SCouleur et forme :SolidMasse moléculaire :238.217Anti-MRSA agent 27
CAS :<p>Anti-MRSA agent 27 (compound 4a) is a potent antimicrobial agent against methicillin-resistant Staphylococcus aureus (MRSA) with a minimum inhibitory concentration (MIC) of 0.0975 μmol/L. It effectively disrupts MRSA biofilms and inhibits the production of hemolysins.</p>Formule :C15H10F3N3OSCouleur et forme :SolidMasse moléculaire :337.32A25822B
CAS :<p>A25822B is an antifungal agent.</p>Formule :C28H45NODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :411.66β-Glucuronidase-IN-2
<p>β-Glucuronidase-IN-2 is a potent inhibitor of E.</p>Formule :C21H17Cl3O7Couleur et forme :SolidMasse moléculaire :487.71Chitin synthase inhibitor 6
<p>Compound 9b inhibits CHS with an IC50 of 0.21 mM; it's a broad-spectrum antifungal, effective against resistant strains.</p>Formule :C24H25N3O6Couleur et forme :SolidMasse moléculaire :451.47Anti-infective agent 10
CAS :<p>Anti-infective agent 10 (Compound Example 30) is an ns5b polymerase inhibitor that functions as an anti-HCV agent.</p>Formule :C26H25N3O7SCouleur et forme :SolidMasse moléculaire :523.56Antibacterial agent 66
<p>Compound 6q, a trifluoromethylpyridine oxadiazole, targets Xanthomonas oryzae with EC50 of 7.2 μg/mL.</p>Formule :C17H10ClF6N3O2SCouleur et forme :SolidMasse moléculaire :469.79(Rac)-Plevitrexed
CAS :<p>(Rac)-Plevitrexed is a racemate of Plevitrexed. Plevitrexed is an orally active and potent inhibitor of thymidylate synthase (TS).</p>Formule :C26H25FN8O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :532.53Cefoxazole
CAS :<p>Cefoxazole is a β-lactam antibiotic featuring an isoxazole structure, known for its antibacterial activity. It can be utilized in the study of infectious diseases.</p>Formule :C21H18ClN3O7SCouleur et forme :SolidMasse moléculaire :491.902Telinavir
CAS :<p>Telinavir (SC-52151) is a potent and selective inhibitor of HIV protease. It effectively inhibits both HIV-1 and HIV-2, as well as lymphotropic, monocytotropic strains, and wild isolates of simian immunodeficiency viruses, with an EC50 of 26 ng/mL (43 nM). Telinavir shows high protein binding in human plasma and a low distribution rate in red blood cells.</p>Formule :C33H44N6O5Couleur et forme :SolidMasse moléculaire :604.74Antimalarial agent 2
<p>Antimalarial agent 2 is an orally active, novel antimalarial agent that exhibits rapid in vitro killing effects.</p>Formule :C27H25N3O5Couleur et forme :SolidMasse moléculaire :471.5HIV-1 inhibitor-14
<p>HIV-1 inhibitor-14: potent, broad HIV-1 RT inhibitor. IC50=0.14μM. Effective against wild-type and resistant strains, EC50=5.79-28.3nM.</p>Formule :C29H32N6O4SCouleur et forme :SolidMasse moléculaire :560.67Antibacterial agent 279
CAS :<p>Antibacterialagent 279 (compound A12) is an effective antibacterial agent. It inhibits the SOS response of Pseudomonas aeruginosa.</p>Formule :C9H11NO2SCouleur et forme :SolidMasse moléculaire :197.25PqsR-IN-2
<p>PqsR-IN-2, potent PqsR inhibitor, curbs Pseudomonas aeruginosa communication, reduces pyocyanin, with low toxicity.</p>Formule :C18H20ClN3OSCouleur et forme :SolidMasse moléculaire :361.89Fenbenicillin potassium
