Microbiologie/Virologie

<p>Chitin Synthase Inhibitor 14 (compound 4n), a potent chitin synthase (CHS) inhibitor, exhibits antifungal activity and is effective against drug-resistant</p>

<p>Mpro 61 is a potent non-covalent inhibitor of SARS-CoV-2 main protease.</p>

<p>AZD-7295 (A-689) is an NS5A inhibitor that may be used to treat HCV infection.</p>

<p>SARS-CoV-2-IN-69 (Compound 7E) is a potent, non-covalent inhibitor of the SARS-CoV-2 main protease (M^pro) with an EC50 of 7.4 μM and also inhibits the papain-</p>

<p>S-Adenosylhomocysteine (SAH) hydrolase is responsible for the reversible hydrolysis of SAH into adenosine and homocysteine. Inhibition of this enzyme leads to the accumulation of SAH within cells, thereby increasing the SAH to S-adenosylmethionine (SAM) ratio and subsequently inhibiting SAM-dependent methyltransferases. (−)-Neplanocin A, a potent and irreversible inhibitor of SAH hydrolase (Ki= 8.39 nM), exhibits significant antitumor activity against mouse leukemia L1210 cells and holds broad-spectrum antiviral properties. Its efficacy notably surpasses that of the reversible inhibitor 3-deazaneplanocin, especially in combating vesicular stomatitis, evidencing a higher potency with ID50 values of 0.07 μg/ml for Neplanocin A versus 0.3 μg/ml for 3-deazaneplanocin.</p>

<p>U 89360E is a peptidic inhibitor.</p>

<p>6-Chloro-7-deazapurine-β-D-riboside shows antifungal activity.</p>

<p>Debrisoquin (Isocaramidine) is a TMPRSS2 inhibitor that prevents SARS-CoV-2 from entering human lung cells through TMPRSS2-dependent pathways, exhibiting an</p>

<p>DHX9-IN-4 is an ATP-dependent RNA helicase DHX9 inhibitor used in cancer research.</p>

<p>Elastase LasB-IN-1 (Compound 4b), a potent and selective inhibitor of elastase LasB, exhibits antibacterial activity and has been determined to possess an IC50</p>

<p>RAD51-IN-4, a potent RAD51 inhibitor, may be useful in researching mitochondrial defect-related conditions.</p>

<p>3β-Hydroxy-hop-22(29)-ene is a potent antiparasitic compound demonstrating moderate efficacy against Trypanosoma cruzi and Leishmania mexicana.</p>

<p>IR415 selectively interacts with Hepatitis B virus X protein (HBx, Kd = 2 nM) and blocks HBV-mediated RNAi suppression, reverses the inhibitory effect of HBx</p>

<p>EBOV-IN-1 is an adamantane dipeptide piperazine inhibitor of Ebola virus (EBOV) that inhibits EBOV infection and suppresses pseudotypic EBOV infection.</p>

<p>CcpA-IN-1 is a Staphylococcus aureus antibiotic exhibiting significant bactericidal activity (MICs=460 nM) [1].</p>

<p>FR194738 free base inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM. </p>

<p>2-Dodecanol suppresses both hyphal development and SIR2 gene expression in Candida albicans [1].</p>

<p>HBV-IN-30, a flavone derivative, inhibits cccDNA in HBV research.</p>

<p>Phenethicillin sodium (α-Phenoxyethylpenicillin) is a penicillin-class antibiotic that exhibits antimicrobial activity [1].</p>

<p>(-)-Verazine is an antifungal agent isolated from the dried roots and rhizome of Veratrum maackii Regel, which induces DNA damage in the cerebellum and cerebral</p>

<p>Cyclopropavir (Filociclovir; MBX-400) is a broad-spectrum anti-herpes drug effective against CMV and HHV-6/8 (EC50: 0.7-8 μM).</p>

<p>PC786 is a potent and selective non-nucleoside RSV L-protein polymerase inhibitor for inhalation therapy of RSV infections,antiviral activity against RSV.</p>

<p>ALS-8112 is a inhibitor of respiratory syncytial virus (RSV) polymerase. The 5'-triphosphate form of ALS-8112 inhibits RSV polymerase (IC50: 0.02 μM).</p>

