Microbiologie/Virologie

<p>Brevicompanine B: fungal metabolite, regulates plant growth/circadian rhythm, inhibits Arabidopsis roots, affects gene transcription, anti-P. falciparum.</p>

<p>Photosensitizer-1 shows promise in treating infections, effective against S. aureus in mouse wounds.</p>

<p>Talviraline (HBY 097) inhibits HIV-1 replication and reduces cell death in various cells and immune cells.</p>

<p>HBV-IN-6 is a potent inhibitor of HBV (EC50: 287.9 nM).</p>

<p>Zika virus-IN-2 (Compd 3) is a Zika virus inhibitor (EC 50= 7.4 μM).</p>

<p>Compound 17b, an amino alcohol-quinoline, targets Pf3D7 (IC50: 14.9 nM) and PfW2 (IC50: 11 nM) with selectivity index &gt;770.</p>

<p>WRNA10 is a potent binding agent for HIV-1TAR RNA (IC50: 10 μM, CC50: 40 μM).</p>

<p>Lagociclovir valactate is a prodrug of Lagociclovir . Lagociclovir valactate is an orally active anti- HBV agent [1] .</p>

<p>T145 halts key bacteria growth at sub μg/ml, deters resistance, and may enhance drug lifespan.</p>

<p>Ulonivirine is an orally active non-nucleoside reverse transcriptase inhibitor that exhibits high antiviral activity and can be used to study HIV-1 infection.</p>

<p>AB-836, an orally active hepatitis B virus (HBV) capsid inhibitor, hampers viral replication by engaging with the HBV core protein.</p>

<p>Teropavimab (3BNC117-LS), an antibody, is utilized in the research of HIV infection [1].</p>

<p>Cladosporin, from Cladosporium cladosporioid fungus, halts dermatophyte growth on agar at 75 μg/mL.</p>

<p>HBV-IN-30, a flavone derivative, inhibits cccDNA in HBV research.</p>

<p>Oxamniquine is an effective compound for the treatment of schistosomiasis.</p>

<p>AVG-233 is an RNA-dependent RNA polymerase (RdRp) inhibitor with antiviral activity for the study of respiratory syncytial virus infections.</p>

<p>3β-Hydroxy-hop-22(29)-ene is a potent antiparasitic compound demonstrating moderate efficacy against Trypanosoma cruzi and Leishmania mexicana.</p>

<p>Myxopyronin A is an inhibitor of bacterial RNA polymerase.</p>

<p>SARS-CoV-2/MERS Mpro-IN-2 is a potent inhibitor of the main proteases of SARS-CoV-2 and MERS, demonstrating IC50 values of 0.21 and 0.07 µM, respectively.</p>

<p>EHNA hydrochloride is a PDE2 and ADA inhibitor with anticancer activity, increasing intracellular adenosine concentration in a treatment time-dependent manner.</p>

<p>Antiviral agent 43 (compound 16) serves as a potent, orally active inhibitor of influenza A virus entry, demonstrating efficacy by inhibiting the replication of the influenza A strains VH04-H5N1 and PR8-H1N1 with EC50 values of 240 nM and 72 nM, respectively [1].</p>

<p>L-742001 Hydrochloride is an RNA polymerase inhibitor.</p>

<p>U 89360E is a peptidic inhibitor.</p>

<p>S-Adenosylhomocysteine (SAH) hydrolase is responsible for the reversible hydrolysis of SAH into adenosine and homocysteine. Inhibition of this enzyme leads to the accumulation of SAH within cells, thereby increasing the SAH to S-adenosylmethionine (SAM) ratio and subsequently inhibiting SAM-dependent methyltransferases. (−)-Neplanocin A, a potent and irreversible inhibitor of SAH hydrolase (Ki= 8.39 nM), exhibits significant antitumor activity against mouse leukemia L1210 cells and holds broad-spectrum antiviral properties. Its efficacy notably surpasses that of the reversible inhibitor 3-deazaneplanocin, especially in combating vesicular stomatitis, evidencing a higher potency with ID50 values of 0.07 μg/ml for Neplanocin A versus 0.3 μg/ml for 3-deazaneplanocin.</p>