CAS :<p>Fenbenicillin (Phenbenicillin) potassium is a semi-synthetic penicillin with antibacterial spectrum activity.</p>Formule :C22H22KN2O5SCouleur et forme :SolidMasse moléculaire :465.584Anticancer agent 36
<p>Compound 11: Sulfonylurea derivative, antimicrobial, anticancer; MIC 0.039-0.156 mg/mL; A549 IC50: 19.7 μg/mL, PC3 IC50: 11.9 μg/mL.</p>Formule :C21H17N3O3S2Couleur et forme :SolidMasse moléculaire :423.51SPR7
<p>SPR7 is a potent and selective rhodesain inhibitor (Ki: 0.51 nM). SPR7 exhibited antiparasitic effects against T. b. brucei (EC50: 1.65 μM).</p>Formule :C30H32ClN3O3Couleur et forme :SolidMasse moléculaire :518.05bc1 Complex-IN-1
CAS :<p>Bc1 Complex-IN-1 (compound 12g) is a potent inhibitor of the bc1 complex, demonstrating fungicidal properties against cucumber downy mildew (CDM).</p>Formule :C16H22N6O5S2Couleur et forme :SolidMasse moléculaire :442.513PFK-IN-1
CAS :<p>PFK-IN-1 (compound 1) is an inhibitor of 6-phosphofructo-1-kinase (PFK), demonstrating IC50 values of 0.41 and 0.23 μM against T. brucei and T. cruzi PFK, respectively, and an ED50 of 15.18 μg/mL for T. brucei. The compound has a half-life of 9.7 minutes in rat liver microsomes and 408 minutes in mouse liver microsomes.</p>Formule :C18H15Cl2N3O4SCouleur et forme :SolidMasse moléculaire :440.3JPL
CAS :JPL is an InhA-cofactor-ligand 3FNG inhibitor and is used for the study of tuberculosis [1].Formule :C19H20Cl2O2Couleur et forme :SolidMasse moléculaire :351.27InhA-IN-7
CAS :<p>InhA-IN-7 (Compound 11), a derivative of Triclocan, shows inhibitory activity against enoyl-acyl carrier protein reductase (InhA) with an IC50 of 96 nM. It effectively inhibits the proliferation of both wildtype and mutant strains of Mycobacterium tuberculosis, exhibiting minimum inhibitory concentrations (MICs) ranging from 19 to 75 μM [1].</p>Formule :C17H18Cl2O2Couleur et forme :SolidMasse moléculaire :325.23Imidocarb dihydrochloride monohydrate
<p>Imidocarb dihydrochloride monohydrate is an effective antiprotozoal agent against the parasite B. bovis (IC50: 87 μg/ml).</p>Formule :C19H24Cl2N6O2Couleur et forme :SolidMasse moléculaire :439.34BPR3P0128
CAS :<p>BPR3P0128, a non-nucleoside RNA-dependent RNA polymerase (RdRp) inhibitor, is effective orally and can inhibit various SARS-CoV-2 variants. It exhibits EC 50 values of 0.62 µM for SARS-CoV-2 and 0.14 µM for HCoV-229E, demonstrating potent anti-pancoronavirus activity at submicromolar concentrations. Additionally, BPR3P0128 displays synergistic antiviral effects when used in combination with Remdesivir [1].</p>Formule :C22H18BrN3O2Couleur et forme :SolidMasse moléculaire :436.30TLR8 agonist 4
<p>TLR8 agonist 4 inhibits wild-type and lamivudine/entecavir-resistant HBV; IC50: 0.15 μM and 0.10 μM.</p>Formule :C28H27N5O5SCouleur et forme :SolidMasse moléculaire :545.61Metallo-β-lactamase-IN-14
CAS :<p>Metallo-β-lactamase-IN-14 (Compound 17e) serves as an inhibitor of Metallo-β-Lactamase, displaying inhibitory activity against VIM-1 and VIM-2. This compound also exhibits antibacterial effects on Gram-negative (GN) bacteria and P. aeruginosa [1].</p>Formule :C20H22N8O2S2Couleur et forme :SolidMasse moléculaire :470.57Alpibectir
CAS :<p>Alpibectir has antibacterial activity [1].</p>Formule :C12H14F6N2O2Couleur et forme :SolidMasse moléculaire :332.24SAG-524