<p>Levofuraltadone is an antiprotozoal and antibacterial agent.</p>

<p>HIV-1 integrase inhibitor 3 is an HIV-1 integrase strand transfer (INST) inhibitor (IC50: 2.7 nM).</p>

<p>CDD-1845, a non-covalent, non-peptide inhibitor, exhibits potent inhibition of SARS-CoV-2 M^pro with a K_i value of 3 nM.</p>

<p>Dihydroaltenuene B inhibits mushroom tyrosinase (IC50: 38.33µM) and binds His244, Met280, Gly281 via hydrogen bonds.</p>

<p>Tirapiravir is an antiviral nucleoside analog that exhibits activity against both the novel coronavirus and influenza virus [1].</p>

<p>FIKK9.1-IN-1 (Compound 1), an antimalarial agent (IC50: 2.68 μg/mL), serves as a FIKK9.1 inhibitor by interacting with the ATP-binding residues within FIKK9.1,</p>

<p>Galidesivir inhibits RdRP; has broad antiviral effects on various RNA viruses; effective against Ebola, Marburg in animals.</p>

<p>Laninamivir Octanoate Monohydrate is a neuraminidase inhibitor.</p>

<p>Rosoxacin (Acrosoxacin) shows antibacterial activities against a broad spectrum of Gram-negative bacteria including Neisseria gonorrhoeae (MIC90 = 0.03mg/ml).</p>

<p>Compound 5k (Antiproliferative Agent-18) is an antiproliferative agent that exhibits moderate antibacterial and antifungal activities [1].</p>

<p>Antifungal agent 77 (Compound 13h) exhibits not only antifungal properties, but also effective insecticidal activity against Mythimna separata, Helicoverpa</p>

<p>CGP 20376: Benzothiazole anthelmintic, modulates eosinophil burst, antifibrillatory, dose-dependent effects.</p>

<p>(+)-Thienamycin, a powerful broad-spectrum antibacterial and β-lactamase inhibitor, is isolated from Streptomyces cattleya [1].</p>

<p>Ianthelliformisamine B TFA, an antibiotic enhancer, is used to against resistant Gram-negative bacteria.</p>

<p>HBV-IN-17 (compound 8) is a potent regulator of HBV capsid assembly (EC50: 511 nM).</p>

<p>FX-06 (Fibrin-derived peptide Bβ15-42) is a peptide derived from the fibrin Bbeta chain.</p>

<p>DB-766: Chagas' treatment candidate with potent, selective trypanocidal action. IC50: 60 nM (bloodstream), 25 nM (intracellular). Promising new lead.</p>

<p>SARS-CoV-2-IN-44, an inhibitor of SARS-CoV-2, effectively suppresses viral replication with an EC50 value of 0.6μM and exhibits negligible cytotoxicity in Calu-</p>

<p>GSK-625433: Homochiral inhibitor blocks HCV genotypes 1a/1b polymerase.</p>

<p>HCV-IN-43 (compound 2), an HCV NS5B protein inhibitor, efficiently inhibits HCV virus replication and is utilized in the study of HCV infection [1].</p>

<p>Antibacterial agent 92 inhibits Salmonella's aaRS; IC50 of 0.58 μM for Se ThrRS. Exhibits antibacterial effects.</p>

<p>Cochliodone A, a bioactive compound isolated from the deep-sea fungus Chaetomium sp., exhibits both antibacterial and anticancer properties.</p>

<p>Glycolithocholic acid 3-sulfate (disodium) demonstrates inhibitory effects on in vitro HIV-1 replication and has potential applications in HIV infection and</p>

<p>Pyrethrin II, an active insecticidal component of pyrethrins, is a biogenic insecticide derived from Chrysanthemum cinerariifolium [1].</p>

<p>ddUTP (2′,3′-Dideoxyuridine-5′-triphosphate) serves as a selective inhibitor of HIV and AMV reverse transcriptases with Ki values of 0.05 µM for HIV and 1 µM</p>

<p>ZINC03129319 is an inhibitor of dengue virus (DENV) NS2B-NS3 protease.</p>

<p>JNJ4796 is an oral fusion inhibitor that neutralizes influenza A group 1 by blocking HA-mediated fusion, mimicking bnAbs.</p>