<p>Antileishmanial agent-23 (compound G1/9), a potent and selective trypanothione reductase (TR) inhibitor, exhibits an IC50 of 2.24 ± 0.52 μM.</p>

<p>Emtricitabine triphosphate tetrasodium salt is the tetrasodium salt form of the phosphorylated anabolite (-)-Emtricitabine triphosphate, an active nucleoside</p>

<p>SARS-CoV-2-IN-66 (1), a derivative of vitamin K, functions as an inhibitor of SARS-CoV-2, exhibiting an effective concentration (EC50) of 70.8 μM in VeroE6/</p>

<p>L 680833 is an orally active monocyclic beta-lactam human polymorphonuclear leukocyte elastase inhibitor.</p>

<p>Ibuzatrelvir (PF-07817883) is an antiviral compound designed to inhibit the SARS-CoV-2 3CL protease, and is utilized in the treatment of COVID-19 [1].</p>

<p>RSV L-protein-IN-5 (Compound E) serves as a potent inhibitor of the Respiratory Syncytial Virus (RSV), with an EC50 value of 0.1 μM.</p>

<p>Oxynitidine, an HBV inhibitor (ID50 = 30.8 µg/mL), effectively suppresses HBV DNA replication and may be utilized in viral infection research [1].</p>

<p>ISPA-28: reversible PSAC antagonist via direct CLAG3 binding.</p>

<p>BLI-489 hydrate is a penicillin β-lactamase inhibitor that acts on classes A and C and some class D β-lactamases.</p>

<p>HCoV-OC43-IN-1 (Compound IV-16) serves as an inhibitor of the coronavirus HCoV-OC43, exhibiting antiviral efficacy with an EC50 of 90 nM.</p>

<p>SARS-CoV-2 3CLpro-IN-15 (compound a), a beta-nitrostyrene derivative, acts as an inhibitor of the SARS-CoV-2 3CL protease (3CLpro), effectively inhibiting viral</p>

<p>G4/HDAC-IN-1, a G4/HDAC dual inhibitor, IC50 1.1 µM, blocks TNBC growth, useful in cancer research.</p>

<p>Compound 8h, also known as SARS-CoV-2-IN-43, is a powerful inhibitor effective in obstructing the replication of SARS-CoV-2, exhibiting significant antiviral</p>

<p>HIV-1 inhibitor-10 is a nanomolar HIV-1 maturation inhibitor.</p>

<p>RyRs activator 2: potent ranibulin receptor stimulant, 30% larvicidal activity, equals chlorfenvinphos, outperforms cyanobenzamide.</p>

<p>Peptide 46 is a short peptide that inhibits SC-dependent DNA synthesis by targeting the bacterial sliding clamp (SC).</p>

<p>Phylloflavan, an antileishmanial compound, exhibits an intracellular half maximal effective concentration (EC50) of 3.2 nM in RAW 264.7 cells and inhibits the</p>

<p>Amoxicillin-clavulanate potassium is an orally administered antibiotic and combination agent indicated for various bacterial infections.</p>

<p>Antimalarial agent 15 halts Plasmodium falciparum growth with a 20 nM IC50.</p>

<p>Tobevibart, an IgG1-lambda humanized monoclonal antibody targeting the hepatitis B virus (HBV) surface envelope protein, exhibits antiviral activity [1].</p>

<p>ThrRS-IN-3: Potent inhibitor of Salmonella enterica ThrRS, IC50 = 19 nM, Kd = 34 nM, with antibacterial effects.</p>

<p>RSV L-protein-IN-4 (Compound C) is a noncompetitive inhibitor of the RSV polymerase with an IC50 of 0.88 μM.</p>

<p>Zika virus-IN-1 is an inhibitor of Zika virus (EC50: 1.56 μM).</p>

<p>BILR-355 is a reverse transcriptase inhibitor.</p>

<p>SARS-CoV-2-IN-69 (Compound 7E) is a potent, non-covalent inhibitor of the SARS-CoV-2 main protease (M^pro) with an EC50 of 7.4 μM and also inhibits the papain-</p>

<p>SA09-Cu is a potent, noncompetitive inhibitor of NDM-1, with an IC50 of 9.6 nM.</p>