CAS :<p>SAG-524 is a powerful oral small molecule that inhibits HBV viral replication. In HepG2.2.15 cells, SAG-524 reduced HBV-DNA and HbsAg levels in the supernatant with IC₅₀ values of 0.92 nM and 1.4 nM, respectively [1].</p>Formule :C30H32ClN5O4SCouleur et forme :SolidMasse moléculaire :594.12iPAF1C
CAS :<p>iPAF1C is a powerful inhibitor of the polymerase-associated factor 1 complex (PAF1C) and exhibits anti-HIV activity [1].</p>Formule :C27H26BrFN4OCouleur et forme :SolidMasse moléculaire :521.42Antibacterial agent 68
<p>Antibacterial agent 68 targets drug-resistant E. coli at 0.007 mM with low cytotoxicity.</p>Formule :C26H25BrN4O7Couleur et forme :SolidMasse moléculaire :585.4Colistin adjuvant-1
<p>Colistin adjuvant-1, inhibits NF-κB (IC50: 0.209 μM), boosts mucin against gram-negative bacteria.</p>Formule :C16H7F9N2OCouleur et forme :SolidMasse moléculaire :414.23Saussureamine C
CAS :<p>Saussureamine C is an inhibitor of H274Y and N294S mutants.</p>Formule :C19H26N2O5Couleur et forme :SolidMasse moléculaire :362.42HIV-1 inhibitor-13
<p>HIV-1 inhibitor-13: oral NNRTI, IC50=0.14μM for HIV-1 RT, effective on resistant strains (EC50=2.85-18nM).</p>Formule :C30H32N6O3Couleur et forme :SolidMasse moléculaire :524.61LpxA-IN-1
CAS :<p>LpxA-IN-1, a novel UDP-N-acetylglucosamine acyltransferase (LpxA) inhibitor exhibiting potent activity (IC 50 2 nM), effectively targets Pseudomonas aeruginosa</p>Formule :C21H11D7F3N5O3Couleur et forme :SolidMasse moléculaire :452.44BRD-4592
CAS :<p>BRD-4592 is an allosteric inhibitor targeting tryptophan synthase (TrpAB) of Mycobacterium tuberculosis. It binds at the α-β subunit interface of TrpAB, with an IC50 of 70.9 nM for the α subunit and 22.6 nM for the β subunit.</p>Formule :C17H15FN2OCouleur et forme :SolidMasse moléculaire :282.312BRL-42715
CAS :<p>BRL-42715 is an effective inhibitor of bacterial beta-lactamases.</p>Formule :C10H7N4NaO3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :286.24ZIKV-IN-4
<p>ZIKV-IN-4 is a low cytotoxic, acid-stable anti-ZIKV agent with an EC50 value of 3.49 μM. ZIKV-IN-4 exhibited potent inhibition of ZIKV NS5 MTase.</p>Formule :C33H37NO4Couleur et forme :SolidMasse moléculaire :511.65RCB18350
CAS :<p>RCB18350 is an antituberculosis agent and an isoxazole derivative. It demonstrates bacteriostatic properties by inhibiting the growth of Mycobacterium tuberculosis, with a minimum inhibitory concentration (MIC) of 1.25 μg/mL. RCB18350 is effective against multi-drug resistant Mycobacterium tuberculosis (MDR-TB) clinical isolates, Mycobacterium bovis BCG, and Mycobacterium avium, all of which are slow-growing mycobacteria.</p>Formule :C19H18F3N3O4SCouleur et forme :SolidMasse moléculaire :441.424CMX990
CAS :<p>CMX990, a SARS-CoV-2 3CL protease inhibitor, exhibits EC90 values of 9.6 nM in human bronchial epithelial cells (HBECs) and 101 nM in HeLa-ACE2 cells. It also demonstrates good ADME and pharmacokinetic properties [1].</p>Formule :C22H32F3N3O6Couleur et forme :SolidMasse moléculaire :491.50HIV-1 inhibitor-17
<p>HIV-1 inhibitor-18 blocks HIV-1 capsid, acts on NL4-3 strain (EC50: 2.57 μM), has low cytotoxicity (MT-4 CC50: >8.55).</p>Formule :C32H32N4O5SCouleur et forme :SolidMasse moléculaire :584.69DHX9-IN-19
