Microbiologie/Virologie

Nodusmicin: a macrolide antibiotic effective against S. aureus, including resistant strains; MIC: UC-76 (125), UC-6685 (250), UC-6690 (250 μg/ml).

DFTamP1 is an antimicrobial peptide that exhibits activity against Staphylococcus aureus USA300, with a minimum inhibitory concentration (MIC) of 3.1 μM [1].

PROTACSARS-CoV-2 Degrader-1 (Compound LLP019) is a PROTAC degrader that targets the main protease (MPro) of SARS-CoV-2 with a DC50 value of 4.7 μM. It facilitates the ubiquitination and proteasomal degradation of MPro, thereby hindering the replication of SARS-CoV-2. This compound holds potential for research into COVID-19 and related coronavirus infections.

CK 683A is a bio-active chemical.

NDM-1 inhibitor-8 (Compound 18b) is a covalent inhibitor of New Delhi metallo-β-lactamase-1 (NDM-1), with an IC50 of 7.03 μM. It effectively inhibits resistant bacterial strains and demonstrates synergistic antibacterial effects when used in combination with Meropenem. In mouse models, NDM-1 inhibitor-8 exhibits anti-infective activity.

furylacryloylglycyl leucinamide is a bioactive chemical.

AAP4 is a potent inhibitor of OfChi-h and OfHex1, exhibiting Ki values of 29.3 nM and 4.9 μM, respectively. It also demonstrates insecticidal activity against the lepidopteran pest Ostrinia furnacalis.

Hirsutide: a fungal peptide with antibacterial and antifungal properties (MICs: bacteria 6-25, fungi 6-25 μg/cm³).

Bactobolin A, a microbial metabolite initially derived from Pseudomonas, exhibits both antibiotic and anticancer properties.

Polynucleotide Kinase is a DNA repair enzyme. It exhibits 5'-kinase activity by catalyzing the transfer of phosphate from ATP to the 5'-hydroxyl (OH) end, and also shows 3'-phosphatase activity by converting the 3'-phosphate end into a 3'-OH end.

α-Guaiene, a sesquiterpene identified in P. cablin, showcases its presence within this species.

AR-201 is a human IgG1 monoclonal antibody that targets the F glycoprotein F0. It exhibits activity against the respiratory syncytial virus (RSV) and can be utilized in studies related to lower respiratory tract infections (LRTI). The recommended isotype control is HumanIgG1kappa, Isotype Control.

ddATP (lithium) (2',3'-Dideoxyadenosine 5'-triphosphate (lithium)) is an active metabolite of 2',3'-dideoxyinosine and acts as a chain extension inhibitor of DNA polymerase. It is employed in DNA sequencing using the Sanger method and is also used in studies related to viral infections.

Antibacterialagent 285 (Compound 3) is a cephalosporin antibiotic. It exhibits significant antibacterial activity against Gram-negative bacteria, with minimum inhibitory concentrations (MIC) of 0.125-0.5 μg/mL for carbapenem-resistant Acinetobacter baumannii (CRAB), 0.125-0.5 μg/mL for Klebsiella pneumoniae (CRE), and 0.125-2 μg/mL for Pseudomonas aeruginosa (CRPA). Antibacterialagent 285 can be utilized in bacterial infection research, including studies on complicated urinary tract infections (cUTI) and kidney infections.

Lucanthone N-oxide is a bioactive chemical.

5-Azacytidine 5'-triphosphate sodium, a cytidine analog, selectively inhibits the incorporation of [3 H]CTP into RNA by DNA-dependent RNA polymerase, without

Dactylocyclines: new tetracycline derivatives from Dactylosporangium fermentation, including isolated glycosides.

Brevinin-1, an antimicrobial peptide, originates from the skin secretions of the European green frog (Rana esculenta) [1].

Isochlortetracycline is an inactive alkaline product of the degradation of the broad-spectrum antibiotic chlortetracycline.

PF-1163A, a depsipeptide antifungal compound isolated from Penicillium, blocks ergosterol synthesis with an IC50 of 12 ng/ml. This compound specifically inhibits the enzyme ERG25p, a C-4 methyl oxidase in the ergosterol biosynthetic pathway, leading to its antifungal activity. Notably, in Saccharomyces cerevisiae modified to express ERG biosynthesis genes, PF-1163A exhibits an inhibition concentration (MIC value) of 12.5 µg/ml against ERG25p, though strains overexpressing ERG25p show resistance. Additionally, PF-1163A effectively suppresses the growth of Candida albicans (MIC = 8 µg/ml), without affecting other Candida species, Aspergillus fumigatus, or HepG2 cells. Remarkably, it enhances the efficacy of fluconazole against azole-resistant C. albicans strains, showing a significant decrease in MICs (1 and 0.0078 µg/ml alone and in combination, respectively). PF-1163A distinguishes itself from PF-1163B by its more polar nature.