Microbiologie/Virologie

<p>Compound B01, an antifungal, inhibits Candida albicans in vitro/vivo for invasive fungal infection research.</p>

<p>Cefalexin lysine is a derivative of Cefalexin which is an antibiotic.</p>

<p>Spergualin trihydrochloride is a natural product that first identified as an antibiotic from culture filtrates of Bacillus laterosporus BMG162-aF2[1].</p>

<p>DHODH-IN-16 is an effective inhibitor of dihydroorotate dehydrogenase (DHODH, IC50 = 0.396 nM for human).</p>

<p>Malachite Green Carbinol Base (MGOH, MGCB), non-fluorescent MG derivative, changes color under UV, releasing OH- for pH shift.</p>

<p>5'-O-TBDMS-dU can be used in the synthesis of oligoribonucleotides.</p>

<p>HIV-1 inhibitor-11, a fused pyridine ring derivative, is a HIV-1 inhibitor.</p>

<p>2,2-Dibromopropanoic acid, with two bromines, is a propionic acid derivative used as a mold inhibitor and food preservative.</p>

<p>BI-1230 is a potent inhibitor of HCV NS3 protease, exhibiting efficacy in the low nanomolar range, and notably suppresses viral replication.</p>

<p>EDA-DA is a probe for labeling bacterial cell wall Peptidoglycan, crucial for division and shape.</p>

<p>PT-129 is a RPOTAC degrader that targets the G3BP1/2NTF2 domain (protein-RNA interaction site), facilitating the breakdown of intracellular stress granules. It prevents the formation of stress granules in stressed cells and deconstructs existing ones, thereby disrupting ATF4 transmission and inhibiting cancer cell proliferation. Stress granules (SGs) are membraneless cytoplasmic compartments formed under stress, which aid in the transfer of ATF4 from fibroblasts to tumor cells, promoting fibroblast-related tumor growth. G3BP1/2 serve as central proteins in the SG network, and inhibiting them may reduce the stress resilience of cancer cells within the tumor microenvironment. PT-129 consists of a target protein ligand (red part) G3BP1/2-Targeting ligand-1, an E3 ligase ligand (blue part) Thalidomide 4-fluoride, and a PROTAC linker (black part) Amino-PEG3-C2-acid; the E3 ligase ligand and linker form the complex Thalidomide-NH-PEG3-propionic acid.</p>

<p>Epicoccone B from C. globosum has DPPH scavenging (IC50=10.8μM) and α-glucosidase inhibition (IC50=27.3μM), also anti-HIV.</p>

<p>7-Oxoganoderic acid Z is a useful organic compound for research related to life sciences. The catalog number is T123920 and the CAS number is 929248-72-6.</p>

<p>Antimicrobial agent-36 (Compound 8b) is an antimicrobial compound that significantly inhibits DNA gyrase with an IC50 value of 4.56 µM. It is also utilized in the preparation of nanoparticle drug formulations and can be employed in the research and development of new antibiotics.</p>

<p>SD49-7 is an inhibitor of histone lysine demethylase 4 (KDM4) with an IC50 of 0.19 µM.</p>

<p>Amoxicillin + potassium clavulanate (4:1) is a broad-spectrum, well-absorbed oral antibiotic blocking cell wall synthesis.</p>

<p>Trinactin is a nonactin homolog that has Immunosuppressive effects.</p>

<p>Ditiocarb speeds up copper cementation, cuts HIV risk, and boosts high-risk breast cancer immunoresearch.</p>

<p>Metallo β-lactamase ligand 1 is an inhibitor of class B β-lactamase exhibiting antibacterial activities.</p>

<p>Pirlimycin Hydrochloride, a Clindamycin analog, is a semi-synthetic lincosaminide antibiotic.</p>