CAS :<p>DHX9-IN-19 (compound 3) is an orally active inhibitor of DHX9, playing a significant role in cancer research.</p>Formule :C20H21ClN4O4S2Couleur et forme :SolidMasse moléculaire :480.988HT1171
CAS :<p>HT1171 is a potent and selective inhibitor of the Mycobacterium tuberculosis proteasome. It exhibits strong antitubercular activity against Mycobacterium tuberculosis H37Rv, with a MIC90 of 2 μg/mL and MIC of 4 μg/mL. At a concentration of 100 μM, HT1171 shows an inhibition rate of 53.8% against normal human liver cells (L02). HT1171 is applicable in antituberculosis drug research.</p>Formule :C7H4N2O4S2Couleur et forme :SolidMasse moléculaire :244.248Antibacterial agent 261
CAS :<p>Antibacterialagent 261 (compound 43) is a potent inhibitor of the peptide deformylase (PDF) enzyme, demonstrating IC50 values of 2.5 nM against Staphylococcus aureus (S. aureus) and 10.6 nM against Escherichia coli (E. coli).</p>Formule :C18H24N4O3S2Couleur et forme :SolidMasse moléculaire :408.538Antibacterial agent 174
CAS :<p>Compound 174 (Compound 5g), an antibacterial agent, exhibits potent anti-infective properties in vivo along with appreciable pharmacokinetic profiles. This highly active substance demonstrates favorable biofilm removal capabilities, low hemolysis, and acceptable mammalian cell toxicity [1].</p>Formule :C25H30FN2NaO5Couleur et forme :SolidMasse moléculaire :480.5Methyl piperazine-2-carboxylate
CAS :<p>Methyl piperazine-2-carboxylate (compound 4) is a potent activator of METTL3/METTL14/WTAP. It enhances the production of HIV-1p24 viral particles and increases the level of N6-methyladenosine in the viral RNA genome.</p>Formule :C6H12N2O2Couleur et forme :SolidMasse moléculaire :144.172Antibacterial agent 172
CAS :<p>Antibacterial Agent 172 (Compound 6a), a <i>Clostridioides difficile (Cd) SpoVD inhibitor with an IC50 value of 89 nM, effectively inhibits the sporulation of Clostridioides difficile. It is useful for research on bacterial infections [1].</p>Formule :C21H21N9O5S2Couleur et forme :SolidMasse moléculaire :543.58MAY0132
CAS :<p>MAY0132 is a potent and selective EPAC2 inhibitor with an IC50 of 0.4 μM. It significantly inhibits the replication of HMPV, AdV, and RSV, reduces cytokine/chemokine production induced by viral infections, and suppresses NF-κB activation. MAY0132 exhibits antiviral activity and can be used in respiratory virus infection research.</p>Formule :C16H15ClF3NCouleur et forme :SolidMasse moléculaire :313.745HBV-IN-11
CAS :<p>HBV-IN-11 is a potent inhibitor of HBsAg secretion (EC50: 0.46 μM).</p>Formule :C21H24ClNO6Couleur et forme :SolidMasse moléculaire :421.87Antifungal agent 12
<p>Antifungal agent 12 is a new fluconazole-like compound that exhibits good antifungal effects.</p>Formule :C20H16F3N7O2S2Couleur et forme :SolidMasse moléculaire :507.51Antibacterial agent 87
<p>Antibacterial agent 87 is an effective antibacterial agent that acts on MRSA (MIC: 0.125 μg/ml), MRSE (MIC: 0.0625 μg/ml) and S. aureus (MIC: 0.0625 μg/ml).</p>Formule :C31H46N2O6SCouleur et forme :SolidMasse moléculaire :574.77FG-2101
CAS :<p>FG-2101 is a selective, orally active non-hydroxamate LpxC inhibitor with an IC50 of approximately 1 nM. It demonstrates exceptional selectivity over other bacterial and human metalloproteases. FG-2101 is useful for studying infections caused by Gram-negative bacteria, including resistant strains.</p>Formule :C30H32N5O6PCouleur et forme :SolidMasse moléculaire :589.579Antibacterial agent 77
<p>Antibacterial agent 77 (compound 12) is an antibacterial agent [1].</p>Formule :C22H27N3OSCouleur et forme :SolidMasse moléculaire :381.53HIV-1 inhibitor-61
CAS :<p>HIV-1 Inhibitor-61 (2c) serves as a potent inhibitor of HIV-1 reverse transcriptase, exhibiting an EC50 value of 0.07 nM in NL4-3 wt MT-4 cells [1].</p>Formule :C24H24F2N2O2SCouleur et forme :SolidMasse moléculaire :442.52GSK-3036656 free base
CAS :<p>GSK656 (GSK3036656) inhibits Mtb LeuRS with IC50 of 0.20 μM, promising for tuberculosis treatment.</p>Formule :C10H13BClNO4Couleur et forme :SolidMasse moléculaire :257.48PptT-IN-3
<p>PptT-IN-3 (5p), an inhibitor of PptT in Mycobacterium tuberculosis, IC50=3.5μM, is key for TB research.</p>Formule :C16H27N5O3SCouleur et forme :SolidMasse moléculaire :369.48RhlR antagonist 1
<p>RhlR antagonist 1: IC50 of 26 μM, selective for RhlR, inhibits P. aeruginosa biofilm and virulence factors.</p>Formule :C12H10F2OCouleur et forme :SolidMasse moléculaire :208.2HBV-IN-18
<p>HBV-IN-18 (Compound 3) is an HBV capsid assembly modulator (CpAM) (EC50: 2790 nM).</p>Formule :C17H15F6N5O2Couleur et forme :SolidMasse moléculaire :435.32SARS-CoV-2 3CLpro-IN-32
CAS :<p>SARS-CoV-2 3CLpro-IN-32 (compound B16) is a potent inhibitor of the SARS-CoV-2 3CLpro enzyme, with an IC50 of 0.109 μM. It also demonstrates antiviral activity against the coronavirus HCoV-OC43, with an EC50 of 1.99 μM.</p>Formule :C30H37N3O4S3Couleur et forme :SolidMasse moléculaire :599.83HBV/HDV-IN-3
CAS :<p>HBV/HDV-IN-3 (Compd 1) acts as a dual inhibitor for HBV and HDV, demonstrating an efficacy (EC 50) below 50 nM against HBV .</p>Formule :C28H27BrF3N5O3Couleur et forme :SolidMasse moléculaire :618.44Chitin synthase inhibitor 8
<p>Chitin synthase inhibitor 8 is a chitin synthase (CHS) inhibitor with broad-spectrum antifungal effects that can be used in studies related to fungal infections</p>Formule :C23H23N3O5Couleur et forme :SolidMasse moléculaire :421.45NS2B/NS3-IN-5
<p>Compound 25b inhibits DENV2/ZIKV NS2B/NS3 proteases; IC50: ZIKV 0.67μM, DENV2 4.38μM.</p>Formule :C14H9IN2O3SCouleur et forme :SolidMasse moléculaire :412.2BM635 hydrochloride
<p>BM635 hydrochloride, an MmpL3 inhibitor, strongly blocks Divergent bacteriophage H37Rv (MIC50: 0.08 μM), with doubled in vivo potency.</p>Formule :C25H30ClFN2OCouleur et forme :SolidMasse moléculaire :428.97NIP-22c
CAS :<p>NIP-22c, a novel inhibitor of coronavirus 3CL pro, exhibits antiviral activity [1]. The compound's EC50 values are 4.6 μM for Verona, 1.1 μM for Calu3, 0.1 μM for Caco2, and 0.6 μM for HBTEC-ALI.</p>Formule :C32H39N5O6Couleur et forme :SolidMasse moléculaire :589.68HCV-IN-40
CAS :<p>HCV-IN-39 is a potent oral drug inhibiting HCV, effective on GT1a (EC50: 0.259μM), GT1b (EC50: 0.434μM), GT1b CES1 (EC50: 0.069μM) replicons.</p>Formule :C21H26BrFN3O9PCouleur et forme :SolidMasse moléculaire :594.32
